LT3446B - Fucolsylated glycosides as inhibitor of bacterial adherence - Google Patents
Fucolsylated glycosides as inhibitor of bacterial adherence Download PDFInfo
- Publication number
- LT3446B LT3446B LTIP1978A LTIP1978A LT3446B LT 3446 B LT3446 B LT 3446B LT IP1978 A LTIP1978 A LT IP1978A LT IP1978 A LTIP1978 A LT IP1978A LT 3446 B LT3446 B LT 3446B
- Authority
- LT
- Lithuania
- Prior art keywords
- fucal
- alkyl
- group
- bridge
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK93761A DK76193D0 (da) | 1993-06-25 | 1993-06-25 | Kulhydratderivater |
Publications (2)
Publication Number | Publication Date |
---|---|
LTIP1978A LTIP1978A (en) | 1995-01-31 |
LT3446B true LT3446B (en) | 1995-10-25 |
Family
ID=8097261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTIP1978A LT3446B (en) | 1993-06-25 | 1994-06-27 | Fucolsylated glycosides as inhibitor of bacterial adherence |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0706528A1 (ja) |
JP (1) | JPH08512026A (ja) |
AU (1) | AU7089194A (ja) |
CA (1) | CA2164961A1 (ja) |
DK (1) | DK76193D0 (ja) |
IL (1) | IL110074A0 (ja) |
IS (1) | IS4181A (ja) |
LT (1) | LT3446B (ja) |
WO (1) | WO1995000527A1 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204431B1 (en) | 1994-03-09 | 2001-03-20 | Abbott Laboratories | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
JPH1160590A (ja) * | 1997-08-22 | 1999-03-02 | Yakult Honsha Co Ltd | オリゴフコース誘導体又はオリゴラムノース誘導体及びその製造法 |
SE9901007D0 (sv) * | 1999-03-19 | 1999-03-19 | Thomas Boren | Use of fucosylated sialylated N-acetyl lactosamin carbohydrate structures for inhibition of bacterial adherence |
CA2618638C (en) * | 2005-08-09 | 2014-03-11 | Glycomimetics, Inc. | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
CA2858099C (en) | 2011-12-22 | 2020-12-15 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
EP2692740A1 (en) * | 2012-07-30 | 2014-02-05 | Le Centre National De La Recherche Scientifique | Glycan compositions, processes for preparing the same and their uses as a drug |
WO2014089269A1 (en) | 2012-12-07 | 2014-06-12 | Glycomimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
MX2015009698A (es) * | 2013-01-31 | 2015-11-06 | Pioneer Hi Bred Int | Lipoquitooligosacaridos sinteticos para el mejoramiento del crecimiento y el rendimiento de las plantas. |
US10086054B2 (en) * | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
WO2016089872A1 (en) | 2014-12-03 | 2016-06-09 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
CA3009836A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
US11072625B2 (en) | 2016-10-07 | 2021-07-27 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
JP7272956B2 (ja) | 2017-03-15 | 2023-05-12 | グリコミメティクス, インコーポレイテッド | E-セレクチンアンタゴニストとしてのガラクトピラノシル-シクロヘキシル誘導体 |
WO2019108750A1 (en) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
CN111566117A (zh) | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | E-选择蛋白和半乳凝素-3的异双功能抑制剂 |
CN111867601A (zh) | 2018-03-05 | 2020-10-30 | 糖模拟物有限公司 | 用于治疗急性髓系白血病及相关病症的方法 |
KR20210057053A (ko) | 2018-08-23 | 2021-05-20 | 씨젠 인크. | 항-tigit 항체 |
AU2019416330A1 (en) | 2018-12-27 | 2021-07-01 | Glycomimetics, Inc. | Galectin-3 inhibiting c-glycosides |
WO2020139962A1 (en) | 2018-12-27 | 2020-07-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1603609A (en) * | 1977-04-14 | 1981-11-25 | Chembiomed Ltd | O-protected 2-azido-2-deoxy-glycosyl nitrates |
FR2509313A1 (fr) * | 1981-07-08 | 1983-01-14 | Choay Sa | Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques |
DE3220427A1 (de) * | 1982-05-29 | 1983-12-01 | Behringwerke Ag, 3550 Marburg | Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung |
DK17685D0 (da) * | 1985-01-14 | 1985-01-14 | Hans Goeran Magnusson | Glycosidderivater |
AU609999B2 (en) * | 1988-06-21 | 1991-05-09 | Marion Laboratories, Inc. | Bismuth (phosph/sulf)ated saccharides |
-
1993
- 1993-06-25 DK DK93761A patent/DK76193D0/da not_active Application Discontinuation
-
1994
- 1994-06-17 WO PCT/SE1994/000604 patent/WO1995000527A1/en not_active Application Discontinuation
- 1994-06-17 CA CA002164961A patent/CA2164961A1/en not_active Abandoned
- 1994-06-17 EP EP94919945A patent/EP0706528A1/en not_active Withdrawn
- 1994-06-17 AU AU70891/94A patent/AU7089194A/en not_active Abandoned
- 1994-06-17 JP JP7502720A patent/JPH08512026A/ja active Pending
- 1994-06-21 IL IL11007494A patent/IL110074A0/xx unknown
- 1994-06-22 IS IS4181A patent/IS4181A/is unknown
- 1994-06-27 LT LTIP1978A patent/LT3446B/lt not_active IP Right Cessation
Non-Patent Citations (15)
Title |
---|
A. R. KATRIZKY: "Handbook of Heterocyclic Chemistry" |
AMVAM-ZOLLO PH, SINAY P: "Streptococcus pneumoniae type XIV polysaccharide: synthesis of a repeating branched tetrasaccharide with dioxa-type spacer-arms", CARBOHYDRATE RESEARCH, 1986, pages 199 - 212 |
D. G. EVANS, D. J. EVANS, JR. GRAHAM, D. Y. G: "Receptor-mediated adherence of Campylobacter pylori to mouse Y-1 adrenal cell monolayers", INFECT. IMMUN., 1989, pages 2272 - 2278 |
H. H. BAER: "Recent synthetic studies in nitrogen-containing and deoxygenated sugars", PURE APPL. CHEM., 1989, pages 1217 - 1234 |
HANS PAULSEN: "Advances in Selective Chemical Syntheses of Complex Oligosaccharides", ANGEWANDTE CHEMIE INTERNATIONAL EDITION IN ENGLISH, 1982, pages 155 - 173 |
J. MARCH, J. WILEY: "Advanced Organic Chemistry - Reaction Mechanisms and Structure", pages: 347 - 389 |
JOHN H. PAZUR: "Affinity Chromatography of Macromolecular Substances on Adsorbents Bearing Carbohydrate Ligands", ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, 1981, pages 405 - 447 |
M.A. JERMYN: "Increasing the sensitivity of the anthrone method for carbohydrate", ANALYTICAL BIOCHEMISTRY, 1975, pages 332 - 335, XP024820798, DOI: doi:10.1016/0003-2697(75)90713-7 |
M.L. WOLFROM, A. THOMPSON: "Methods in Carbohydrate Chemistry Vol. II", pages: 211 - 215 |
N. SHARON: "Nomenclature of glycoproteins, glycopeptides and peptidoglycans (Recommendations 1985)", PURE AND APPLIED CHEMISTRY, 1988, pages 1389 - 1988 |
R. R. SCHMIDT: "New Methods for the Synthesis of Glycosides and Oligosaccharides - Are There Alternatives to the Koenigs-Knorr Method?", ANGEWANDTE CHEMIE INTERNATIONAL EDITION IN ENGLISH, 1986, pages 212 - 235, XP002360565, DOI: doi:10.1002/anie.198602121 |
RED. T. W. GREENE, P. G. M. WUTS ET AL.: "Protective Groups in Organic Synthesis" |
RESEARCH ARTICLE PREV. ARTICLE NEXT: "2-(Trimethylsilyl)ethyl glycosides. 3. Synthesis, anomeric deblocking, and transformation into 1,2-trans 1-O-acyl sugars", J. ORG. CHEM., 1988, pages 5629 - 5647, XP055334967, DOI: doi:10.1021/jo00259a006 |
STINABRITT NILSSON ET AL.: "Synthesis of an H type 2 and a Y (Ley) glycoside from thioglycoside intermediates", GLYCOCONJUGATE JOURNAL, 1989, pages 21 - 34 |
Y. C. LEE, R. T. LEE: "Glycoconjugates", pages: 57 - 83 |
Also Published As
Publication number | Publication date |
---|---|
IL110074A0 (en) | 1994-10-07 |
WO1995000527A1 (en) | 1995-01-05 |
DK76193D0 (da) | 1993-06-25 |
CA2164961A1 (en) | 1995-01-05 |
LTIP1978A (en) | 1995-01-31 |
JPH08512026A (ja) | 1996-12-17 |
EP0706528A1 (en) | 1996-04-17 |
IS4181A (is) | 1994-12-26 |
AU7089194A (en) | 1995-01-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM9A | Lapsed patents |
Effective date: 19960627 |