LT5034B - Mezoprogestinai (progesteroninių receptorių moduliatoriai), skirti hormonų sąlygotų gėrybinių ginekologinių sutrikimų gydymui ir prevencijai - Google Patents

Mezoprogestinai (progesteroninių receptorių moduliatoriai), skirti hormonų sąlygotų gėrybinių ginekologinių sutrikimų gydymui ir prevencijai Download PDF

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Publication number
LT5034B
LT5034B LT2002031A LT2002031A LT5034B LT 5034 B LT5034 B LT 5034B LT 2002031 A LT2002031 A LT 2002031A LT 2002031 A LT2002031 A LT 2002031A LT 5034 B LT5034 B LT 5034B
Authority
LT
Lithuania
Prior art keywords
treatment
methoxymethyl
oxime
mesoprogestins
disorders
Prior art date
Application number
LT2002031A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2002031A (en
Inventor
Kristof Chwalisz
Walter Elger
Gerd Schubert
Original Assignee
Jenapharm Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm Gmbh & Co. Kg filed Critical Jenapharm Gmbh & Co. Kg
Publication of LT2002031A publication Critical patent/LT2002031A/xx
Publication of LT5034B publication Critical patent/LT5034B/lt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
LT2002031A 1999-08-31 2002-03-21 Mezoprogestinai (progesteroninių receptorių moduliatoriai), skirti hormonų sąlygotų gėrybinių ginekologinių sutrikimų gydymui ir prevencijai LT5034B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38614199A 1999-08-31 1999-08-31

Publications (2)

Publication Number Publication Date
LT2002031A LT2002031A (en) 2003-02-25
LT5034B true LT5034B (lt) 2003-07-25

Family

ID=23524338

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2002031A LT5034B (lt) 1999-08-31 2002-03-21 Mezoprogestinai (progesteroninių receptorių moduliatoriai), skirti hormonų sąlygotų gėrybinių ginekologinių sutrikimų gydymui ir prevencijai

Country Status (34)

Country Link
EP (1) EP1229906B1 (es)
JP (1) JP2003535029A (es)
KR (3) KR20080066095A (es)
AR (1) AR025457A1 (es)
AT (1) ATE375160T1 (es)
AU (1) AU781840B2 (es)
BG (1) BG65817B1 (es)
BR (1) BR0014161A (es)
CA (1) CA2382580C (es)
CO (1) CO5200772A1 (es)
CZ (1) CZ2002704A3 (es)
DE (1) DE60036723T2 (es)
DK (1) DK1229906T3 (es)
EA (1) EA007854B1 (es)
EE (1) EE05172B1 (es)
ES (1) ES2295050T3 (es)
HR (1) HRP20020267A2 (es)
HU (1) HUP0202429A3 (es)
IL (1) IL148416A0 (es)
LT (1) LT5034B (es)
LV (1) LV12941B (es)
ME (1) MEP13808A (es)
MX (1) MXPA02002191A (es)
NO (1) NO20020999L (es)
NZ (1) NZ517471A (es)
PE (1) PE20010578A1 (es)
PL (1) PL198790B1 (es)
PT (1) PT1229906E (es)
RO (1) RO122179B1 (es)
RS (1) RS50283B (es)
SI (1) SI20852B (es)
SK (1) SK287192B6 (es)
UA (1) UA78184C2 (es)
WO (1) WO2001015679A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10236405A1 (de) 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
ES2273061T3 (es) * 2002-08-02 2007-05-01 Schering Aktiengesellschaft Agentes moduladores de receptores de progesterona con actividad antigonadotropa elevada para el control de fertilidad femenina y para la terapia por reemplazo hormonal.
US20040097591A1 (en) * 2002-11-18 2004-05-20 Kristof Chwalisz Use of selective progesterone receptor modulators for the treatment of androgen deficiency
DE102007011105A1 (de) 2007-03-02 2008-09-04 Bayer Schering Pharma Aktiengesellschaft Mineralcorticoid-Rezeptor-Antagonisten zur Behandlung von Endometriose
EP2455077B1 (en) * 2009-06-17 2014-06-11 National University Corporation Kumamoto University Prophylactic and/or therapeutic agent for dysmenorrhea
US8399432B2 (en) * 2009-10-27 2013-03-19 Lipogen Ltd. Compositions and methods of treatment for alleviating premenstrual syndrome symptoms
JP2022548314A (ja) * 2019-09-23 2022-11-17 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 妊娠を遷延させるためおよび月経または妊娠の合併症の処置の方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0266303A2 (de) 1986-09-26 1988-05-04 Schering Aktiengesellschaft Antigestagene zur Hemmung der uterinen Prostaglandinsynthese
DE4332284A1 (de) 1993-09-20 1995-03-23 Jenapharm Gmbh Neue 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332283A1 (de) 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
WO1996023503A1 (de) 1995-02-02 1996-08-08 Schering Aktiengesellschaft Progesteronantagonisten für die herstellung von arzneimitteln zur behandlung von dysfunktionellen uterinen blutungen

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681817A (en) * 1994-02-04 1997-10-28 The Medical College Of Hampton Roads Treatment of ovarian estrogen dependent conditions
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
US5688808A (en) * 1994-12-22 1997-11-18 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
CZ176197A3 (cs) * 1994-12-22 1998-09-16 Ligand Pharmaceuticals Incorporated Modulátory steroidových receptorů a způsoby jejich přípravy a použití
DE19604231A1 (de) * 1996-01-29 1997-07-31 Schering Ag Pharmazeutisches Kombinationspräparat und seine Verwendung zur Behandlung von gynäkologischen Störungen
ES2152671T3 (es) * 1996-05-01 2001-02-01 Us Gov Health & Human Serv Derivados de progesterona sustituidos en posicion 21 como nuevos agentes antiprogestacionales.
WO1998005679A2 (en) * 1996-08-05 1998-02-12 Duke University Mixed agonists of the progesterone receptor and assays therefor
DE19809845A1 (de) * 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
IL144031A0 (en) * 1999-01-14 2002-04-21 Bayer Ag Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
AU4501800A (en) * 1999-05-04 2000-11-17 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0266303A2 (de) 1986-09-26 1988-05-04 Schering Aktiengesellschaft Antigestagene zur Hemmung der uterinen Prostaglandinsynthese
DE4332284A1 (de) 1993-09-20 1995-03-23 Jenapharm Gmbh Neue 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332283A1 (de) 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
WO1996023503A1 (de) 1995-02-02 1996-08-08 Schering Aktiengesellschaft Progesteronantagonisten für die herstellung von arzneimitteln zur behandlung von dysfunktionellen uterinen blutungen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ELGER W. ET AL.: "Endometrial and myometrial effects of progesterone antagonists in pregnant quinea pigs", AM. J. OBSTET. GYNECOL, 1987, pages 1065 - 1074
ELGER W. ET AL.: "Mechanism of action of progesterone antagonists in pregnant quinea pigs", CONTRACEPTION, 1986, pages 47 - 62

Also Published As

Publication number Publication date
EE200200104A (et) 2003-04-15
PT1229906E (pt) 2008-01-18
WO2001015679A3 (en) 2001-11-22
NO20020999L (no) 2002-03-14
RS50283B (sr) 2009-09-08
PL353930A1 (en) 2003-12-15
HUP0202429A2 (en) 2002-10-28
BG106442A (bg) 2002-09-30
DE60036723T2 (de) 2008-07-17
PE20010578A1 (es) 2001-06-04
AU6946600A (en) 2001-03-26
AR025457A1 (es) 2002-11-27
KR20020027616A (ko) 2002-04-13
KR20080066095A (ko) 2008-07-15
NO20020999D0 (no) 2002-02-28
BR0014161A (pt) 2002-05-21
MXPA02002191A (es) 2002-09-30
EA007854B1 (ru) 2007-02-27
MEP13808A (en) 2010-06-10
UA78184C2 (en) 2007-03-15
EA200200282A1 (ru) 2002-10-31
ES2295050T3 (es) 2008-04-16
RO122179B1 (ro) 2009-02-27
EP1229906A2 (en) 2002-08-14
WO2001015679A2 (en) 2001-03-08
DE60036723D1 (de) 2007-11-22
SI20852B (sl) 2009-06-30
KR100755109B1 (ko) 2007-09-04
ATE375160T1 (de) 2007-10-15
YU14002A (sh) 2006-01-16
EP1229906B1 (en) 2007-10-10
LT2002031A (en) 2003-02-25
PL198790B1 (pl) 2008-07-31
NZ517471A (en) 2004-02-27
CA2382580A1 (en) 2001-03-08
HRP20020267A2 (en) 2004-04-30
KR20070058023A (ko) 2007-06-07
CA2382580C (en) 2009-05-19
BG65817B1 (bg) 2010-01-29
IL148416A0 (en) 2002-09-12
EE05172B1 (et) 2009-06-15
CO5200772A1 (es) 2002-09-27
DK1229906T3 (da) 2008-02-11
SI20852A (sl) 2002-10-31
SK2992002A3 (en) 2002-07-02
LV12941B (en) 2003-06-20
AU781840B2 (en) 2005-06-16
CZ2002704A3 (cs) 2003-02-12
HUP0202429A3 (en) 2004-04-28
SK287192B6 (sk) 2010-02-08
JP2003535029A (ja) 2003-11-25
KR100864547B1 (ko) 2008-10-20

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Owner name: SCHERING AKTIENGESELLSCHAFT, DE

Effective date: 20050104

MM9A Lapsed patents

Effective date: 20100831