EA200801000A1 - Производные пиразоло[1,5-альфа]пиримидила, полезные в качестве антагонистов рецептора рилизинг-фактора кортикотропина (crf) - Google Patents

Производные пиразоло[1,5-альфа]пиримидила, полезные в качестве антагонистов рецептора рилизинг-фактора кортикотропина (crf)

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Publication number
EA200801000A1
EA200801000A1 EA200801000A EA200801000A EA200801000A1 EA 200801000 A1 EA200801000 A1 EA 200801000A1 EA 200801000 A EA200801000 A EA 200801000A EA 200801000 A EA200801000 A EA 200801000A EA 200801000 A1 EA200801000 A1 EA 200801000A1
Authority
EA
Eurasian Patent Office
Prior art keywords
corticotropine
crf
pyrazolo
pyrimidyl
antagonists
Prior art date
Application number
EA200801000A
Other languages
English (en)
Inventor
Франк Хосснер
Original Assignee
Эс Би ФАРМКО ПУЭРТО РИКО ИНК.
Ньюрокрайн Байосайенсиз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35395069&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200801000(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эс Би ФАРМКО ПУЭРТО РИКО ИНК., Ньюрокрайн Байосайенсиз Инк. filed Critical Эс Би ФАРМКО ПУЭРТО РИКО ИНК.
Publication of EA200801000A1 publication Critical patent/EA200801000A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к полиморфной форме 2 [3-(4-метокси-2-метилфенил)-2,5-диметилпиразоло[1,5-a]пиримидин-7-ил]-[(S)-1-(3-метил[1,2,4]оксадиазол-5-ил)пропил]амина. Настоящее изобретение также относится к фармакологической композиции, содержащей данное соединение, и способам его применения.
EA200801000A 2005-09-30 2006-09-28 Производные пиразоло[1,5-альфа]пиримидила, полезные в качестве антагонистов рецептора рилизинг-фактора кортикотропина (crf) EA200801000A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0519957.5A GB0519957D0 (en) 2005-09-30 2005-09-30 Chemical compound
PCT/US2005/037576 WO2006044958A1 (en) 2004-10-19 2005-10-19 Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (crf) receptor antagonists
PCT/EP2006/009531 WO2007039264A1 (en) 2005-09-30 2006-09-28 Pyrazolo [1, 5 -alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (crf) receptor antagonists

Publications (1)

Publication Number Publication Date
EA200801000A1 true EA200801000A1 (ru) 2009-02-27

Family

ID=35395069

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801000A EA200801000A1 (ru) 2005-09-30 2006-09-28 Производные пиразоло[1,5-альфа]пиримидила, полезные в качестве антагонистов рецептора рилизинг-фактора кортикотропина (crf)

Country Status (21)

Country Link
US (1) US7879862B2 (ru)
EP (2) EP1802627B1 (ru)
JP (2) JP4901744B2 (ru)
KR (2) KR20070088621A (ru)
CN (1) CN101273043B (ru)
AR (2) AR051461A1 (ru)
AU (2) AU2005295353B2 (ru)
BR (1) BRPI0616767A2 (ru)
CA (2) CA2584567C (ru)
CR (1) CR9918A (ru)
EA (1) EA200801000A1 (ru)
GB (1) GB0519957D0 (ru)
IL (1) IL190225A0 (ru)
MA (1) MA29850B1 (ru)
NO (2) NO20072541L (ru)
NZ (1) NZ554082A (ru)
PE (2) PE20060586A1 (ru)
RU (1) RU2007118683A (ru)
TW (2) TW200626599A (ru)
UA (1) UA92756C2 (ru)
WO (2) WO2006044958A1 (ru)

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Also Published As

Publication number Publication date
IL190225A0 (en) 2009-09-22
EP1802627B1 (en) 2012-08-29
KR20070088621A (ko) 2007-08-29
AU2005295353B2 (en) 2012-01-12
RU2007118683A (ru) 2008-11-27
PE20060586A1 (es) 2006-09-20
NZ554082A (en) 2010-12-24
JP4901744B2 (ja) 2012-03-21
CA2584567C (en) 2013-04-30
JP2009510004A (ja) 2009-03-12
EP1934222B1 (en) 2012-07-25
EP1934222A1 (en) 2008-06-25
JP2008517067A (ja) 2008-05-22
CA2624699A1 (en) 2007-04-12
CR9918A (es) 2009-02-03
AR056104A1 (es) 2007-09-19
US7879862B2 (en) 2011-02-01
AU2005295353A1 (en) 2006-04-27
TW200626599A (en) 2006-08-01
KR20080063760A (ko) 2008-07-07
MA29850B1 (fr) 2008-10-03
WO2006044958A1 (en) 2006-04-27
TW200745121A (en) 2007-12-16
NO20081941L (no) 2008-04-23
BRPI0616767A2 (pt) 2011-06-28
UA92756C2 (ru) 2010-12-10
AU2006298995B2 (en) 2012-06-14
WO2007039264A1 (en) 2007-04-12
US20080194589A1 (en) 2008-08-14
PE20070845A1 (es) 2007-08-25
CN101273043B (zh) 2011-08-03
WO2006044958A8 (en) 2006-06-08
CA2584567A1 (en) 2006-04-27
GB0519957D0 (en) 2005-11-09
AR051461A1 (es) 2007-01-17
CN101273043A (zh) 2008-09-24
NO20072541L (no) 2007-06-25
AU2006298995A1 (en) 2007-04-12
EP1802627A1 (en) 2007-07-04

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