LV13033B - Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplantant rejection - Google Patents

Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplantant rejection Download PDF

Info

Publication number
LV13033B
LV13033B LVP-03-25A LV030025A LV13033B LV 13033 B LV13033 B LV 13033B LV 030025 A LV030025 A LV 030025A LV 13033 B LV13033 B LV 13033B
Authority
LV
Latvia
Prior art keywords
methyl
ccr1 receptor
chloro
receptor antagonist
phenoxy
Prior art date
Application number
LVP-03-25A
Other languages
English (en)
Latvian (lv)
Inventor
Richard Horuk
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of LV13033B publication Critical patent/LV13033B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LVP-03-25A 2000-07-31 2003-02-28 Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplantant rejection LV13033B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22205300P 2000-07-31 2000-07-31
US23128200P 2000-09-08 2000-09-08
US09/915,411 US6740636B2 (en) 2000-07-31 2001-07-25 Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection

Publications (1)

Publication Number Publication Date
LV13033B true LV13033B (en) 2004-02-20

Family

ID=27397025

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-03-25A LV13033B (en) 2000-07-31 2003-02-28 Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplantant rejection

Country Status (28)

Country Link
US (1) US6740636B2 (da)
EP (1) EP1305047B1 (da)
JP (1) JP2004530630A (da)
KR (1) KR20030048000A (da)
CN (1) CN1655818A (da)
AT (1) ATE330634T1 (da)
AU (2) AU2001278073B2 (da)
BG (1) BG107502A (da)
BR (1) BR0113140A (da)
CA (1) CA2417636A1 (da)
CY (1) CY1105321T1 (da)
DE (1) DE60120986T2 (da)
DK (1) DK1305047T3 (da)
EE (1) EE200300047A (da)
ES (1) ES2261447T3 (da)
HR (1) HRP20030121A2 (da)
HU (1) HUP0300686A3 (da)
IL (1) IL153933A0 (da)
LV (1) LV13033B (da)
MX (1) MXPA03000836A (da)
NO (1) NO20030475L (da)
NZ (1) NZ523688A (da)
PL (1) PL364521A1 (da)
PT (1) PT1305047E (da)
SI (1) SI21123A (da)
SK (1) SK1222003A3 (da)
WO (1) WO2002009762A2 (da)
YU (1) YU6703A (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1838957A (zh) * 2003-08-22 2006-09-27 舍林股份公司 抑制趋化因子的哌嗪衍生物及其治疗心肌炎的用途
US7917195B2 (en) 2004-03-05 2011-03-29 Lifesciences Solutions LLC Systems, methods and computer program products for heart monitoring
US10499828B2 (en) * 2004-03-05 2019-12-10 Lifescience Solutions, Llc System and method for heart monitoring
US8103065B2 (en) * 2006-01-05 2012-01-24 Lifescience Solutions Llc Assessment of medical conditions
US20110009758A1 (en) * 2009-07-10 2011-01-13 Lifescience Solutions Llc System and method for heart monitoring

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
EA002146B1 (ru) 1997-02-26 2001-12-24 Пфайзер Инк. Производные амида гетероарил-гексановой кислоты, их получение и их применение в качестве селективных ингибиторов связывания mip-1-альфа с его рецептором ccr1
US6207665B1 (en) * 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
WO1999037619A1 (en) 1998-01-21 1999-07-29 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
HUP0101320A3 (en) 1998-01-21 2002-11-28 Kyowa Hakko Kogyo Kk Benzo- and pyridobenzoxepine and -benzazepine derivatives and use thereof
AU752407B2 (en) 1998-02-05 2002-09-19 Pfizer Products Inc. Novel dihydroxyhexanoic acid derivatives
EP1000626A1 (en) 1998-09-18 2000-05-17 Applied Research Systems ARS Holding N.V. Chemokine receptor antagonist and cyclosporin in combined therapy
WO2000044365A1 (en) 1999-01-29 2000-08-03 Millennium Pharmaceuticals, Inc. Methods for preventing graft rejection and ischemia-reperfusion injury

Also Published As

Publication number Publication date
DE60120986T2 (de) 2006-11-23
HUP0300686A3 (en) 2005-03-29
EP1305047A2 (en) 2003-05-02
BG107502A (en) 2003-07-31
NO20030475D0 (no) 2003-01-30
BR0113140A (pt) 2003-06-24
NO20030475L (no) 2003-03-28
HUP0300686A2 (hu) 2003-08-28
SI21123A (sl) 2003-08-31
PL364521A1 (en) 2004-12-13
AU7807301A (en) 2002-02-13
DK1305047T3 (da) 2006-10-23
KR20030048000A (ko) 2003-06-18
JP2004530630A (ja) 2004-10-07
CN1655818A (zh) 2005-08-17
ES2261447T3 (es) 2006-11-16
IL153933A0 (en) 2003-07-31
MXPA03000836A (es) 2003-06-06
WO2002009762A2 (en) 2002-02-07
SK1222003A3 (en) 2003-09-11
ATE330634T1 (de) 2006-07-15
EP1305047B1 (en) 2006-06-21
EE200300047A (et) 2004-10-15
CY1105321T1 (el) 2010-03-03
CA2417636A1 (en) 2002-02-07
US20020039997A1 (en) 2002-04-04
HRP20030121A2 (en) 2005-02-28
WO2002009762A3 (en) 2003-01-09
NZ523688A (en) 2005-04-29
AU2001278073B2 (en) 2005-06-30
US6740636B2 (en) 2004-05-25
YU6703A (sh) 2006-05-25
PT1305047E (pt) 2006-11-30
DE60120986D1 (de) 2006-08-03

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