LTIP390A - Triazolpiridazino junginiai,jų gavimo būdas ir panaudojimas - Google Patents
Triazolpiridazino junginiai,jų gavimo būdas ir panaudojimasInfo
- Publication number
- LTIP390A LTIP390A LTIP390A LTIP390A LTIP390A LT IP390 A LTIP390 A LT IP390A LT IP390 A LTIP390 A LT IP390A LT IP390 A LTIP390 A LT IP390A LT IP390 A LTIP390 A LT IP390A
- Authority
- LT
- Lithuania
- Prior art keywords
- optionally substituted
- group
- lower alkyl
- alkyl group
- production
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical compound N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 102000002045 Endothelin Human genes 0.000 abstract 1
- 108050009340 Endothelin Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000000702 anti-platelet effect Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000002617 leukotrienes Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
Naujas junginys aprašomas 1 formule@@@@@@@@@@@Kurioje R1 reiškia H, pasirinktinai pakeistą žemesnio alkilo grupę arba halogeną; R2 ir R3 kiekvienas reiškia vandenilį arba pasirinktinai pakeistą žemesnio alkilo grupę, arba R2 ir R3 gali, paėmus kartu su gretima -C=C- grupę, sudaryti 5-7-narį žiedą; X reiškia O, SO arba SO2; Y reiškia formules@@@@@@@@@grupę (R4 ir R5 atitinkamai reiškia H arba pasirinktinai pakeistą žemesnio alkilo grupę) arba dvivalentę grupę, išvestą iš pasirinktinai pakeisto 3-7-nario homociklinio arba heterociklinio žiedo; R6 ir R7 kiekvienas reiškia H, pasirinktinai pakeistą žemesnio alkilo grupe, pasirinktinai pakeistą cikloalkilo grupę arba pasirinktinai pakeistą arilo grupę, arba R6 ir R7 paimtos kartu su gretimu N, gali sudaryti pasirinktinai pakeistą N turinčią heterociklinę grupę; m reiškia sveiką skaičių nuo 0 iki 4; n reiškia sveiką skaičių nuo 0 iki 4; arba jo druska, kurie turi puikų poveikį prieš trombocitų aktyvavimo faktorius, prieš leukoterieną ir prieš endoteliną, ir yra vertingi kaip antiasminiai agentai, ir jų gamyba, tarpiniai produktai ir farmaciniai mišiniai.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6178092 | 1992-03-18 | ||
| JP21890492 | 1992-08-18 | ||
| JP1456093 | 1993-02-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP390A true LTIP390A (lt) | 1994-08-25 |
| LT3200B LT3200B (en) | 1995-03-27 |
Family
ID=27280691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP390A LT3200B (en) | 1992-03-18 | 1993-03-05 | Triazolopyridazine methodfor production thereof and use |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5389633A (lt) |
| EP (1) | EP0562439B1 (lt) |
| CN (1) | CN1040874C (lt) |
| AT (1) | ATE181075T1 (lt) |
| AU (1) | AU654430B2 (lt) |
| CA (1) | CA2091874A1 (lt) |
| DE (1) | DE69325199T2 (lt) |
| DK (1) | DK0562439T3 (lt) |
| EE (1) | EE9400357A (lt) |
| ES (1) | ES2132147T3 (lt) |
| FI (1) | FI104076B1 (lt) |
| GR (1) | GR3030817T3 (lt) |
| HU (2) | HU218791B (lt) |
| LT (1) | LT3200B (lt) |
| LV (1) | LV10456B (lt) |
| MY (1) | MY108967A (lt) |
| NO (1) | NO300774B1 (lt) |
| NZ (1) | NZ247171A (lt) |
| PH (1) | PH29998A (lt) |
| RU (1) | RU2130458C1 (lt) |
| TW (1) | TW255891B (lt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5571821A (en) * | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5464853A (en) * | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5736509A (en) * | 1990-12-14 | 1998-04-07 | Texas Biotechnology Corporation | Cyclic peptide surface feature mimics of endothelin |
| US5482939A (en) * | 1992-03-18 | 1996-01-09 | Takeda Chemical Industries, Ltd. | Triazolopyridazine compounds, their production and use |
| EP0620224B1 (en) * | 1993-04-12 | 1998-07-15 | Takeda Chemical Industries, Ltd. | Triazolopyridazine derivatives, their production and use |
| US6030991A (en) * | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| TW304878B (lt) * | 1993-09-21 | 1997-05-11 | Takeda Pharm Industry Co Ltd | |
| WO1996008496A1 (en) * | 1994-09-16 | 1996-03-21 | Takeda Chemical Industries, Ltd. | Triazolopyridazines process and intermediates for their preparation and their use as medicaments |
| US5977117A (en) * | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5958905A (en) * | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
| US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
| ATE283270T1 (de) | 1997-04-25 | 2004-12-15 | Takeda Chemical Industries Ltd | Condensierte pyridazine derivate,deren herstellung und verwendung |
| EA003993B1 (ru) | 1997-04-28 | 2003-12-25 | Инсизив Фармасьютикэлз Инк. | Сульфонамиды для лечения заболеваний, связанных с эндотелином |
| US5783705A (en) * | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| WO1999044611A1 (en) * | 1998-03-04 | 1999-09-10 | Takeda Chemical Industries, Ltd. | Triazolo-pyridazine derivatives for the treatment of chronic obstructive pulmonary diseases |
| US6610694B1 (en) | 1998-10-06 | 2003-08-26 | Takeda Chemical Industries, Ltd. | Condensed pyridazine compounds, their production and use |
| ATE256128T1 (de) | 1998-10-21 | 2003-12-15 | Takeda Chemical Industries Ltd | Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung |
| RU2194494C1 (ru) * | 2001-04-28 | 2002-12-20 | Общество с ограниченной ответственностью "Абидофарма" | Мазь "тамидерм" |
| KR20100120139A (ko) * | 2008-02-05 | 2010-11-12 | 사노피-아벤티스 | Ｐａｒ１ 억제제로서의 트리아졸륨 염, 이들의 제조방법, 및 약제로서의 용도 |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| WO2013005057A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | New compounds |
| WO2013005041A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Tricyclic heterocyclic compounds as kinase inhibitors |
| WO2013004984A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Tricyclic compounds for use as kinase inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3915968A (en) | 1973-09-21 | 1975-10-28 | Lepetit Spa | Triazolopyridazines |
| US4136182A (en) | 1976-05-26 | 1979-01-23 | The Dow Chemical Company | Triazolopyridazines used to alleviate bronchial spasms |
| AU593109B2 (en) * | 1986-06-05 | 1990-02-01 | Merrell Dow Pharmaceuticals Inc. | 2,3-dihydro-1-(8-methyl-1,2,4-triazolo-{4,3-b}pyridazin-6-YL )-4(1H)-pyridinone |
| PH27291A (en) * | 1989-01-31 | 1993-05-04 | Takeda Chemical Industries Ltd | Imidazolpyrimidazines their production and use |
| EP0440119A1 (en) * | 1990-01-31 | 1991-08-07 | Takeda Chemical Industries, Ltd. | Imidazopyridazine compounds, their production and use |
| EP0444549B1 (en) * | 1990-03-01 | 1995-01-25 | Takeda Chemical Industries, Ltd. | Imidazopyridazines their production and use |
-
1993
- 1993-03-05 LT LTIP390A patent/LT3200B/lt not_active IP Right Cessation
- 1993-03-06 TW TW082101665A patent/TW255891B/zh active
- 1993-03-10 MY MYPI93000429A patent/MY108967A/en unknown
- 1993-03-12 RU RU93004584A patent/RU2130458C1/ru active
- 1993-03-16 NZ NZ247171A patent/NZ247171A/en unknown
- 1993-03-16 AU AU35269/93A patent/AU654430B2/en not_active Ceased
- 1993-03-17 FI FI931190A patent/FI104076B1/fi active
- 1993-03-17 AT AT93104367T patent/ATE181075T1/de not_active IP Right Cessation
- 1993-03-17 DK DK93104367T patent/DK0562439T3/da active
- 1993-03-17 DE DE69325199T patent/DE69325199T2/de not_active Expired - Fee Related
- 1993-03-17 ES ES93104367T patent/ES2132147T3/es not_active Expired - Lifetime
- 1993-03-17 PH PH45897A patent/PH29998A/en unknown
- 1993-03-17 HU HU9300759A patent/HU218791B/hu not_active IP Right Cessation
- 1993-03-17 EP EP93104367A patent/EP0562439B1/en not_active Expired - Lifetime
- 1993-03-17 LV LVP-93-189A patent/LV10456B/en unknown
- 1993-03-17 NO NO930974A patent/NO300774B1/no not_active IP Right Cessation
- 1993-03-17 CA CA002091874A patent/CA2091874A1/en not_active Abandoned
- 1993-03-17 US US08/032,296 patent/US5389633A/en not_active Expired - Fee Related
- 1993-03-18 CN CN93103370A patent/CN1040874C/zh not_active Expired - Fee Related
-
1994
- 1994-11-10 EE EE9400357A patent/EE9400357A/xx unknown
-
1995
- 1995-05-31 HU HU95P/P00146P patent/HU211326A9/hu unknown
-
1999
- 1999-07-20 GR GR990401905T patent/GR3030817T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2132147T3 (es) | 1999-08-16 |
| ATE181075T1 (de) | 1999-06-15 |
| CA2091874A1 (en) | 1993-09-19 |
| FI104076B (fi) | 1999-11-15 |
| PH29998A (en) | 1996-10-29 |
| MY108967A (en) | 1996-11-30 |
| LV10456A (lv) | 1995-02-20 |
| NO300774B1 (no) | 1997-07-21 |
| DE69325199D1 (de) | 1999-07-15 |
| US5389633A (en) | 1995-02-14 |
| RU2130458C1 (ru) | 1999-05-20 |
| AU3526993A (en) | 1993-09-23 |
| HU218791B (hu) | 2000-12-28 |
| GR3030817T3 (en) | 1999-11-30 |
| NZ247171A (en) | 1994-09-27 |
| EE9400357A (et) | 1996-04-15 |
| AU654430B2 (en) | 1994-11-03 |
| HU211326A9 (en) | 1995-11-28 |
| FI931190A7 (fi) | 1993-09-19 |
| DK0562439T3 (da) | 1999-11-15 |
| CN1077958A (zh) | 1993-11-03 |
| HU9300759D0 (en) | 1993-06-28 |
| DE69325199T2 (de) | 1999-12-16 |
| TW255891B (lt) | 1995-09-01 |
| EP0562439A1 (en) | 1993-09-29 |
| LT3200B (en) | 1995-03-27 |
| EP0562439B1 (en) | 1999-06-09 |
| HK1009700A1 (en) | 1999-06-04 |
| FI931190A0 (fi) | 1993-03-17 |
| FI104076B1 (fi) | 1999-11-15 |
| HUT65935A (en) | 1994-08-29 |
| NO930974L (no) | 1993-09-20 |
| LV10456B (en) | 1995-10-20 |
| CN1040874C (zh) | 1998-11-25 |
| NO930974D0 (no) | 1993-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 19970305 |