LU82757A1 - Genes de la proinsuline humaine et de pre-proinsuline humaine,leur procede de preparation et leurs applications - Google Patents

Genes de la proinsuline humaine et de pre-proinsuline humaine,leur procede de preparation et leurs applications Download PDF

Info

Publication number
LU82757A1
LU82757A1 LU82757A LU82757A LU82757A1 LU 82757 A1 LU82757 A1 LU 82757A1 LU 82757 A LU82757 A LU 82757A LU 82757 A LU82757 A LU 82757A LU 82757 A1 LU82757 A1 LU 82757A1
Authority
LU
Luxembourg
Prior art keywords
sequence
proinsulin
human
coding
radical
Prior art date
Application number
LU82757A
Other languages
English (en)
French (fr)
Inventor
H Goodman
G Bell
W Rutter
R Pictet
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of LU82757A1 publication Critical patent/LU82757A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
LU82757A 1979-09-12 1980-09-10 Genes de la proinsuline humaine et de pre-proinsuline humaine,leur procede de preparation et leurs applications LU82757A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7519279A 1979-09-12 1979-09-12
US7519279 1979-09-12

Publications (1)

Publication Number Publication Date
LU82757A1 true LU82757A1 (fr) 1981-02-02

Family

ID=22124154

Family Applications (1)

Application Number Title Priority Date Filing Date
LU82757A LU82757A1 (fr) 1979-09-12 1980-09-10 Genes de la proinsuline humaine et de pre-proinsuline humaine,leur procede de preparation et leurs applications

Country Status (28)

Country Link
EP (1) EP0026598A1 (ru)
JP (1) JP2637393B2 (ru)
KR (1) KR870000501B1 (ru)
AT (1) AT377003B (ru)
AU (1) AU538154B2 (ru)
BE (1) BE885196A (ru)
BG (2) BG41137A3 (ru)
CA (1) CA1180289A (ru)
CZ (2) CZ278883B6 (ru)
DD (3) DD155004A5 (ru)
DK (1) DK385980A (ru)
ES (3) ES495030A0 (ru)
FI (1) FI802837A (ru)
FR (1) FR2464997B1 (ru)
GR (1) GR70279B (ru)
IE (1) IE52781B1 (ru)
IL (1) IL61041A (ru)
IT (1) IT1129250B (ru)
LU (1) LU82757A1 (ru)
NZ (1) NZ194786A (ru)
PH (1) PH26475A (ru)
PL (1) PL226725A1 (ru)
PT (1) PT71790B (ru)
RO (1) RO80005A (ru)
SK (1) SK278191B6 (ru)
SU (1) SU1491345A3 (ru)
YU (1) YU233480A (ru)
ZA (1) ZA805341B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
DE3001928A1 (de) * 1980-01-19 1981-08-06 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
US4249952A (en) * 1980-03-03 1981-02-10 Pennsylvania Engineering Corporation Method for producing cement clinker from cement kiln waste dust
AU545912B2 (en) * 1980-03-10 1985-08-08 Cetus Corporation Cloned heterologous jive products in bacillies
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
ZA824218B (en) * 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
WO1983003413A1 (en) * 1982-03-31 1983-10-13 Genetics Inst Creation of dna sequences encoding modified proinsulin precursors
NZ206534A (en) * 1982-12-13 1988-05-30 Florey Howard Inst Molecular cloning and characterisation of gene sequence coding for human relaxin
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
IL71991A (en) 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
DE3751863T2 (de) * 1986-05-20 1996-12-12 Gen Hospital Corp Bestimmung der Insulin Expression
ATE386811T1 (de) 1996-04-05 2008-03-15 Novartis Vaccines & Diagnostic Alphaviren-vektors mit eine reduzierte inhibierung der synthese von zellmakromolekülen
AUPP655698A0 (en) * 1998-10-16 1998-11-05 Commonwealth Scientific And Industrial Research Organisation Delivery system for porcine somatotropin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
GR71687B (ru) * 1977-11-08 1983-06-21 Genentech Inc
DE2862495D1 (en) * 1977-11-08 1989-05-24 Genentech Inc Plasmid for transforming bacterial host to render it capable of polypeptide expression
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
IE48385B1 (en) * 1978-08-11 1984-12-26 Univ California Synthesis of a eucaryotic protein by a microorganism

Also Published As

Publication number Publication date
SU1491345A3 (ru) 1989-06-30
RO80005B (ro) 1983-06-30
SK621580A3 (en) 1996-03-06
PH26475A (en) 1992-07-27
BE885196A (fr) 1980-12-31
KR870000501B1 (ko) 1987-03-12
JP2637393B2 (ja) 1997-08-06
BG41136A3 (en) 1987-04-15
PT71790A (en) 1980-10-01
ES8300857A1 (es) 1982-11-16
DD155004A5 (de) 1982-05-05
RO80005A (ro) 1983-07-07
ES503567A0 (es) 1983-04-01
NZ194786A (en) 1984-02-03
ATA458580A (de) 1984-06-15
ES503568A0 (es) 1982-11-16
DK385980A (da) 1981-03-13
GR70279B (ru) 1982-09-03
DD208989A5 (de) 1984-04-18
AU538154B2 (en) 1984-08-02
FI802837A (fi) 1981-03-13
PL226725A1 (en) 1983-07-18
CZ621580A3 (en) 1994-03-16
IE801912L (en) 1981-03-12
IT8068405A0 (it) 1980-09-11
ES8107307A1 (es) 1981-10-01
ZA805341B (en) 1982-01-27
IE52781B1 (en) 1988-03-02
FR2464997B1 (fr) 1985-05-24
FR2464997A1 (fr) 1981-03-20
AT377003B (de) 1985-01-25
IT1129250B (it) 1986-06-04
AU6232480A (en) 1981-03-19
KR830003576A (ko) 1983-06-21
IL61041A (en) 1984-02-29
YU233480A (en) 1984-02-29
PT71790B (en) 1981-07-07
CZ278883B6 (en) 1994-08-17
ES495030A0 (es) 1981-10-01
CZ548884A3 (en) 1996-08-14
JPS5695199A (en) 1981-08-01
CA1180289A (en) 1985-01-02
IL61041A0 (en) 1980-11-30
DD201693A5 (de) 1983-08-03
SK278191B6 (en) 1996-03-06
BG41137A3 (en) 1987-04-15
EP0026598A1 (en) 1981-04-08
ES8305420A1 (es) 1983-04-01

Similar Documents

Publication Publication Date Title
US4431740A (en) DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes
DK166784B1 (da) Rekombinant dna-sekvens, en mikroorganisme indeholdende sekvensen og en fremgangsmaade til fremstilling af et eucaryot protein
KR101299417B1 (ko) 카복시-말단 아미드화 펩티드를 제조하는 방법
JP2686090B2 (ja) 新規融合蛋白質およびその精製方法
FR2460330A1 (fr) Procede de production d'un vecteur de clonage duplicable comportant un gene quasi-synthetique codant une proteine, vecteur de clonage ainsi obtenu et procede d'obtention de la proteine codee par le gene quasi-synthetique
CS219257B2 (en) Method of making the eukaryotic protein
FR2730495A1 (fr) Derive de proinsuline et procede pour la production d'insuline humaine
LU82757A1 (fr) Genes de la proinsuline humaine et de pre-proinsuline humaine,leur procede de preparation et leurs applications
FR2555199A1 (fr) Procede de clivage d'adn bicatenaire en n'importe quel point donne
JP2892596B2 (ja) ヒト−レラキシン遺伝子
JP2000504574A (ja) カルシトニン・フラグメントの組換え調製、ならびにカルシトニンおよび関連アナログの調製におけるその使用
Izard et al. Physical and conformational properties of synthetic idealized signal sequences parallel their biological function
EP0229046A1 (fr) Procede d'obtention d'adn, arn, peptides, polypeptides ou proteines, par une technique de recombinaison d'adn.
JPS59156284A (ja) ヒト−レラキシンｈ２遺伝子
JPH0376580A (ja) 大腸菌発現ベクターとそれを利用した抗ウイルス性タンパク質の製造方法
JPH03503596A (ja) 蛋白質若しくはポリペプチドの調製方法、該ポリペプチドをコードするｄｎａ配列、該ｄｎａ配列およびポリペプチドを有する微生物および該ポリペプチドの薬学的製剤としての利用
EP0252894A2 (fr) Polypeptides hybrides comprenant la somatocrinine et l'alpha1-antitrypsine, méthode pour leur production à partir de clones bactériens et leur utilisation pour la production de somatocrinine
EP0259891B1 (en) [Leu 13] motilin, DNAs coding for same and methods for producing same
RU2144957C1 (ru) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pPINS07, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД, СОДЕРЖАЩИЙ ПРОИНСУЛИН ЧЕЛОВЕКА, И ШТАММ БАКТЕРИЙ Escherichia coli - ПРОДУЦЕНТ ГИБРИДНОГО ПОЛИПЕПТИДА, СОДЕРЖАЩЕГО ПРОИНСУЛИН ЧЕЛОВЕКА
JP2612264B2 (ja) Ｄｎａ配列体
KR0161656B1 (ko) 글루카곤의 생산방법
CA1302321C (en) Preparation of polypeptides
JPS60502136A (ja) 微生物によるインタ−ル−キン２の形質発現
Honda et al. Method for producing Leu 13! motilin
JPS60501989A (ja) インシュリン様成長因子の微生物発現