MA32349B1 - Antagonistes de la voie hedgehog a base de phtalazines disubstituees - Google Patents
Antagonistes de la voie hedgehog a base de phtalazines disubstitueesInfo
- Publication number
- MA32349B1 MA32349B1 MA33284A MA33284A MA32349B1 MA 32349 B1 MA32349 B1 MA 32349B1 MA 33284 A MA33284 A MA 33284A MA 33284 A MA33284 A MA 33284A MA 32349 B1 MA32349 B1 MA 32349B1
- Authority
- MA
- Morocco
- Prior art keywords
- antagonists
- phtalazines
- disubstituted
- hedgehog pathway
- pathway based
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 230000037361 pathway Effects 0.000 title abstract 2
- 150000003020 phtalazines Chemical class 0.000 title abstract 2
- 241000027355 Ferocactus setispinus Species 0.000 title 1
- 241000289669 Erinaceus europaeus Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4872908P | 2008-04-29 | 2008-04-29 | |
| PCT/US2009/039065 WO2009134574A2 (en) | 2008-04-29 | 2009-04-01 | Disubstituted phthalazine hedgehog pathway antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32349B1 true MA32349B1 (fr) | 2011-06-01 |
Family
ID=40846962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA33284A MA32349B1 (fr) | 2008-04-29 | 2010-10-25 | Antagonistes de la voie hedgehog a base de phtalazines disubstituees |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7981892B2 (enExample) |
| EP (1) | EP2294061A2 (enExample) |
| JP (1) | JP5442717B2 (enExample) |
| KR (1) | KR101260116B1 (enExample) |
| CN (1) | CN102066353B (enExample) |
| AU (1) | AU2009241561B2 (enExample) |
| BR (1) | BRPI0911618A2 (enExample) |
| CA (1) | CA2723042A1 (enExample) |
| CO (1) | CO6300945A2 (enExample) |
| CR (1) | CR11741A (enExample) |
| DO (1) | DOP2010000302A (enExample) |
| EA (1) | EA201071248A1 (enExample) |
| EC (1) | ECSP10010577A (enExample) |
| HN (1) | HN2010002157A (enExample) |
| IL (1) | IL208211A0 (enExample) |
| MA (1) | MA32349B1 (enExample) |
| MX (1) | MX2010011948A (enExample) |
| MY (1) | MY159491A (enExample) |
| NZ (1) | NZ588001A (enExample) |
| UA (1) | UA102250C2 (enExample) |
| WO (1) | WO2009134574A2 (enExample) |
| ZA (1) | ZA201006695B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102066353B (zh) | 2008-04-29 | 2013-12-11 | 伊莱利利公司 | 二取代的酞嗪Hedgehog通路拮抗剂 |
| ES2418479T3 (es) | 2008-11-03 | 2013-08-14 | Eli Lilly And Company | Antagonistas de la ruta erizo de ftalazinas disustituidas |
| MX2011005177A (es) | 2008-11-17 | 2011-05-30 | Lilly Co Eli | Antagonistas de la trayectoria hedgehog de piridazinas tetrasustituidas. |
| JP5518088B2 (ja) | 2008-11-17 | 2014-06-11 | イーライ リリー アンド カンパニー | 四置換ピリダジンヘッジホッグ経路アンタゴニスト |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| JP2013511526A (ja) * | 2009-11-18 | 2013-04-04 | ノバルティス アーゲー | 固形腫瘍及びその他の悪性腫瘍を治療するための方法及び組成物 |
| CN102702108A (zh) * | 2012-06-27 | 2012-10-03 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
| CA2878082A1 (en) * | 2012-09-17 | 2014-03-20 | Duke University | Smoothened modulators and methods of use thereof |
| CN102863393A (zh) * | 2012-09-26 | 2013-01-09 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
| GB201309508D0 (en) | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| GB2528298A (en) * | 2014-07-16 | 2016-01-20 | Redx Pharma Plc | Compounds |
| CN105985319B (zh) * | 2015-02-11 | 2019-02-26 | 复旦大学 | 芳基酞嗪化合物及其制备方法和用途 |
| CN105985321B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 吡唑酞嗪化合物及其制备方法和用途 |
| CN105985320B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 苄基酞嗪化合物及其制备方法和用途 |
| CN107163028B (zh) * | 2017-05-24 | 2019-07-12 | 东南大学 | 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用 |
| US12605377B2 (en) | 2020-10-13 | 2026-04-21 | Endeavor Biomedicines, Inc. | Methods of treating fibrosis |
| JP7868066B2 (ja) | 2020-10-13 | 2026-06-01 | エンデバー バイオメディシンズ， インコーポレイテッド | 線維症を処置する方法 |
| CN119907797A (zh) * | 2022-09-23 | 2025-04-29 | 默沙东有限责任公司 | 用作nod样受体蛋白3抑制剂的酞嗪衍生物 |
| US12447148B2 (en) | 2024-03-05 | 2025-10-21 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| AU717744B2 (en) | 1996-01-15 | 2000-03-30 | Janssen Pharmaceutica N.V. | Angiogenesis inhibiting pyridazinamines |
| US6432970B2 (en) * | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| JP5067986B2 (ja) | 1998-04-09 | 2012-11-07 | ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン | ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用 |
| GB0013674D0 (en) | 1999-06-08 | 2000-07-26 | Lorantis Ltd | Therapeutic use |
| AU2003231032B2 (en) | 2002-04-22 | 2008-07-10 | Johns Hopkins University School Of Medicine | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
| AU2003265853A1 (en) | 2002-08-29 | 2004-03-19 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| WO2005033288A2 (en) | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
| WO2005080378A1 (ja) | 2004-02-24 | 2005-09-01 | Mitsubishi Pharma Corporation | 縮合ピリダジン誘導体 |
| EP1745039A4 (en) | 2004-05-08 | 2009-07-22 | Neurogen Corp | 3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES |
| WO2006028958A2 (en) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| EP1900731A1 (de) | 2006-09-07 | 2008-03-19 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
| US8536168B2 (en) * | 2007-03-15 | 2013-09-17 | Novartis Ag | Benzyl and pyridinyl derivatives as modulators of the hedgehog signaling pathway |
| US8153633B2 (en) * | 2007-06-25 | 2012-04-10 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| AU2008300019A1 (en) | 2007-09-07 | 2009-03-19 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling |
| CN102066353B (zh) | 2008-04-29 | 2013-12-11 | 伊莱利利公司 | 二取代的酞嗪Hedgehog通路拮抗剂 |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| ES2418479T3 (es) | 2008-11-03 | 2013-08-14 | Eli Lilly And Company | Antagonistas de la ruta erizo de ftalazinas disustituidas |
| MX2011005177A (es) | 2008-11-17 | 2011-05-30 | Lilly Co Eli | Antagonistas de la trayectoria hedgehog de piridazinas tetrasustituidas. |
| JP5518088B2 (ja) | 2008-11-17 | 2014-06-11 | イーライ リリー アンド カンパニー | 四置換ピリダジンヘッジホッグ経路アンタゴニスト |
| AR077014A1 (es) * | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
-
2009
- 2009-04-01 CN CN2009801152085A patent/CN102066353B/zh not_active Expired - Fee Related
- 2009-04-01 MY MYPI2010005097A patent/MY159491A/en unknown
- 2009-04-01 UA UAA201012722A patent/UA102250C2/ru unknown
- 2009-04-01 EP EP09739376A patent/EP2294061A2/en not_active Withdrawn
- 2009-04-01 KR KR1020107024209A patent/KR101260116B1/ko not_active Expired - Fee Related
- 2009-04-01 MX MX2010011948A patent/MX2010011948A/es active IP Right Grant
- 2009-04-01 US US12/935,655 patent/US7981892B2/en not_active Expired - Fee Related
- 2009-04-01 CA CA2723042A patent/CA2723042A1/en not_active Abandoned
- 2009-04-01 JP JP2011507512A patent/JP5442717B2/ja not_active Expired - Fee Related
- 2009-04-01 EA EA201071248A patent/EA201071248A1/ru unknown
- 2009-04-01 NZ NZ588001A patent/NZ588001A/en not_active IP Right Cessation
- 2009-04-01 BR BRPI0911618A patent/BRPI0911618A2/pt not_active IP Right Cessation
- 2009-04-01 AU AU2009241561A patent/AU2009241561B2/en not_active Ceased
- 2009-04-01 WO PCT/US2009/039065 patent/WO2009134574A2/en not_active Ceased
-
2010
- 2010-09-16 IL IL208211A patent/IL208211A0/en unknown
- 2010-09-17 ZA ZA2010/06695A patent/ZA201006695B/en unknown
- 2010-10-11 DO DO2010000302A patent/DOP2010000302A/es unknown
- 2010-10-15 CR CR11741A patent/CR11741A/es unknown
- 2010-10-21 HN HN2010002157A patent/HN2010002157A/es unknown
- 2010-10-25 MA MA33284A patent/MA32349B1/fr unknown
- 2010-10-27 EC EC2010010577A patent/ECSP10010577A/es unknown
- 2010-11-11 CO CO10141824A patent/CO6300945A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009241561A1 (en) | 2009-11-05 |
| US20110046143A1 (en) | 2011-02-24 |
| KR101260116B1 (ko) | 2013-05-02 |
| CR11741A (es) | 2011-01-05 |
| WO2009134574A2 (en) | 2009-11-05 |
| BRPI0911618A2 (pt) | 2019-09-24 |
| JP5442717B2 (ja) | 2014-03-12 |
| ZA201006695B (en) | 2012-09-26 |
| KR20100126580A (ko) | 2010-12-01 |
| HN2010002157A (es) | 2014-09-08 |
| AU2009241561B2 (en) | 2013-05-16 |
| CO6300945A2 (es) | 2011-07-21 |
| MX2010011948A (es) | 2010-12-14 |
| MY159491A (en) | 2017-01-13 |
| CA2723042A1 (en) | 2009-11-05 |
| WO2009134574A3 (en) | 2014-09-04 |
| CN102066353B (zh) | 2013-12-11 |
| ECSP10010577A (es) | 2010-11-30 |
| EA201071248A1 (ru) | 2011-06-30 |
| NZ588001A (en) | 2012-06-29 |
| US7981892B2 (en) | 2011-07-19 |
| UA102250C2 (ru) | 2013-06-25 |
| DOP2010000302A (es) | 2010-11-15 |
| JP2011527666A (ja) | 2011-11-04 |
| CN102066353A (zh) | 2011-05-18 |
| IL208211A0 (en) | 2010-12-30 |
| EP2294061A2 (en) | 2011-03-16 |
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