LV10189B - TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3a,8,8a-HEXAHYDRO-1,3a,8-TRIMETHYLPYROLO£2,3-b|INDOLE - Google Patents
TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3a,8,8a-HEXAHYDRO-1,3a,8-TRIMETHYLPYROLO£2,3-b|INDOLE Download PDFInfo
- Publication number
- LV10189B LV10189B LVP-93-575A LV930575A LV10189B LV 10189 B LV10189 B LV 10189B LV 930575 A LV930575 A LV 930575A LV 10189 B LV10189 B LV 10189B
- Authority
- LV
- Latvia
- Prior art keywords
- cis
- compound
- trimethylpyrrolo
- carbamate
- tetrahydroisoquinolinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (18)
- LV10189 IZGUDROJUMA FORMULA TETRAHIDROIZOHINOLINILKARBAMĀTA 1,2,3,33,8,8a - HEKSAHIDRO - 1,3a,8 -TRIMETILPIROLO [2,3-b] INDOLA 1. Savienojums ar formulu (I)kurā R - ūdeņradis vai zemākā alkil grupa, bet X - ūdeņradis, zemākā alkil grupa, halogēns, zemākais alkoksi vai hidroksi grupa un tā farmaceitiski saderīga skābes aktīvā sāls.
- 2. Savienojums pēc 1. p-ta, kurā R - ūdeņradis vai metil grupa.
- 3. Savienojums pēc 1. p-ta, kurā X - ūdeņradis vai halogēns.
- 4. Savienojums pēc 1. p-ta, kurā R ir ūdeņradis vai metil grupa, bet X ir ūdeņradis vai halogēns.
- 5. Savienojums pēc 1. p-ta, kurš (3aS - cis) -1,2,3,3a,8,8a - heksahidro -1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēru maisījums.
- 6. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a, - heksohidro -1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (1 - metil -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēru maisījums.
- 7. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a, heksohidro -1,3a,8 - t. trimetilpirolo [2,3-b] indol - 5 - ol, (1 - etil -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēru maisījums.
- 8. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a, - heksohidro -1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (1 - propil -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēru maisījums.
- 9. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a, - heksohidro -1,3a,8 -trimetilpirolo [2,3-b] indol - 5 -ol, (1 - butil -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēru maisījums.
- 10. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,38,8,83, - heksohidro - 1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (6 - hlor -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēru maisījums.
- 11. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a - heksohidro -1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (7 - hlor -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aS-cis) izomērs, vai divu izomēru maisījums.
- 12. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a, - heksohidro - 1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (6 - hlor -1 metil -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēru maisījums.
- 13. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,38,8,83, - heksohidro -1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (7 - hlor -1 metil -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēru maisījums.
- 14. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a, - heksohodro - 1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (6 - hidroksi -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aS-cis) izomērs, vai divu izomēru maisījums.
- 15. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a, - heksohidro -1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (7 - hidroksi -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēr maisījums.
- 16. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a, - heksohidro - 1,3a,8 -trimetilpirolo [2,3-b] indol - 5 ol, (6 - hidroksi -1 -metil -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aS-cis) izomērs, vai divu izomēru maisījums.
- 17. Savienojums pēc 1. p-ta, kurš ir (3aS-cis) -1,2,3,3a,8,8a, - heksohidro -1,3a,8 -trimetilpirolo [2,3-b] indol - 5 - ol, (7 - hidroksi -1 - metil -1,2,3,4 - tetrahidroizohinolinil) karbamāts vai tā (3aR-cis) izomērs, vai divu izomēru maisījums.
- 18. Farmaceitiska kompozīcija atšķiras ar to, ka tā ietver sevī efektīgu daudzumu 1 .p-tā norādītā savienojuma un tam atbilstoša nesēja, traucētu atmiņas funkciju uzlabošanai, kas raksturīgas holīnerģiskam deficītam.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1990/003552 WO1992000072A1 (en) | 1990-06-27 | 1990-06-27 | Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole |
Publications (2)
Publication Number | Publication Date |
---|---|
LV10189A LV10189A (lv) | 1994-10-20 |
LV10189B true LV10189B (en) | 1995-08-20 |
Family
ID=22220922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-93-575A LV10189B (en) | 1990-06-27 | 1993-06-15 | TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3a,8,8a-HEXAHYDRO-1,3a,8-TRIMETHYLPYROLO£2,3-b|INDOLE |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0538248B1 (lv) |
KR (1) | KR0172971B1 (lv) |
AT (1) | ATE163183T1 (lv) |
AU (1) | AU649953B2 (lv) |
BG (1) | BG61188B1 (lv) |
DE (1) | DE69032046T2 (lv) |
DK (1) | DK0538248T3 (lv) |
ES (1) | ES2113859T3 (lv) |
FI (1) | FI97229C (lv) |
GE (1) | GEP19991747B (lv) |
LT (1) | LT3598B (lv) |
LV (1) | LV10189B (lv) |
MC (1) | MC2287A1 (lv) |
NO (1) | NO179910C (lv) |
RO (1) | RO110501B1 (lv) |
RU (1) | RU2124516C1 (lv) |
SG (1) | SG70968A1 (lv) |
WO (1) | WO1992000072A1 (lv) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
IT1271679B (it) * | 1994-07-18 | 1997-06-04 | Mediolanum Farmaceutici Srl | Derivati del fenilcarbammato atti all'impiego come anticolinesterasici |
US5665880A (en) * | 1996-10-31 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseretholes |
US5677457A (en) * | 1996-12-19 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseroline ethers |
DK1149079T3 (da) * | 1999-02-04 | 2004-08-16 | Sk Corp | Tetrahydroisoquinolinalkanolderivater og farmaceutiske præparater indeholdende samme |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
DK168069B1 (da) * | 1987-11-11 | 1994-01-31 | Hoffmann La Roche | Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne |
US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
AU634380B2 (en) * | 1990-05-17 | 1993-02-18 | Hoechst-Roussel Pharmaceuticals Incorporated | Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments |
-
1990
- 1990-06-27 AT AT90910230T patent/ATE163183T1/de not_active IP Right Cessation
- 1990-06-27 RU RU92016550A patent/RU2124516C1/ru active
- 1990-06-27 WO PCT/US1990/003552 patent/WO1992000072A1/en active IP Right Grant
- 1990-06-27 RO RO92-01561A patent/RO110501B1/ro unknown
- 1990-06-27 DE DE69032046T patent/DE69032046T2/de not_active Expired - Fee Related
- 1990-06-27 KR KR1019920703313A patent/KR0172971B1/ko not_active IP Right Cessation
- 1990-06-27 SG SG1996003071A patent/SG70968A1/en unknown
- 1990-06-27 EP EP90910230A patent/EP0538248B1/en not_active Expired - Lifetime
- 1990-06-27 ES ES90910230T patent/ES2113859T3/es not_active Expired - Lifetime
- 1990-06-27 MC MC90@@D patent/MC2287A1/xx unknown
- 1990-06-27 DK DK90910230T patent/DK0538248T3/da active
- 1990-06-27 AU AU59313/90A patent/AU649953B2/en not_active Ceased
-
1992
- 1992-12-23 NO NO925008A patent/NO179910C/no not_active IP Right Cessation
- 1992-12-23 BG BG97231A patent/BG61188B1/bg unknown
- 1992-12-23 FI FI925872A patent/FI97229C/fi active
-
1993
- 1993-06-15 LV LVP-93-575A patent/LV10189B/en unknown
- 1993-07-29 GE GEAP19931278A patent/GEP19991747B/en unknown
- 1993-09-03 LT LTIP923A patent/LT3598B/lt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0538248T3 (da) | 1998-09-23 |
DE69032046D1 (de) | 1998-03-19 |
FI97229C (fi) | 1996-11-11 |
RU2124516C1 (ru) | 1999-01-10 |
FI97229B (fi) | 1996-07-31 |
NO179910C (no) | 1997-01-08 |
SG70968A1 (en) | 2000-03-21 |
NO925008L (no) | 1992-12-23 |
BG61188B1 (bg) | 1997-02-28 |
NO925008D0 (no) | 1992-12-23 |
AU5931390A (en) | 1992-01-23 |
ES2113859T3 (es) | 1998-05-16 |
EP0538248A4 (lv) | 1994-08-03 |
KR0172971B1 (ko) | 1999-02-01 |
BG97231A (bg) | 1993-12-24 |
MC2287A1 (fr) | 1993-07-14 |
LT3598B (en) | 1995-12-27 |
LTIP923A (en) | 1995-03-27 |
EP0538248B1 (en) | 1998-02-11 |
AU649953B2 (en) | 1994-06-09 |
FI925872A0 (fi) | 1992-12-23 |
GEP19991747B (en) | 1999-09-10 |
DE69032046T2 (de) | 1998-08-27 |
ATE163183T1 (de) | 1998-02-15 |
FI925872A (fi) | 1992-12-23 |
NO179910B (no) | 1996-09-30 |
LV10189A (lv) | 1994-10-20 |
RO110501B1 (ro) | 1996-01-30 |
EP0538248A1 (en) | 1993-04-28 |
WO1992000072A1 (en) | 1992-01-09 |
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