DE60132017D1 - Neue benzazepine und ähnliche heterocyclische derivate,die als orexin rezeptor antagonisten geeignet sind - Google Patents
Neue benzazepine und ähnliche heterocyclische derivate,die als orexin rezeptor antagonisten geeignet sindInfo
- Publication number
- DE60132017D1 DE60132017D1 DE60132017T DE60132017T DE60132017D1 DE 60132017 D1 DE60132017 D1 DE 60132017D1 DE 60132017 T DE60132017 T DE 60132017T DE 60132017 T DE60132017 T DE 60132017T DE 60132017 D1 DE60132017 D1 DE 60132017D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor antagonists
- heterocyclic derivatives
- orexin receptor
- derivatives suitable
- similar heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2000/013289 WO2002051232A2 (en) | 2000-12-27 | 2000-12-27 | Novel benzazepines and related heterocyclic derivatives |
WOPCT/EP00/13289 | 2000-12-27 | ||
PCT/EP2001/015074 WO2002051838A1 (en) | 2000-12-27 | 2001-12-19 | Novel benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60132017D1 true DE60132017D1 (de) | 2008-01-31 |
DE60132017T2 DE60132017T2 (de) | 2008-12-04 |
Family
ID=8164232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60132017T Expired - Lifetime DE60132017T2 (de) | 2000-12-27 | 2001-12-19 | Neue benzazepine und ähnliche heterocyclische derivate,die als orexin rezeptor antagonisten geeignet sind |
Country Status (18)
Country | Link |
---|---|
US (1) | US7192950B2 (de) |
EP (1) | EP1347967B1 (de) |
JP (1) | JP4219166B2 (de) |
KR (1) | KR100849569B1 (de) |
CN (1) | CN1261430C (de) |
AT (1) | ATE381560T1 (de) |
AU (1) | AU2002240855B2 (de) |
BR (1) | BR0116505A (de) |
CA (1) | CA2431982C (de) |
DE (1) | DE60132017T2 (de) |
ES (1) | ES2296825T3 (de) |
HU (1) | HUP0301665A3 (de) |
IL (2) | IL155806A0 (de) |
MX (1) | MXPA03004779A (de) |
NO (1) | NO326158B1 (de) |
NZ (1) | NZ525613A (de) |
WO (2) | WO2002051232A2 (de) |
ZA (1) | ZA200303697B (de) |
Families Citing this family (89)
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US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
ES2297413T3 (es) | 2003-04-28 | 2008-05-01 | Actelion Pharmaceuticals Ltd. | Derivados de quinoxalinona-3-ona utilizados como antagonistas del receptor de orexina. |
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ATE547404T1 (de) | 2003-09-22 | 2012-03-15 | Msd Kk | Piperidinderivate |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
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EP1922336B1 (de) | 2005-08-11 | 2012-11-21 | Amylin Pharmaceuticals, LLC | Hybridpolypeptide mit auswählbaren eigenschaften |
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US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
GB201718256D0 (en) * | 2017-11-03 | 2017-12-20 | Heptares Therapeutics Ltd | Ox1 antagonists |
JP2022507805A (ja) | 2018-11-20 | 2022-01-18 | ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ | α-アミノ-β-カルボキシムコン酸セミアルデヒドデカルボキシラーゼ阻害剤 |
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US3236838A (en) | 1964-06-09 | 1966-02-22 | Hoffmann La Roche | Certain 1-substituted-benzodiazepin-2-one compounds |
US3480714A (en) * | 1966-02-07 | 1969-11-25 | Ciba Geigy Corp | N-substituted isoquinolines as antiprotozoal agents |
ATE316969T1 (de) * | 1998-10-08 | 2006-02-15 | Smithkline Beecham Plc | Tetrahydrobenzazepin-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel) |
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2000
- 2000-12-27 WO PCT/EP2000/013289 patent/WO2002051232A2/en active Application Filing
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2001
- 2001-12-19 US US10/450,420 patent/US7192950B2/en not_active Expired - Fee Related
- 2001-12-19 MX MXPA03004779A patent/MXPA03004779A/es active IP Right Grant
- 2001-12-19 AU AU2002240855A patent/AU2002240855B2/en not_active Ceased
- 2001-12-19 AT AT01988048T patent/ATE381560T1/de active
- 2001-12-19 BR BR0116505-4A patent/BR0116505A/pt not_active IP Right Cessation
- 2001-12-19 ES ES01988048T patent/ES2296825T3/es not_active Expired - Lifetime
- 2001-12-19 KR KR1020037008764A patent/KR100849569B1/ko not_active IP Right Cessation
- 2001-12-19 HU HU0301665A patent/HUP0301665A3/hu unknown
- 2001-12-19 JP JP2002552933A patent/JP4219166B2/ja not_active Expired - Fee Related
- 2001-12-19 EP EP01988048A patent/EP1347967B1/de not_active Expired - Lifetime
- 2001-12-19 DE DE60132017T patent/DE60132017T2/de not_active Expired - Lifetime
- 2001-12-19 CN CNB018208762A patent/CN1261430C/zh not_active Expired - Fee Related
- 2001-12-19 IL IL15580601A patent/IL155806A0/xx active IP Right Grant
- 2001-12-19 WO PCT/EP2001/015074 patent/WO2002051838A1/en active IP Right Grant
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2003
- 2003-05-08 IL IL155806A patent/IL155806A/en not_active IP Right Cessation
- 2003-05-13 ZA ZA200303697A patent/ZA200303697B/en unknown
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HUP0301665A3 (en) | 2008-12-29 |
NO326158B1 (no) | 2008-10-13 |
JP2004516324A (ja) | 2004-06-03 |
CA2431982A1 (en) | 2002-07-04 |
WO2002051838A1 (en) | 2002-07-04 |
KR20030069199A (ko) | 2003-08-25 |
IL155806A (en) | 2008-03-20 |
CN1481380A (zh) | 2004-03-10 |
NO20032905D0 (no) | 2003-06-24 |
ATE381560T1 (de) | 2008-01-15 |
CA2431982C (en) | 2010-07-20 |
US20040058912A1 (en) | 2004-03-25 |
IL155806A0 (en) | 2003-12-23 |
KR100849569B1 (ko) | 2008-07-31 |
WO2002051232A2 (en) | 2002-07-04 |
MXPA03004779A (es) | 2003-09-25 |
HUP0301665A2 (en) | 2008-07-28 |
CN1261430C (zh) | 2006-06-28 |
NO20032905L (no) | 2003-06-24 |
US7192950B2 (en) | 2007-03-20 |
BR0116505A (pt) | 2004-02-03 |
ZA200303697B (en) | 2004-08-13 |
JP4219166B2 (ja) | 2009-02-04 |
ES2296825T3 (es) | 2008-05-01 |
AU2002240855B2 (en) | 2006-08-17 |
EP1347967A1 (de) | 2003-10-01 |
NZ525613A (en) | 2005-01-28 |
EP1347967B1 (de) | 2007-12-19 |
DE60132017T2 (de) | 2008-12-04 |
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