MA32174B1 - Preparation solide orodispersible - Google Patents

Preparation solide orodispersible

Info

Publication number
MA32174B1
MA32174B1 MA33210A MA33210A MA32174B1 MA 32174 B1 MA32174 B1 MA 32174B1 MA 33210 A MA33210 A MA 33210A MA 33210 A MA33210 A MA 33210A MA 32174 B1 MA32174 B1 MA 32174B1
Authority
MA
Morocco
Prior art keywords
fine granules
solid
orodispersible
preparation
pharmaceutically acceptable
Prior art date
Application number
MA33210A
Other languages
Arabic (ar)
English (en)
Inventor
Takashi Kurasawa
Yasuko Watanabe
Yoshihiro Omachi
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40791576&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32174(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA32174B1 publication Critical patent/MA32174B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une préparation solide orodispersible de type comprimé obtenu par compression de fines granules à capacité de libération contrôlée d'un principe actif acceptable sur le plan pharmaceutique et d'un additif, et analogues; ladite préparation solide orodispersible contenant de fines granules enrobées d'une couche d'enrobage qui contient un polymère permettant d'obtenir une coulée de film présentant un allongement à la rupture compris entre environ 100 et environ 700 %. Au moyen de ladite préparation, la rupture des fines granules pendant la compression peut être éliminée lors de la production d'une préparation solide orodispersible contenant de fines granules à capacité de libération contrôlée d'un principe actif acceptable sur le plan pharmaceutique.
MA33210A 2008-03-11 2010-09-29 Preparation solide orodispersible MA32174B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008061673 2008-03-11
JP2008334920 2008-12-26
PCT/JP2009/054983 WO2009113703A2 (fr) 2008-03-11 2009-03-10 Préparation solide orodispersible

Publications (1)

Publication Number Publication Date
MA32174B1 true MA32174B1 (fr) 2011-03-01

Family

ID=40791576

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33210A MA32174B1 (fr) 2008-03-11 2010-09-29 Preparation solide orodispersible

Country Status (26)

Country Link
US (2) US9241910B2 (fr)
EP (1) EP2254556A2 (fr)
JP (1) JP5604304B2 (fr)
KR (1) KR20100129761A (fr)
CN (2) CN104127368A (fr)
AR (1) AR070863A1 (fr)
AU (1) AU2009224254A1 (fr)
BR (1) BRPI0909439A2 (fr)
CA (1) CA2717947C (fr)
CL (1) CL2009000557A1 (fr)
CO (1) CO6321224A2 (fr)
CR (1) CR11709A (fr)
DO (1) DOP2010000273A (fr)
EA (1) EA021792B1 (fr)
EC (1) ECSP10010538A (fr)
GE (1) GEP20135845B (fr)
IL (1) IL207989A0 (fr)
MA (1) MA32174B1 (fr)
MX (1) MX2010009824A (fr)
MY (1) MY173730A (fr)
NZ (1) NZ588407A (fr)
PE (2) PE20141034A1 (fr)
TW (1) TWI441658B (fr)
UY (1) UY31698A (fr)
WO (1) WO2009113703A2 (fr)
ZA (1) ZA201006679B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20135845B (en) 2008-03-11 2013-06-10 Takeda Pharmaceutical Orally-disintegrating solid formulation
CA2729015A1 (fr) * 2008-06-26 2009-12-30 Mcneil-Ppc, Inc. Particules enrobees contenant des agents pharmaceutiquement actifs
EP3031451B1 (fr) * 2009-01-26 2018-03-07 Shin-Etsu Chemical Co., Ltd Procédé de fabrication de comprimés à granulation par voie humide utilisant une dispersion aqueuse de cellulose hydroxypropyle substituée faible
EP2319504A1 (fr) * 2009-11-07 2011-05-11 Laboratorios Del. Dr. Esteve, S.A. Forme pharmaceutique solide
WO2012001705A2 (fr) * 2010-06-29 2012-01-05 Cadila Healthcare Limited Compositions pharmaceutiques de (r)-lansoprazole
SG10201602311XA (en) * 2010-12-27 2016-04-28 Takeda Pharmaceutical Orally disintegrating tablet
CN102716097A (zh) * 2012-05-29 2012-10-10 浙江华海药业股份有限公司 控制口腔崩解片药物释放速率的方法
FI126168B (en) 2012-09-18 2016-07-29 Novaldmedical Ltd Oy A method for coating pharmaceutical substrates
US10195153B2 (en) 2013-08-12 2019-02-05 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
JP6371463B2 (ja) 2014-07-17 2018-08-08 ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド 即時放出性乱用抑止性液体充填剤形
EP3209282A4 (fr) 2014-10-20 2018-05-23 Pharmaceutical Manufacturing Research Services, Inc. Forme galénique anti-abus de remplissage de liquide à libération prolongée
DK3257511T3 (en) * 2015-02-10 2019-01-21 Fujifilm Corp ORAL SOLUBLE TABLE AND METHOD OF PREPARING IT
EP3288556A4 (fr) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Compositions à désintégration par voie orale
JP6905972B2 (ja) * 2016-02-23 2021-07-21 ニプロ株式会社 医薬組成物粒子とそれを含む口腔内崩壊製剤、医薬組成物粒子の製造方法
GB201607548D0 (en) * 2016-04-29 2016-06-15 Univ Central Lancashire Solid dosage form
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
JOP20190008A1 (ar) 2016-07-26 2019-01-24 Purdue Pharma Lp علاج ومنع اضطرابات النوم
JP7057287B2 (ja) * 2016-12-28 2022-04-19 富士フイルム富山化学株式会社 医薬組成物
CN109789120A (zh) * 2017-02-21 2019-05-21 Ea制药株式会社 颗粒制剂
JP7235193B2 (ja) * 2017-04-26 2023-03-08 大正製薬株式会社 固形組成物
JP7009288B2 (ja) * 2017-05-18 2022-01-25 エルメッド株式会社 湿製錠剤の製造方法及び湿製錠剤の品質向上方法
JP7336187B2 (ja) * 2017-11-30 2023-08-31 日本ケミファ株式会社 多層構造を有する粒子状医薬組成物
WO2019143744A1 (fr) 2018-01-16 2019-07-25 Applied Materials, Inc. Compositions médicamenteuses encapsulées d'oxyde métallique et leurs procédés de préparation
KR20200103045A (ko) 2018-01-24 2020-09-01 퍼듀 퍼머 엘피 수면 장애 치료 및 예방
WO2019156904A1 (fr) * 2018-02-08 2019-08-15 Taiwanj Pharmaceuticals Co., Ltd. Formulation pharmaceutique pour une forme posologique solide d'antagonistes du récepteur des opioïdes
BR112021010184A2 (pt) 2019-01-31 2021-08-17 Purdue Pharma L.P. formas polimórficas de um composto de piperidina em ponte tipo quinoxalina substituída
GB202001237D0 (en) * 2020-01-29 2020-03-11 Sisteks D O O Granular pharmaceutical product for oral administration from a pre-filled straw and method of manufacturing such pharmaceutical product
WO2021155254A1 (fr) 2020-01-31 2021-08-05 Nanocopoeia, Llc Microparticules de nilotinib amorphe et leurs utilisations
WO2021222739A1 (fr) 2020-04-30 2021-11-04 Nanocopoeia, Llc Comprimé à désintégration orale comprenant une dispersion solide amorphe de nilotinib
TW202216124A (zh) 2020-10-02 2022-05-01 美商應用材料股份有限公司 製備氧化矽塗佈藥品的低溫處理
CN112121067A (zh) * 2020-11-16 2020-12-25 深圳科兴药业有限公司 一种婴儿型双歧杆菌微胶囊及其制备方法
CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
WO2022216977A1 (fr) 2021-04-07 2022-10-13 Batelle Memorial Institute Technologies de conception, de construction, de test et d'apprentissage rapides pour identifier et utiliser des vecteurs non viraux
WO2023182332A1 (fr) * 2022-03-22 2023-09-28 株式会社ダイセル Composition d'additifs pour comprimés orodispersible

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62277322A (ja) 1986-02-13 1987-12-02 Takeda Chem Ind Ltd 安定化された腸溶性抗潰瘍固形組成物
CA1327010C (fr) 1986-02-13 1994-02-15 Tadashi Makino Compositions pharmaceutiques contenant un compose anti-ulcereux de type benzimidazole et sa production
US5464632C1 (en) * 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
FR2679451B1 (fr) 1991-07-22 1994-09-09 Prographarm Laboratoires Comprime multiparticulaire a delitement rapide.
SE9402431D0 (sv) 1994-07-08 1994-07-08 Astra Ab New tablet formulation
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US6096340A (en) 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6328994B1 (en) 1998-05-18 2001-12-11 Takeda Chemical Industries, Ltd. Orally disintegrable tablets
TWI257311B (en) 1998-07-28 2006-07-01 Takeda Chemical Industries Ltd Rapidly disintegrable solid preparation
EP1117384A1 (fr) 1998-10-01 2001-07-25 Elan Pharma International Limited Liberation regulee de compositions nanoparticulaires
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
TWI275587B (en) * 1999-06-17 2007-03-11 Takeda Chemical Industries Ltd A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
GB0025208D0 (en) 2000-10-13 2000-11-29 Euro Celtique Sa Delayed release pharmaceutical formulations
ATE380022T1 (de) * 2001-01-31 2007-12-15 Evonik Roehm Gmbh Multipartikuläre arzneiform, enthaltend mindestens zwei unterschiedlich überzogene pelletformen
BR0211117A (pt) 2001-07-16 2004-06-22 Astrazeneca Ab Tablete multiparticulado, processo para a manufatura e uso do mesmo, e, método e tratamento de distúrbios gastrointestinais
DE10208335A1 (de) 2002-02-27 2003-09-04 Roehm Gmbh Arzneiform und Verfahren zu ihrer Herstellung
AUPS167602A0 (en) 2002-04-12 2002-05-16 F.H. Faulding & Co. Limited An improved modified release preparation
JP4493970B2 (ja) 2002-10-16 2010-06-30 武田薬品工業株式会社 持続性製剤
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
US20040096497A1 (en) 2002-11-19 2004-05-20 Ponder Garratt W. Methods of providing controlled-release pharmaceutical compositions and controlled-release pharmaceutical compositions
MXPA04010956A (es) * 2003-01-30 2005-01-25 Roehm Gmbh Forma de dosis farmaceutica y metodo para la produccion de la misma.
US20060115529A1 (en) * 2003-05-07 2006-06-01 Seonghoon Jeong Fast-melting tablets having taste-masking and sustained release properties
BRPI0412697A (pt) 2003-07-17 2006-10-03 Reddys Lab Inc Dr composições farmacêuticas que apresentam um revestimento expansìvel
CA2540059C (fr) 2003-09-26 2013-08-06 Alza Corporation Formulations a liberation commandee presentant un taux croisssant de liberation
GB0323232D0 (en) * 2003-10-03 2003-11-05 Rolls Royce Plc Electrical machine
US20070196396A1 (en) 2004-02-11 2007-08-23 Rubicon Research Private Limited Controlled release pharmaceutical compositions with improved bioavailability
US20050181052A1 (en) 2004-02-17 2005-08-18 Patel Satishkumar A. Lansoprazole microtablets
US20050214372A1 (en) 2004-03-03 2005-09-29 Simona Di Capua Stable pharmaceutical composition comprising an acid labile drug
JPWO2005084649A1 (ja) 2004-03-04 2007-11-29 武田薬品工業株式会社 安定なカプセル剤
US8545881B2 (en) * 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
RU2382637C2 (ru) * 2004-04-30 2010-02-27 Астеллас Фарма Инк. Фармацевтическая композиция для перорального введения в форме частиц с рассчитанным временем высвобождения и быстро распадающиеся таблетки, содержащие указанную композицию
DE102004035936A1 (de) 2004-07-23 2006-03-16 Röhm GmbH & Co. KG Mehrschichtige Arzneiform
JP5209876B2 (ja) 2004-12-28 2013-06-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 速崩壊性錠剤及びその製造方法
GB0502479D0 (en) 2005-02-07 2005-03-16 Sb Pharmco Inc Novel compositions
FR2885526B1 (fr) * 2005-05-13 2007-07-27 Flamel Technologies Sa Medicament oral a base d'inhibiteur de pompe a protons
DE102005024614A1 (de) * 2005-05-25 2006-11-30 Röhm Gmbh Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug
AU2006230974C1 (en) 2005-07-11 2012-02-02 Takeda Pharma A/S Benzimidazole formulation
DE102005032806A1 (de) 2005-07-12 2007-01-18 Röhm Gmbh Verwendung eines teilneutralisierten, anionischen (Meth)acrylat-Copolymers als Überzug für die Herstellung einer Arzneiform mit einer Wirkstofffreisetzung bei erniedrigten pH-Werten
JPWO2007037259A1 (ja) 2005-09-29 2009-04-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 生体内での崩壊性を向上させたパルス製剤
FR2891459B1 (fr) 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
EP1813275A1 (fr) * 2005-12-20 2007-08-01 Teva Pharmaceutical Industries Ltd Comprime oral desintegrable de lansoprazole
CA2630235A1 (fr) * 2005-12-20 2007-07-12 Teva Pharmaceutical Industries Ltd. Comprimes a desintegration orale de lansoprazole
US20070141151A1 (en) 2005-12-20 2007-06-21 Silver David I Lansoprazole orally disintegrating tablets
EP1962844A2 (fr) 2005-12-20 2008-09-03 Teva Pharmaceutical Industries Ltd Comprime oral desintegrable de lansoprazole
JP5053865B2 (ja) 2005-12-28 2012-10-24 武田薬品工業株式会社 口腔内崩壊性固形製剤の製造法
KR100762847B1 (ko) 2006-01-27 2007-10-04 씨제이 주식회사 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법
EP1837016A3 (fr) 2006-03-08 2008-01-02 KRKA, tovarna zdravil, d.d., Novo mesto Composition pharmaceutique en multiple-unité
EP2012756A4 (fr) 2006-04-20 2013-01-23 Inventia Healthcare Private Ltd Compositions à unités multiples
EP2010158B1 (fr) 2006-04-26 2016-02-17 Alphapharm Pty Ltd. Formulations à libération contrôlée qui comprennent une ou plusieurs unités discrètes non enrobées et une matrice à libération retardée
US8747920B2 (en) 2006-04-28 2014-06-10 Wockhardt Ltd. Pharmaceutical compositions comprising non-steroidal antiinflammatory drug, antipyretic-analgesic drug and proton pump inhibitor
RU2009101309A (ru) 2006-06-19 2010-07-27 МакНЕЙЛ-ППС, ИНК. (US) Частицы с энтеросолюбильным покрытием, содержащие активный ингредиент
SI2040684T1 (sl) 2006-07-11 2013-06-28 Lek Pharmaceuticals D.D. Večenotne tablete
WO2008014175A2 (fr) 2006-07-28 2008-01-31 Dr. Reddy's Laboratories Ltd. Compositions pharmaceutiques granulaires
MX2009002235A (es) * 2006-08-30 2009-03-13 Jagotec Ag Formulaciones de dosis oral, solidas, de liberacion controlada que comprenden nisoldipina.
JP5366558B2 (ja) 2006-12-28 2013-12-11 武田薬品工業株式会社 口腔内崩壊性固形製剤
DE102007009243A1 (de) 2007-02-22 2008-09-18 Evonik Röhm Gmbh Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets
DE102007009242A1 (de) * 2007-02-22 2008-09-18 Evonik Röhm Gmbh Pellets mit magensaftresistenter Wirkstoff-Matix
SI2152250T1 (sl) 2007-05-07 2020-06-30 Evonik Operations Gmbh Trdne dozirne oblike, ki vsebujejo enterično oplaščenje s pospešenim sproščanjem zdravila
GEP20135845B (en) 2008-03-11 2013-06-10 Takeda Pharmaceutical Orally-disintegrating solid formulation
US20100015239A1 (en) 2008-07-17 2010-01-21 Ahmed Salah U Orally Disintegrating Solid Pharmaceutical Dosage Forms Comprising Delayed-Release Lansoprazole and Methods of Making and Using the Same
SG10201602311XA (en) 2010-12-27 2016-04-28 Takeda Pharmaceutical Orally disintegrating tablet

Also Published As

Publication number Publication date
ECSP10010538A (es) 2010-11-30
MY173730A (en) 2020-02-18
UY31698A (es) 2009-11-10
CN102026627A (zh) 2011-04-20
PE20141034A1 (es) 2014-09-10
ZA201006679B (en) 2011-11-30
TWI441658B (zh) 2014-06-21
EA021792B1 (ru) 2015-09-30
JP5604304B2 (ja) 2014-10-08
IL207989A0 (en) 2010-12-30
AU2009224254A1 (en) 2009-09-17
CO6321224A2 (es) 2011-09-20
MX2010009824A (es) 2010-09-28
JP2011513204A (ja) 2011-04-28
CA2717947A1 (fr) 2009-09-17
US9241910B2 (en) 2016-01-26
US20150037423A1 (en) 2015-02-05
AU2009224254A2 (en) 2010-11-18
TW200944249A (en) 2009-11-01
CL2009000557A1 (es) 2010-10-01
WO2009113703A3 (fr) 2010-06-17
BRPI0909439A2 (pt) 2015-12-15
NZ588407A (en) 2012-07-27
EP2254556A2 (fr) 2010-12-01
DOP2010000273A (es) 2010-09-30
WO2009113703A2 (fr) 2009-09-17
CR11709A (es) 2010-11-04
EA201071054A1 (ru) 2011-04-29
AR070863A1 (es) 2010-05-12
CN102026627B (zh) 2016-10-26
PE20091620A1 (es) 2009-11-12
US20110091563A1 (en) 2011-04-21
CA2717947C (fr) 2020-07-07
CN104127368A (zh) 2014-11-05
GEP20135845B (en) 2013-06-10
KR20100129761A (ko) 2010-12-09

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