HUP9904067A2 - A G-protein-funkció gátlására és daganatos betegségek kezelésére alkalmazható triciklusos vegyületek - Google Patents
A G-protein-funkció gátlására és daganatos betegségek kezelésére alkalmazható triciklusos vegyületekInfo
- Publication number
- HUP9904067A2 HUP9904067A2 HU9904067A HUP9904067A HUP9904067A2 HU P9904067 A2 HUP9904067 A2 HU P9904067A2 HU 9904067 A HU9904067 A HU 9904067A HU P9904067 A HUP9904067 A HU P9904067A HU P9904067 A2 HUP9904067 A2 HU P9904067A2
- Authority
- HU
- Hungary
- Prior art keywords
- general formula
- powder
- treatment
- pipe
- tricyclic compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- -1 amidino- Chemical class 0.000 abstract 5
- 239000000843 powder Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000010985 leather Substances 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- JQQSUOJIMKJQHS-UHFFFAOYSA-N pentaphenyl group Chemical group C1=CC=CC2=CC3=CC=C4C=C5C=CC=CC5=CC4=C3C=C12 JQQSUOJIMKJQHS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgyát (1.0) általánős képletű farnezil-prőtein-transzferáz inhibitőr hatású, új, triciklűsős vegyületek -, ahől a nitrőgénatőm, b, c és d metincsőpőrt; R1, R2, R3 és R4 egymástól függetlenül hidrőgén- vagy halőgénatőm; R5, R6, R7 és R8 hidrőgénatőm; A és B az 5-ös és 6-ős szénatőm közötti egyszeres vagy kettős kötéstőlfüggően egy-egy vagy két-két hidrőgénatőm; X szén- vagy nitrőgénatőm vagy CH képletű csőpőrt; és R adőtt esetben szűbsztitűált acil-, imidőil-, amidinő-, szűlfamőil-,karbamőil-, szűlfőnil-, főszfinil-, alkil-, aril-, aralkil-,ciklőalkil-, heterőciklőalkil-, heterőaril- vagy 1-aminő-2-nitrő-vinil-csőpőrt, cianőcsőpőrt vagy egy cűkőrból származtatható csőpőrt-, és ezeket tartalmazó gyógyszerkészítmények, valamint daganatősbetegségek kezelésére való alkalmazásűk képezik. Az (1.0) általánősképletű vegyületeket egy (19.0), (21.0) vagy (21.1) általánős képletűvegyület ismert módőn történő szűbsztitúciójával és adőtt esetben avegyület tővábbi átalakításával és/vagy a védőcsőpőrt(ők)eltávőlításával állítják elő. (1.0) (19.0) (21.0) (21.1) ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71332696A | 1996-09-13 | 1996-09-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP9904067A2 true HUP9904067A2 (hu) | 2000-05-28 |
Family
ID=24865700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9904067A HUP9904067A2 (hu) | 1996-09-13 | 1997-09-11 | A G-protein-funkció gátlására és daganatos betegségek kezelésére alkalmazható triciklusos vegyületek |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0927178B1 (hu) |
JP (1) | JP3152438B2 (hu) |
KR (1) | KR20000036059A (hu) |
CN (1) | CN1237169A (hu) |
AT (1) | ATE213736T1 (hu) |
AU (1) | AU729810B2 (hu) |
BR (1) | BR9712819A (hu) |
CA (1) | CA2264569C (hu) |
CZ (1) | CZ83499A3 (hu) |
DE (1) | DE69710741T2 (hu) |
ES (1) | ES2169420T3 (hu) |
HK (1) | HK1018267A1 (hu) |
HU (1) | HUP9904067A2 (hu) |
ID (1) | ID22045A (hu) |
IL (1) | IL128949A0 (hu) |
NO (1) | NO991230L (hu) |
NZ (1) | NZ334340A (hu) |
PL (1) | PL332240A1 (hu) |
SK (1) | SK33199A3 (hu) |
TR (1) | TR199900561T2 (hu) |
WO (1) | WO1998011096A1 (hu) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
DE69928226T8 (de) | 1998-01-21 | 2006-10-19 | Millennium Pharmaceuticals, Inc., Cambridge | Chemokin rezeptor antagonisten und verwendung |
EP1047675A1 (en) | 1998-01-21 | 2000-11-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
WO2005017160A2 (en) | 2003-08-13 | 2005-02-24 | Children's Hospital Medical Center | Mobilization of hematopoietic cells |
ATE524445T1 (de) | 2005-06-23 | 2011-09-15 | Merck Sharp & Dohme | Benzocycloheptapyridine als inhibitoren der tyrosinkinase met |
TW200813021A (en) | 2006-07-10 | 2008-03-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
TW201024283A (en) | 2008-12-01 | 2010-07-01 | Targacept Inc | Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine |
JP6959332B2 (ja) | 2016-09-27 | 2021-11-02 | ミッション セラピューティクス リミティド | Usp30の阻害剤としての活性を有するシアノピロリジン誘導体 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2164717T3 (es) * | 1993-10-15 | 2002-03-01 | Schering Corp | Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas. |
DK0723538T3 (da) * | 1993-10-15 | 2002-03-18 | Schering Corp | Tricykliske carbamatforbindelser, der er nyttige til inhibition af funktion af G-protein og til behandling af proliferative sygdomme |
IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
-
1997
- 1997-09-11 ID IDW990090D patent/ID22045A/id unknown
- 1997-09-11 AT AT97941474T patent/ATE213736T1/de not_active IP Right Cessation
- 1997-09-11 WO PCT/US1997/015900 patent/WO1998011096A1/en not_active Application Discontinuation
- 1997-09-11 EP EP97941474A patent/EP0927178B1/en not_active Expired - Lifetime
- 1997-09-11 PL PL97332240A patent/PL332240A1/xx unknown
- 1997-09-11 CZ CZ99834A patent/CZ83499A3/cs unknown
- 1997-09-11 AU AU43373/97A patent/AU729810B2/en not_active Ceased
- 1997-09-11 SK SK331-99A patent/SK33199A3/sk unknown
- 1997-09-11 IL IL12894997A patent/IL128949A0/xx unknown
- 1997-09-11 HU HU9904067A patent/HUP9904067A2/hu unknown
- 1997-09-11 KR KR1019997002062A patent/KR20000036059A/ko not_active Application Discontinuation
- 1997-09-11 CN CN97199586A patent/CN1237169A/zh active Pending
- 1997-09-11 BR BR9712819-8A patent/BR9712819A/pt unknown
- 1997-09-11 TR TR1999/00561T patent/TR199900561T2/xx unknown
- 1997-09-11 NZ NZ334340A patent/NZ334340A/xx unknown
- 1997-09-11 ES ES97941474T patent/ES2169420T3/es not_active Expired - Lifetime
- 1997-09-11 DE DE69710741T patent/DE69710741T2/de not_active Expired - Fee Related
- 1997-09-11 JP JP51375998A patent/JP3152438B2/ja not_active Expired - Fee Related
- 1997-09-11 CA CA002264569A patent/CA2264569C/en not_active Expired - Fee Related
-
1999
- 1999-03-12 NO NO991230A patent/NO991230L/no not_active Application Discontinuation
- 1999-07-26 HK HK99103194A patent/HK1018267A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ334340A (en) | 2000-09-29 |
AU729810B2 (en) | 2001-02-08 |
TR199900561T2 (xx) | 1999-06-21 |
ATE213736T1 (de) | 2002-03-15 |
AU4337397A (en) | 1998-04-02 |
BR9712819A (pt) | 1999-11-23 |
EP0927178A1 (en) | 1999-07-07 |
CA2264569A1 (en) | 1998-03-19 |
ES2169420T3 (es) | 2002-07-01 |
EP0927178B1 (en) | 2002-02-27 |
CA2264569C (en) | 2003-11-11 |
HK1018267A1 (en) | 1999-12-17 |
KR20000036059A (ko) | 2000-06-26 |
JP2000502727A (ja) | 2000-03-07 |
NO991230D0 (no) | 1999-03-12 |
DE69710741D1 (de) | 2002-04-04 |
IL128949A0 (en) | 2000-02-17 |
SK33199A3 (en) | 1999-12-10 |
NO991230L (no) | 1999-05-14 |
DE69710741T2 (de) | 2002-10-24 |
JP3152438B2 (ja) | 2001-04-03 |
ID22045A (id) | 1999-08-26 |
CN1237169A (zh) | 1999-12-01 |
CZ83499A3 (cs) | 1999-07-14 |
WO1998011096A1 (en) | 1998-03-19 |
PL332240A1 (en) | 1999-08-30 |
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