LT4701B - Tiesioginė peptidų ekspresija į augimo terpė - Google Patents

Tiesioginė peptidų ekspresija į augimo terpė Download PDF

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Publication number
LT4701B
LT4701B LT99-133A LT99133A LT4701B LT 4701 B LT4701 B LT 4701B LT 99133 A LT99133 A LT 99133A LT 4701 B LT4701 B LT 4701B
Authority
LT
Lithuania
Prior art keywords
peptide
peptide product
vector
medium
psct
Prior art date
Application number
LT99-133A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT99133A (en
Inventor
Nozar M. Mehta
Martha V.L. Ray
Christopher P. Meenan
Angelo P. Consalvo
Original Assignee
Unigene Laboratories Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unigene Laboratories Inc. filed Critical Unigene Laboratories Inc.
Publication of LT99133A publication Critical patent/LT99133A/xx
Publication of LT4701B publication Critical patent/LT4701B/lt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/23Calcitonins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/585Calcitonins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/71Expression systems using regulatory sequences derived from the trp-operon
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/72Expression systems using regulatory sequences derived from the lac-operon
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
LT99-133A 1997-04-16 1999-11-10 Tiesioginė peptidų ekspresija į augimo terpė LT4701B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4370097P 1997-04-16 1997-04-16

Publications (2)

Publication Number Publication Date
LT99133A LT99133A (en) 2000-04-25
LT4701B true LT4701B (lt) 2000-09-25

Family

ID=21928441

Family Applications (1)

Application Number Title Priority Date Filing Date
LT99-133A LT4701B (lt) 1997-04-16 1999-11-10 Tiesioginė peptidų ekspresija į augimo terpė

Country Status (14)

Country Link
US (5) US6103495A (ja)
EP (2) EP2088188B1 (ja)
JP (2) JP4907751B2 (ja)
AT (2) ATE522598T1 (ja)
AU (1) AU742270B2 (ja)
CA (1) CA2285658C (ja)
DE (1) DE69841939D1 (ja)
DK (2) DK1005526T3 (ja)
ES (1) ES2375330T3 (ja)
HU (1) HUP0001272A3 (ja)
LT (1) LT4701B (ja)
NO (1) NO327325B1 (ja)
RU (1) RU2218407C2 (ja)
WO (1) WO1998046722A1 (ja)

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KR100385298B1 (ko) * 2000-09-05 2003-05-23 한국생명공학연구원 단백질 생산방법
US7166575B2 (en) * 2002-12-17 2007-01-23 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
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US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US20050215476A1 (en) * 2004-01-21 2005-09-29 Unigene Laboratories Inc. Amidated parathyroid hormone fragments and uses thereof
US8227241B2 (en) * 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides
US7648965B2 (en) * 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US7531518B2 (en) * 2004-05-14 2009-05-12 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060089723A1 (en) * 2004-10-25 2006-04-27 Murphy Kieran P Method for bone augmentation
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WO2006132925A2 (en) * 2005-06-01 2006-12-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy
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KR101193722B1 (ko) 2006-07-24 2013-01-11 바이오렉시스 파마슈티칼 코포레이션 엑센딘 융합 단백질
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
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US9399773B2 (en) 2012-08-10 2016-07-26 Shi-Lung Lin Production and extraction of MicroRNA precursor as drug for cancer therapy
JP5753097B2 (ja) 2009-01-22 2015-07-22 ユニジーン・ラボラトリーズ・インコーポレーテッド 肥満の治療
CN103764669B (zh) 2011-06-15 2017-08-15 雷索特制药公司 抗炎药物产品
WO2013025248A1 (en) 2011-08-12 2013-02-21 Mello Biotechnology, Inc. Inducable expression from the eukaryotic pol -2 promoter in prokaryotes
CN103998052B (zh) 2011-11-02 2016-08-17 关键生物科学有限公司 用于治疗疾病和紊乱的肽类似物
ES2673617T3 (es) 2011-11-02 2018-06-25 Keybioscience Ag Miméticos de calcitonina para tratar enfermedades y trastornos
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US9102751B2 (en) * 2012-05-18 2015-08-11 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US10196662B2 (en) 2012-08-10 2019-02-05 Mello Biotechnology, Inc. Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors
CA2904327C (en) 2013-03-05 2021-06-08 Enteris Biopharma, Inc. Pharmaceuticals for oral delivery
MX2016004282A (es) 2013-10-03 2016-10-12 Janssen Biotech Inc Variantes de protoxina-ii y metodos de uso.
LT3321278T (lt) 2013-11-14 2019-03-12 Keybioscience Ag Kalcitonino mimetikai, skirti ligų ir sutrikimų gydymui
CN103709236B (zh) * 2013-12-23 2015-04-15 江南大学 一种可提高分泌效率的信号肽及其应用
KR102294577B1 (ko) 2015-01-12 2021-08-26 엔터리스 바이오파마, 인크. 고체 경구 제형
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
WO2016161100A1 (en) 2015-04-02 2016-10-06 Janssen Biotech, Inc. Protoxin-ii variants and methods of use
WO2017095458A1 (en) 2015-12-02 2017-06-08 Chih-Li Lin A COMPOSITION AND METHOD OF USING miR-302 PRECURSORS AS DRUGS FOR TREATING ALZHEIMER'S DISEASES
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GB201707955D0 (en) 2017-05-18 2017-07-05 Keybioscience Ag Dual amylin and calcitonin receptor agonists for treating diseases and disorders
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EP0308067A2 (en) 1987-08-14 1989-03-22 Unigene Laboratories Inc. Alpha-amidating enzyme compositions and processes for their production and use
EP0382403A2 (en) 1989-02-06 1990-08-16 Unigene Laboratories Inc. Expression systems for amidating enzyme
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US4708934A (en) 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
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EP0308067A2 (en) 1987-08-14 1989-03-22 Unigene Laboratories Inc. Alpha-amidating enzyme compositions and processes for their production and use
US5223407A (en) 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
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Also Published As

Publication number Publication date
AU742270B2 (en) 2001-12-20
CA2285658C (en) 2011-10-04
US6737250B2 (en) 2004-05-18
CA2285658A1 (en) 1998-10-22
HUP0001272A1 (hu) 2000-08-28
NO995014D0 (no) 1999-10-14
US7968311B2 (en) 2011-06-28
EP2088188A1 (en) 2009-08-12
EP1005526A1 (en) 2000-06-07
LT99133A (en) 2000-04-25
US6103495A (en) 2000-08-15
US20010055789A1 (en) 2001-12-27
EP2088188B1 (en) 2011-08-31
RU2218407C2 (ru) 2003-12-10
WO1998046722A9 (en) 1999-11-18
JP2002501379A (ja) 2002-01-15
WO1998046722A1 (en) 1998-10-22
US6210925B1 (en) 2001-04-03
DK2088188T3 (da) 2012-01-02
US6627438B2 (en) 2003-09-30
JP4907751B2 (ja) 2012-04-04
ATE522598T1 (de) 2011-09-15
JP2012024108A (ja) 2012-02-09
EP1005526A4 (en) 2005-02-09
US20040191865A1 (en) 2004-09-30
US20020045211A1 (en) 2002-04-18
DK1005526T3 (da) 2011-02-07
ES2375330T3 (es) 2012-02-28
NO995014L (no) 1999-12-13
JP5634971B2 (ja) 2014-12-03
HUP0001272A3 (en) 2012-12-28
NO327325B1 (no) 2009-06-08
DE69841939D1 (de) 2010-11-25
ATE484572T1 (de) 2010-10-15
EP1005526B1 (en) 2010-10-13
AU7127998A (en) 1998-11-11

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