WO1995000497A1
(fr)
*
|
1993-06-18 |
1995-01-05 |
Merck & Co., Inc. |
Inhibiteurs de farnesyle-proteine transferase
|
US5721236A
(en)
*
|
1993-10-15 |
1998-02-24 |
Schering Corporation |
Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
US6524832B1
(en)
|
1994-02-04 |
2003-02-25 |
Arch Development Corporation |
DNA damaging agents in combination with tyrosine kinase inhibitors
|
US5700806A
(en)
*
|
1995-03-24 |
1997-12-23 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
US5856326A
(en)
*
|
1995-03-29 |
1999-01-05 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
IL117797A0
(en)
*
|
1995-04-07 |
1996-08-04 |
Pharmacopeia Inc |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
IL117798A
(en)
*
|
1995-04-07 |
2001-11-25 |
Schering Plough Corp |
Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
|
US5801175A
(en)
*
|
1995-04-07 |
1998-09-01 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
US5712280A
(en)
*
|
1995-04-07 |
1998-01-27 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
AU724331B2
(en)
*
|
1995-07-13 |
2000-09-14 |
University Of Cincinnati, The |
Compounds useful in the treatment of neurofibromatosis
|
PL185597B1
(pl)
*
|
1995-12-22 |
2003-06-30 |
Schering Corp |
Tricykliczne amidy, środek farmaceutyczny i ich zastosowania
|
US5874442A
(en)
*
|
1995-12-22 |
1999-02-23 |
Schering-Plough Corporation |
Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
|
US6028201A
(en)
*
|
1996-01-30 |
2000-02-22 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
AU6605196A
(en)
*
|
1996-02-29 |
1997-09-16 |
Duke University |
Method of treating hepatitis delta virus infection
|
DE19624659A1
(de)
|
1996-06-20 |
1998-01-08 |
Klinge Co Chem Pharm Fab |
Neue Pyridylalken- und Pyridylalkinsäureamide
|
US6451816B1
(en)
|
1997-06-20 |
2002-09-17 |
Klinge Pharma Gmbh |
Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
|
US5925757A
(en)
*
|
1996-07-26 |
1999-07-20 |
Schering Corporation |
Method for preparing carboxamides
|
PE92098A1
(es)
*
|
1996-07-31 |
1998-12-31 |
Schering Corp |
N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo
|
US6040305A
(en)
*
|
1996-09-13 |
2000-03-21 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US5985879A
(en)
*
|
1996-09-13 |
1999-11-16 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
HUP9904067A2
(hu)
*
|
1996-09-13 |
2000-05-28 |
Schering Corporation |
A G-protein-funkció gátlására és daganatos betegségek kezelésére alkalmazható triciklusos vegyületek
|
US6071907A
(en)
*
|
1996-09-13 |
2000-06-06 |
Schering Corporation |
Tricyclic compounds useful as FPT inhibitors
|
US5994364A
(en)
|
1996-09-13 |
1999-11-30 |
Schering Corporation |
Tricyclic antitumor farnesyl protein transferase inhibitors
|
TR199901273T2
(xx)
*
|
1996-09-13 |
1999-09-21 |
Schering Corporation |
Farnezil protein transferaz inhibisyonu i�in yararl� bile�ikler.
|
EP0931077B1
(fr)
*
|
1996-09-13 |
2005-04-27 |
Schering Corporation |
Benzocycloheptapyridine substituee utile en tant qu'inhibiteur de la farnesyl-proteine transferase
|
IL128931A0
(en)
*
|
1996-09-13 |
2000-02-17 |
Schering Corp |
Tricylic antitumor compounds being farnesyl protein transferase inhibitors
|
ID21218A
(id)
*
|
1996-09-13 |
1999-05-06 |
Schering Corp |
Senyawa trisiklik piperidinil baru yang berguna sebagai penghambat transferase farnesil protein
|
US5958890A
(en)
*
|
1996-09-13 |
1999-09-28 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
KR20000036110A
(ko)
*
|
1996-09-13 |
2000-06-26 |
둘락 노먼 씨. |
파르네실 단백질 전이효소의 억제에 유용한 삼환식 화합물
|
NZ334453A
(en)
*
|
1996-09-13 |
2000-08-25 |
Schering Corp |
Tricyclic inhibitors of farnesyl protein transferase
|
US5861395A
(en)
*
|
1996-09-13 |
1999-01-19 |
Schering Corporation |
Compounds useful for inhibition of farnesyl proteins transferase
|
US5945429A
(en)
*
|
1996-09-13 |
1999-08-31 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US5965570A
(en)
*
|
1996-09-13 |
1999-10-12 |
Schering Corporation |
Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase
|
US6030982A
(en)
*
|
1996-09-13 |
2000-02-29 |
Schering Corporationm |
Compounds useful for inhibition of farnesyl protein transferase
|
US6130229A
(en)
*
|
1996-10-09 |
2000-10-10 |
Schering Corporation |
Tricyclic compounds having activity as RAS-FPT inhibitors
|
ATE239020T1
(de)
*
|
1996-10-09 |
2003-05-15 |
Schering Corp |
Tricyclische verbindungen als ras-fpt inhibitoren
|
US5760232A
(en)
*
|
1997-06-16 |
1998-06-02 |
Schering Corporation |
Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds
|
US6051582A
(en)
*
|
1997-06-17 |
2000-04-18 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US6689789B2
(en)
|
1997-06-17 |
2004-02-10 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
EP0989984A1
(fr)
*
|
1997-06-17 |
2000-04-05 |
Schering Corporation |
Composes de bispyrido-cycloheptane utiles pour l'inhibition de farnesyl proteine transferase
|
US5877177A
(en)
*
|
1997-06-17 |
1999-03-02 |
Schering Corporation |
Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
US6225322B1
(en)
|
1997-06-17 |
2001-05-01 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US5925639A
(en)
*
|
1997-06-17 |
1999-07-20 |
Schering Corporation |
Keto amide derivatives useful as farnesyl protein transferase inhibitors
|
KR100640672B1
(ko)
*
|
1997-06-17 |
2006-11-02 |
파마코페이아 드럭 디스커버리, 인크. |
파르네실 단백질 트랜스퍼라제의 억제에 유용한 벤즈피리도 사이클로헵탄 화합물 및 이를 포함하는 약제학적 조성물
|
US6218401B1
(en)
|
1997-06-17 |
2001-04-17 |
Schering Corporation |
Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
|
EP0989981A1
(fr)
*
|
1997-06-17 |
2000-04-05 |
Schering Corporation |
Nouveaux composes tricycliques de phenyle substitues inhibiteurs de farnesyl proteine transferase
|
CN1286690A
(zh)
*
|
1997-06-17 |
2001-03-07 |
先灵公司 |
用于抑制法尼基蛋白转移酶的化合物
|
NZ501614A
(en)
*
|
1997-06-17 |
2001-10-26 |
Schering Corp |
Benzo[5,6]cyclohepta[1,2-b]pyridine derivatives useful for inhibition of farnesyl protein transferase
|
WO1998057964A1
(fr)
*
|
1997-06-17 |
1998-12-23 |
Schering Corporation |
Composes tricycliques utilises comme inhibiteurs de la fonction de la proteine et pour le traitement de maladies proliferantes
|
US6576639B1
(en)
|
1997-06-17 |
2003-06-10 |
Schering Corporation |
Compounds for the inhibition of farnesyl protein transferase
|
US6228865B1
(en)
|
1997-06-17 |
2001-05-08 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US6159984A
(en)
|
1997-06-17 |
2000-12-12 |
Schering Corporation |
Farnesyl protein transferase inhibitors
|
US6239140B1
(en)
|
1997-06-17 |
2001-05-29 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US6211193B1
(en)
|
1997-06-17 |
2001-04-03 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US5925648A
(en)
*
|
1997-07-29 |
1999-07-20 |
Schering Corporation |
Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase
|
US5958940A
(en)
*
|
1997-09-11 |
1999-09-28 |
Schering Corporation |
Tricyclic compounds useful as inhibitors of farnesyl-protein transferase
|
EP1021436A1
(fr)
*
|
1997-10-10 |
2000-07-26 |
Schering Corporation |
POLYMORPHE D'ETHYL 4-(8-CHLORO-5, 6,-DIHYDRO-11H- BENZO 5,6]CYCLOHEPTA 1,2-b]PYRIDINE -11-YLIDENE)-1- PIPERIDENE CARBOXYLATE
|
US6903118B1
(en)
|
1997-12-17 |
2005-06-07 |
Klinge Pharma Gmbh |
Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
|
DE19756212A1
(de)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
|
DE19756235A1
(de)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
|
DE19756261A1
(de)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
|
US6632455B2
(en)
|
1997-12-22 |
2003-10-14 |
Schering Corporation |
Molecular dispersion composition with enhanced bioavailability
|
EP1091736A4
(fr)
|
1998-07-02 |
2001-10-24 |
Merck & Co Inc |
Inhibiteurs de prenyl-proteine transferase
|
US6410534B1
(en)
|
1998-07-02 |
2002-06-25 |
Merck & Co., Inc. |
Inhibitors of prenyl-protein transferase
|
US6372747B1
(en)
|
1998-12-18 |
2002-04-16 |
Schering Corporation |
Farnesyl protein transferase inhibitors
|
EP1031564A1
(fr)
|
1999-02-26 |
2000-08-30 |
Klinge Pharma GmbH |
Inhibiteurs de la formation du nicotinamide mononucléotide et leur utilisation dans le traitement du cancer
|
US6686502B1
(en)
|
1999-03-26 |
2004-02-03 |
Ucb S.A. |
Compounds and methods for treatment of asthma, allergy and inflammatory disorders
|
PE20001566A1
(es)
|
1999-03-26 |
2001-02-05 |
Ucb Sa |
Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
|
US6316462B1
(en)
|
1999-04-09 |
2001-11-13 |
Schering Corporation |
Methods of inducing cancer cell death and tumor regression
|
WO2001018006A1
(fr)
*
|
1999-09-09 |
2001-03-15 |
Merck & Co., Inc. |
Inhibiteurs de prenyl-proteine transferase
|
AU2002359412A1
(en)
|
2001-11-13 |
2003-05-26 |
Bristol-Myers Squibb Company |
Process for the preparation of 3,7-disubstituted-2,3,4,5- tetrahydro-1h-1,4-benzodiazepine compounds
|
EP1507774A1
(fr)
*
|
2003-03-12 |
2005-02-23 |
Biogal Gyogyszergyar Rt. |
Procedes de preparation de formes polymorphiques de la desloratadine
|
EP1656156A2
(fr)
|
2003-08-13 |
2006-05-17 |
Children's Hospital Medical Center |
Mobilisation de cellules hematopoietques
|
WO2006123182A2
(fr)
|
2005-05-17 |
2006-11-23 |
Merck Sharp & Dohme Limited |
Sulfones de cyclohexyle pour le traitement du cancer
|
US20090131423A1
(en)
*
|
2005-10-21 |
2009-05-21 |
Merck & Co., Inc. |
Tyrosine Kinase Inhibitors
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
PL2010528T3
(pl)
|
2006-04-19 |
2018-03-30 |
Novartis Ag |
6-0-podstawione związki benzoksazolowe i benzotiazolowe i sposoby hamowania sygnalizacji csf-1r
|
EP2946778A1
(fr)
|
2006-09-22 |
2015-11-25 |
Merck Sharp & Dohme Corp. |
Procédé de traitement utilisant des inhibiteurs de la synthèse d'acides gras
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
EP2109608B1
(fr)
|
2007-01-10 |
2011-03-23 |
Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. |
Indazoles à substitution amide utilisés comme inhibiteurs de la poly(adp-ribose)polymérase (parp)
|
EA019951B1
(ru)
|
2007-03-01 |
2014-07-30 |
Новартис Аг |
Ингибиторы киназы pim и способы их применения
|
KR20100017866A
(ko)
|
2007-05-21 |
2010-02-16 |
노파르티스 아게 |
Csf-1r 억제제, 조성물 및 사용 방법
|
EP3103791B1
(fr)
|
2007-06-27 |
2018-01-31 |
Merck Sharp & Dohme Corp. |
Dérivés de 4-carboxybenzylamino utilisés comme inhibiteurs de l'histone désacétylase
|
WO2010114780A1
(fr)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibiteurs de l'activité akt
|
WO2010144909A1
(fr)
|
2009-06-12 |
2010-12-16 |
Novartis Ag |
Composés hétérocycliques fondus et leurs utilisations
|
CN104945382B
(zh)
|
2009-10-14 |
2020-02-07 |
默沙东公司 |
提高p53活性的取代的哌啶和其用途
|
EP2519517B1
(fr)
|
2009-12-29 |
2015-03-25 |
Dana-Farber Cancer Institute, Inc. |
Inhibiteurs de kinase raf de type ii
|
EA201290919A1
(ru)
|
2010-03-16 |
2013-03-29 |
Дана-Фарбер Кэнсер Инститьют, Инк. |
Индазольные соединения и их применение
|
US8999957B2
(en)
|
2010-06-24 |
2015-04-07 |
Merck Sharp & Dohme Corp. |
Heterocyclic compounds as ERK inhibitors
|
JP6043285B2
(ja)
|
2010-08-02 |
2016-12-14 |
サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. |
低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害
|
CN108676800B
(zh)
|
2010-08-17 |
2022-11-11 |
瑟纳治疗公司 |
使用短干扰核酸(siNA)的乙型肝炎病毒(HBV)基因表达的RNA干扰介导的抑制
|
EP2608669B1
(fr)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
Nouveaux dérivés de pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs de mtor
|
EP2613782B1
(fr)
|
2010-09-01 |
2016-11-02 |
Merck Sharp & Dohme Corp. |
Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
ES2663009T3
(es)
|
2010-10-29 |
2018-04-10 |
Sirna Therapeutics, Inc. |
Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
|
EP2654748B1
(fr)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
|
CN103732592A
(zh)
|
2011-04-21 |
2014-04-16 |
默沙东公司 |
胰岛素样生长因子-1受体抑制剂
|
WO2013063214A1
(fr)
|
2011-10-27 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Nouveaux composés qui sont des inhibiteurs d'erk
|
JP6106685B2
(ja)
|
2011-11-17 |
2017-04-05 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
C−jun−n−末端キナーゼ(jnk)の阻害剤
|
EP3358013B1
(fr)
|
2012-05-02 |
2020-06-24 |
Sirna Therapeutics, Inc. |
Compositions d'acide nucléique interférent court (sina)
|
CN105050598B
(zh)
|
2012-09-28 |
2018-04-27 |
默沙东公司 |
作为erk抑制剂的新型化合物
|
EP2909194A1
(fr)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibiteurs de cycline-dépendante kinase 7 (cdk7)
|
USRE48175E1
(en)
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
CA2892361A1
(fr)
|
2012-11-28 |
2014-06-05 |
Merck Sharp & Dohme Corp. |
Utilisation d'un inhibiteur wee1 pour traiter un cancer caracterise par de faibles niveaux d'expression de proteines tyrosine et threonine kinases 1 (pkmyt1) associee a la membrane
|
AU2013361694B2
(en)
|
2012-12-20 |
2017-10-26 |
Merck Sharp & Dohme Corp. |
Substituted imidazopyridines as HDM2 inhibitors
|
WO2014120748A1
(fr)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
|
EP3041938A1
(fr)
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Polynucléotides circulaires
|
AU2014337044A1
(en)
|
2013-10-18 |
2016-05-05 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
|
WO2015058126A1
(fr)
|
2013-10-18 |
2015-04-23 |
Syros Pharmaceuticals, Inc. |
Composés hétéroaromatiques utiles dans le traitement de maladies prolifératives
|
WO2015164604A1
(fr)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Inhibiteurs de janus kinase marqués de manière hydrophobe et utilisations associées
|
US10017477B2
(en)
|
2014-04-23 |
2018-07-10 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
JO3589B1
(ar)
|
2014-08-06 |
2020-07-05 |
Novartis Ag |
مثبطات كيناز البروتين c وطرق استخداماتها
|
AU2015371251B2
(en)
|
2014-12-23 |
2020-06-11 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
US10550121B2
(en)
|
2015-03-27 |
2020-02-04 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
CA2986441A1
(fr)
|
2015-06-12 |
2016-12-15 |
Dana-Farber Cancer Institute, Inc. |
Therapie d'association utilisant des inhibiteurs de transcription et des inhibiteurs de kinases
|
CA2996978A1
(fr)
|
2015-09-09 |
2017-03-16 |
Dana-Farber Cancer Institute, Inc. |
Inhibiteurs de kinases cycline-dependantes
|
JOP20190055A1
(ar)
|
2016-09-26 |
2019-03-24 |
Merck Sharp & Dohme |
أجسام مضادة ضد cd27
|
EP3525785A4
(fr)
|
2016-10-12 |
2020-03-25 |
Merck Sharp & Dohme Corp. |
Inhibiteurs de kdm5
|
AU2018252546A1
(en)
|
2017-04-13 |
2019-10-10 |
Sairopa B.V. |
Anti-SIRPα antibodies
|
WO2019094311A1
(fr)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Inhibiteurs de prmt5
|
WO2019148412A1
(fr)
|
2018-02-01 |
2019-08-08 |
Merck Sharp & Dohme Corp. |
Anticorps bispécifiques anti-pd-1/lag3
|
WO2020033282A1
(fr)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Inhibiteurs de prmt5
|
US11981701B2
(en)
|
2018-08-07 |
2024-05-14 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|