LTC2548560I2 - Kompozicijos ir būdai, skirti SMN2 splaisingo moduliavimui - Google Patents
Kompozicijos ir būdai, skirti SMN2 splaisingo moduliavimuiInfo
- Publication number
- LTC2548560I2 LTC2548560I2 LTPA2017037C LTPA2017037C LTC2548560I2 LT C2548560 I2 LTC2548560 I2 LT C2548560I2 LT PA2017037 C LTPA2017037 C LT PA2017037C LT PA2017037 C LTPA2017037 C LT PA2017037C LT C2548560 I2 LTC2548560 I2 LT C2548560I2
- Authority
- LT
- Lithuania
- Prior art keywords
- compositions
- techniques
- smn2 splicing
- modulating smn2
- modulating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/33—Alteration of splicing
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69354205P | 2005-06-23 | 2005-06-23 | |
| EP06773838A EP1910395B1 (en) | 2005-06-23 | 2006-06-23 | Compositions and methods for modulation of SMN2 splicing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTPA2017037I1 LTPA2017037I1 (lt) | 2017-11-27 |
| LTC2548560I2 true LTC2548560I2 (lt) | 2018-11-12 |
Family
ID=37595872
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP17185196.7T LT3308788T (lt) | 2005-06-23 | 2006-06-23 | Kompozicijos ir būdai, skirti smn2 splaisingo moduliavimui |
| LTPA2017037C LTC2548560I2 (lt) | 2005-06-23 | 2017-11-10 | Kompozicijos ir būdai, skirti SMN2 splaisingo moduliavimui |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP17185196.7T LT3308788T (lt) | 2005-06-23 | 2006-06-23 | Kompozicijos ir būdai, skirti smn2 splaisingo moduliavimui |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US8361977B2 (lt) |
| EP (5) | EP1910395B1 (lt) |
| CY (2) | CY2017040I1 (lt) |
| DK (3) | DK1910395T3 (lt) |
| ES (3) | ES2702531T3 (lt) |
| HK (2) | HK1181307A1 (lt) |
| HU (2) | HUE027486T2 (lt) |
| LT (2) | LT3308788T (lt) |
| LU (1) | LUC00046I2 (lt) |
| PL (3) | PL2548560T3 (lt) |
| PT (3) | PT1910395E (lt) |
| SI (2) | SI2548560T1 (lt) |
| WO (1) | WO2007002390A2 (lt) |
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| EP2203173B1 (en) | 2007-10-26 | 2015-12-23 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| US8637478B2 (en) | 2007-11-13 | 2014-01-28 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating protein expression |
| US8633019B2 (en) | 2008-05-27 | 2014-01-21 | Ptc Therapeutics, Inc. | Methods for treating spinal muscular atrophy |
| WO2010019236A1 (en) | 2008-08-13 | 2010-02-18 | Ptc Therapeutics, Inc | Methods for treating spinal muscular atrophy |
| KR101881596B1 (ko) | 2008-12-02 | 2018-07-24 | 웨이브 라이프 사이언시스 재팬 인코포레이티드 | 인 원자 변형된 핵산의 합성 방법 |
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| FR2645345A1 (fr) | 1989-03-31 | 1990-10-05 | Thomson Csf | Procede de modulation dirigee de la composition ou du dopage de semi-conducteurs, notamment pour la realisation de composants electroniques monolithiques de type planar, utilisation et produits correspondants |
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| EP0698092B1 (en) | 1993-05-11 | 2007-07-25 | The University Of North Carolina At Chapel Hill | Antisense oligonucleotides which combat aberrant splicing and methods of using the same |
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| US6376508B1 (en) * | 2000-12-13 | 2002-04-23 | Academia Sinica | Treatments for spinal muscular atrophy |
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| GB0425625D0 (en) | 2004-11-22 | 2004-12-22 | Royal College Of Surgeons Ie | Treatment of disease |
| US7838657B2 (en) | 2004-12-03 | 2010-11-23 | University Of Massachusetts | Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences |
| PL2548560T3 (pl) | 2005-06-23 | 2015-11-30 | Biogen Ma Inc | Kompozycje i sposoby modulowania splicingu SMN2 |
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| NZ597071A (en) | 2009-06-17 | 2014-05-30 | Isis Pharmaceuticals Inc | Compositions and methods for modulation of smn2 splicing in a subject |
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2006
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- 2006-06-23 EP EP18192730.2A patent/EP3470072A1/en active Pending
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