HK1018267A1 - Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases - Google Patents

Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Info

Publication number
HK1018267A1
HK1018267A1 HK99103194A HK99103194A HK1018267A1 HK 1018267 A1 HK1018267 A1 HK 1018267A1 HK 99103194 A HK99103194 A HK 99103194A HK 99103194 A HK99103194 A HK 99103194A HK 1018267 A1 HK1018267 A1 HK 1018267A1
Authority
HK
Hong Kong
Prior art keywords
inhibition
treatment
compounds useful
proliferative diseases
protein function
Prior art date
Application number
HK99103194A
Other languages
English (en)
Inventor
Dinanath F Rane
Alan K Mallams
Arthur G Taveras
F George Njoroge
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1018267A1 publication Critical patent/HK1018267A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
HK99103194A 1996-09-13 1999-07-26 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases HK1018267A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71332696A 1996-09-13 1996-09-13
PCT/US1997/015900 WO1998011096A1 (en) 1996-09-13 1997-09-11 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Publications (1)

Publication Number Publication Date
HK1018267A1 true HK1018267A1 (en) 1999-12-17

Family

ID=24865700

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99103194A HK1018267A1 (en) 1996-09-13 1999-07-26 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Country Status (21)

Country Link
EP (1) EP0927178B1 (xx)
JP (1) JP3152438B2 (xx)
KR (1) KR20000036059A (xx)
CN (1) CN1237169A (xx)
AT (1) ATE213736T1 (xx)
AU (1) AU729810B2 (xx)
BR (1) BR9712819A (xx)
CA (1) CA2264569C (xx)
CZ (1) CZ83499A3 (xx)
DE (1) DE69710741T2 (xx)
ES (1) ES2169420T3 (xx)
HK (1) HK1018267A1 (xx)
HU (1) HUP9904067A2 (xx)
ID (1) ID22045A (xx)
IL (1) IL128949A0 (xx)
NO (1) NO991230L (xx)
NZ (1) NZ334340A (xx)
PL (1) PL332240A1 (xx)
SK (1) SK33199A3 (xx)
TR (1) TR199900561T2 (xx)
WO (1) WO1998011096A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO1999037619A1 (en) 1998-01-21 1999-07-29 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
IL137266A0 (en) 1998-01-21 2001-07-24 Millennium Pharm Inc Heterocyclic chemokine receptor antagonists and pharmaceutical compositions containing the same
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
EP1656156A2 (en) 2003-08-13 2006-05-17 Children's Hospital Medical Center Mobilization of hematopoietic cells
EP1896421B1 (en) 2005-06-23 2011-09-14 Merck Sharp & Dohme Corp. Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
TW201024283A (en) * 2008-12-01 2010-07-01 Targacept Inc Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine
EP3519385B1 (en) 2016-09-27 2020-11-18 Mission Therapeutics Limited Cyanopyrrolidine derivatives with activity as inhibitors of usp30

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2174105C (en) * 1993-10-15 2002-02-12 W. Robert Bishop Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
HUT76057A (en) * 1993-10-15 1997-06-30 Schering Corp Tricyclic sulfonamide compounds, pharmaceutical compositions containing them, which are useful for inhibition of g-protein function and for treatment of proliferative diseases and process for producing them

Also Published As

Publication number Publication date
JP2000502727A (ja) 2000-03-07
WO1998011096A1 (en) 1998-03-19
HUP9904067A2 (hu) 2000-05-28
PL332240A1 (en) 1999-08-30
DE69710741D1 (de) 2002-04-04
EP0927178B1 (en) 2002-02-27
CA2264569C (en) 2003-11-11
NO991230D0 (no) 1999-03-12
TR199900561T2 (xx) 1999-06-21
NZ334340A (en) 2000-09-29
NO991230L (no) 1999-05-14
BR9712819A (pt) 1999-11-23
JP3152438B2 (ja) 2001-04-03
ATE213736T1 (de) 2002-03-15
ES2169420T3 (es) 2002-07-01
AU4337397A (en) 1998-04-02
EP0927178A1 (en) 1999-07-07
KR20000036059A (ko) 2000-06-26
IL128949A0 (en) 2000-02-17
CN1237169A (zh) 1999-12-01
CZ83499A3 (cs) 1999-07-14
DE69710741T2 (de) 2002-10-24
ID22045A (id) 1999-08-26
SK33199A3 (en) 1999-12-10
CA2264569A1 (en) 1998-03-19
AU729810B2 (en) 2001-02-08

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20050911