LU82514A1 - Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique - Google Patents

Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique Download PDF

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Publication number
LU82514A1
LU82514A1 LU82514A LU82514A LU82514A1 LU 82514 A1 LU82514 A1 LU 82514A1 LU 82514 A LU82514 A LU 82514A LU 82514 A LU82514 A LU 82514A LU 82514 A1 LU82514 A1 LU 82514A1
Authority
LU
Luxembourg
Prior art keywords
vinblastine
ethyl
deacetyl
carboxamide
acid
Prior art date
Application number
LU82514A
Other languages
English (en)
French (fr)
Inventor
Andre B Trouet
Jean A Hannart
Sivaprasada Bushana Kandukuri
Original Assignee
Omnium Chimique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to OA56972A priority Critical patent/OA06421A/xx
Application filed by Omnium Chimique Sa filed Critical Omnium Chimique Sa
Priority to LU82514A priority patent/LU82514A1/fr
Priority to ES502644A priority patent/ES502644A0/es
Priority to AU71262/81A priority patent/AU541747B2/en
Priority to GR65133A priority patent/GR74565B/el
Priority to NZ197299A priority patent/NZ197299A/en
Priority to US06/269,876 priority patent/US4388305A/en
Priority to IL63038A priority patent/IL63038A0/xx
Priority to CA000379041A priority patent/CA1196326A/en
Priority to IE1275/81A priority patent/IE51403B1/en
Priority to ZA00813781A priority patent/ZA813781B/xx
Priority to DE19813122479 priority patent/DE3122479A1/de
Priority to AT0253881A priority patent/AT390793B/de
Priority to JP8798581A priority patent/JPS5728094A/ja
Priority to IT67782/81A priority patent/IT1144601B/it
Priority to GB8117454A priority patent/GB2078730A/en
Priority to SE8103594A priority patent/SE8103594L/xx
Priority to AT81870028T priority patent/ATE9475T1/de
Priority to DK250181A priority patent/DK160614C/da
Priority to BE0/205032A priority patent/BE889136A/fr
Priority to DE8181870028T priority patent/DE3166150D1/de
Priority to FR8111330A priority patent/FR2483926A1/fr
Priority to PT73161A priority patent/PT73161B/pt
Priority to DD81230660A priority patent/DD160417A5/de
Priority to EP81870028A priority patent/EP0041935B1/fr
Priority to HU811725A priority patent/HU185261B/hu
Priority to NL8102802A priority patent/NL8102802A/nl
Publication of LU82514A1 publication Critical patent/LU82514A1/fr
Priority to US06/446,708 priority patent/US4639456A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
LU82514A 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique LU82514A1 (fr)

Priority Applications (28)

Application Number Priority Date Filing Date Title
OA56972A OA06421A (fr) 1980-06-10 1979-12-13 Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
ES502644A ES502644A0 (es) 1980-06-10 1981-05-30 Procedimiento de obtencion de nuevos derivados de la vin- blastina
AU71262/81A AU541747B2 (en) 1980-06-10 1981-06-02 N-(vinblastinoyl-23)derivatives of amino acid and peptides
GR65133A GR74565B (nl) 1980-06-10 1981-06-02
NZ197299A NZ197299A (en) 1980-06-10 1981-06-03 N-(vinblastin-23-oyl)derivatives of aminoacids
US06/269,876 US4388305A (en) 1980-06-10 1981-06-03 Vinblastin-23-oyl amino acid derivatives for use as antitumor agents
IL63038A IL63038A0 (en) 1980-06-10 1981-06-04 Vinblastine derivatives
CA000379041A CA1196326A (en) 1980-06-10 1981-06-04 Vinblastin-23-oyl amino acid derivatives
IE1275/81A IE51403B1 (en) 1980-06-10 1981-06-04 N-(vinblastinolyl-23)derivatives of amino acid and peptides and methods for their preparation
ZA00813781A ZA813781B (en) 1980-06-10 1981-06-05 N-(vinblastinoyl-23)derivatives of amino acid and peptides
DE19813122479 DE3122479A1 (de) 1980-06-10 1981-06-05 N-(vinblastin-23-oyl)-aminosaeurederivate
AT0253881A AT390793B (de) 1980-06-10 1981-06-05 Verfahren zur herstellung von neuen n-(vinblastin-23-oyl)-aminosaeurederivaten und von deren saeureadditionssalzen
JP8798581A JPS5728094A (en) 1980-06-10 1981-06-08 N-(vinblastine-23-oyl)amino acid derivative
IT67782/81A IT1144601B (it) 1980-06-10 1981-06-08 Derivati della vinblastina procedimento per la loro preparazione e composizioni farmaceutiche contenenti tali derivati
GB8117454A GB2078730A (en) 1980-06-10 1981-06-08 N-(vinblastinoyl-23) derivatives of amino acid and peptides
DE8181870028T DE3166150D1 (en) 1980-06-10 1981-06-09 N-(vinblastinoyl-23) derivatives of amino acids and peptides and their preparation
AT81870028T ATE9475T1 (de) 1980-06-10 1981-06-09 Aminosaeure- und peptid-n-(vinblastinoyl-23)derivate und ihre herstellung.
DK250181A DK160614C (da) 1980-06-10 1981-06-09 Analogifremgangsmaade til fremstilling af vinblastinderivater og farmaceutisk acceptable salte deraf
BE0/205032A BE889136A (fr) 1980-06-10 1981-06-09 Derives n-(vinglastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
SE8103594A SE8103594L (sv) 1980-06-10 1981-06-09 N-(vinblastin-23-oyl)aminosyraderivat
FR8111330A FR2483926A1 (fr) 1980-06-10 1981-06-09 Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
PT73161A PT73161B (fr) 1980-06-10 1981-06-09 Procede pour la preparation de derives de n-(vynblastinoyl-23) aux amino-acides et peptides et son application terapeutique
DD81230660A DD160417A5 (de) 1980-06-10 1981-06-09 Verfahren zur herstellung von n-(vinblastin-23-oyl)-aminosaeurederivate
EP81870028A EP0041935B1 (fr) 1980-06-10 1981-06-09 Dérivés n-(vinblastinoyl-23) d'acides aminés et de peptides ainsi que leur préparation
HU811725A HU185261B (en) 1980-06-10 1981-06-10 Process for preparing n-/vinblastinoyl-23/-derivatives of some aminoacids and peptides
NL8102802A NL8102802A (nl) 1980-06-10 1981-06-10 N-(vinblastin-23-oyl)aminozuurderivaten.
US06/446,708 US4639456A (en) 1980-06-10 1982-12-03 Vinblastin-23-oyl amino acid derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU82514 1980-06-10

Publications (1)

Publication Number Publication Date
LU82514A1 true LU82514A1 (fr) 1982-01-20

Family

ID=19729417

Family Applications (1)

Application Number Title Priority Date Filing Date
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique

Country Status (4)

Country Link
JP (1) JPS5728094A (nl)
BE (1) BE889136A (nl)
LU (1) LU82514A1 (nl)
ZA (1) ZA813781B (nl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0233101A1 (fr) * 1986-01-13 1987-08-19 Ire-Celltarg S.A. Dérivés de vinblastine et composition pharmaceutique les contenant
CA2790602C (en) * 2010-02-22 2016-12-13 The Scripps Research Institute 10'-fluorinated vinca alkaloids provide enhanced biological activity against mdr cancer cells

Also Published As

Publication number Publication date
JPS5728094A (en) 1982-02-15
JPH0210836B2 (nl) 1990-03-09
BE889136A (fr) 1981-12-09
ZA813781B (en) 1982-06-30

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