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Application filed by Sandoz SafiledCriticalSandoz Sa
Priority to PT8388386ApriorityCriticalpatent/PT83883B/en
Publication of PT83883ApublicationCriticalpatent/PT83883A/en
Publication of PT83883BpublicationCriticalpatent/PT83883B/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
-benzo(4,5)cyclohepta(1,2b) thiophen-4-ylidene) acetic acids (I) and their hydrolysable esters and salts are new. (I) is esp. a cpd. of formula (Ia). R1 = H or 1-4C alkyl; R2 = halogen. 2-Chloro-10-methoxy-4H-benzo (4,5)cyclohepta(1,2-b)thiophen- 4-ylidene) acetic acid (Ib) and the corresp. 4-bromo cpds., and their Et esters are specifically claimed. The cpds. are esp. in cis-iso-meric form.
PT8388386A1986-12-051986-12-05
PROCESS FOR THE PREPARATION OF 4H-BENZO (4,5) CYCLOHEPTA (1,2-B) THIOPHENE DERIVATIVES
PT83883B
(en)
Analogous Process for Preparing the Therapeutically Active Compound (S) -7- (3-Amino-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, an in vivo readily cleavable lower alkyl ester or a pharmaceutically acceptable salt
DERIVATIVES OF ACID A- (HYDROXY-7 TETRAHYDRO-4,5,6,7 THIENO (3,2-C) PYRIDYL-5) ACETIC PHENYL, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM