MA32385B1 - Forme posologique pharmaceutique en capsule comprenant une formulation en suspension d'un derive d'indolinone - Google Patents
Forme posologique pharmaceutique en capsule comprenant une formulation en suspension d'un derive d'indolinoneInfo
- Publication number
- MA32385B1 MA32385B1 MA33402A MA33402A MA32385B1 MA 32385 B1 MA32385 B1 MA 32385B1 MA 33402 A MA33402 A MA 33402A MA 33402 A MA33402 A MA 33402A MA 32385 B1 MA32385 B1 MA 32385B1
- Authority
- MA
- Morocco
- Prior art keywords
- capsule
- dosage form
- pharmaceutical dosage
- suspension formulation
- indolinone derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne une formulation en suspension dont le principe actif est le 3-z-[1-(4- (n-((4-méthyl-pipérazin-1-yl)-méthylcarbonyl)-n-méthyl-amino)-anilino)-1-phényl-méthylène]-6- méthoxycarbonyl-2- indolinone-monoéthane-sulphonate. L'invention concerne également, d'une part une forme posologique pharmaceutique en capsule contenant ladite formulation en suspension, d'autre part un procédé d'élaboration de ladite formulation en suspension, mais aussi un procédé d'élaboration de ladite capsule comprenant ladite formulation en suspension, et également le matériau d'enveloppe de la capsule.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08157748 | 2008-06-06 | ||
PCT/EP2009/056878 WO2009147212A1 (fr) | 2008-06-06 | 2009-06-04 | Forme posologique pharmaceutique en capsule comprenant une formulation en suspension d'un dérivé d'indolinone |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32385B1 true MA32385B1 (fr) | 2011-06-01 |
Family
ID=40911908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33402A MA32385B1 (fr) | 2008-06-06 | 2010-12-06 | Forme posologique pharmaceutique en capsule comprenant une formulation en suspension d'un derive d'indolinone |
Country Status (35)
Country | Link |
---|---|
US (4) | US20110301177A1 (fr) |
EP (1) | EP2299987B1 (fr) |
JP (2) | JP5661031B2 (fr) |
KR (2) | KR101725469B1 (fr) |
CN (2) | CN105193720B (fr) |
AR (1) | AR072059A1 (fr) |
AU (1) | AU2009254548B2 (fr) |
BR (1) | BRPI0913434B8 (fr) |
CA (1) | CA2726267C (fr) |
CL (1) | CL2010001279A1 (fr) |
CO (1) | CO6280467A2 (fr) |
CY (1) | CY1120533T1 (fr) |
DK (1) | DK2299987T3 (fr) |
EA (1) | EA029996B1 (fr) |
EC (1) | ECSP10010660A (fr) |
ES (1) | ES2669469T3 (fr) |
HR (1) | HRP20180709T1 (fr) |
HU (1) | HUE039187T2 (fr) |
IL (1) | IL208954A (fr) |
LT (1) | LT2299987T (fr) |
MA (1) | MA32385B1 (fr) |
MX (2) | MX2010013203A (fr) |
MY (1) | MY158930A (fr) |
NO (1) | NO2299987T3 (fr) |
NZ (1) | NZ603162A (fr) |
PE (1) | PE20100254A1 (fr) |
PL (1) | PL2299987T3 (fr) |
PT (1) | PT2299987T (fr) |
RS (1) | RS57142B1 (fr) |
SI (1) | SI2299987T1 (fr) |
TW (1) | TW201002691A (fr) |
UA (1) | UA104590C2 (fr) |
UY (1) | UY31879A (fr) |
WO (1) | WO2009147212A1 (fr) |
ZA (1) | ZA201007636B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2299987T (lt) | 2008-06-06 | 2018-05-25 | Boehringer Ingelheim International Gmbh | Farmacinės vaisto formos kapsulė, apimanti indolinono darinio suspensijos kompoziciją |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
UA107560C2 (uk) * | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
JO3659B1 (ar) * | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
DK2575784T3 (en) | 2010-06-02 | 2018-10-15 | Astellas Deutschland Gmbh | ORAL DOSAGE FORMS OF BENDAMUSTIN |
GB201020032D0 (en) * | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
BR112015006363A2 (pt) | 2012-09-28 | 2017-08-08 | Boehringer Ingelheim Int | combinações farmacêuticas compreendendo ligantes angiopoietina-2/dll4 duplos e agentes anti-vegf-r |
US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
US20150209360A1 (en) * | 2014-01-30 | 2015-07-30 | Orbz, Llc | Oral caffeine delivery composition |
CN112156081A (zh) * | 2015-03-13 | 2021-01-01 | 江苏豪森药业集团有限公司 | 含有吲哚满酮衍生物混悬液的药物制剂及其制备方法 |
CN107019697A (zh) * | 2016-02-02 | 2017-08-08 | 瑞阳(苏州)生物科技有限公司 | 预防或治疗纤维化疾病的药物组合物及其应用 |
WO2018080795A1 (fr) * | 2016-10-25 | 2018-05-03 | Glykon Technologies Group, Llc | Composés d'acide hydroxycitrique et administration de liquide en capsule |
CN108066343A (zh) * | 2016-11-08 | 2018-05-25 | 瑞阳(苏州)生物科技有限公司 | 一种预防或治疗肾纤维化疾病的药物 |
WO2018108669A1 (fr) | 2016-12-12 | 2018-06-21 | Boehringer Ingelheim International Gmbh | Nintédanib destiné à être utilisé dans des méthodes de traitement de maladies pulmonaires interstitielles par co-administration d'olodatérol |
WO2018177893A1 (fr) | 2017-03-28 | 2018-10-04 | Boehringer Ingelheim International Gmbh | Nintedanib destiné à être utilisé dans des procédés de traitement de dystrophie musculaire |
CN107184549B (zh) * | 2017-04-11 | 2020-11-20 | 江苏大学 | 一种尼达尼布自微乳制剂和其制成的软胶囊及制备方法 |
AU2018357775B2 (en) | 2017-10-23 | 2024-02-15 | Boehringer Ingelheim International Gmbh | New combination of active agents for the treatment of progressive fibrosing interstitial lung diseases (PF-ILD) |
WO2019106692A1 (fr) * | 2017-11-29 | 2019-06-06 | Sun Pharmaceutical Industries Limited | Suspension orale de nintedanib esylate |
WO2019173653A1 (fr) | 2018-03-07 | 2019-09-12 | Pliant Therapeutics, Inc. | Composés d'acides aminés et leurs procédés d'utilisation |
TWI815137B (zh) | 2018-06-15 | 2023-09-11 | 漢達生技醫藥股份有限公司 | 尼洛替尼十二烷基硫酸鹽之結晶 |
CN113301884A (zh) * | 2018-09-13 | 2021-08-24 | 夫特弗制药私人有限公司 | 非水性化疗口服悬浮液 |
CN113164402A (zh) * | 2018-10-15 | 2021-07-23 | 希普拉有限公司 | 药物制剂 |
CN112386580B (zh) * | 2019-08-13 | 2022-07-08 | 齐鲁制药有限公司 | 具有改善的溶出度和稳定性的尼达尼布药物制剂、制备方法及其应用 |
JP2023504415A (ja) | 2019-12-04 | 2023-02-03 | イドーシア ファーマシューティカルズ リミテッド | 線維性疾患の治療に使用するためのアゼチジンlpa1受容体アンタゴニストのピルフェニドン及び/又はニンテダニブとの合剤 |
WO2021198253A1 (fr) | 2020-04-01 | 2021-10-07 | Boehringer Ingelheim International Gmbh | Utilisation de biomarqueurs dans le traitement d'états fibrotiques |
EP4098246A1 (fr) | 2021-05-31 | 2022-12-07 | Lotus Pharmaceutical Co., Ltd. | Formulation de nintedanib |
CN114404382B (zh) * | 2022-01-24 | 2023-05-12 | 南京康川济医药科技有限公司 | 乙磺酸尼达尼布软胶囊及其制备方法 |
WO2023161668A1 (fr) | 2022-02-28 | 2023-08-31 | Nuformix Technologies Limited | Compositions et méthodes de traitement de la fibrose pulmonaire idiopathique |
WO2024037982A1 (fr) | 2022-08-16 | 2024-02-22 | Boehringer Ingelheim International Gmbh | Formulations pharmaceutiques de nintédanib pour utilisation intraoculaire |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2870062A (en) | 1956-04-27 | 1959-01-20 | Scherer Corp R P | Gelatin composition for capsules |
GB8305693D0 (en) | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
DE3579384D1 (de) | 1984-07-24 | 1990-10-04 | Scherer Gmbh R P | Oxytetracyclin-hc1-weichgelatinekapseln und verfahren zu ihrer herstellung. |
GB9313329D0 (en) * | 1993-06-28 | 1993-08-11 | Scherer Ltd R P | Softgel capsule shell compositions |
DE19603402A1 (de) | 1995-02-24 | 1996-08-29 | Basf Ag | Weichgelatinekapseln |
US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
CZ20032959A3 (cs) * | 2001-05-01 | 2004-01-14 | Pfizer Products Inc. | Způsob přípravy farmaceutické kompozice s nízkou dávkou léčiva mající rovnoměrnou distribuci a účinnost léčiva |
DE10233500A1 (de) | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
US20060293260A1 (en) * | 2005-05-24 | 2006-12-28 | Wyeth | Useful high load concentrate compositions for control of ecto-and endo-parasites |
EP1948180B1 (fr) * | 2005-11-11 | 2013-03-13 | Boehringer Ingelheim International GmbH | Traitement combine du cancer comprenant des inhibiteurs de egfr/her2 |
UA107560C2 (uk) | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
KR101760657B1 (ko) * | 2008-06-06 | 2017-07-24 | 베링거 인겔하임 인터내셔날 게엠베하 | 약제학적 병용물 |
LT2299987T (lt) | 2008-06-06 | 2018-05-25 | Boehringer Ingelheim International Gmbh | Farmacinės vaisto formos kapsulė, apimanti indolinono darinio suspensijos kompoziciją |
US20120157472A1 (en) | 2009-01-14 | 2012-06-21 | Boehringer Ingelheim International Gmbh | Method for treating colorectal cancer |
US8802384B2 (en) | 2009-03-12 | 2014-08-12 | Boehringer Ingelheim International Gmbh | Method or system using biomarkers for the monitoring of a treatment |
JP2012526766A (ja) | 2009-05-14 | 2012-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 腫瘍性及び線維性疾患の処置における新規な併用療法 |
-
2009
- 2009-06-04 LT LTEP09757593.0T patent/LT2299987T/lt unknown
- 2009-06-04 CN CN201510660732.8A patent/CN105193720B/zh not_active Ceased
- 2009-06-04 AU AU2009254548A patent/AU2009254548B2/en active Active
- 2009-06-04 US US12/995,869 patent/US20110301177A1/en not_active Abandoned
- 2009-06-04 DK DK09757593.0T patent/DK2299987T3/en active
- 2009-06-04 PL PL09757593T patent/PL2299987T3/pl unknown
- 2009-06-04 NZ NZ60316209A patent/NZ603162A/en unknown
- 2009-06-04 NO NO09757593A patent/NO2299987T3/no unknown
- 2009-06-04 UA UAA201100098A patent/UA104590C2/ru unknown
- 2009-06-04 ES ES09757593.0T patent/ES2669469T3/es active Active
- 2009-06-04 JP JP2011512128A patent/JP5661031B2/ja active Active
- 2009-06-04 PT PT97575930T patent/PT2299987T/pt unknown
- 2009-06-04 EA EA201001856A patent/EA029996B1/ru not_active IP Right Cessation
- 2009-06-04 CA CA2726267A patent/CA2726267C/fr active Active
- 2009-06-04 KR KR1020107027317A patent/KR101725469B1/ko active IP Right Grant
- 2009-06-04 MX MX2010013203A patent/MX2010013203A/es active IP Right Grant
- 2009-06-04 HU HUE09757593A patent/HUE039187T2/hu unknown
- 2009-06-04 EP EP09757593.0A patent/EP2299987B1/fr active Active
- 2009-06-04 SI SI200931833T patent/SI2299987T1/en unknown
- 2009-06-04 KR KR1020177004310A patent/KR20170020557A/ko not_active Application Discontinuation
- 2009-06-04 MX MX2014006908A patent/MX359229B/es unknown
- 2009-06-04 MY MYPI2010005645A patent/MY158930A/en unknown
- 2009-06-04 WO PCT/EP2009/056878 patent/WO2009147212A1/fr active Application Filing
- 2009-06-04 PE PE2009000782A patent/PE20100254A1/es not_active Application Discontinuation
- 2009-06-04 RS RS20180491A patent/RS57142B1/sr unknown
- 2009-06-04 BR BRPI0913434A patent/BRPI0913434B8/pt active IP Right Grant
- 2009-06-04 CN CN200980121067.8A patent/CN102056598B/zh not_active Ceased
- 2009-06-05 TW TW098118825A patent/TW201002691A/zh unknown
- 2009-06-05 AR ARP090102039A patent/AR072059A1/es unknown
- 2009-06-08 UY UY0001031879A patent/UY31879A/es not_active Application Discontinuation
-
2010
- 2010-10-26 ZA ZA2010/07636A patent/ZA201007636B/en unknown
- 2010-10-26 IL IL208954A patent/IL208954A/en active IP Right Grant
- 2010-11-22 CL CL2010001279A patent/CL2010001279A1/es unknown
- 2010-12-03 CO CO10152519A patent/CO6280467A2/es not_active Application Discontinuation
- 2010-12-03 EC EC2010010660A patent/ECSP10010660A/es unknown
- 2010-12-06 MA MA33402A patent/MA32385B1/fr unknown
-
2013
- 2013-08-30 US US14/015,186 patent/US20140004187A1/en not_active Abandoned
-
2014
- 2014-08-11 JP JP2014163667A patent/JP5905542B2/ja active Active
-
2015
- 2015-10-07 US US14/877,132 patent/US20160022672A1/en not_active Abandoned
-
2016
- 2016-07-07 US US15/204,277 patent/US9907756B2/en active Active
-
2018
- 2018-05-07 HR HRP20180709TT patent/HRP20180709T1/hr unknown
- 2018-05-15 CY CY20181100499T patent/CY1120533T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA32385B1 (fr) | Forme posologique pharmaceutique en capsule comprenant une formulation en suspension d'un derive d'indolinone | |
MX2015003653A (es) | Derivados de amida del acido benzoimidazol-carboxilico como moduladores del receptor apj. | |
EA201590118A1 (ru) | Производные пирролидина и их применение в качестве модуляторов пути активации комплемента | |
TR201904614T4 (tr) | Novel pyrazole derivative. | |
BR112015000578A2 (pt) | moduladores da via do complemento e usos dos mesmos | |
MA39088B1 (fr) | Compositions et procédés pour moduler des récepteurs farnesoïde x | |
UA106636C2 (uk) | Морфолінотіазоли як позитивні алостеричні модулятори альфа 7 | |
EA201290654A1 (ru) | Новые замещенные триазольные производные как модуляторы гамма-секретазы | |
BR112014027841A8 (pt) | Derivado de pirazola e o uso do mesmo para fins médicos | |
CU23914B1 (es) | DERIVADOS DE 2-(1,5-DIHIDRO-5-OXO-1,2,4-TRIAZOL-4-IL/2-OXOIMIDAZOLIDIN-1-IL)PIRIDIN-4-CARBOXAMIDA ACTIVOS COMO MODULADORES DE ESTEAROIL CoA | |
EA201171363A1 (ru) | Новые замещенные производные индазола и азаиндазола в качестве модуляторов гамма-секретазы | |
IN2014MN00258A (fr) | ||
UA109421C2 (uk) | Фармацевтична композиція, яка містить ліганди сигма-рецептора | |
EA200801184A1 (ru) | Производные пипередин-4-ил-пиридазин-3-иламина как быстро диссоциирующие антагонисты рецептора дофамина 2 | |
EA201170829A1 (ru) | Замещенные бициклические производные имидазола в качестве модуляторов гамма-секретазы | |
EA201201050A1 (ru) | Пиразолы в качестве антагонистов crth2 | |
NO20092535L (no) | Fumaratsalt av (alfa S, beta R)-6-brom-alfa-[2-(dimetylamino)etyl]-2-metoksy-alfa-1-naftalenyl-beta-fenyl-3-kinolinetanol | |
NO20043367L (no) | Oralt farmasoytisk preparat | |
MA32386B1 (fr) | Forme posologique pharmaceutique pour libération immédiate de dérivé d'indolinone | |
PH12019502562A1 (en) | N-substituted indole derivatives | |
CR20110704A (es) | Composiciones de dosis fija farmacéuticas sólidas que comprenden irbesartán y amilodipina, su preparación y su aplicación terapéutica | |
BR112015022758A2 (pt) | derivados de pirrolidina, composições farmacêuticas contendo os mesmos e seu uso em terapia | |
MA38679B1 (fr) | Modulateurs du récepteur de cxcr7 | |
MA38854B1 (fr) | Dérivés amides utilisés en tant qu'antagonistes des récepteurs de l'acide lysophosphatidique | |
RU2009131745A (ru) | Лекарственное средство для профилактического и/или терапевтического лечения деменции по типу альцгеймера |