LT3465B - Process for preparing deacylated 10-baccatine iii - Google Patents
Process for preparing deacylated 10-baccatine iii Download PDFInfo
- Publication number
- LT3465B LT3465B LTIP1398A LTIP1398A LT3465B LT 3465 B LT3465 B LT 3465B LT IP1398 A LTIP1398 A LT IP1398A LT IP1398 A LTIP1398 A LT IP1398A LT 3465 B LT3465 B LT 3465B
- Authority
- LT
- Lithuania
- Prior art keywords
- deacetyl
- process according
- baccatin iii
- organic solvent
- aqueous solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Extraction Or Liquid Replacement (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9211745A FR2696462B1 (fr) | 1992-10-05 | 1992-10-05 | Procédé d'obtention de la désacétyl-10 baccatine III. |
Publications (2)
Publication Number | Publication Date |
---|---|
LTIP1398A LTIP1398A (en) | 1994-11-25 |
LT3465B true LT3465B (en) | 1995-10-25 |
Family
ID=9434123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTIP1398A LT3465B (en) | 1992-10-05 | 1993-10-04 | Process for preparing deacylated 10-baccatine iii |
Country Status (30)
Country | Link |
---|---|
US (2) | US5393896A (ru) |
EP (1) | EP0663909B1 (ru) |
JP (1) | JP3299753B2 (ru) |
KR (1) | KR100301238B1 (ru) |
CN (1) | CN1041310C (ru) |
AT (1) | ATE147381T1 (ru) |
AU (1) | AU680440B2 (ru) |
CA (2) | CA2146248C (ru) |
CZ (2) | CZ286452B6 (ru) |
DE (1) | DE69307333T2 (ru) |
DK (1) | DK0663909T3 (ru) |
EE (1) | EE03124B1 (ru) |
ES (1) | ES2095672T3 (ru) |
FI (1) | FI109797B (ru) |
FR (1) | FR2696462B1 (ru) |
GE (1) | GEP19981433B (ru) |
GR (1) | GR3022229T3 (ru) |
HU (1) | HU225969B1 (ru) |
LT (1) | LT3465B (ru) |
LV (1) | LV10620B (ru) |
MX (1) | MX9305770A (ru) |
NO (1) | NO310414B1 (ru) |
NZ (1) | NZ256449A (ru) |
PL (1) | PL173993B1 (ru) |
RU (1) | RU2108330C1 (ru) |
SK (1) | SK280335B6 (ru) |
TW (1) | TW404944B (ru) |
UA (1) | UA40601C2 (ru) |
WO (1) | WO1994007881A1 (ru) |
ZA (1) | ZA937312B (ru) |
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FR2714053B1 (fr) * | 1993-12-22 | 1996-03-08 | Pf Medicament | Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III. |
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FR2736355B1 (fr) * | 1995-07-07 | 1997-11-07 | Pf Medicament | Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii |
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US6281368B1 (en) | 2000-03-16 | 2001-08-28 | Napro Biotherapeutics, Inc. | Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4814470A (en) | 1986-07-17 | 1989-03-21 | Rhone-Poulenc Sante | Taxol derivatives, their preparation and pharmaceutical compositions containing them |
US4857653A (en) | 1986-07-17 | 1989-08-15 | Rhone-Poulenc Sante | Process for the preparation of taxol and 10-deacetyltaxol |
US4924012A (en) | 1988-04-06 | 1990-05-08 | Rhone-Poulenc Sante | Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III |
EP0400971A2 (en) | 1989-05-31 | 1990-12-05 | Florida State University | Method for preparation of taxol |
EP0428376A1 (en) | 1989-11-14 | 1991-05-22 | Florida State University | Method for preparation of taxol using an oxazinone |
WO1992007842A1 (en) | 1990-11-02 | 1992-05-14 | University Of Florida | Method for the isolation and purification of taxane derivatives |
WO1992009589A1 (fr) | 1990-11-23 | 1992-06-11 | Rhone-Poulenc Rorer S.A. | Procede de preparation de derives du taxane, nouveaux derives obtenus et compositions pharmaceutiques qui les contiennent |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
US5019504A (en) * | 1989-03-23 | 1991-05-28 | The United States Of America As Represented By The Secretary Of Agriculture | Production of taxol or taxol-like compounds in cell culture |
US5279953A (en) * | 1992-06-24 | 1994-01-18 | Esca Genetics Corporation | In vivo production of taxanes |
FR2696463B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
FR2703049B1 (fr) * | 1993-03-22 | 1995-04-21 | Rhone Poulenc Rorer Sa | Procédé de purification des taxoïdes. |
-
1992
- 1992-10-05 FR FR9211745A patent/FR2696462B1/fr not_active Expired - Lifetime
-
1993
- 1993-01-27 US US08/010,084 patent/US5393896A/en not_active Expired - Lifetime
- 1993-04-21 CN CN93104617A patent/CN1041310C/zh not_active Expired - Lifetime
- 1993-09-21 MX MX9305770A patent/MX9305770A/es unknown
- 1993-10-01 ZA ZA937312A patent/ZA937312B/xx unknown
- 1993-10-02 TW TW082108097A patent/TW404944B/zh not_active IP Right Cessation
- 1993-10-04 DK DK93921986.1T patent/DK0663909T3/da active
- 1993-10-04 SK SK431-95A patent/SK280335B6/sk not_active IP Right Cessation
- 1993-10-04 CA CA002146248A patent/CA2146248C/fr not_active Expired - Lifetime
- 1993-10-04 RU RU95110662/04A patent/RU2108330C1/ru active
- 1993-10-04 GE GEAP19932496A patent/GEP19981433B/en unknown
- 1993-10-04 UA UA95038243A patent/UA40601C2/ru unknown
- 1993-10-04 WO PCT/FR1993/000971 patent/WO1994007881A1/fr active IP Right Grant
- 1993-10-04 CZ CZ1995844A patent/CZ286452B6/cs not_active IP Right Cessation
- 1993-10-04 AT AT93921986T patent/ATE147381T1/de active
- 1993-10-04 ES ES93921986T patent/ES2095672T3/es not_active Expired - Lifetime
- 1993-10-04 CA CA002470124A patent/CA2470124C/fr not_active Expired - Lifetime
- 1993-10-04 PL PL93308243A patent/PL173993B1/pl unknown
- 1993-10-04 EP EP93921986A patent/EP0663909B1/fr not_active Expired - Lifetime
- 1993-10-04 KR KR1019950701305A patent/KR100301238B1/ko not_active IP Right Cessation
- 1993-10-04 LV LVP-93-1119A patent/LV10620B/xx unknown
- 1993-10-04 LT LTIP1398A patent/LT3465B/lt not_active IP Right Cessation
- 1993-10-04 HU HU9500969A patent/HU225969B1/hu unknown
- 1993-10-04 NZ NZ256449A patent/NZ256449A/en not_active IP Right Cessation
- 1993-10-04 JP JP50879194A patent/JP3299753B2/ja not_active Expired - Lifetime
- 1993-10-04 DE DE69307333T patent/DE69307333T2/de not_active Expired - Lifetime
- 1993-10-04 AU AU51154/93A patent/AU680440B2/en not_active Expired
-
1994
- 1994-11-18 EE EE9400336A patent/EE03124B1/xx unknown
-
1995
- 1995-04-03 NO NO19951281A patent/NO310414B1/no not_active IP Right Cessation
- 1995-04-04 FI FI951590A patent/FI109797B/fi not_active IP Right Cessation
- 1995-06-07 US US08/481,208 patent/US5736366A/en not_active Expired - Lifetime
-
1997
- 1997-01-09 GR GR960402652T patent/GR3022229T3/el unknown
- 1997-12-15 CZ CZ19974038A patent/CZ286593B6/cs not_active IP Right Cessation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4814470A (en) | 1986-07-17 | 1989-03-21 | Rhone-Poulenc Sante | Taxol derivatives, their preparation and pharmaceutical compositions containing them |
US4857653A (en) | 1986-07-17 | 1989-08-15 | Rhone-Poulenc Sante | Process for the preparation of taxol and 10-deacetyltaxol |
US4924012A (en) | 1988-04-06 | 1990-05-08 | Rhone-Poulenc Sante | Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III |
EP0400971A2 (en) | 1989-05-31 | 1990-12-05 | Florida State University | Method for preparation of taxol |
EP0428376A1 (en) | 1989-11-14 | 1991-05-22 | Florida State University | Method for preparation of taxol using an oxazinone |
WO1992007842A1 (en) | 1990-11-02 | 1992-05-14 | University Of Florida | Method for the isolation and purification of taxane derivatives |
WO1992009589A1 (fr) | 1990-11-23 | 1992-06-11 | Rhone-Poulenc Rorer S.A. | Procede de preparation de derives du taxane, nouveaux derives obtenus et compositions pharmaceutiques qui les contiennent |
Non-Patent Citations (1)
Title |
---|
HUANG CH ET AL.: "New taxanes from Taxus brevifolia, 2.", J NAT PROD., 1986, pages 665 - 669 |
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