FR2935143B1 - Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux - Google Patents

Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux

Info

Publication number
FR2935143B1
FR2935143B1 FR0855629A FR0855629A FR2935143B1 FR 2935143 B1 FR2935143 B1 FR 2935143B1 FR 0855629 A FR0855629 A FR 0855629A FR 0855629 A FR0855629 A FR 0855629A FR 2935143 B1 FR2935143 B1 FR 2935143B1
Authority
FR
France
Prior art keywords
alkyl
aminoalkylaminoalkylamide
epipodophyllotoxin
urea
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0855629A
Other languages
English (en)
French (fr)
Other versions
FR2935143A1 (fr
Inventor
Thierry Imbert
Yves Guminski
Jean Marc Barret
Anna Kruczynski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR0855629A priority Critical patent/FR2935143B1/fr
Priority to TW098127718A priority patent/TW201011034A/zh
Priority to US12/737,645 priority patent/US8288567B2/en
Priority to BRPI0917237A priority patent/BRPI0917237A2/pt
Priority to PCT/EP2009/060739 priority patent/WO2010020663A1/en
Priority to JP2011523421A priority patent/JP5558470B2/ja
Priority to UAA201103228A priority patent/UA106876C2/uk
Priority to MX2011001348A priority patent/MX2011001348A/es
Priority to EP09782006.2A priority patent/EP2326653B1/en
Priority to CN200980132593.4A priority patent/CN102131814B/zh
Priority to NZ590625A priority patent/NZ590625A/en
Priority to AU2009284086A priority patent/AU2009284086B2/en
Priority to GEAP200912109A priority patent/GEP20125689B/en
Priority to HK11110954.0A priority patent/HK1156621B/xx
Priority to RU2011108485/04A priority patent/RU2529676C2/ru
Priority to CA2733688A priority patent/CA2733688A1/en
Priority to ARP090103186A priority patent/AR073089A1/es
Priority to KR1020117003236A priority patent/KR20110041513A/ko
Publication of FR2935143A1 publication Critical patent/FR2935143A1/fr
Application granted granted Critical
Publication of FR2935143B1 publication Critical patent/FR2935143B1/fr
Priority to ZA2011/00650A priority patent/ZA201100650B/en
Priority to MA33569A priority patent/MA32513B1/fr
Priority to IL211268A priority patent/IL211268A0/en
Priority to US13/551,119 priority patent/US8492567B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR0855629A 2008-08-19 2008-08-19 Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux Expired - Fee Related FR2935143B1 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR0855629A FR2935143B1 (fr) 2008-08-19 2008-08-19 Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux
TW098127718A TW201011034A (en) 2008-08-19 2009-08-18 New (poly) aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
CA2733688A CA2733688A1 (en) 2008-08-19 2009-08-19 New (poly)aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
PCT/EP2009/060739 WO2010020663A1 (en) 2008-08-19 2009-08-19 New (poly)aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
JP2011523421A JP5558470B2 (ja) 2008-08-19 2009-08-19 エピポドフィロトキシンの新規な（ポリ）アミノアルキルアミノアルキルアミド、アルキル−尿素またはアルキル−スルホンアミド誘導体、それらの製造方法、および治療における抗癌剤としてのそれらの応用
UAA201103228A UA106876C2 (uk) 2008-08-19 2009-08-19 (полі)аміноалкіламіноалкіламідні, алкілсечовинні або алкілсульфонамідні похідні епіподофілотоксину, спосіб їх одержання та їх застосування в терапії як протиракових засобів
MX2011001348A MX2011001348A (es) 2008-08-19 2009-08-19 Nuevos derivados de (poli)aminoalquilamino, alquil-urea, o alquilsulfonamida de la epipodofilotoxina, un proceso para prepararlos y su aplicacion en la terapia como agentes anticancer.
EP09782006.2A EP2326653B1 (en) 2008-08-19 2009-08-19 New (poly)aminoalkylaminoalkyl-urea derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
CN200980132593.4A CN102131814B (zh) 2008-08-19 2009-08-19 新型表鬼臼毒素的(多)氨基烷基氨基烷基酰胺、烷基-脲或烷基-磺酰胺衍生物、其制备方法及其作为抗癌剂在治疗中的用途
NZ590625A NZ590625A (en) 2008-08-19 2009-08-19 New (poly)aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
AU2009284086A AU2009284086B2 (en) 2008-08-19 2009-08-19 New (poly)aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
GEAP200912109A GEP20125689B (en) 2008-08-19 2009-08-19 New (poly)aminoalkylaminoalkylamide, alkyl-urea, or alkylsulfonamide derivatives of epipodophyllotoxin, preparation process thereof, and application thereat therapy as anticancer agents
US12/737,645 US8288567B2 (en) 2008-08-19 2009-08-19 (Poly) aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
RU2011108485/04A RU2529676C2 (ru) 2008-08-19 2009-08-19 Новые (поли)аминоалкиламиноалкиламидные, алкил-мочевинные или алкил-сульфонамидные производные эпиподофиллотоксина, способ их получения и их применение в терапии в качестве противораковых средств
BRPI0917237A BRPI0917237A2 (pt) 2008-08-19 2009-08-19 derivados de (poli)aminoalquilaminoalquilamida, alquil-ureia, ou alquilsulfonamida de epipodofilotoxina, um processo para prepará-los, e aplicação dos mesmos em terapia como agentes anticâncer
ARP090103186A AR073089A1 (es) 2008-08-19 2009-08-19 DERIVADOS DE (POLI)AMINOALQUILAMINOALQUILAMIDAS, ALQUIL-UREA O ALQUILSULFONAMIDA DE EPIPODOFILOTOXINA, UN PROCESO PARA PREPARARLOS, SU APLICACIoN EN TERAPIA COMO AGENTES ANTICANCER Y COMPOSICION FARMACEUTICA QUE LOS CONTIENEN.
KR1020117003236A KR20110041513A (ko) 2008-08-19 2009-08-19 에피포도필로톡신의 새로운 (폴리)아미노알킬아미노알킬아미드, 알킬-우레아, 또는 알킬-술폰아미드 유도체, 이들 제조방법, 및 항암제로서의 치료적 용도
HK11110954.0A HK1156621B (en) 2008-08-19 2009-08-19 New (poly)aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
ZA2011/00650A ZA201100650B (en) 2008-08-19 2011-01-26 New (poly)aminoalkylaminoalkylamide,alkyl-urea,or alkyl-sulfonamide derivatives of epipodophyllotoxin,a process for preparing them,and application thereof in therapy as anticancer agents
MA33569A MA32513B1 (fr) 2008-08-19 2011-01-28 Nouveaux derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeutique comme agent anticancereux
IL211268A IL211268A0 (en) 2008-08-19 2011-02-17 New (poly) aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
US13/551,119 US8492567B2 (en) 2008-08-19 2012-07-17 (Poly)Aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0855629A FR2935143B1 (fr) 2008-08-19 2008-08-19 Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux

Publications (2)

Publication Number Publication Date
FR2935143A1 FR2935143A1 (fr) 2010-02-26
FR2935143B1 true FR2935143B1 (fr) 2010-12-03

Family

ID=40332868

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0855629A Expired - Fee Related FR2935143B1 (fr) 2008-08-19 2008-08-19 Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux

Country Status (20)

Country Link
US (2) US8288567B2 (enExample)
EP (1) EP2326653B1 (enExample)
JP (1) JP5558470B2 (enExample)
KR (1) KR20110041513A (enExample)
CN (1) CN102131814B (enExample)
AR (1) AR073089A1 (enExample)
AU (1) AU2009284086B2 (enExample)
BR (1) BRPI0917237A2 (enExample)
CA (1) CA2733688A1 (enExample)
FR (1) FR2935143B1 (enExample)
GE (1) GEP20125689B (enExample)
IL (1) IL211268A0 (enExample)
MA (1) MA32513B1 (enExample)
MX (1) MX2011001348A (enExample)
NZ (1) NZ590625A (enExample)
RU (1) RU2529676C2 (enExample)
TW (1) TW201011034A (enExample)
UA (1) UA106876C2 (enExample)
WO (1) WO2010020663A1 (enExample)
ZA (1) ZA201100650B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102603761B (zh) * 2012-02-02 2013-12-25 华东师范大学 含有异羟肟酸结构的表鬼臼毒化合物及制备方法和用途
CN103664977B (zh) * 2013-12-26 2018-01-30 天津工业大学 4‑斯德酮取代苯氨基表鬼臼毒素衍生物及其制备方法和应用
CN104945409A (zh) * 2015-05-15 2015-09-30 东华大学 一种抗肿瘤活性化合物鬼臼毒素ppt的前药及其制备方法
CN110294764B (zh) * 2019-07-15 2021-04-20 中国科学院兰州化学物理研究所 一种偶氮键连接的鬼臼毒素衍生物及其制备方法
CN113200994B (zh) * 2021-04-27 2022-05-17 济宁市第一人民医院 鬼臼毒素羧酸酯类衍生物在制备抗肿瘤产品中的应用
CN113214281B (zh) * 2021-05-19 2022-05-17 济宁市第一人民医院 一类苯磺酰胺苯丁酸鬼臼毒素酯类衍生物的合成及在抗癌药物中的应用
CN113801129A (zh) * 2021-09-30 2021-12-17 大连民族大学 一种鬼臼毒素脂质衍生物、纳米载体及其制备方法和在肿瘤治疗中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300500A (en) * 1989-02-23 1994-04-05 The University Of North Carolina At Chapel Hill 4 beta-amino podophyllotoxin analog compounds and methods
TW221441B (enExample) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
FR2742439B1 (fr) 1995-12-14 1998-03-06 Pf Medicament Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine
FR2810321B1 (fr) * 2000-06-20 2002-07-26 Adir Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1377588B1 (en) 2002-03-28 2005-08-10 Council of Scientific and Industrial Research 4-beta-1''-[(2''-(substituted benzoyl)anilino] podophyllotoxin analogues useful as anticancer agents
US6566393B1 (en) * 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof
US7176236B2 (en) * 2002-06-21 2007-02-13 University Of North Carolina At Chapel Hill Water-soluble etoposide analogs and methods of use thereof
EP1599485A2 (en) * 2003-02-18 2005-11-30 Ranbaxy Laboratories, Ltd. Podophyllotoxin derivatives as antitumor agents
FR2859208B1 (fr) * 2003-09-02 2006-01-21 Servier Lab Nouveaux derives de 9-amino-podophyllotoxine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2869035B1 (fr) * 2004-04-16 2006-07-14 Pierre Fabre Medicament Sa Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
FR2921369B1 (fr) * 2007-09-25 2014-07-11 Pf Medicament Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux.

Also Published As

Publication number Publication date
JP5558470B2 (ja) 2014-07-23
NZ590625A (en) 2012-01-12
RU2011108485A (ru) 2012-09-27
RU2529676C2 (ru) 2014-09-27
US20110172257A1 (en) 2011-07-14
US20120283281A1 (en) 2012-11-08
KR20110041513A (ko) 2011-04-21
HK1156621A1 (en) 2012-06-15
CA2733688A1 (en) 2010-02-25
MX2011001348A (es) 2011-03-29
ZA201100650B (en) 2011-09-28
US8492567B2 (en) 2013-07-23
AR073089A1 (es) 2010-10-13
CN102131814A (zh) 2011-07-20
CN102131814B (zh) 2014-03-26
MA32513B1 (fr) 2011-07-03
FR2935143A1 (fr) 2010-02-26
GEP20125689B (en) 2012-11-12
WO2010020663A1 (en) 2010-02-25
JP2012500249A (ja) 2012-01-05
EP2326653A1 (en) 2011-06-01
EP2326653B1 (en) 2013-12-11
IL211268A0 (en) 2011-04-28
UA106876C2 (uk) 2014-10-27
US8288567B2 (en) 2012-10-16
BRPI0917237A2 (pt) 2015-11-10
TW201011034A (en) 2010-03-16
AU2009284086A1 (en) 2010-02-25
AU2009284086B2 (en) 2014-02-06

Similar Documents

Publication Publication Date Title
FR2962437B1 (fr) Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique
WO2008012470A3 (fr) Derives d'imidazolones substitues, preparation et utilisations
FR2935143B1 (fr) Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux
ZA200805939B (en) Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
IL205665A (en) The history of terroiril, the process of preparing them, the drugs containing them and their use in the preparation of drugs
WO2010141796A3 (en) PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES
EP2273975B8 (en) Pharmaceutical solutions, process of preparation and therapeutic uses
WO2007100902A3 (en) Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation
IL215065A (en) Proline derivatives, their preparation process, their pharmaceutical compositions and their uses in drug preparation
IL222120A (en) Annals (indole-1-yl) -carbonylalkyl, process for preparation, pharmaceutical preparations containing them and their use in the preparation of cancer drugs
IL203206A (en) 2-Amino Derivatives, 4-Amido Quinazoline, Drugs Containing and Using Theirs, and Process for Manufacturing
WO2010038081A3 (en) 4-amino-5- (hetero) aryl-2-phenylamino-pyrimidine or pyridine and their use as dna gyrase and/or topoisomerase iv inhibitors
EP2189452A4 (en) ASCORBINIC ACID DERIVATIVE OR SALT, MANUFACTURING METHOD AND COSMETIC PREPARATION
IL196280A0 (en) Use of ampk-activating imidazole derivatives, preparation process therefor and pharmaceutical compositions comprising them
FR2945534B1 (fr) DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
IL193341A0 (en) Novel azacyclyl-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments
FR2934596B1 (fr) Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
FR2937972B1 (fr) Derives d'oxoazetidine, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique
WO2007093880A3 (en) Novel pyrone-indole derivatives and process for their preparation
BRPI0811849A2 (pt) Composto, composição farmacêutica, e, métodos para preparar o compost e para tratar doenças ou condições mediadas por ccr1
FR2939433B1 (fr) Procede de preparation d'allophanate, allophanate et composition de faible viscosite comprenant l'allophanate
IL213983A (en) Derivatives of pyridazinone that are converted into heteroaryl, their process, their pharmaceutical preparations and their use in the preparation of drugs
IL212942A (en) History of Rifamycin, Methods of Preparation, Pharmaceutical Preparations Containing Them and Their Uses
IL205710A (en) History of Spiro [Pipyridine-Benzopyran] Pharmaceuticals Containing Them, Methods of Preparing and Using Their @
FR2945533B1 (fr) Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique

Legal Events

Date Code Title Description
CJ Change in legal form
PLFP Fee payment

Year of fee payment: 9

PLFP Fee payment

Year of fee payment: 10

PLFP Fee payment

Year of fee payment: 11

PLFP Fee payment

Year of fee payment: 12

ST Notification of lapse

Effective date: 20210405