LT3446B - Fucolsylated glycosides as inhibitor of bacterial adherence - Google Patents

Fucolsylated glycosides as inhibitor of bacterial adherence Download PDF

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Publication number
LT3446B
LT3446B LTIP1978A LTIP1978A LT3446B LT 3446 B LT3446 B LT 3446B LT IP1978 A LTIP1978 A LT IP1978A LT IP1978 A LTIP1978 A LT IP1978A LT 3446 B LT3446 B LT 3446B
Authority
LT
Lithuania
Prior art keywords
fucal
alkyl
group
bridge
compound
Prior art date
Application number
LTIP1978A
Other languages
English (en)
Lithuanian (lt)
Inventor
Karin Eklind
Hans Loenn
Anna-Karin Tiden
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of LTIP1978A publication Critical patent/LTIP1978A/xx
Publication of LT3446B publication Critical patent/LT3446B/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
LTIP1978A 1993-06-25 1994-06-27 Fucolsylated glycosides as inhibitor of bacterial adherence LT3446B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK93761A DK76193D0 (da) 1993-06-25 1993-06-25 Kulhydratderivater

Publications (2)

Publication Number Publication Date
LTIP1978A LTIP1978A (en) 1995-01-31
LT3446B true LT3446B (en) 1995-10-25

Family

ID=8097261

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1978A LT3446B (en) 1993-06-25 1994-06-27 Fucolsylated glycosides as inhibitor of bacterial adherence

Country Status (9)

Country Link
EP (1) EP0706528A1 (fr)
JP (1) JPH08512026A (fr)
AU (1) AU7089194A (fr)
CA (1) CA2164961A1 (fr)
DK (1) DK76193D0 (fr)
IL (1) IL110074A0 (fr)
IS (1) IS4181A (fr)
LT (1) LT3446B (fr)
WO (1) WO1995000527A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204431B1 (en) 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
JPH1160590A (ja) * 1997-08-22 1999-03-02 Yakult Honsha Co Ltd オリゴフコース誘導体又はオリゴラムノース誘導体及びその製造法
SE9901007D0 (sv) * 1999-03-19 1999-03-19 Thomas Boren Use of fucosylated sialylated N-acetyl lactosamin carbohydrate structures for inhibition of bacterial adherence
AU2006280101B2 (en) * 2005-08-09 2012-06-28 Glycomimetics, Inc. Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
WO2012037034A1 (fr) 2010-09-14 2012-03-22 Glycomimetics, Inc. Antagonistes de l'e-sélectine
JP2015500887A (ja) 2011-12-22 2015-01-08 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
EP2692740A1 (fr) * 2012-07-30 2014-02-05 Le Centre National De La Recherche Scientifique Compositions de glycane, leurs procédés de préparation et leurs utilisations en tant que médicament
AU2013355238B2 (en) 2012-12-07 2017-12-14 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
CN105101972A (zh) * 2013-01-31 2015-11-25 先锋国际良种公司 用于改善植物生长和产量的合成型脂质几丁寡糖
EP3013365B1 (fr) * 2013-06-26 2019-06-05 Academia Sinica Antigènes rm2 et leur utilisation
SI3227310T1 (sl) 2014-12-03 2019-11-29 Glycomimetics Inc Heterobifunkcionalni inhibitorji e-selektinov in receptorjev kemokina CXCR4
CA3009836A1 (fr) 2016-01-22 2017-07-27 Glycomimetics, Inc. Inhibiteurs glycomimetiques des lectines pa-il et pa-iil
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
WO2018031445A1 (fr) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combinaison d'inhibiteurs des points de contrôle des lymphocytes t avec des inhibiteurs de e-sélectine ou de cxcr4, ou avec des inhibiteurs hétérobifonctionnels de e-sélectine et de cxcr4
JP7069136B2 (ja) 2016-10-07 2022-05-17 グリコミメティクス， インコーポレイテッド 極めて強力な多量体ｅ－セレクチンアンタゴニスト
EP3596096A1 (fr) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Dérivés de galactopyranosyle-cyclohexyle utilisés en tant qu'antagonistes d'e-sélectine
JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
JP7455064B2 (ja) 2018-03-05 2024-03-25 グリコミメティクス， インコーポレイテッド 急性骨髄性白血病および関連状態を処置する方法
KR20210057053A (ko) 2018-08-23 2021-05-20 씨젠 인크. 항-tigit 항체
AU2019416330A1 (en) 2018-12-27 2021-07-01 Glycomimetics, Inc. Galectin-3 inhibiting c-glycosides
WO2020139962A1 (fr) 2018-12-27 2020-07-02 Glycomimetics, Inc. Inhibiteurs hétérobifonctionnels d'e-sélectine et de galectine-3

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1603609A (en) * 1977-04-14 1981-11-25 Chembiomed Ltd O-protected 2-azido-2-deoxy-glycosyl nitrates
FR2509313A1 (fr) * 1981-07-08 1983-01-14 Choay Sa Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques
DE3220427A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung
DK17685D0 (da) * 1985-01-14 1985-01-14 Hans Goeran Magnusson Glycosidderivater
AU609999B2 (en) * 1988-06-21 1991-05-09 Marion Laboratories, Inc. Bismuth (phosph/sulf)ated saccharides

Non-Patent Citations (15)

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Title
A. R. KATRIZKY: "Handbook of Heterocyclic Chemistry"
AMVAM-ZOLLO PH, SINAY P: "Streptococcus pneumoniae type XIV polysaccharide: synthesis of a repeating branched tetrasaccharide with dioxa-type spacer-arms", CARBOHYDRATE RESEARCH, 1986, pages 199 - 212
D. G. EVANS, D. J. EVANS, JR. GRAHAM, D. Y. G: "Receptor-mediated adherence of Campylobacter pylori to mouse Y-1 adrenal cell monolayers", INFECT. IMMUN., 1989, pages 2272 - 2278
H. H. BAER: "Recent synthetic studies in nitrogen-containing and deoxygenated sugars", PURE APPL. CHEM., 1989, pages 1217 - 1234
HANS PAULSEN: "Advances in Selective Chemical Syntheses of Complex Oligosaccharides", ANGEWANDTE CHEMIE INTERNATIONAL EDITION IN ENGLISH, 1982, pages 155 - 173
J. MARCH, J. WILEY: "Advanced Organic Chemistry - Reaction Mechanisms and Structure", pages: 347 - 389
JOHN H. PAZUR: "Affinity Chromatography of Macromolecular Substances on Adsorbents Bearing Carbohydrate Ligands", ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, 1981, pages 405 - 447
M.A. JERMYN: "Increasing the sensitivity of the anthrone method for carbohydrate", ANALYTICAL BIOCHEMISTRY, 1975, pages 332 - 335, XP024820798, DOI: doi:10.1016/0003-2697(75)90713-7
M.L. WOLFROM, A. THOMPSON: "Methods in Carbohydrate Chemistry Vol. II", pages: 211 - 215
N. SHARON: "Nomenclature of glycoproteins, glycopeptides and peptidoglycans (Recommendations 1985)", PURE AND APPLIED CHEMISTRY, 1988, pages 1389 - 1988
R. R. SCHMIDT: "New Methods for the Synthesis of Glycosides and Oligosaccharides - Are There Alternatives to the Koenigs-Knorr Method?", ANGEWANDTE CHEMIE INTERNATIONAL EDITION IN ENGLISH, 1986, pages 212 - 235, XP002360565, DOI: doi:10.1002/anie.198602121
RED. T. W. GREENE, P. G. M. WUTS ET AL.: "Protective Groups in Organic Synthesis"
RESEARCH ARTICLE PREV. ARTICLE NEXT: "2-(Trimethylsilyl)ethyl glycosides. 3. Synthesis, anomeric deblocking, and transformation into 1,2-trans 1-O-acyl sugars", J. ORG. CHEM., 1988, pages 5629 - 5647, XP055334967, DOI: doi:10.1021/jo00259a006
STINABRITT NILSSON ET AL.: "Synthesis of an H type 2 and a Y (Ley) glycoside from thioglycoside intermediates", GLYCOCONJUGATE JOURNAL, 1989, pages 21 - 34
Y. C. LEE, R. T. LEE: "Glycoconjugates", pages: 57 - 83

Also Published As

Publication number Publication date
AU7089194A (en) 1995-01-17
WO1995000527A1 (fr) 1995-01-05
LTIP1978A (en) 1995-01-31
JPH08512026A (ja) 1996-12-17
CA2164961A1 (fr) 1995-01-05
DK76193D0 (da) 1993-06-25
IS4181A (is) 1994-12-26
IL110074A0 (en) 1994-10-07
EP0706528A1 (fr) 1996-04-17

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Effective date: 19960627