MA21344A1 - 1,4-dihydropyridines, leur procede de preparation et leur application . - Google Patents

1,4-dihydropyridines, leur procede de preparation et leur application .

Info

Publication number
MA21344A1
MA21344A1 MA21587A MA21587A MA21344A1 MA 21344 A1 MA21344 A1 MA 21344A1 MA 21587 A MA21587 A MA 21587A MA 21587 A MA21587 A MA 21587A MA 21344 A1 MA21344 A1 MA 21344A1
Authority
MA
Morocco
Prior art keywords
methyl
dihydropyridines
application
preparation process
substd
Prior art date
Application number
MA21587A
Other languages
English (en)
French (fr)
Inventor
Fernandez Torija Carlos
Alvaro Galiano Ramos Joaquin
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of MA21344A1 publication Critical patent/MA21344A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MA21587A 1987-08-03 1988-08-01 1,4-dihydropyridines, leur procede de preparation et leur application . MA21344A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87401799A EP0302980B1 (fr) 1987-08-03 1987-08-03 1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments

Publications (1)

Publication Number Publication Date
MA21344A1 true MA21344A1 (fr) 1989-04-01

Family

ID=8198243

Family Applications (1)

Application Number Title Priority Date Filing Date
MA21587A MA21344A1 (fr) 1987-08-03 1988-08-01 1,4-dihydropyridines, leur procede de preparation et leur application .

Country Status (34)

Country Link
US (1) US4952592A (OSRAM)
EP (1) EP0302980B1 (OSRAM)
JP (1) JPH0733383B2 (OSRAM)
KR (1) KR960001724B1 (OSRAM)
CN (1) CN1038587C (OSRAM)
AT (1) ATE61588T1 (OSRAM)
BE (1) BE1001055A4 (OSRAM)
CA (2) CA1306261C (OSRAM)
CH (1) CH675999A5 (OSRAM)
CZ (1) CZ282077B6 (OSRAM)
DD (1) DD282008A5 (OSRAM)
DE (2) DE3768658D1 (OSRAM)
DK (1) DK430288A (OSRAM)
ES (1) ES2007543A6 (OSRAM)
FI (1) FI91406C (OSRAM)
GB (1) GB2208861B (OSRAM)
GR (2) GR880100507A (OSRAM)
HU (1) HU204523B (OSRAM)
IE (1) IE60358B1 (OSRAM)
IL (1) IL87321A (OSRAM)
IN (1) IN167550B (OSRAM)
IS (1) IS1549B (OSRAM)
IT (1) IT1235013B (OSRAM)
LU (1) LU87297A1 (OSRAM)
MA (1) MA21344A1 (OSRAM)
NO (1) NO170934C (OSRAM)
NZ (1) NZ225661A (OSRAM)
PH (1) PH25645A (OSRAM)
PT (1) PT88173B (OSRAM)
RU (1) RU2036922C1 (OSRAM)
SK (1) SK541388A3 (OSRAM)
TN (1) TNSN88081A1 (OSRAM)
YU (1) YU46547B (OSRAM)
ZA (1) ZA885684B (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242933A (en) * 1990-07-10 1993-09-07 Adir Et Compagnie Piperidine, tetrahydropyridine and pyrrolidine compounds
DE69616364T2 (de) * 1995-08-02 2002-07-11 Smithkline Beecham Corp., Philadelphia Endothelinrezeptorantagonisten
RU2168987C2 (ru) * 1997-04-15 2001-06-20 Санкт-Петербургская Государственная Химико-Фармацевтическая Академия Гипотензивное средство
RU2155036C2 (ru) * 1998-11-11 2000-08-27 Азад Зияд Оглы Абышев Средство для лечения ишемической болезни сердца
IT1304513B1 (it) * 1998-12-30 2001-03-19 Endura Spa Processo per la sintesi di 5-(alfa-idrossialchil)benzo(1,3)diossoli.
PL201513B1 (pl) * 2000-04-11 2009-04-30 Sankyo Co Stabilizowana kompozycja farmaceutyczna zawierająca bloker wapnia
RU2187303C2 (ru) * 2000-10-12 2002-08-20 Азад Зияд Оглы Абышев Способ получения таблеток диуманкала - forte по 0,01 г
KR100668539B1 (ko) 2002-08-19 2007-01-16 화이자 프로덕츠 인크. 과증식성 질환에 대한 조합요법
MX2007000979A (es) * 2004-07-26 2007-07-11 Cotherix Inc Tratamiento de la hipertension pulmonar por iloprost inhalado con una formulacion microparticulada.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
ATE551059T1 (de) * 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
HK1213886A1 (zh) 2013-04-17 2016-07-15 辉瑞大药厂 用於治療心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
PH12021551686A1 (en) 2019-01-18 2022-05-16 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd 1,4−ジヒドロピリジン−3,5−ジカルボン酸エステル誘導体
ES8507495A1 (es) * 1984-03-27 1985-09-01 Inst Investigacion Desarrollo Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
JPH068294B2 (ja) * 1985-02-26 1994-02-02 富山化学工業株式会社 新規な1,4−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (en) * 1984-09-01 1989-06-07 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPH01207267A (ja) * 1987-03-05 1989-08-21 Yamanouchi Pharmaceut Co Ltd ピリジン誘導体及び該化合物を含有する肝疾患治療剤

Also Published As

Publication number Publication date
SK278775B6 (sk) 1998-02-04
SK541388A3 (en) 1998-02-04
ZA885684B (en) 1989-04-26
IE882364L (en) 1989-02-03
JPH01294675A (ja) 1989-11-28
DK430288A (da) 1989-02-03
GB8818356D0 (en) 1988-09-07
ES2007543A6 (es) 1989-06-16
FI883603A7 (fi) 1989-02-04
FI91406C (fi) 1994-06-27
ATE61588T1 (de) 1991-03-15
FI91406B (fi) 1994-03-15
IN167550B (OSRAM) 1990-11-10
PT88173B (pt) 1995-03-01
CZ541388A3 (en) 1997-01-15
CA1306262C (fr) 1992-08-11
CN1031531A (zh) 1989-03-08
DK430288D0 (da) 1988-08-02
YU147088A (en) 1990-04-30
DE3825962A1 (de) 1989-02-16
NO883406D0 (no) 1988-08-01
BE1001055A4 (fr) 1989-06-20
DD282008A5 (de) 1990-08-29
HUT54142A (en) 1991-01-28
AU2033088A (en) 1989-02-09
NO170934C (no) 1992-12-30
YU46547B (sh) 1993-11-16
IE60358B1 (en) 1994-06-29
IS3378A7 (is) 1989-02-04
PT88173A (pt) 1989-06-30
IT8848259A0 (it) 1988-08-02
PH25645A (en) 1991-08-21
IT1235013B (it) 1992-06-16
NO170934B (no) 1992-09-21
AU606441B2 (en) 1991-02-07
RU2036922C1 (ru) 1995-06-09
GB2208861B (en) 1991-07-17
GB2208861A (en) 1989-04-19
DE3768658D1 (de) 1991-04-18
CH675999A5 (en) 1990-11-30
GR880100507A (el) 1989-05-25
CA1306261C (fr) 1992-08-11
IS1549B (is) 1994-06-08
KR960001724B1 (ko) 1996-02-03
EP0302980B1 (fr) 1991-03-13
LU87297A1 (fr) 1989-02-02
FI883603A0 (fi) 1988-08-01
IL87321A0 (en) 1989-01-31
CN1038587C (zh) 1998-06-03
EP0302980A1 (fr) 1989-02-15
NO883406L (no) 1989-02-06
IL87321A (en) 1993-04-04
KR890003743A (ko) 1989-04-17
HU204523B (en) 1992-01-28
JPH0733383B2 (ja) 1995-04-12
US4952592A (en) 1990-08-28
GR3001984T3 (en) 1992-11-23
NZ225661A (en) 1990-08-28
TNSN88081A1 (fr) 1990-07-10
CZ282077B6 (cs) 1997-05-14

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