CN102066353B - 二取代的酞嗪Hedgehog通路拮抗剂 - Google Patents

二取代的酞嗪Hedgehog通路拮抗剂 Download PDF

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Publication number
CN102066353B
CN102066353B CN2009801152085A CN200980115208A CN102066353B CN 102066353 B CN102066353 B CN 102066353B CN 2009801152085 A CN2009801152085 A CN 2009801152085A CN 200980115208 A CN200980115208 A CN 200980115208A CN 102066353 B CN102066353 B CN 102066353B
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China
Prior art keywords
trifluoromethyl
compound
pharmaceutically acceptable
acceptable salt
cancer
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Expired - Fee Related
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CN2009801152085A
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English (en)
Chinese (zh)
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CN102066353A (zh
Inventor
P·A·希普斯金德
T·威尔逊
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Eli Lilly and Co
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Eli Lilly and Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2009801152085A 2008-04-29 2009-04-01 二取代的酞嗪Hedgehog通路拮抗剂 Expired - Fee Related CN102066353B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4872908P 2008-04-29 2008-04-29
US61/048,729 2008-04-29
PCT/US2009/039065 WO2009134574A2 (en) 2008-04-29 2009-04-01 Disubstituted phthalazine hedgehog pathway antagonists

Publications (2)

Publication Number Publication Date
CN102066353A CN102066353A (zh) 2011-05-18
CN102066353B true CN102066353B (zh) 2013-12-11

Family

ID=40846962

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801152085A Expired - Fee Related CN102066353B (zh) 2008-04-29 2009-04-01 二取代的酞嗪Hedgehog通路拮抗剂

Country Status (22)

Country Link
US (1) US7981892B2 (enExample)
EP (1) EP2294061A2 (enExample)
JP (1) JP5442717B2 (enExample)
KR (1) KR101260116B1 (enExample)
CN (1) CN102066353B (enExample)
AU (1) AU2009241561B2 (enExample)
BR (1) BRPI0911618A2 (enExample)
CA (1) CA2723042A1 (enExample)
CO (1) CO6300945A2 (enExample)
CR (1) CR11741A (enExample)
DO (1) DOP2010000302A (enExample)
EA (1) EA201071248A1 (enExample)
EC (1) ECSP10010577A (enExample)
HN (1) HN2010002157A (enExample)
IL (1) IL208211A0 (enExample)
MA (1) MA32349B1 (enExample)
MX (1) MX2010011948A (enExample)
MY (1) MY159491A (enExample)
NZ (1) NZ588001A (enExample)
UA (1) UA102250C2 (enExample)
WO (1) WO2009134574A2 (enExample)
ZA (1) ZA201006695B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5442717B2 (ja) 2008-04-29 2014-03-12 イーライ リリー アンド カンパニー 二置換フタラジンヘッジホッグ経路アンタゴニスト
PE20110433A1 (es) * 2008-11-03 2011-07-09 Lilly Co Eli Antagonistas de la via hedgehog de ftalazina disustituida
EP2358703B1 (en) 2008-11-17 2013-12-25 Eli Lilly and Company Tetrasubstituted pyridazines hedgehog pathway antagonists
HRP20120762T1 (hr) 2008-11-17 2012-10-31 Eli Lilly And Company Tetrasupstituirani piridazini kao inhibitori hedgehog puta
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
US20120232087A1 (en) * 2009-11-18 2012-09-13 Silvia Buonamici Methods and compositions for treating solid tumors and other malignancies
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
CA2878082A1 (en) * 2012-09-17 2014-03-20 Duke University Smoothened modulators and methods of use thereof
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN107163028B (zh) * 2017-05-24 2019-07-12 东南大学 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用
WO2022081661A1 (en) 2020-10-13 2022-04-21 Endeavor Biomedicines, Inc. Methods of treating fibrosis
EP4590672A1 (en) * 2022-09-23 2025-07-30 Merck Sharp & Dohme LLC Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
US12447148B2 (en) 2024-03-05 2025-10-21 Endeavor Biomedicines, Inc. Methods of improving lung function

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
WO2006028958A2 (en) * 2004-09-02 2006-03-16 Genentech, Inc. Pyridyl inhibitors of hedgehog signalling

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
CN1104430C (zh) 1996-01-15 2003-04-02 詹森药业有限公司 抑制血管生成的哒嗪胺
WO1999052534A1 (en) 1998-04-09 1999-10-21 Johns Hopkins University School Of Medicine Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
ES2233383T3 (es) 1999-06-08 2005-06-16 Lorantis Limited Utilizacion terapeutica de un ihibidor de la via de señalizacion hedgehog.
US7655674B2 (en) 2002-04-22 2010-02-02 The Johns Hopkins University Modulators of hedgehog signaling pathways, compositions and uses related thereto
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005080378A1 (ja) 2004-02-24 2005-09-01 Mitsubishi Pharma Corporation 縮合ピリダジン誘導体
CA2564996A1 (en) 2004-05-08 2006-01-12 Taeyoung Yoon 3-aryl-5,6-disubstituted pyridazines
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
BRPI0809193A2 (pt) * 2007-03-15 2014-09-23 Novartis Ag Compostos orgânicos e seus usos
AU2008269128B2 (en) 2007-06-25 2012-08-02 Amgen Inc. Phthalazine compounds, compositions and methods of use
AU2008300019A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
JP5442717B2 (ja) 2008-04-29 2014-03-12 イーライ リリー アンド カンパニー 二置換フタラジンヘッジホッグ経路アンタゴニスト
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
PE20110433A1 (es) 2008-11-03 2011-07-09 Lilly Co Eli Antagonistas de la via hedgehog de ftalazina disustituida
EP2358703B1 (en) 2008-11-17 2013-12-25 Eli Lilly and Company Tetrasubstituted pyridazines hedgehog pathway antagonists
HRP20120762T1 (hr) 2008-11-17 2012-10-31 Eli Lilly And Company Tetrasupstituirani piridazini kao inhibitori hedgehog puta
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
WO2006028958A2 (en) * 2004-09-02 2006-03-16 Genentech, Inc. Pyridyl inhibitors of hedgehog signalling

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WO2006028958A2A2 2006.03.16

Also Published As

Publication number Publication date
WO2009134574A2 (en) 2009-11-05
MY159491A (en) 2017-01-13
UA102250C2 (ru) 2013-06-25
NZ588001A (en) 2012-06-29
CO6300945A2 (es) 2011-07-21
JP5442717B2 (ja) 2014-03-12
US7981892B2 (en) 2011-07-19
BRPI0911618A2 (pt) 2019-09-24
CN102066353A (zh) 2011-05-18
DOP2010000302A (es) 2010-11-15
EP2294061A2 (en) 2011-03-16
WO2009134574A3 (en) 2014-09-04
ZA201006695B (en) 2012-09-26
AU2009241561A1 (en) 2009-11-05
KR20100126580A (ko) 2010-12-01
US20110046143A1 (en) 2011-02-24
JP2011527666A (ja) 2011-11-04
KR101260116B1 (ko) 2013-05-02
HN2010002157A (es) 2014-09-08
IL208211A0 (en) 2010-12-30
AU2009241561B2 (en) 2013-05-16
EA201071248A1 (ru) 2011-06-30
MA32349B1 (fr) 2011-06-01
CA2723042A1 (en) 2009-11-05
ECSP10010577A (es) 2010-11-30
MX2010011948A (es) 2010-12-14
CR11741A (es) 2011-01-05

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