SI20852B - Mezoprogestini (modulatorji receptorja progesterona) za zdravljenje in preprečevanje benignih hormonsko povzročenih ginekoloških motenj - Google Patents

Mezoprogestini (modulatorji receptorja progesterona) za zdravljenje in preprečevanje benignih hormonsko povzročenih ginekoloških motenj Download PDF

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Publication number
SI20852B
SI20852B SI200020042A SI200020042A SI20852B SI 20852 B SI20852 B SI 20852B SI 200020042 A SI200020042 A SI 200020042A SI 200020042 A SI200020042 A SI 200020042A SI 20852 B SI20852 B SI 20852B
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SI
Slovenia
Prior art keywords
prevention
treatment
mesoprogestins
disorders
progesterone receptor
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SI200020042A
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English (en)
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SI20852A (sl
Inventor
Kristof Chwalisz
Walter Elger
Gerd Schubert
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Bayer Schering Pharma Ag
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Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of SI20852A publication Critical patent/SI20852A/sl
Publication of SI20852B publication Critical patent/SI20852B/sl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Pričujoči izum opisuje uporabo mezoprogestinov, novega razreda modulatorjev receptorja progesterona (PRM) za zdravljenje in preprečevanje benignih hormonsko povzročenih ginekoloških motenj: a) za zdravljenje ginekoloških motenj, kot so endometrioza, maternični fibroidi, postoperativne peritonealne adhezije, disfunkcijska krvavitev (metroragija, menoragija) in dismenoreja; b) za preprečevanje ginekoloških motenj, kot so postoperativne, peritonealne adhezije, disfunkcijska krvavitev maternice (metroragija,menoragija) in dismenoreja; in c) postopek zdravljenja in preprečevanja zgoraj omenjenih motenj pri samici, prednostno ženski, ki potrebuje zdravljenje in preprečevanje ene ali več teh motenj z učinkovito količino mezoprogestina. Mezoprogestini so definirani kot spojine, ki imajo tako agonistične kot antagonistične aktivnosti na receptorju progesterona (PR) in vivo. Stabilizirajo funkcijo PR na intermediatni stopnji agonista in antagonista. Ustreznih funkcijskih stanj ne moremo doseči s progestini aliantiprogestini. Dnevni odmerek mezoprogestina je 0,5 do 100 mg, prednostno 5,0 do 50 mg in najbolj prednostno 10 do 25 mg. J867, J912, J956 in J1042 so prednostni mezoprogestini v smislu izuma.

Claims (3)

1/1 Sl 20852 Mezoprogestini za zdravljenje in preprečevanje benignih hormonsko povzročenih ginekoloških motenj Patentni zahtevki 1. Uporaba učinkovite količine mezoprogestina, izbranega iz skupine, ki jo sestavljajo J867, J912 in J956 za izdelavo zdravila za zdravljenje endometrioze, uterinih fibroidov, disfunkcijske krvavitve maternice (metroragija, menoragija) in dismenoreje, pri čemer je dnevni odmerek mezoprogestina 5,0 do 50 mg.
2. Uporaba učinkovite količine mezoprogestina, izbranega iz skupine, ki jo sestavljajo J867, J912 in J956 za izdelavo zdravila za preprečevanje disfunkcijske krvavitve maternice (metroragija, menoragija) in dismenoreje, pri čemer je dnevni odmerek mezoprogestina 5,0 do 50 mg.
3. Uporaba po zahtevku 1 ali 2, kjer je dnevni odmerek mezoprogestina 10 do 25 mg.
SI200020042A 1999-08-31 2000-08-31 Mezoprogestini (modulatorji receptorja progesterona) za zdravljenje in preprečevanje benignih hormonsko povzročenih ginekoloških motenj SI20852B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38614199A 1999-08-31 1999-08-31
PCT/US2000/023770 WO2001015679A2 (en) 1999-08-31 2000-08-31 Mesoprogestins for the treatment and prevention of benign hormone dependent gynecological disorders

Publications (2)

Publication Number Publication Date
SI20852A SI20852A (sl) 2002-10-31
SI20852B true SI20852B (sl) 2009-06-30

Family

ID=23524338

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200020042A SI20852B (sl) 1999-08-31 2000-08-31 Mezoprogestini (modulatorji receptorja progesterona) za zdravljenje in preprečevanje benignih hormonsko povzročenih ginekoloških motenj

Country Status (34)

Country Link
EP (1) EP1229906B1 (sl)
JP (1) JP2003535029A (sl)
KR (3) KR100755109B1 (sl)
AR (1) AR025457A1 (sl)
AT (1) ATE375160T1 (sl)
AU (1) AU781840B2 (sl)
BG (1) BG65817B1 (sl)
BR (1) BR0014161A (sl)
CA (1) CA2382580C (sl)
CO (1) CO5200772A1 (sl)
CZ (1) CZ2002704A3 (sl)
DE (1) DE60036723T2 (sl)
DK (1) DK1229906T3 (sl)
EA (1) EA007854B1 (sl)
EE (1) EE05172B1 (sl)
ES (1) ES2295050T3 (sl)
HR (1) HRP20020267A2 (sl)
HU (1) HUP0202429A3 (sl)
IL (1) IL148416A0 (sl)
LT (1) LT5034B (sl)
LV (1) LV12941B (sl)
ME (1) MEP13808A (sl)
MX (1) MXPA02002191A (sl)
NO (1) NO20020999L (sl)
NZ (1) NZ517471A (sl)
PE (1) PE20010578A1 (sl)
PL (1) PL198790B1 (sl)
PT (1) PT1229906E (sl)
RO (1) RO122179B1 (sl)
RS (1) RS50283B (sl)
SI (1) SI20852B (sl)
SK (1) SK287192B6 (sl)
UA (1) UA78184C2 (sl)
WO (1) WO2001015679A2 (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10236405A1 (de) 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
DE50304970D1 (de) * 2002-08-02 2006-10-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie
US20040097591A1 (en) * 2002-11-18 2004-05-20 Kristof Chwalisz Use of selective progesterone receptor modulators for the treatment of androgen deficiency
DE102007011105A1 (de) 2007-03-02 2008-09-04 Bayer Schering Pharma Aktiengesellschaft Mineralcorticoid-Rezeptor-Antagonisten zur Behandlung von Endometriose
WO2010147184A1 (ja) * 2009-06-17 2010-12-23 国立大学法人熊本大学 月経困難症の予防及び／又は治療薬
US8399432B2 (en) * 2009-10-27 2013-03-19 Lipogen Ltd. Compositions and methods of treatment for alleviating premenstrual syndrome symptoms
JP2022548314A (ja) * 2019-09-23 2022-11-17 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 妊娠を遷延させるためおよび月経または妊娠の合併症の処置の方法

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
DE3633244A1 (de) 1986-09-26 1988-03-31 Schering Ag Antigestagene zur hemmung der uterinen prostaglandinsynthese
DE4332284C2 (de) 1993-09-20 1997-05-28 Jenapharm Gmbh 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5681817A (en) * 1994-02-04 1997-10-28 The Medical College Of Hampton Roads Treatment of ovarian estrogen dependent conditions
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
US5688810A (en) * 1994-12-22 1997-11-18 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
EP1382597A3 (en) * 1994-12-22 2004-04-07 Ligand Pharmaceuticals, Inc. Steroid receptor modulator compounds and methods
ES2196063T3 (es) 1995-02-02 2003-12-16 Schering Ag Utilizacion de agentes antagonistas competitivos de progesterona para la preparacion de medicamentos destinados al tratamiento de hemorragias uterinas disfuncionales.
DE19604231A1 (de) * 1996-01-29 1997-07-31 Schering Ag Pharmazeutisches Kombinationspräparat und seine Verwendung zur Behandlung von gynäkologischen Störungen
AU710139B2 (en) * 1996-05-01 1999-09-16 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The 21-substituted progesterone derivatives as new antiprogestational agents
WO1998005679A2 (en) * 1996-08-05 1998-02-12 Duke University Mixed agonists of the progesterone receptor and assays therefor
DE19809845A1 (de) * 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
HUP0105134A2 (hu) * 1999-01-14 2002-04-29 Bayer Corporation Szubsztituált 2-arilimino-heterociklusok és ilyen vegyületeket tartalmazó készítmények progeszteron receptorhoz kötődő szerekként való alkalmazásra
WO2000066590A2 (en) * 1999-05-04 2000-11-09 Ligand Pharmaceuticals, Inc. Tetracyclic progesterone receptor modulator compounds and methods

Also Published As

Publication number Publication date
AR025457A1 (es) 2002-11-27
LT2002031A (en) 2003-02-25
LV12941B (en) 2003-06-20
EP1229906B1 (en) 2007-10-10
MEP13808A (en) 2010-06-10
SI20852A (sl) 2002-10-31
IL148416A0 (en) 2002-09-12
CZ2002704A3 (cs) 2003-02-12
KR20020027616A (ko) 2002-04-13
PL198790B1 (pl) 2008-07-31
NZ517471A (en) 2004-02-27
ES2295050T3 (es) 2008-04-16
BG106442A (bg) 2002-09-30
BR0014161A (pt) 2002-05-21
DE60036723D1 (de) 2007-11-22
EP1229906A2 (en) 2002-08-14
EA007854B1 (ru) 2007-02-27
DE60036723T2 (de) 2008-07-17
AU781840B2 (en) 2005-06-16
YU14002A (sh) 2006-01-16
CA2382580A1 (en) 2001-03-08
RS50283B (sr) 2009-09-08
KR100755109B1 (ko) 2007-09-04
PL353930A1 (en) 2003-12-15
EE05172B1 (et) 2009-06-15
HRP20020267A2 (en) 2004-04-30
WO2001015679A3 (en) 2001-11-22
RO122179B1 (ro) 2009-02-27
PT1229906E (pt) 2008-01-18
KR20080066095A (ko) 2008-07-15
SK2992002A3 (en) 2002-07-02
KR100864547B1 (ko) 2008-10-20
JP2003535029A (ja) 2003-11-25
KR20070058023A (ko) 2007-06-07
EE200200104A (et) 2003-04-15
WO2001015679A2 (en) 2001-03-08
UA78184C2 (en) 2007-03-15
AU6946600A (en) 2001-03-26
NO20020999L (no) 2002-03-14
MXPA02002191A (es) 2002-09-30
CA2382580C (en) 2009-05-19
SK287192B6 (sk) 2010-02-08
HUP0202429A2 (en) 2002-10-28
CO5200772A1 (es) 2002-09-27
DK1229906T3 (da) 2008-02-11
NO20020999D0 (no) 2002-02-28
ATE375160T1 (de) 2007-10-15
LT5034B (lt) 2003-07-25
BG65817B1 (bg) 2010-01-29
PE20010578A1 (es) 2001-06-04
EA200200282A1 (ru) 2002-10-31
HUP0202429A3 (en) 2004-04-28

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Legal Events

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SP73 Change of data on owner

Owner name: SCHERING AKTIENGESELLSCHAFT; DE

Effective date: 20041118

IF Valid on the event date
OU02 Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims

Effective date: 20090422

SP73 Change of data on owner

Owner name: BAYER SCHERING PHARMA AG; DE

Effective date: 20090325

KO00 Lapse of patent

Effective date: 20110413