LV10189B - TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3a,8,8a-HEXAHYDRO-1,3a,8-TRIMETHYLPYROLO£2,3-b|INDOLE - Google Patents

TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3a,8,8a-HEXAHYDRO-1,3a,8-TRIMETHYLPYROLO£2,3-b|INDOLE Download PDF

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Publication number
LV10189B
LV10189B LVP-93-575A LV930575A LV10189B LV 10189 B LV10189 B LV 10189B LV 930575 A LV930575 A LV 930575A LV 10189 B LV10189 B LV 10189B
Authority
LV
Latvia
Prior art keywords
cis
compound
trimethylpyrrolo
carbamate
tetrahydroisoquinolinyl
Prior art date
Application number
LVP-93-575A
Other languages
English (en)
Latvian (lv)
Other versions
LV10189A (lv
Inventor
Hamer Russell Richard Lee
Helsley Grover Cleveland
Glamkowski Edward Joseph
Chiang Yulin
Freed Brian Scott
Kurys Barbara Elaine
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of LV10189A publication Critical patent/LV10189A/xx
Publication of LV10189B publication Critical patent/LV10189B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LVP-93-575A 1990-06-27 1993-06-15 TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3a,8,8a-HEXAHYDRO-1,3a,8-TRIMETHYLPYROLO£2,3-b|INDOLE LV10189B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/003552 WO1992000072A1 (en) 1990-06-27 1990-06-27 Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole

Publications (2)

Publication Number Publication Date
LV10189A LV10189A (lv) 1994-10-20
LV10189B true LV10189B (en) 1995-08-20

Family

ID=22220922

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-93-575A LV10189B (en) 1990-06-27 1993-06-15 TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3a,8,8a-HEXAHYDRO-1,3a,8-TRIMETHYLPYROLO£2,3-b|INDOLE

Country Status (18)

Country Link
EP (1) EP0538248B1 (lt)
KR (1) KR0172971B1 (lt)
AT (1) ATE163183T1 (lt)
AU (1) AU649953B2 (lt)
BG (1) BG61188B1 (lt)
DE (1) DE69032046T2 (lt)
DK (1) DK0538248T3 (lt)
ES (1) ES2113859T3 (lt)
FI (1) FI97229C (lt)
GE (1) GEP19991747B (lt)
LT (1) LT3598B (lt)
LV (1) LV10189B (lt)
MC (1) MC2287A1 (lt)
NO (1) NO179910C (lt)
RO (1) RO110501B1 (lt)
RU (1) RU2124516C1 (lt)
SG (1) SG70968A1 (lt)
WO (1) WO1992000072A1 (lt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1271679B (it) * 1994-07-18 1997-06-04 Mediolanum Farmaceutici Srl Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
US5665880A (en) * 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) * 1996-12-19 1997-10-14 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseroline ethers
CA2361805A1 (en) * 1999-02-04 2000-08-10 Sk Corporation Tetrahydro isoquino linealkanol derivatives and pharmaceutical compositions containing same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
DK168069B1 (da) * 1987-11-11 1994-01-31 Hoffmann La Roche Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
AU634380B2 (en) * 1990-05-17 1993-02-18 Hoechst-Roussel Pharmaceuticals Incorporated Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
NO925008L (no) 1992-12-23
EP0538248A1 (en) 1993-04-28
AU649953B2 (en) 1994-06-09
RU2124516C1 (ru) 1999-01-10
EP0538248A4 (lt) 1994-08-03
BG97231A (bg) 1993-12-24
DE69032046D1 (de) 1998-03-19
DE69032046T2 (de) 1998-08-27
RO110501B1 (ro) 1996-01-30
KR0172971B1 (ko) 1999-02-01
FI925872A0 (fi) 1992-12-23
ATE163183T1 (de) 1998-02-15
ES2113859T3 (es) 1998-05-16
BG61188B1 (bg) 1997-02-28
AU5931390A (en) 1992-01-23
GEP19991747B (en) 1999-09-10
SG70968A1 (en) 2000-03-21
DK0538248T3 (da) 1998-09-23
FI97229B (fi) 1996-07-31
NO925008D0 (no) 1992-12-23
FI925872A (fi) 1992-12-23
LV10189A (lv) 1994-10-20
LT3598B (en) 1995-12-27
EP0538248B1 (en) 1998-02-11
MC2287A1 (fr) 1993-07-14
FI97229C (fi) 1996-11-11
NO179910C (no) 1997-01-08
WO1992000072A1 (en) 1992-01-09
LTIP923A (en) 1995-03-27
NO179910B (no) 1996-09-30

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