|
US5545553A
(en)
*
|
1994-09-26 |
1996-08-13 |
The Rockefeller University |
Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
|
|
US6753165B1
(en)
*
|
1999-01-14 |
2004-06-22 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
US7153943B2
(en)
*
|
1997-07-14 |
2006-12-26 |
Bolder Biotechnology, Inc. |
Derivatives of growth hormone and related proteins, and methods of use thereof
|
|
US7270809B2
(en)
*
|
1997-07-14 |
2007-09-18 |
Bolder Biotechnology, Inc. |
Cysteine variants of alpha interferon-2
|
|
US20080076706A1
(en)
|
1997-07-14 |
2008-03-27 |
Bolder Biotechnology, Inc. |
Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
|
|
US6608183B1
(en)
*
|
1997-07-14 |
2003-08-19 |
Bolder Biotechnology, Inc. |
Derivatives of growth hormone and related proteins
|
|
US7495087B2
(en)
*
|
1997-07-14 |
2009-02-24 |
Bolder Biotechnology, Inc. |
Cysteine muteins in the C-D loop of human interleukin-11
|
|
US6639050B1
(en)
*
|
1997-07-21 |
2003-10-28 |
Ohio University |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
|
US6570062B1
(en)
*
|
1997-07-21 |
2003-05-27 |
Ohio University |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
|
US7378506B2
(en)
*
|
1997-07-21 |
2008-05-27 |
Ohio University |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
|
US6451986B1
(en)
|
1998-06-22 |
2002-09-17 |
Immunex Corporation |
Site specific protein modification
|
|
US20070212422A1
(en)
*
|
1999-11-10 |
2007-09-13 |
Manfred Keller |
Dry powder for inhalation
|
|
US6696063B1
(en)
*
|
1998-12-30 |
2004-02-24 |
Applied Research Systems Ars Holding N.V. |
Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
|
|
US8288126B2
(en)
|
1999-01-14 |
2012-10-16 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
AU2008202371B2
(en)
*
|
1999-01-14 |
2012-08-02 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
US6946265B1
(en)
|
1999-05-12 |
2005-09-20 |
Xencor, Inc. |
Nucleic acids and proteins with growth hormone activity
|
|
WO2000068385A2
(en)
*
|
1999-05-12 |
2000-11-16 |
Xencor, Inc. |
Novel nucleic acids and proteins with growth hormone activity
|
|
AT408721B
(de)
|
1999-10-01 |
2002-02-25 |
Cistem Biotechnologies Gmbh |
Pharmazeutische zusammensetzung enthaltend ein antigen
|
|
AR025984A1
(es)
*
|
1999-10-07 |
2002-12-26 |
Maxygen Aps |
Polipeptidos oligomericos de cadena simple
|
|
DE10005301A1
(de)
*
|
2000-02-07 |
2001-08-09 |
Trutnau Hans Heinrich |
Multi-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren
|
|
JP2003532430A
(ja)
*
|
2000-05-12 |
2003-11-05 |
ユニバーシティ オブ ウェールズ カレッジ オブ メディスン |
ヒトにおける成長ホルモン異形の検出方法、上記異形及びそれらの使用
|
|
GB0011459D0
(en)
*
|
2000-05-12 |
2000-06-28 |
Univ Wales Medicine |
Sequences
|
|
NZ522847A
(en)
|
2000-05-16 |
2004-11-26 |
Bolder Biotechnology Inc |
Methods for refolding proteins containing free cysteine residues
|
|
EP2316944A3
(en)
|
2000-06-16 |
2011-11-02 |
Asterion Limited |
Binding agents: chimeric ligand/receptor proteins
|
|
US8044259B2
(en)
|
2000-08-03 |
2011-10-25 |
The Regents Of The University Of Michigan |
Determining the capability of a test compound to affect solid tumor stem cells
|
|
US20080194022A1
(en)
*
|
2000-08-03 |
2008-08-14 |
Clarke Michael F |
Isolation and use of solid tumor stem cells
|
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
JP2004515467A
(ja)
|
2000-08-07 |
2004-05-27 |
ネクター セラピューティックス |
吸入可能な、噴霧乾燥した、最少の凝集物を有する4−ヘリックスバンドルタンパク質粉末
|
|
WO2002038609A2
(en)
*
|
2000-11-10 |
2002-05-16 |
Proteopharma Aps |
Apolipoprotein conjugates
|
|
US20060183197A1
(en)
*
|
2001-01-11 |
2006-08-17 |
Andersen Kim V |
Variant growth hormone molecules conjugated with macromolecules compounds
|
|
AU2002219021A1
(en)
*
|
2001-01-11 |
2002-07-24 |
Maxygen Aps |
Variant growth hormone molecules conjugated with macromolecular compounds
|
|
US7060675B2
(en)
|
2001-02-15 |
2006-06-13 |
Nobex Corporation |
Methods of treating diabetes mellitus
|
|
US6867183B2
(en)
*
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US6858580B2
(en)
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6828305B2
(en)
*
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6835802B2
(en)
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
|
US6713452B2
(en)
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US7713932B2
(en)
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
|
US6828297B2
(en)
*
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
EP1801240A1
(en)
*
|
2001-06-05 |
2007-06-27 |
Auckland Uniservices Limited |
Methods and compositions for assessment of pulmonary function and disorders
|
|
US7521175B2
(en)
|
2001-06-14 |
2009-04-21 |
The Regents Of The University Of California |
Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
|
|
US7196059B2
(en)
*
|
2001-09-07 |
2007-03-27 |
Biocon Limited |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US20040186051A1
(en)
*
|
2001-10-02 |
2004-09-23 |
Kelley Robert F |
Apo-2 ligand variants and uses thereof
|
|
US6908963B2
(en)
*
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
US8008252B2
(en)
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
|
US7399613B2
(en)
*
|
2001-10-10 |
2008-07-15 |
Neose Technologies, Inc. |
Sialic acid nucleotide sugars
|
|
ES2561985T3
(es)
*
|
2001-10-10 |
2016-03-01 |
Ratiopharm Gmbh |
Remodelación y glicoconjugación de anticuerpos
|
|
US7696163B2
(en)
|
2001-10-10 |
2010-04-13 |
Novo Nordisk A/S |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US7179617B2
(en)
*
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US20040161802A1
(en)
*
|
2001-10-30 |
2004-08-19 |
Applied Molecular Evolution |
Methods for producing and improving therapeutic potency of binding polypeptides
|
|
AU2002360349A1
(en)
*
|
2001-11-09 |
2003-05-26 |
Pharmacia And Upjohn Company |
Single nucleotide polymorphisms in gh-1
|
|
CA2463639A1
(en)
*
|
2001-11-12 |
2003-05-22 |
University Of Wales College Of Medicine |
Growth hormone variations in humans and their uses
|
|
OA13063A
(en)
*
|
2001-11-20 |
2006-11-10 |
Pharmacia Corp |
Chemically-modified human growth hormone conjugates.
|
|
US20030171285A1
(en)
*
|
2001-11-20 |
2003-09-11 |
Finn Rory F. |
Chemically-modified human growth hormone conjugates
|
|
US7473680B2
(en)
|
2001-11-28 |
2009-01-06 |
Neose Technologies, Inc. |
Remodeling and glycoconjugation of peptides
|
|
GB2384001B
(en)
*
|
2001-12-14 |
2004-02-04 |
Asterion Ltd |
Chimeric growth hormone-growth hormone receptor proteins
|
|
RU2216346C1
(ru)
*
|
2002-06-10 |
2003-11-20 |
Семенова Наталья Викторовна |
Средство и способ для биогенной стимуляции организма
|
|
WO2003105768A2
(en)
|
2002-06-13 |
2003-12-24 |
Nobex Corporation |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
DE60336555D1
(de)
|
2002-06-21 |
2011-05-12 |
Novo Nordisk Healthcare Ag |
Pegylierte glykoformen von faktor vii
|
|
WO2004001009A2
(en)
|
2002-06-24 |
2003-12-31 |
Genentech, Inc. |
Apo-2 ligand/trail variants and uses thereof
|
|
US20040048315A1
(en)
*
|
2002-08-28 |
2004-03-11 |
Pharmacia Corporation |
Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
|
|
US20040121407A1
(en)
*
|
2002-09-06 |
2004-06-24 |
Elixir Pharmaceuticals, Inc. |
Regulation of the growth hormone/IGF-1 axis
|
|
EP1539960B1
(en)
*
|
2002-09-09 |
2010-04-28 |
Hanall Pharmaceutical Co., Ltd. |
Protease-resistant modified interferon alpha polypeptides
|
|
US7470779B2
(en)
*
|
2002-09-20 |
2008-12-30 |
Pfizer Inc. |
Process for decreasing aggregate levels of pegylated protein
|
|
EP1545428B1
(en)
*
|
2002-09-20 |
2009-12-30 |
Pharmacia Corporation |
Process for decreasing aggregate levels of pegylated protein
|
|
TWI281864B
(en)
*
|
2002-11-20 |
2007-06-01 |
Pharmacia Corp |
N-terminally monopegylated human growth hormone conjugates and process for their preparation
|
|
CA2423904A1
(en)
*
|
2002-12-19 |
2004-06-19 |
University Of Wales College Of Medicine |
Haplotype partitioning in the proximal promoter of the human growth hormone (gh1) gene
|
|
CA2512052C
(en)
*
|
2002-12-31 |
2016-06-21 |
Altus Pharmaceuticals Inc. |
Human growth hormone crystals and methods for preparing them
|
|
BRPI0408358A
(pt)
|
2003-03-14 |
2006-03-21 |
Neose Technologies Inc |
polìmeros hidrossolúveis ramificados e seus conjugados
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
EP2055189A1
(en)
|
2003-04-09 |
2009-05-06 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
US7691603B2
(en)
*
|
2003-04-09 |
2010-04-06 |
Novo Nordisk A/S |
Intracellular formation of peptide conjugates
|
|
WO2006127896A2
(en)
*
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated factor ix
|
|
JP2007527695A
(ja)
*
|
2003-04-09 |
2007-10-04 |
アステリオン・リミテッド |
グリコシルホスファチジルイノシトールを含有するポリペプチド
|
|
ES2380093T3
(es)
|
2003-05-09 |
2012-05-08 |
Biogenerix Ag |
Composiciones y métodos para la preparación de mutantes de glucosilación de la hormona del crecimiento humana
|
|
US20060252120A1
(en)
*
|
2003-05-09 |
2006-11-09 |
Kieliszewski Marcia J |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
|
WO2005005601A2
(en)
*
|
2003-06-09 |
2005-01-20 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
GB0315182D0
(en)
*
|
2003-06-28 |
2003-08-06 |
Asterion Ltd |
Cytokine variant polypeptides
|
|
US9005625B2
(en)
|
2003-07-25 |
2015-04-14 |
Novo Nordisk A/S |
Antibody toxin conjugates
|
|
GB0326632D0
(en)
|
2003-11-14 |
2003-12-17 |
Jagotec Ag |
Dry powder formulations
|
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
|
US7842661B2
(en)
|
2003-11-24 |
2010-11-30 |
Novo Nordisk A/S |
Glycopegylated erythropoietin formulations
|
|
CA2547140A1
(en)
*
|
2003-11-24 |
2005-06-09 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US20080305992A1
(en)
*
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US20080318850A1
(en)
*
|
2003-12-03 |
2008-12-25 |
Neose Technologies, Inc. |
Glycopegylated Factor Ix
|
|
US20070254836A1
(en)
*
|
2003-12-03 |
2007-11-01 |
Defrees Shawn |
Glycopegylated Granulocyte Colony Stimulating Factor
|
|
US20060040856A1
(en)
*
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
US7956032B2
(en)
*
|
2003-12-03 |
2011-06-07 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
CN101072789B
(zh)
*
|
2004-01-08 |
2013-05-15 |
生物种属学股份公司 |
肽的o-连接的糖基化
|
|
WO2005069845A2
(en)
*
|
2004-01-14 |
2005-08-04 |
Ohio University |
Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
|
|
ES2642214T3
(es)
|
2004-01-21 |
2017-11-15 |
Novo Nordisk Health Care Ag |
Conjugación de péptidos mediante transglutaminasa
|
|
BRPI0507169A
(pt)
*
|
2004-02-02 |
2007-06-26 |
Ambrx Inc |
polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
|
|
JP2007526455A
(ja)
*
|
2004-02-03 |
2007-09-13 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法
|
|
MXPA06007848A
(es)
*
|
2004-02-09 |
2006-09-04 |
Pharmacia Corp |
Conjugados de antagonistas del receptor de hormona del crecimiento humana modificados quimicamente.
|
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
|
US8623812B2
(en)
|
2004-04-19 |
2014-01-07 |
Ohio University |
Cross-linkable glycoproteins and methods of making the same
|
|
EP1751115A4
(en)
|
2004-05-23 |
2010-10-20 |
Gerard M Housey |
THERAMUTEINMODULATOREN
|
|
DE602004031982D1
(de)
*
|
2004-06-23 |
2011-05-05 |
Usv Ltd |
Chimeres, von den placenta- und hypophysenisoformen abgeleitetes humanes wachstumshormon und verfahren zur gewinnung der chimere
|
|
CA2601716C
(en)
|
2004-06-25 |
2011-05-31 |
Board Of Regents, The University Of Texas System |
Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia
|
|
EP1771066A2
(en)
|
2004-07-13 |
2007-04-11 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1
|
|
KR101309770B1
(ko)
|
2004-07-19 |
2013-09-30 |
바이오콘 리미티드 |
인슐린―올리고머 접합체,제형 및 이들의 용도
|
|
AU2009212311B8
(en)
|
2004-07-21 |
2013-05-30 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
|
NZ553224A
(en)
*
|
2004-07-26 |
2009-05-31 |
Asterion Ltd |
Linkers
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
US8268967B2
(en)
|
2004-09-10 |
2012-09-18 |
Novo Nordisk A/S |
Glycopegylated interferon α
|
|
US20080182783A1
(en)
*
|
2004-10-18 |
2008-07-31 |
Novo Nordisk A/S |
Growth Hormone Conjugates
|
|
ES2566670T3
(es)
|
2004-10-29 |
2016-04-14 |
Ratiopharm Gmbh |
Remodelación y glucopegilación del factor de crecimiento de fibroblastos (FGF)
|
|
US7998930B2
(en)
|
2004-11-04 |
2011-08-16 |
Hanall Biopharma Co., Ltd. |
Modified growth hormones
|
|
US20070298094A1
(en)
*
|
2004-11-18 |
2007-12-27 |
Terumo Kabushiki Kaisha |
Medicinal Composition, Preparation and Combined Preparation
|
|
KR20070090023A
(ko)
*
|
2004-12-22 |
2007-09-04 |
암브룩스, 인코포레이티드 |
변형 인간 성장 호르몬
|
|
CA2590462C
(en)
|
2004-12-22 |
2017-02-28 |
Ambrx, Inc. |
Methods for expression and purification of recombinant human growth hormone
|
|
EP1833993A4
(en)
|
2004-12-22 |
2009-07-22 |
Ambrx Inc |
HUMAN GROWTH HORMONE FORMULATIONS COMPRISING AN AMINO ACID CODED NON-NATURALLY
|
|
WO2006074279A1
(en)
*
|
2005-01-06 |
2006-07-13 |
Neose Technologies, Inc. |
Glycoconjugation using saccharyl fragments
|
|
MX2007008229A
(es)
|
2005-01-10 |
2007-09-11 |
Neose Technologies Inc |
Factor estimulador de colonias de granulocitos glicopegilado.
|
|
US20060188498A1
(en)
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
|
CA2602951A1
(en)
*
|
2005-03-23 |
2006-09-28 |
Bio-Rad Laboratories, Inc. |
Diverse chemical libraries bound to small particles with paramagnetic properties
|
|
EP1869230B1
(en)
*
|
2005-03-23 |
2017-08-30 |
Bio-Rad Laboratories, Inc. |
Method for purifying proteins
|
|
US20060233740A1
(en)
*
|
2005-03-23 |
2006-10-19 |
Bossard Mary J |
Conjugates of an hGH moiety and a polymer
|
|
US20090247421A1
(en)
*
|
2005-03-23 |
2009-10-01 |
Egisto Boschetti |
Diverse chemical libraries bound to small particles with paramagnetic properties
|
|
WO2006105426A2
(en)
*
|
2005-03-30 |
2006-10-05 |
Neose Technologies, Inc. |
Manufacturing process for the production of peptides grown in insect cell lines
|
|
EP2386571B1
(en)
*
|
2005-04-08 |
2016-06-01 |
ratiopharm GmbH |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
|
BRPI0609355A2
(pt)
*
|
2005-04-13 |
2010-03-30 |
Univ Erasmus Medical Ct |
uso de um antagonista do hormÈnio de crescimento, e de uma somatostatina ou de um agonista da somatostatina, na preparação de uma composição para atenuar os efeitos do hormÈnio de crescimento
|
|
EP1896607A4
(en)
*
|
2005-05-10 |
2009-12-16 |
Synergenz Bioscience Ltd |
METHOD AND COMPOSITIONS FOR THE ASSESSMENT OF LUNG FUNCTION AND RESPIRATORY DISEASE
|
|
MX2007014220A
(es)
*
|
2005-05-19 |
2009-02-16 |
Synergenz Bioscience Ltd |
Metodos para la valoracion del riesgo de desarrollar cancer de pulmon usando un analisis de polimorfismos geneticos.
|
|
US7933722B2
(en)
*
|
2005-05-20 |
2011-04-26 |
Synergenz Bioscience Limited |
Methods of analysis of polymorphisms and uses thereof
|
|
US8431110B2
(en)
|
2005-05-23 |
2013-04-30 |
Hmi Medical Innovations, Llc. |
Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
|
|
WO2006135886A2
(en)
*
|
2005-06-13 |
2006-12-21 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
EP1896134A2
(en)
|
2005-06-13 |
2008-03-12 |
Rigel Pharmaceuticals, Inc. |
Methods and compositions for treating degenerative bone disorders
|
|
US20080242834A1
(en)
*
|
2005-07-08 |
2008-10-02 |
Ohio University |
Methods of Predicting Hyp-Glycosylation Sites For Proteins Expressed and Secreted in Plant Cells, and Related Methods and Products
|
|
BRPI0614839A2
(pt)
*
|
2005-08-19 |
2009-05-19 |
Neose Technologies Inc |
fator vii e fator viia glicopeguilados
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
|
US8329866B2
(en)
*
|
2005-10-03 |
2012-12-11 |
Bolder Biotechnology, Inc. |
Long acting VEGF inhibitors and methods of use
|
|
US7723477B2
(en)
|
2005-10-31 |
2010-05-25 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
|
|
AU2006308870B2
(en)
|
2005-10-31 |
2012-08-16 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
|
AU2006308847C1
(en)
*
|
2005-10-31 |
2012-05-10 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for treating and diagnosing cancer
|
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
|
US20090275070A1
(en)
|
2005-11-23 |
2009-11-05 |
Housey Gerard M |
Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators
|
|
US8841255B2
(en)
|
2005-12-20 |
2014-09-23 |
Duke University |
Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
|
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US20090023629A1
(en)
*
|
2005-12-23 |
2009-01-22 |
Altus Pharmaceuticals Inc. |
Compositions comprising polycation-complexed protein crystals and methods of treatment using them
|
|
GB0602897D0
(en)
*
|
2006-02-13 |
2006-03-22 |
Jagotec Ag |
Improvements In Or Relating To Dry Powder Inhaler Devices
|
|
WO2007100640A2
(en)
*
|
2006-02-21 |
2007-09-07 |
The Regents Of The University Of Michigan |
Growth hormone receptor antagonist cancer treatment
|
|
GB0606946D0
(en)
*
|
2006-04-06 |
2006-05-17 |
Asterion Ltd |
Polypeptide antagonist
|
|
US7531341B1
(en)
|
2006-06-12 |
2009-05-12 |
Biomarin Pharmaceutical Inc. |
Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
|
|
US7534595B2
(en)
|
2006-06-12 |
2009-05-19 |
Biomarin Pharmaceutical Inc. |
Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
|
|
US20080064039A1
(en)
*
|
2006-07-06 |
2008-03-13 |
Pienkos Philip T |
Dominant negative ligand drug discovery system
|
|
US9187532B2
(en)
|
2006-07-21 |
2015-11-17 |
Novo Nordisk A/S |
Glycosylation of peptides via O-linked glycosylation sequences
|
|
WO2008057683A2
(en)
|
2006-10-03 |
2008-05-15 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates
|
|
MX2009003470A
(es)
*
|
2006-10-04 |
2009-04-14 |
Novo Nordisk As |
Azucares y glicopeptidos pegilados enlazados a glicerol.
|
|
US20080207487A1
(en)
*
|
2006-11-02 |
2008-08-28 |
Neose Technologies, Inc. |
Manufacturing process for the production of polypeptides expressed in insect cell-lines
|
|
GB0622818D0
(en)
*
|
2006-11-15 |
2006-12-27 |
Jagotec Ag |
Improvements in or relating to organic compounds
|
|
EP2102355B1
(en)
|
2006-12-14 |
2016-03-02 |
Bolder Biotechnology, Inc. |
Long acting proteins and peptides and methods of making and using the same
|
|
GB0625303D0
(en)
*
|
2006-12-19 |
2007-01-24 |
Jagotec Ag |
Improvements in and relating to metered dose inhalers
|
|
WO2008092002A2
(en)
*
|
2007-01-24 |
2008-07-31 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing pancreatic cancer
|
|
EA017770B1
(ru)
|
2007-04-03 |
2013-03-29 |
Биодженерикс Аг |
Способы лечения с использованием гликопэгилированного g-csf
|
|
US20090053167A1
(en)
*
|
2007-05-14 |
2009-02-26 |
Neose Technologies, Inc. |
C-, S- and N-glycosylation of peptides
|
|
CN101778859B
(zh)
|
2007-06-12 |
2014-03-26 |
诺和诺德公司 |
改良的用于生产核苷酸糖的方法
|
|
US7560263B2
(en)
|
2007-08-17 |
2009-07-14 |
Biomarin Pharmaceutical Inc. |
Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
|
|
US8207112B2
(en)
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
|
EP2195333A1
(en)
*
|
2007-09-12 |
2010-06-16 |
Anaphore, Inc. |
Hsp70-based treatment for autoimmune diseases
|
|
GB0719818D0
(en)
*
|
2007-10-11 |
2007-11-21 |
Asterion Ltd |
Growth hormone fusion polypeptides
|
|
PT2203181T
(pt)
|
2007-10-16 |
2018-05-10 |
Biocon Ltd |
Uma composição farmacêutica sólida para administração por via oral e o seu processo de fabrico
|
|
US20110027267A1
(en)
*
|
2007-11-09 |
2011-02-03 |
Anaphore, Inc. |
Fusion Proteins of Mannose Binding Lectins for Treatment of Disease
|
|
EP2626080A3
(en)
|
2008-02-27 |
2014-03-05 |
Novo Nordisk A/S |
Conjugated factor VIII molecules
|
|
CN105727261A
(zh)
|
2008-06-27 |
2016-07-06 |
杜克大学 |
包含弹性蛋白样肽的治疗剂
|
|
WO2010014225A2
(en)
|
2008-07-30 |
2010-02-04 |
Biomarin Pharmaceutical Inc. |
Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase
|
|
KR20110039348A
(ko)
*
|
2008-08-06 |
2011-04-15 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
연장된 생체내 효능을 가지는 콘쥬게이트된 단백질
|
|
US7982013B2
(en)
|
2008-09-26 |
2011-07-19 |
Oncomed Pharmaceuticals, Inc. |
Frizzled-binding agents and uses thereof
|
|
EP2379585A2
(en)
|
2008-10-10 |
2011-10-26 |
Anaphore, Inc. |
Polypeptides that bind trail-ri and trail-r2
|
|
JP5816097B2
(ja)
|
2009-01-22 |
2015-11-18 |
ノヴォ・ノルディスク・ヘルス・ケア・アーゲー |
安定な成長ホルモン化合物
|
|
US8703717B2
(en)
|
2009-02-03 |
2014-04-22 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
|
JP5843357B2
(ja)
|
2009-02-03 |
2016-01-13 |
アムニクス オペレーティング インコーポレイテッド |
延長組換えポリペプチドおよび延長組換えポリペプチドを含む組成物
|
|
US8680050B2
(en)
|
2009-02-03 |
2014-03-25 |
Amunix Operating Inc. |
Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
|
|
US9849188B2
(en)
|
2009-06-08 |
2017-12-26 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
|
US8445953B2
(en)
*
|
2009-07-08 |
2013-05-21 |
Taiwan Semiconductor Manufacturing Company, Ltd. |
Structure for flash memory cells
|
|
CN105963710A
(zh)
|
2009-08-06 |
2016-09-28 |
诺沃—诺迪斯克保健股份有限公司 |
具有延长的体内功效的生长激素
|
|
US20110086770A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Combinatorial Libraries Based on C-type Lectin-like Domain
|
|
US20110086806A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that Bind IL-23R
|
|
EP2332929A1
(en)
|
2009-11-25 |
2011-06-15 |
ArisGen SA |
Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions
|
|
TWI535445B
(zh)
|
2010-01-12 |
2016-06-01 |
安可美德藥物股份有限公司 |
Wnt拮抗劑及治療和篩選方法
|
|
BR112012018162A2
(pt)
|
2010-01-22 |
2017-10-03 |
Novo Nordisk Healthcare Ag |
Compostos de hormônio do crescimento estáveis
|
|
RU2605627C2
(ru)
|
2010-01-22 |
2016-12-27 |
Ново Нордиск Хелс Кеа Аг |
Гормоны роста с пролонгированной эффективностью in vivo
|
|
US20130039898A1
(en)
|
2010-02-04 |
2013-02-14 |
Biomarin Pharmaceutical Inc. |
Compositions of prokaryotic phenylalanine ammonia-lyase variants and methods of using compositions thereof
|
|
AU2011235904B2
(en)
|
2010-04-01 |
2015-10-08 |
Oncomed Pharmaceuticals, Inc. |
Frizzled-binding agents and uses thereof
|
|
US20130045215A1
(en)
|
2010-04-28 |
2013-02-21 |
University Of Southern California |
Growth hormone receptor deficiency causes a major reduction in pro-aging signaling, cancer and diabetes in humans
|
|
CN103269720A
(zh)
|
2010-07-22 |
2013-08-28 |
诺沃—诺迪斯克保健股份有限公司 |
生长激素缀合物
|
|
EP2446898A1
(en)
|
2010-09-30 |
2012-05-02 |
Laboratorios Del. Dr. Esteve, S.A. |
Use of growth hormone to enhance the immune response in immunosuppressed patients
|
|
CA2834776A1
(en)
|
2011-05-03 |
2012-11-08 |
Genentech, Inc. |
Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies
|
|
EP2526971A1
(en)
|
2011-05-25 |
2012-11-28 |
ArisGen SA |
Mucosal delivery of drugs
|
|
AU2013214698B2
(en)
|
2012-02-03 |
2017-02-16 |
Antisense Therapeutics Ltd |
Combination therapy comprising a growth hormone variant and an oligonucleotide targeted to the growth hormone receptor
|
|
US10039813B2
(en)
|
2012-02-07 |
2018-08-07 |
Massachusetts Institute Of Technology |
Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
|
|
JP2015536933A
(ja)
|
2012-10-23 |
2015-12-24 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
Wnt経路結合剤を用いて神経内分泌腫瘍を処置する方法
|
|
AU2014212081A1
(en)
|
2013-02-04 |
2015-08-13 |
Oncomed Pharmaceuticals, Inc. |
Methods and monitoring of treatment with a Wnt pathway inhibitor
|
|
CN105229035A
(zh)
*
|
2013-03-11 |
2016-01-06 |
诺和诺德保健股份有限公司 |
生长激素化合物
|
|
US20160017017A1
(en)
*
|
2013-03-11 |
2016-01-21 |
Novo Nordisk Healthcare Ag |
Growth Hormone Compounds
|
|
US9168300B2
(en)
|
2013-03-14 |
2015-10-27 |
Oncomed Pharmaceuticals, Inc. |
MET-binding agents and uses thereof
|
|
WO2014144231A1
(en)
|
2013-03-15 |
2014-09-18 |
Massachusetts Institute Of Technology |
Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
|
|
US11045523B2
(en)
|
2013-04-05 |
2021-06-29 |
Novo Nordisk Healthcare Ag |
Formulation of growth hormone albumin-binder conjugate
|
|
KR20180021234A
(ko)
|
2013-08-12 |
2018-02-28 |
제넨테크, 인크. |
보체-연관 상태의 치료를 위한 조성물 및 방법
|
|
JP2017515811A
(ja)
|
2014-05-01 |
2017-06-15 |
ジェネンテック, インコーポレイテッド |
抗d因子抗体変異体及びその使用法
|
|
CN104693433B
(zh)
*
|
2015-02-04 |
2017-06-06 |
国家纳米科学中心 |
一种聚乙二醇化氨磷汀、制备方法及其用途
|
|
WO2016138099A1
(en)
|
2015-02-24 |
2016-09-01 |
Massachusetts Institute Of Technology |
Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
|
|
WO2016193380A1
(en)
|
2015-06-02 |
2016-12-08 |
Novo Nordisk A/S |
Insulins with polar recombinant extensions
|
|
MA43348A
(fr)
|
2015-10-01 |
2018-08-08 |
Novo Nordisk As |
Conjugués de protéines
|
|
CN108472382A
(zh)
|
2015-10-30 |
2018-08-31 |
豪夫迈·罗氏有限公司 |
抗-因子d抗体变体缀合物及其用途
|
|
CN108289951A
(zh)
|
2015-10-30 |
2018-07-17 |
豪夫迈·罗氏有限公司 |
抗-因子d抗体和缀合物
|
|
GB201520021D0
(en)
|
2015-11-13 |
2015-12-30 |
Asterion Ltd |
Fusion polypeptide
|
|
WO2018185131A2
(en)
|
2017-04-05 |
2018-10-11 |
Novo Nordisk A/S |
Oligomer extended insulin-fc conjugates
|
|
WO2019125002A1
(ko)
*
|
2017-12-20 |
2019-06-27 |
(주)알테오젠 |
신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질
|
|
KR102167827B1
(ko)
*
|
2017-12-20 |
2020-10-20 |
주식회사 알테오젠 |
신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질
|
|
WO2019211842A1
(en)
*
|
2018-04-30 |
2019-11-07 |
Opko Biologics Ltd. |
Long-acting human growth hormone-antagonists and methods of producing the same
|
|
CA3141128A1
(en)
*
|
2019-06-17 |
2020-12-24 |
Molecular Technologies Laboratories Llc |
Therapeutic pegylated growth hormone antagonists
|
|
EP4126949A1
(en)
|
2020-03-24 |
2023-02-08 |
Genentech, Inc. |
Tie2-binding agents and methods of use
|
|
EP4378925A4
(en)
*
|
2021-07-29 |
2025-05-28 |
Novocodex Biopharmaceuticals Co., Ltd. |
Unnatural amino acid and use thereof, recombinant protein therewith and recombinant protein conjugate
|
|
EP4378926A4
(en)
*
|
2021-07-29 |
2025-05-28 |
Novocodex Biopharmaceuticals Co., Ltd. |
Unnatural amino acid and use thereof, recombinant protein therewith and recombinant protein conjugate
|
|
JP2025524901A
(ja)
|
2022-07-29 |
2025-08-01 |
ユニバーシティ オブ ロチェスター |
テストステロン及び成長ホルモンの組み合わせによる筋量、筋強度、又は筋機能を改善するための方法
|
|
TW202448921A
(zh)
|
2023-05-12 |
2024-12-16 |
丹麥商諾佛 儂迪克股份有限公司 |
長效生長激素受體拮抗劑及其用途
|
|
KR20240172522A
(ko)
*
|
2023-06-01 |
2024-12-10 |
(주)알테오젠 |
지속형 호르몬 수용체 길항제의 생산 방법
|
|
WO2025259466A1
(en)
|
2024-06-13 |
2025-12-18 |
University Of Rochester |
Gm-csf and gm-csf-induced dendritic cells enhance fracture healing and bone repair
|