MA29850B1 - Composes de type pyrazolo [1.5 -alpha] pyrimidinyle pouvant etre employes en tant qu'antagonistes du recepteur du facteur de liberation de la corticotropine (crf) - Google Patents

Composes de type pyrazolo [1.5 -alpha] pyrimidinyle pouvant etre employes en tant qu'antagonistes du recepteur du facteur de liberation de la corticotropine (crf)

Info

Publication number
MA29850B1
MA29850B1 MA30813A MA30813A MA29850B1 MA 29850 B1 MA29850 B1 MA 29850B1 MA 30813 A MA30813 A MA 30813A MA 30813 A MA30813 A MA 30813A MA 29850 B1 MA29850 B1 MA 29850B1
Authority
MA
Morocco
Prior art keywords
crf
pyrazolo
alpha
factor receptor
release factor
Prior art date
Application number
MA30813A
Other languages
English (en)
Inventor
Frank Hossner
Original Assignee
Sb Pharmco Inc
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35395069&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA29850(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sb Pharmco Inc, Neurocrine Biosciences Inc filed Critical Sb Pharmco Inc
Publication of MA29850B1 publication Critical patent/MA29850B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Dérivés de pyrazolo[l,5-alpha]pyrimidinyle utiles comme antagonistes des récepeurs du facteur de libération de corticotrophine (CRF) La présente invention concerne de manière générale la forme polymorphe 2 de [3-(4-méthoxy-2-méthylphényl)-2, 5-diméthylpyrazolo [1, 5-a] pyrimidine-7-yl]-[(S)-l-(3-méthyl-[l, 2, 4] oxadiazole-5-yl) propyl] amine. La présente invention concerne également des compositions pharmaceutiques comprenant celle-ci et des méthodes pour leur utilisation.
MA30813A 2005-09-30 2008-04-04 Composes de type pyrazolo [1.5 -alpha] pyrimidinyle pouvant etre employes en tant qu'antagonistes du recepteur du facteur de liberation de la corticotropine (crf) MA29850B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0519957.5A GB0519957D0 (en) 2005-09-30 2005-09-30 Chemical compound
PCT/US2005/037576 WO2006044958A1 (fr) 2004-10-19 2005-10-19 Derives de pyrazolo[1,5-alpha]pyrimidinyle utiles comme antagonistes vis-a-vis du recepteur du facteur de liberation de la corticotropine (crf)

Publications (1)

Publication Number Publication Date
MA29850B1 true MA29850B1 (fr) 2008-10-03

Family

ID=35395069

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30813A MA29850B1 (fr) 2005-09-30 2008-04-04 Composes de type pyrazolo [1.5 -alpha] pyrimidinyle pouvant etre employes en tant qu'antagonistes du recepteur du facteur de liberation de la corticotropine (crf)

Country Status (21)

Country Link
US (1) US7879862B2 (fr)
EP (2) EP1802627B1 (fr)
JP (2) JP4901744B2 (fr)
KR (2) KR20070088621A (fr)
CN (1) CN101273043B (fr)
AR (2) AR051461A1 (fr)
AU (2) AU2005295353B2 (fr)
BR (1) BRPI0616767A2 (fr)
CA (2) CA2584567C (fr)
CR (1) CR9918A (fr)
EA (1) EA200801000A1 (fr)
GB (1) GB0519957D0 (fr)
IL (1) IL190225A0 (fr)
MA (1) MA29850B1 (fr)
NO (2) NO20072541L (fr)
NZ (1) NZ554082A (fr)
PE (2) PE20060586A1 (fr)
RU (1) RU2007118683A (fr)
TW (2) TW200626599A (fr)
UA (1) UA92756C2 (fr)
WO (2) WO2006044958A1 (fr)

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US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
CN101932583A (zh) 2007-12-19 2010-12-29 沃泰克斯药物股份有限公司 用作JAK2抑制剂的吡唑并[1,5-a]嘧啶类
CN102007133B (zh) * 2008-04-15 2013-06-12 卫材R&D管理有限公司 3-苯基吡唑并[5,1-b]噻唑化合物
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
EP2487177A1 (fr) * 2009-10-08 2012-08-15 Eisai R&D Management Co., Ltd. Composé de pyrazolooxazole
AR078521A1 (es) * 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
WO2011092293A2 (fr) 2010-02-01 2011-08-04 Novartis Ag Dérivés de cyclohexylamide utilisés en tant qu'antagonistes du récepteur du crf
EP2531510B1 (fr) 2010-02-01 2014-07-23 Novartis AG Dérivés de pyrazolo[5,1-b]utilisés en tant qu'antagonistes du récepteur de crf-1
US8835444B2 (en) * 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists
AR086554A1 (es) 2011-05-27 2014-01-08 Novartis Ag Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina
US20140309226A1 (en) 2011-11-16 2014-10-16 Array Biopharma Inc. Piperidinyl-substituted cyclic ureas as gpr119 modulators
WO2013160317A2 (fr) * 2012-04-23 2013-10-31 Holsboermaschmeyer Neurochemie Gmbh Antagonistes de crhr1 pour une utilisation dans le traitement de patients présentant une hyperactivité de la crh
CA2867043A1 (fr) 2012-05-03 2013-11-07 Novartis Ag Sel de l-malate de derives de 2,7-diaza-spiro[4.5]dec-7-yle et ses formes cristallines a titre d'agonistes des recepteurs de ghreline
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JP6585625B2 (ja) 2014-01-21 2019-10-02 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト
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BR112019016775A2 (pt) 2017-02-17 2020-03-31 Trevena, Inc. Compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 7 membros, métodos de uso e produção dos mesmos
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Also Published As

Publication number Publication date
IL190225A0 (en) 2009-09-22
EP1802627B1 (fr) 2012-08-29
KR20070088621A (ko) 2007-08-29
AU2005295353B2 (en) 2012-01-12
RU2007118683A (ru) 2008-11-27
PE20060586A1 (es) 2006-09-20
NZ554082A (en) 2010-12-24
JP4901744B2 (ja) 2012-03-21
CA2584567C (fr) 2013-04-30
JP2009510004A (ja) 2009-03-12
EP1934222B1 (fr) 2012-07-25
EP1934222A1 (fr) 2008-06-25
JP2008517067A (ja) 2008-05-22
CA2624699A1 (fr) 2007-04-12
CR9918A (es) 2009-02-03
AR056104A1 (es) 2007-09-19
US7879862B2 (en) 2011-02-01
AU2005295353A1 (en) 2006-04-27
TW200626599A (en) 2006-08-01
KR20080063760A (ko) 2008-07-07
WO2006044958A1 (fr) 2006-04-27
TW200745121A (en) 2007-12-16
NO20081941L (no) 2008-04-23
BRPI0616767A2 (pt) 2011-06-28
UA92756C2 (ru) 2010-12-10
AU2006298995B2 (en) 2012-06-14
WO2007039264A1 (fr) 2007-04-12
US20080194589A1 (en) 2008-08-14
PE20070845A1 (es) 2007-08-25
CN101273043B (zh) 2011-08-03
WO2006044958A8 (fr) 2006-06-08
CA2584567A1 (fr) 2006-04-27
GB0519957D0 (en) 2005-11-09
AR051461A1 (es) 2007-01-17
EA200801000A1 (ru) 2009-02-27
CN101273043A (zh) 2008-09-24
NO20072541L (no) 2007-06-25
AU2006298995A1 (en) 2007-04-12
EP1802627A1 (fr) 2007-07-04

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