TW200640929A - N-[3-(8-substituted-imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-sulfonamides, n-[3-(8-substituted-imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-carboxamides, compositions, and methods related thereto - Google Patents

N-[3-(8-substituted-imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-sulfonamides, n-[3-(8-substituted-imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-carboxamides, compositions, and methods related thereto

Info

Publication number
TW200640929A
TW200640929A TW095104176A TW95104176A TW200640929A TW 200640929 A TW200640929 A TW 200640929A TW 095104176 A TW095104176 A TW 095104176A TW 95104176 A TW95104176 A TW 95104176A TW 200640929 A TW200640929 A TW 200640929A
Authority
TW
Taiwan
Prior art keywords
imidazo
pyrimidin
phenyl
substituted
carboxamides
Prior art date
Application number
TW095104176A
Other languages
Chinese (zh)
Inventor
Luis Anglada
Albert Palomer
Antonio Guglietta
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of TW200640929A publication Critical patent/TW200640929A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to compounds of formula I: wherein R1, R2, R3 and X are defined in the claims. The compounds have specific affinity for the GABAA receptor and are therefore useful in the treatment and prevention of diseases modulated by the α1 and α2- GABAA receptors.
TW095104176A 2005-02-10 2006-02-08 N-[3-(8-substituted-imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-sulfonamides, n-[3-(8-substituted-imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-carboxamides, compositions, and methods related thereto TW200640929A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05100941 2005-02-10

Publications (1)

Publication Number Publication Date
TW200640929A true TW200640929A (en) 2006-12-01

Family

ID=36384333

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095104176A TW200640929A (en) 2005-02-10 2006-02-08 N-[3-(8-substituted-imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-sulfonamides, n-[3-(8-substituted-imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-carboxamides, compositions, and methods related thereto

Country Status (5)

Country Link
AR (1) AR054733A1 (en)
PE (1) PE20061288A1 (en)
TW (1) TW200640929A (en)
UY (1) UY29368A1 (en)
WO (1) WO2006084835A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7046827B2 (en) * 2016-04-06 2022-04-04 リソソーマル・セラピューティクス・インコーポレイテッド Imidazo [1,5-a] pyrimidinylcarboxamide compounds and their use in the treatment of medical disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US6399621B1 (en) * 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
ES2222813B1 (en) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N- (3- (3-SUBSTITUTES-PIRAZOLO (1,5-A) PIRIMIDIN-7-IL) -PENYL) -SULPHONAMIDS AND RELATED COMPOSITIONS AND METHODS
ES2222814B1 (en) * 2003-07-24 2005-12-01 Ferrer Internacional, S.A. 3-NITRO-PIRAZOLO (1,5-A) PYRIMIDINS 7-REPLACED AND RELATED COMPOSITIONS AND METHODS.

Also Published As

Publication number Publication date
UY29368A1 (en) 2006-05-31
WO2006084835A1 (en) 2006-08-17
AR054733A1 (en) 2007-07-11
PE20061288A1 (en) 2006-11-29

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