LTIP390A - Triazolopyridazine methodfor production thereof and use - Google Patents
Triazolopyridazine methodfor production thereof and useInfo
- Publication number
- LTIP390A LTIP390A LTIP390A LTIP390A LTIP390A LT IP390 A LTIP390 A LT IP390A LT IP390 A LTIP390 A LT IP390A LT IP390 A LTIP390 A LT IP390A LT IP390 A LTIP390 A LT IP390A
- Authority
- LT
- Lithuania
- Prior art keywords
- optionally substituted
- group
- lower alkyl
- alkyl group
- production
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical compound N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 102000002045 Endothelin Human genes 0.000 abstract 1
- 108050009340 Endothelin Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000000702 anti-platelet effect Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000002617 leukotrienes Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
Naujas junginys aprašomas 1 formule@@@@@@@@@@@Kurioje R1 reiškia H, pasirinktinai pakeistą žemesnio alkilo grupę arba halogeną; R2 ir R3 kiekvienas reiškia vandenilį arba pasirinktinai pakeistą žemesnio alkilo grupę, arba R2 ir R3 gali, paėmus kartu su gretima -C=C- grupę, sudaryti 5-7-narį žiedą; X reiškia O, SO arba SO2; Y reiškia formules@@@@@@@@@grupę (R4 ir R5 atitinkamai reiškia H arba pasirinktinai pakeistą žemesnio alkilo grupę) arba dvivalentę grupę, išvestą iš pasirinktinai pakeisto 3-7-nario homociklinio arba heterociklinio žiedo; R6 ir R7 kiekvienas reiškia H, pasirinktinai pakeistą žemesnio alkilo grupe, pasirinktinai pakeistą cikloalkilo grupę arba pasirinktinai pakeistą arilo grupę, arba R6 ir R7 paimtos kartu su gretimu N, gali sudaryti pasirinktinai pakeistą N turinčią heterociklinę grupę; m reiškia sveiką skaičių nuo 0 iki 4; n reiškia sveiką skaičių nuo 0 iki 4; arba jo druska, kurie turi puikų poveikį prieš trombocitų aktyvavimo faktorius, prieš leukoterieną ir prieš endoteliną, ir yra vertingi kaip antiasminiai agentai, ir jų gamyba, tarpiniai produktai ir farmaciniai mišiniai.A novel compound is described in Formula 1 @@@@@@@@@@ In which R1 represents H, an optionally substituted lower alkyl group or halogen; R 2 and R 3 each represent hydrogen or an optionally substituted lower alkyl group, or R 2 and R 3 may, taken together with the adjacent -C = C- group, form a 5-7 membered ring; X represents O, SO or SO2; Y represents formulas @@@@@@@@@@ (R4 and R5 respectively represent H or an optionally substituted lower alkyl group) or a bivalent group derived from an optionally substituted 3-7 membered homocyclic or heterocyclic ring; R6 and R7 each represent H, optionally substituted with a lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R6 and R7 taken together with an adjacent N may form an optionally substituted N-containing heterocyclic group; m represents an integer from 0 to 4; n represents an integer from 0 to 4; or a salt thereof, which has excellent anti-platelet activation factor, leukotriene, and endothelin, and are valuable as antimycotic agents and their production, intermediates and pharmaceutical compositions.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6178092 | 1992-03-18 | ||
| JP21890492 | 1992-08-18 | ||
| JP1456093 | 1993-02-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP390A true LTIP390A (en) | 1994-08-25 |
| LT3200B LT3200B (en) | 1995-03-27 |
Family
ID=27280691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP390A LT3200B (en) | 1992-03-18 | 1993-03-05 | Triazolopyridazine methodfor production thereof and use |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5389633A (en) |
| EP (1) | EP0562439B1 (en) |
| CN (1) | CN1040874C (en) |
| AT (1) | ATE181075T1 (en) |
| AU (1) | AU654430B2 (en) |
| CA (1) | CA2091874A1 (en) |
| DE (1) | DE69325199T2 (en) |
| DK (1) | DK0562439T3 (en) |
| EE (1) | EE9400357A (en) |
| ES (1) | ES2132147T3 (en) |
| FI (1) | FI104076B1 (en) |
| GR (1) | GR3030817T3 (en) |
| HU (2) | HU218791B (en) |
| LT (1) | LT3200B (en) |
| LV (1) | LV10456B (en) |
| MY (1) | MY108967A (en) |
| NO (1) | NO300774B1 (en) |
| NZ (1) | NZ247171A (en) |
| PH (1) | PH29998A (en) |
| RU (1) | RU2130458C1 (en) |
| TW (1) | TW255891B (en) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5571821A (en) * | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5464853A (en) * | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5736509A (en) * | 1990-12-14 | 1998-04-07 | Texas Biotechnology Corporation | Cyclic peptide surface feature mimics of endothelin |
| US5482939A (en) * | 1992-03-18 | 1996-01-09 | Takeda Chemical Industries, Ltd. | Triazolopyridazine compounds, their production and use |
| ATE168376T1 (en) * | 1993-04-12 | 1998-08-15 | Takeda Chemical Industries Ltd | TRIAZOLOPYRIDAZINE DERIVATIVES, THEIR PREPARATION AND USE |
| US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6030991A (en) * | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| TW304878B (en) * | 1993-09-21 | 1997-05-11 | Takeda Pharm Industry Co Ltd | |
| ATE201875T1 (en) * | 1994-09-16 | 2001-06-15 | Takeda Chemical Industries Ltd | TRIAZOLOPYRIDAZINE, PROCESS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
| US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5958905A (en) * | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
| US5804585A (en) * | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
| DE69827786T2 (en) * | 1997-04-25 | 2005-11-24 | Takeda Pharmaceutical Co. Ltd. | CONDENSED PYRIDAZINE DERIVATIVES, THEIR PREPARATION AND USE |
| NZ336898A (en) | 1997-04-28 | 2001-10-26 | Texas Biotechnology Corp | Sulfonamides for treatment of endothelin-mediated disorders |
| US5783705A (en) * | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| WO1999044611A1 (en) * | 1998-03-04 | 1999-09-10 | Takeda Chemical Industries, Ltd. | Triazolo-pyridazine derivatives for the treatment of chronic obstructive pulmonary diseases |
| CA2346659A1 (en) | 1998-10-06 | 2000-04-13 | Michiyo Gyoten | Condensed pyridazine compounds, their production and use |
| KR20010087738A (en) | 1998-10-21 | 2001-09-21 | 다케다 야쿠힌 고교 가부시키가이샤 | Fused pyridazine derivatives, process for the preparation of the same and uses thereof |
| RU2194494C1 (en) * | 2001-04-28 | 2002-12-20 | Общество с ограниченной ответственностью "Абидофарма" | Ointment "tamiderm" |
| EP2240486B1 (en) * | 2008-02-05 | 2015-09-09 | Sanofi | Triazolium salts as par1 inhibitors, their manufacture and their application as medicine |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| WO2013004984A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Tricyclic compounds for use as kinase inhibitors |
| WO2013005041A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Tricyclic heterocyclic compounds as kinase inhibitors |
| WO2013005057A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | New compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3915968A (en) | 1973-09-21 | 1975-10-28 | Lepetit Spa | Triazolopyridazines |
| US4136182A (en) | 1976-05-26 | 1979-01-23 | The Dow Chemical Company | Triazolopyridazines used to alleviate bronchial spasms |
| NZ220521A (en) * | 1986-06-05 | 1989-11-28 | Merrell Dow Pharma | 2,3-dihydro-1-(8-methyl-1,2,4-triapyridazin-6-yl)-4(1h)-pyridinone and pharmaceutical compositions |
| PH27291A (en) * | 1989-01-31 | 1993-05-04 | Takeda Chemical Industries Ltd | Imidazolpyrimidazines their production and use |
| EP0440119A1 (en) * | 1990-01-31 | 1991-08-07 | Takeda Chemical Industries, Ltd. | Imidazopyridazine compounds, their production and use |
| DE69106902T2 (en) * | 1990-03-01 | 1995-07-06 | Takeda Chemical Industries Ltd | Imidazopyridazines, their production and use. |
-
1993
- 1993-03-05 LT LTIP390A patent/LT3200B/en not_active IP Right Cessation
- 1993-03-06 TW TW082101665A patent/TW255891B/zh active
- 1993-03-10 MY MYPI93000429A patent/MY108967A/en unknown
- 1993-03-12 RU RU93004584A patent/RU2130458C1/en active
- 1993-03-16 AU AU35269/93A patent/AU654430B2/en not_active Ceased
- 1993-03-16 NZ NZ247171A patent/NZ247171A/en unknown
- 1993-03-17 DK DK93104367T patent/DK0562439T3/en active
- 1993-03-17 AT AT93104367T patent/ATE181075T1/en not_active IP Right Cessation
- 1993-03-17 DE DE69325199T patent/DE69325199T2/en not_active Expired - Fee Related
- 1993-03-17 LV LVP-93-189A patent/LV10456B/en unknown
- 1993-03-17 US US08/032,296 patent/US5389633A/en not_active Expired - Fee Related
- 1993-03-17 EP EP93104367A patent/EP0562439B1/en not_active Expired - Lifetime
- 1993-03-17 CA CA002091874A patent/CA2091874A1/en not_active Abandoned
- 1993-03-17 PH PH45897A patent/PH29998A/en unknown
- 1993-03-17 FI FI931190A patent/FI104076B1/en active
- 1993-03-17 NO NO930974A patent/NO300774B1/en not_active IP Right Cessation
- 1993-03-17 ES ES93104367T patent/ES2132147T3/en not_active Expired - Lifetime
- 1993-03-17 HU HU9300759A patent/HU218791B/en not_active IP Right Cessation
- 1993-03-18 CN CN93103370A patent/CN1040874C/en not_active Expired - Fee Related
-
1994
- 1994-11-10 EE EE9400357A patent/EE9400357A/en unknown
-
1995
- 1995-05-31 HU HU95P/P00146P patent/HU211326A9/en unknown
-
1999
- 1999-07-20 GR GR990401905T patent/GR3030817T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69325199D1 (en) | 1999-07-15 |
| LV10456B (en) | 1995-10-20 |
| CN1077958A (en) | 1993-11-03 |
| HU9300759D0 (en) | 1993-06-28 |
| CN1040874C (en) | 1998-11-25 |
| NO300774B1 (en) | 1997-07-21 |
| PH29998A (en) | 1996-10-29 |
| ATE181075T1 (en) | 1999-06-15 |
| HU218791B (en) | 2000-12-28 |
| FI931190A0 (en) | 1993-03-17 |
| LV10456A (en) | 1995-02-20 |
| RU2130458C1 (en) | 1999-05-20 |
| MY108967A (en) | 1996-11-30 |
| LT3200B (en) | 1995-03-27 |
| NZ247171A (en) | 1994-09-27 |
| NO930974L (en) | 1993-09-20 |
| CA2091874A1 (en) | 1993-09-19 |
| US5389633A (en) | 1995-02-14 |
| NO930974D0 (en) | 1993-03-17 |
| TW255891B (en) | 1995-09-01 |
| ES2132147T3 (en) | 1999-08-16 |
| HU211326A9 (en) | 1995-11-28 |
| AU654430B2 (en) | 1994-11-03 |
| EP0562439B1 (en) | 1999-06-09 |
| EE9400357A (en) | 1996-04-15 |
| DK0562439T3 (en) | 1999-11-15 |
| FI104076B (en) | 1999-11-15 |
| HUT65935A (en) | 1994-08-29 |
| HK1009700A1 (en) | 1999-06-04 |
| GR3030817T3 (en) | 1999-11-30 |
| EP0562439A1 (en) | 1993-09-29 |
| DE69325199T2 (en) | 1999-12-16 |
| FI104076B1 (en) | 1999-11-15 |
| FI931190A7 (en) | 1993-09-19 |
| AU3526993A (en) | 1993-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 19970305 |