MA26427A1 - Trihydrate de mesylate de 5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indole-2-one, procede pour sa preparation et compositions pharmaceutiques le contenant - Google Patents

Trihydrate de mesylate de 5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indole-2-one, procede pour sa preparation et compositions pharmaceutiques le contenant

Info

Publication number
MA26427A1
MA26427A1 MA24594A MA24594A MA26427A1 MA 26427 A1 MA26427 A1 MA 26427A1 MA 24594 A MA24594 A MA 24594A MA 24594 A MA24594 A MA 24594A MA 26427 A1 MA26427 A1 MA 26427A1
Authority
MA
Morocco
Prior art keywords
benzisothiazole
piperazinyl
indole
dihydro
chloro
Prior art date
Application number
MA24594A
Other languages
English (en)
Inventor
A Rose Carol
R Busch Frank
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA26427A1 publication Critical patent/MA26427A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA24594A 1996-05-07 1997-05-06 Trihydrate de mesylate de 5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indole-2-one, procede pour sa preparation et compositions pharmaceutiques le contenant MA26427A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1653796P 1996-05-07 1996-05-07

Publications (1)

Publication Number Publication Date
MA26427A1 true MA26427A1 (fr) 2004-12-20

Family

ID=21777622

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24594A MA26427A1 (fr) 1996-05-07 1997-05-06 Trihydrate de mesylate de 5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indole-2-one, procede pour sa preparation et compositions pharmaceutiques le contenant

Country Status (46)

Country Link
US (1) US6110918A (fr)
EP (1) EP0904273B1 (fr)
JP (1) JP3102896B2 (fr)
KR (1) KR100333214B1 (fr)
CN (1) CN1092658C (fr)
AP (1) AP838A (fr)
AR (1) AR007003A1 (fr)
AT (1) ATE236902T1 (fr)
AU (1) AU730856C (fr)
BG (1) BG63601B1 (fr)
BR (1) BR9708932A (fr)
CA (1) CA2252895C (fr)
CO (1) CO4940465A1 (fr)
CZ (1) CZ289216B6 (fr)
DE (1) DE69720719T2 (fr)
DK (1) DK0904273T3 (fr)
DZ (1) DZ2221A1 (fr)
EA (1) EA001180B1 (fr)
EG (1) EG24401A (fr)
ES (1) ES2192264T3 (fr)
GT (1) GT199700042A (fr)
HK (1) HK1017893A1 (fr)
HN (1) HN1997000040A (fr)
HR (1) HRP970235B1 (fr)
HU (1) HU229057B1 (fr)
ID (1) ID17504A (fr)
IL (1) IL126590A (fr)
IS (1) IS2301B (fr)
MA (1) MA26427A1 (fr)
ME (1) ME00901B (fr)
MY (1) MY128051A (fr)
NO (1) NO312513B1 (fr)
NZ (2) NZ332219A (fr)
OA (1) OA10908A (fr)
PL (1) PL188164B1 (fr)
PT (1) PT904273E (fr)
SI (1) SI0904273T1 (fr)
SK (1) SK282674B6 (fr)
TN (1) TNSN97073A1 (fr)
TR (1) TR199802241T2 (fr)
TW (1) TW427989B (fr)
UA (1) UA47467C2 (fr)
UY (1) UY24543A1 (fr)
WO (1) WO1997042190A1 (fr)
YU (1) YU49398B (fr)
ZA (1) ZA973875B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1996000101A (es) * 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
TW491847B (en) 1996-05-07 2002-06-21 Pfizer Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
PT985414E (pt) * 1998-05-26 2004-01-30 Pfizer Prod Inc Metodo de tratamento de glaucoma e retinopatia isquemica
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
DZ3227A1 (fr) 1999-12-23 2001-07-05 Pfizer Prod Inc Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees
BR0111271A (pt) * 2000-06-02 2003-06-10 Pfizer Prod Inc S-metil-dihidro-ziprasidona para tratamento de distúrbios psiquiátricos e oculares
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
UY27668A1 (es) * 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
US7488729B2 (en) 2002-12-04 2009-02-10 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
WO2004050655A1 (fr) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Formes polymorphes de ziprasidone et son chlorhydrate
CA2525866A1 (fr) * 2003-05-16 2004-11-25 Pfizer Products Inc. Traitement de troubles psychotiques et depressifs
BRPI0410419A (pt) * 2003-05-16 2006-05-30 Pfizer Prod Inc tratamento para a ansiedade com ziprasidona
MXPA05012325A (es) * 2003-05-16 2006-01-30 Pfizer Prod Inc Procedimiento para potenciar la cognicion usando zipirasidona.
CA2528192A1 (fr) * 2003-06-03 2005-02-24 Teva Pharmaceutical Industries Ltd Chlorhydrate de ziprasidone cristallin et ses procedes de preparation
BRPI0414082A (pt) * 2003-09-02 2006-10-24 Pfizer Prod Inc formas de dosagem de liberação sustentada de ziprasidona
US7667037B2 (en) * 2003-10-24 2010-02-23 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
US20050197347A1 (en) * 2003-12-18 2005-09-08 Judith Aronhime Polymorphic form B2 of ziprasidone base
EP1703898A2 (fr) * 2003-12-31 2006-09-27 Alpharma, Inc. Formulations de ziprasidone
ATE451367T1 (de) * 2004-02-27 2009-12-15 Ranbaxy Lab Ltd Verfahren zur herstellung von ziprasidon
WO2006026426A2 (fr) * 2004-08-27 2006-03-09 University Of Kentucky Research Foundation Enzyme d'inactivation de peptide amyloide pour traiter la maladie d'alzheimer de façon peripherique
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
JP5324098B2 (ja) * 2004-11-16 2013-10-23 アルケルメス ファーマ アイルランド リミテッド 注射可能なナノ粒子のオランザピン製剤
EP1863806A1 (fr) * 2005-02-11 2007-12-12 Teva Pharmaceutical Industries Ltd Ziprasidone mesylate amorphe
WO2006096462A1 (fr) * 2005-03-03 2006-09-14 Elan Pharma International Limited Compositions nanoparticulaires de derives d'amide heterocyclique
ITMI20050346A1 (it) 2005-03-07 2006-09-08 Dipharma Spa Forma solida di ziprasidone cloridrato
US20060270684A1 (en) * 2005-03-14 2006-11-30 Judith Aronhime Crystalline forms of ziprasidone mesylate
WO2006099452A1 (fr) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Mesylate de ziprasidone anhydre et son procede de preparation
MX2009011681A (es) * 2007-05-18 2009-11-10 Scidose Llc Formulaciones de ziprasidona.
KR100948126B1 (ko) * 2007-12-10 2010-03-18 씨제이제일제당 (주) 결정형의 지프라시돈 술폰산염, 그 제조방법, 및 그것를포함하는 약제학적 조성물
CN102234273B (zh) * 2010-04-21 2015-08-05 上海医药工业研究院 甲磺酸齐拉西酮半水合物及其制备方法
SI23610A (sl) 2011-01-13 2012-07-31 Diagen@d@o@o Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji
EP3610890A1 (fr) 2012-11-14 2020-02-19 The Johns Hopkins University Procédés et compositions de traitement de la schizophrénie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5312925A (en) * 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5359068A (en) * 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one

Also Published As

Publication number Publication date
AU1936897A (en) 1997-11-26
HU229057B1 (en) 2013-07-29
IL126590A0 (en) 1999-08-17
EP0904273A1 (fr) 1999-03-31
CN1216990A (zh) 1999-05-19
BR9708932A (pt) 1999-08-03
MY128051A (en) 2007-01-31
OA10908A (en) 2001-10-26
CN1092658C (zh) 2002-10-16
CZ289216B6 (cs) 2001-12-12
PT904273E (pt) 2003-06-30
DK0904273T3 (da) 2003-07-07
SK150598A3 (en) 2000-03-13
AU730856C (en) 2001-11-15
IS2301B (is) 2007-10-15
SK282674B6 (sk) 2002-11-06
ATE236902T1 (de) 2003-04-15
WO1997042190A1 (fr) 1997-11-13
IL126590A (en) 2001-11-25
ZA973875B (en) 1998-11-06
ID17504A (id) 1998-01-08
EA001180B1 (ru) 2000-10-30
NO312513B1 (no) 2002-05-21
US6110918A (en) 2000-08-29
HRP970235B1 (en) 2002-08-31
HN1997000040A (es) 1997-06-05
NO985193L (no) 1998-11-06
HUP9902808A3 (en) 2000-04-28
HRP970235A2 (en) 1998-06-30
NZ332219A (en) 2005-02-25
TNSN97073A1 (fr) 2005-03-15
PL329880A1 (en) 1999-04-12
CZ349498A3 (cs) 1999-09-15
JPH11509865A (ja) 1999-08-31
GT199700042A (es) 1998-10-02
BG102893A (en) 1999-09-30
JP3102896B2 (ja) 2000-10-23
CO4940465A1 (es) 2000-07-24
IS4878A (is) 1998-10-23
DE69720719D1 (de) 2003-05-15
EA199800909A1 (ru) 1999-04-29
HK1017893A1 (en) 1999-12-03
AU730856B2 (en) 2001-03-15
UA47467C2 (uk) 2002-07-15
KR20000010822A (ko) 2000-02-25
TR199802241T2 (fr) 1999-02-22
AP838A (en) 2000-05-03
CA2252895C (fr) 2002-08-20
AP9700978A0 (en) 1997-07-31
TW427989B (en) 2001-04-01
SI0904273T1 (en) 2003-08-31
HUP9902808A2 (hu) 2000-03-28
YU17397A (sh) 2000-10-30
BG63601B1 (bg) 2002-06-28
DZ2221A1 (fr) 2002-12-03
CA2252895A1 (fr) 1997-11-13
EP0904273B1 (fr) 2003-04-09
PL188164B1 (pl) 2004-12-31
ES2192264T3 (es) 2003-10-01
NO985193D0 (no) 1998-11-06
NZ508303A (en) 2001-07-27
YU49398B (sh) 2005-11-28
ME00901B (me) 2005-11-28
EG24401A (en) 2009-04-29
AR007003A1 (es) 1999-10-13
UY24543A1 (es) 2000-09-29
DE69720719T2 (de) 2003-11-06
KR100333214B1 (ko) 2002-06-20

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