LU90809I2 - Vaccin comprenant des saccharides pneumococciques de serotypes 4,6b,9v,14,18c19f et 23f, chacun d'entre eux conjugu- avec une prot-ine porteuse crm 197 - Google Patents

Vaccin comprenant des saccharides pneumococciques de serotypes 4,6b,9v,14,18c19f et 23f, chacun d'entre eux conjugu- avec une prot-ine porteuse crm 197

Info

Publication number
LU90809I2
LU90809I2 LU90809C LU90809C LU90809I2 LU 90809 I2 LU90809 I2 LU 90809I2 LU 90809 C LU90809 C LU 90809C LU 90809 C LU90809 C LU 90809C LU 90809 I2 LU90809 I2 LU 90809I2
Authority
LU
Luxembourg
Prior art keywords
capsular
bacterial
capsular polymer
immunogenic
fragment
Prior art date
Application number
LU90809C
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of LU90809I2 publication Critical patent/LU90809I2/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/102Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/831Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/832Drug, bio-affecting and body treating compositions involving bacterial toxin that has modified amino acid sequence
LU90809C 1986-05-05 2001-07-25 Vaccin comprenant des saccharides pneumococciques de serotypes 4,6b,9v,14,18c19f et 23f, chacun d'entre eux conjugu- avec une prot-ine porteuse crm 197 LU90809I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/859,975 US4902506A (en) 1983-07-05 1986-05-05 Immunogenic conjugates

Publications (1)

Publication Number Publication Date
LU90809I2 true LU90809I2 (fr) 2001-09-25

Family

ID=25332206

Family Applications (2)

Application Number Title Priority Date Filing Date
LU90808C LU90808I2 (fr) 1986-05-05 2001-07-25 Conjugue serotype 18c d'oligosaccharide pneumococcique
LU90809C LU90809I2 (fr) 1986-05-05 2001-07-25 Vaccin comprenant des saccharides pneumococciques de serotypes 4,6b,9v,14,18c19f et 23f, chacun d'entre eux conjugu- avec une prot-ine porteuse crm 197

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LU90808C LU90808I2 (fr) 1986-05-05 2001-07-25 Conjugue serotype 18c d'oligosaccharide pneumococcique

Country Status (14)

Country Link
US (1) US4902506A (fr)
EP (1) EP0245045B1 (fr)
JP (2) JP2559438B2 (fr)
AT (1) ATE96676T1 (fr)
AU (1) AU601742B2 (fr)
CA (1) CA1276109C (fr)
DE (3) DE3787995T2 (fr)
DK (1) DK175489B1 (fr)
ES (1) ES2059372T3 (fr)
HK (1) HK1003326A1 (fr)
IE (1) IE60897B1 (fr)
LU (2) LU90808I2 (fr)
NL (2) NL300051I2 (fr)
WO (1) WO1987006838A1 (fr)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360897A (en) * 1981-08-31 1994-11-01 The University Of Rochester Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad
ATE87215T1 (de) * 1987-07-21 1993-04-15 Stolle Res & Dev Verfahren zum erhalten von immunregulierenden faktoren mittels saeugetierimmunisierung.
US5785973A (en) * 1988-02-01 1998-07-28 Praxis Biologics, Inc. Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
WO1989006974A2 (fr) * 1988-02-01 1989-08-10 Praxis Biologics, Inc. Epitopes de cellules t a titre de molecules porteuses pour vaccins conjugues
DE3919915A1 (de) * 1989-06-19 1990-12-20 Boehringer Mannheim Gmbh Aminoalkylmaleimide und davon abgeleitete hapten- und antigenderivate sowie konjugate mit peptiden oder proteinen
CA2064194A1 (fr) * 1989-07-27 1991-01-28 Nelson Teng Produits de conjugaison entre un lipide a et un vecteur immunogene et leur utilisation comme vaccin
US5648241A (en) 1989-09-15 1997-07-15 The General Hospital Corporation Conjugate vaccine against group B streptococcus
CA2047073A1 (fr) * 1990-07-19 1992-01-20 William J. Leanza Vaccins coconjugues comportant une proteine immunogene, des peptides lies a vih et des fractions anioniques
IE912535A1 (en) * 1990-07-27 1992-01-29 Res Dev Foundation Liposomes that Provide Thymic Dependent Help to Weak Vaccine¹Antigens
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
FR2682388B1 (fr) * 1991-10-10 1995-06-09 Pasteur Merieux Serums Vacc Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal.
DE4224884A1 (de) * 1992-07-28 1994-02-03 Batenus Gmbh & Co Kg Verfahren zur Rückgewinnung von Rohstoffen aus vorsortiert gesammeltem, verbrauchten Gut, insbesondere aus verbrauchten elektrochemischen Batterien und Akkumulatoren
US5445817A (en) * 1992-08-21 1995-08-29 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines
ZA937034B (en) * 1992-09-24 1995-06-23 Brigham & Womens Hospital Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines
JP4163251B2 (ja) * 1992-09-24 2008-10-08 ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド グループbストレプトコッカス・タイプ▲ii▼およびタイプ▲v▼多糖−蛋白質接合ワクチン
US5274122A (en) * 1992-10-15 1993-12-28 Merck & Co., Inc. Acidic derivatives of homocysteine thiolactone
ES2126616T3 (es) * 1992-10-27 1999-04-01 American Cyanamid Co Vacuna pediatrica combinada, con una inmunogenecidad aumentada de cada componente de la vacuna.
US5554730A (en) * 1993-03-09 1996-09-10 Middlesex Sciences, Inc. Method and kit for making a polysaccharide-protein conjugate
US6153406A (en) * 1993-07-23 2000-11-28 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
US5565204A (en) * 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
GB9422096D0 (en) * 1994-11-02 1994-12-21 Biocine Spa Combined meningitis vaccine
US6284884B1 (en) 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
US5811102A (en) 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines
EP0831901B2 (fr) * 1995-06-07 2005-12-07 SMITHKLINE BEECHAM BIOLOGICALS s.a. Vaccins comprenant un conjugue antigene de polysaccharide-proteine porteuse et une proteine porteuse libre
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
DK0939647T4 (da) 1996-08-27 2006-10-23 Novartis Vaccines & Diagnostic Neisseria Meningitidis-serogruppe B-glycokonjugat og fremgangsmåde til anvendelse deraf
US6267961B1 (en) 1996-11-22 2001-07-31 Baxter International Inc. Direct methods for molar-mass determination of fragments of Haemophilus influenzae type b capsular polysaccharides and vaccine preparation
US6426074B1 (en) * 1997-03-19 2002-07-30 The Brigham And Women's Hospital Inc. Group B Streptococcus vaccine
US6676943B1 (en) * 1997-04-24 2004-01-13 Regents Of The University Of Minnesota Human complement C3-degrading protein from Streptococcus pneumoniae
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
GB9808932D0 (en) 1998-04-27 1998-06-24 Chiron Spa Polyepitope carrier protein
US6306404B1 (en) 1998-07-14 2001-10-23 American Cyanamid Company Adjuvant and vaccine compositions containing monophosphoryl lipid A
US8609614B2 (en) 1998-07-22 2013-12-17 Vanderbilt University GBS toxin receptor compositions and methods of use
KR100704826B1 (ko) * 1998-08-19 2007-04-09 박스터 헬쓰케어 에스.에이. N-아크릴로일화된 폴리사카라이드를 사용하여 제조된백신으로서 사용하기에 적합한 면역원성β-프로피온아미도-결합 폴리사카라이드 단백질 컨쥬게이트
FR2791895B1 (fr) * 1999-03-23 2001-06-15 Pasteur Merieux Serums Vacc Utilisation de trehalose pour stabiliser un vaccin liquide
US6635261B2 (en) 1999-07-13 2003-10-21 Wyeth Holdings Corporation Adjuvant and vaccine compositions containing monophosphoryl lipid A
US6846486B1 (en) * 2000-02-24 2005-01-25 Advanced Biotherapy Concepts, Inc. Method of treating allergy by administering an anti-histamine antibody
EP2957300B1 (fr) 2001-01-23 2021-07-14 Sanofi Pasteur Inc. Vaccin conjugué de protéine et de polysaccharide pour méningococcie polyvalente
JP2004533236A (ja) * 2001-04-13 2004-11-04 ワイエス 化膿性連鎖球菌(Streptococcuspyogenes)の表面タンパク質
US20070128229A1 (en) * 2002-04-12 2007-06-07 Wyeth Surface proteins of Streptococcus pyogenes
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
WO2003015815A1 (fr) 2001-08-21 2003-02-27 The Brigham And Women's Hospital, Inc. Vaccins conjugues ameliores
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en) * 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
FR2850106B1 (fr) 2003-01-17 2005-02-25 Aventis Pasteur Conjugues obtenus par amination reductrice du polysaccharide capsulaire du pneumocoque de serotype 5
EP2289546A3 (fr) 2003-01-30 2011-03-30 Novartis Vaccines and Diagnostics S.r.l. Vaccins injectables contre les multiples serogroupes du meningocoque
WO2005044861A1 (fr) * 2003-10-31 2005-05-19 Wyeth Holdings Corporation Polysaccharides de helicobacter pylori
SG149013A1 (en) 2003-12-17 2009-01-29 Wyeth Corp Immunogenic peptide carrier conjugates and methods of producing same
MY144231A (en) 2003-12-17 2011-08-15 Wyeth Corp Aß IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME
US7858101B2 (en) 2004-11-01 2010-12-28 The Brigham And Women's Hospital, Inc. Modified streptococcal polysaccharides and uses thereof
JP2008523815A (ja) 2004-12-15 2008-07-10 エラン ファーマ インターナショナル リミテッド 認知の改善における使用のためのヒト化アミロイドβ抗体
US7709001B2 (en) * 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US20070184072A1 (en) * 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
TWI445545B (zh) 2005-04-08 2014-07-21 Wyeth Corp 多價肺炎球菌多醣-蛋白質共軛物組合物
US7955605B2 (en) * 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
AU2011253684B8 (en) * 2005-04-08 2013-07-11 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US10828361B2 (en) 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
SI2004225T1 (sl) 2006-03-22 2012-08-31 Novartis Ag Reĺ˝imi za imunizacijo z meningokoknimi konjugati
AR060187A1 (es) * 2006-03-30 2008-05-28 Glaxosmithkline Biolog Sa Composicion inmunogenica
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
TW200806315A (en) 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
ES2498040T3 (es) 2007-07-27 2014-09-24 Janssen Alzheimer Immunotherapy Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
US8563523B2 (en) 2007-09-07 2013-10-22 University Of Georgia Research Foundation, Inc. Synthetic lipid A derivative
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
EP2356135B1 (fr) 2008-11-05 2017-10-25 Wyeth LLC Composition immunogène à multiples composants pour la prévention d'une maladie streptococcique bêta-hémolytique (bhs)
EP2387417B1 (fr) 2009-01-16 2016-05-11 University of Maryland, Baltimore Vaccin à large spectre contre les salmonelles non typhoïdiques
BRPI1014494A2 (pt) 2009-04-30 2016-08-02 Coley Pharm Group Inc vacina pneumocócica e usos da mesma
US8568735B2 (en) 2009-06-22 2013-10-29 Wyeth Llc Immunogenic compositions of Staphylococcus aureus antigens
KR20140119165A (ko) 2009-06-22 2014-10-08 와이어쓰 엘엘씨 황색포도상구균 혈청형 5 및 8 협막 다당류 접합체 면역원성 조성물 및 이의 제조 방법
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
PL2394663T3 (pl) * 2010-05-31 2022-02-21 Laboratorios Farmaceuticos Rovi, S.A. Kompozycje do wstrzykiwania implantów biodegradowalnych in-situ
EP3626263A1 (fr) 2010-06-04 2020-03-25 Wyeth LLC Formulations vaccinales
US20130259896A1 (en) 2010-12-22 2013-10-03 Lakshmi Khandke Stable Immunogenic Compositions of Staphylococcus Aureus Antigens
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
KR102057217B1 (ko) 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
KR20140075196A (ko) 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
KR20140075201A (ko) 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
WO2014097099A2 (fr) 2012-12-20 2014-06-26 Pfizer Inc. Procédé de glycoconjugaison
US11708411B2 (en) 2013-12-20 2023-07-25 Wake Forest University Health Sciences Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines
US11160855B2 (en) 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
US11241489B2 (en) 2016-08-05 2022-02-08 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
CA3031797A1 (fr) 2016-08-05 2018-02-08 Sanofi Pasteur, Inc. Composition d'un conjugue polysaccharide-proteine pneumococcique multivalent
IL265623B2 (en) 2016-09-30 2023-04-01 Biological E Ltd Multivalent vaccines for lung spot that include polysaccharide-protein conjugates
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
WO2018144438A1 (fr) 2017-01-31 2018-08-09 Merck Sharp & Dohme Corp. Procédés de production de conjugués protéine-polysaccharide capsulaire à partir du sérotype 19f de streptococcus pneumoniae
CA3052621A1 (fr) 2017-02-03 2018-08-09 Schadeck, Eva Barbara Compositions de conjugue saccharide d'haemophilus influenzae-excipient et leurs utilisations
CA3066911C (fr) 2017-06-10 2022-05-24 Inventprise, Llc Vaccins conjugues multivalents avec des polysaccharides conjugues bivalents ou multivalents qui conferent une immunogenicite et une avidite ameliorees
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
KR20200051004A (ko) 2017-09-07 2020-05-12 머크 샤프 앤드 돔 코포레이션 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도
PE20201338A1 (es) 2017-12-06 2020-11-25 Merck Sharp & Dohme Composiciones que comprenden conjugados de polisacarido de streptococcus pneumoniae con proteina y metodos de uso de estos
CN113453708A (zh) 2018-12-19 2021-09-28 默沙东公司 包含肺炎链球菌多糖-蛋白缀合物的组合物及其使用方法
JP2022542316A (ja) 2019-07-31 2022-09-30 サノフィ パスツール インコーポレイテッド 多価肺炎球菌多糖体-タンパク質コンジュゲート組成物およびその使用方法
KR20220102871A (ko) 2021-01-14 2022-07-21 (주)셀트리온 다가 폐렴구균 다당류-단백질 접합체를 포함하는 면역원성 조성물
TW202245835A (zh) 2021-02-04 2022-12-01 美商默沙東有限責任公司 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2407262A1 (fr) * 1977-10-27 1979-05-25 Cassenne Lab Sa Nouveaux polysaccharides extraits de corps microbiens d'haemophilus influenzae, procede de preparation et application a titre de medicaments de ces nouveaux produits
US4220717A (en) * 1977-12-22 1980-09-02 American Cyanamid Company Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.
US4196192A (en) * 1977-10-28 1980-04-01 American Cyanamid Company Combined Haemophilus influenzae type b and pertussis vaccine
NZ199866A (en) * 1981-03-09 1984-11-09 Cetus Corp Vaccine for prevention of gastroenteric disease:non-pathogenic strain genetically engineered to comprise genes for adhesin and/or toxoids
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4411888A (en) * 1981-06-22 1983-10-25 The University Of Rochester Composition of a novel immunogen for protection against diarrheal disease caused by enterotoxigenic Escherichia coli
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4451446A (en) * 1982-03-04 1984-05-29 Smithkline-Rit Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
EP0109688A3 (fr) * 1982-11-23 1986-12-03 The Wellcome Foundation Limited Complexes, procédés pour leur obtention et formulations contenant de tels complexes
US4459286A (en) * 1983-01-31 1984-07-10 Merck & Co., Inc. Coupled H. influenzae type B vaccine
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers

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EP0245045A2 (fr) 1987-11-11
EP0245045B1 (fr) 1993-11-03
DE3787995D1 (de) 1993-12-09
HK1003326A1 (en) 1998-10-23
DE10199036I1 (de) 2002-01-10
ATE96676T1 (de) 1993-11-15
IE60897B1 (en) 1994-08-24
CA1276109C (fr) 1990-11-13
DK2588A (da) 1988-01-05
US4902506A (en) 1990-02-20
DK2588D0 (da) 1988-01-05
NL300052I1 (nl) 2001-10-01
JPH08283282A (ja) 1996-10-29
AU601742B2 (en) 1990-09-20
JP2559438B2 (ja) 1996-12-04
EP0245045A3 (en) 1989-04-26
ES2059372T3 (es) 1994-11-16
DK175489B1 (da) 2004-11-08
JPH01500036A (ja) 1989-01-12
JP2736248B2 (ja) 1998-04-02
NL300051I1 (nl) 2001-10-01
IE871185L (en) 1987-11-05
WO1987006838A1 (fr) 1987-11-19
AU7393587A (en) 1987-12-01
DE10199037I1 (de) 2001-11-22
DE3787995T2 (de) 1994-05-19
NL300051I2 (nl) 2002-07-01
LU90808I2 (fr) 2001-09-25

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