CA2164961A1 - Glycosides fucosyles, inhibiteurs de l'adherence bacterienne - Google Patents
Glycosides fucosyles, inhibiteurs de l'adherence bacterienneInfo
- Publication number
- CA2164961A1 CA2164961A1 CA002164961A CA2164961A CA2164961A1 CA 2164961 A1 CA2164961 A1 CA 2164961A1 CA 002164961 A CA002164961 A CA 002164961A CA 2164961 A CA2164961 A CA 2164961A CA 2164961 A1 CA2164961 A1 CA 2164961A1
- Authority
- CA
- Canada
- Prior art keywords
- beta
- fuc
- spacer
- alpha
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Dérivés glycosidiques de mono, di, tri ou oligosaccharides présentant au moins un groupe terminal dérivé du L-fucose. Ces composés sont efficaces dans la thérapie ou la prophylaxie chez l'homme d'états relatifs à l'infection de la muqueuse gastrique par l'Heliobacter pylori; ainsi que leur méthode de préparation et celle de compositions pharmaceutiques les contenant.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK0761/93 | 1993-06-25 | ||
DK93761A DK76193D0 (da) | 1993-06-25 | 1993-06-25 | Kulhydratderivater |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2164961A1 true CA2164961A1 (fr) | 1995-01-05 |
Family
ID=8097261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002164961A Abandoned CA2164961A1 (fr) | 1993-06-25 | 1994-06-17 | Glycosides fucosyles, inhibiteurs de l'adherence bacterienne |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0706528A1 (fr) |
JP (1) | JPH08512026A (fr) |
AU (1) | AU7089194A (fr) |
CA (1) | CA2164961A1 (fr) |
DK (1) | DK76193D0 (fr) |
IL (1) | IL110074A0 (fr) |
IS (1) | IS4181A (fr) |
LT (1) | LT3446B (fr) |
WO (1) | WO1995000527A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014120799A1 (fr) * | 2013-01-31 | 2014-08-07 | Pioneer Hi-Bred International, Inc. | Lipochitooligosaccharides synthétiques pour l'amélioration de la croissance et du rendement des plantes |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204431B1 (en) | 1994-03-09 | 2001-03-20 | Abbott Laboratories | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
JPH1160590A (ja) * | 1997-08-22 | 1999-03-02 | Yakult Honsha Co Ltd | オリゴフコース誘導体又はオリゴラムノース誘導体及びその製造法 |
SE9901007D0 (sv) * | 1999-03-19 | 1999-03-19 | Thomas Boren | Use of fucosylated sialylated N-acetyl lactosamin carbohydrate structures for inhibition of bacterial adherence |
CN101291946B (zh) * | 2005-08-09 | 2011-06-29 | 糖模拟物有限公司 | 对来自假单胞菌的pa-il凝集素、pa-iil凝集素或其两者的糖模拟物抑制剂 |
WO2012037034A1 (fr) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | Antagonistes de l'e-sélectine |
CA2858099C (fr) | 2011-12-22 | 2020-12-15 | Glycomimetics, Inc. | Composes antagonistes de la selectine e, compositions et methodes d'utilisation |
EP2692740A1 (fr) * | 2012-07-30 | 2014-02-05 | Le Centre National De La Recherche Scientifique | Compositions de glycane, leurs procédés de préparation et leurs utilisations en tant que médicament |
DK2928476T3 (en) | 2012-12-07 | 2018-05-22 | Glycomimetics Inc | RELATIONSHIPS, COMPOSITIONS AND METHODS OF USING E-SELECTIN ANTAGONISTS FOR MOBILIZATION OF HEMATOPOIETIC CELLS |
US10086054B2 (en) * | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
DK3227310T3 (da) | 2014-12-03 | 2019-09-30 | Glycomimetics Inc | Heterobifunktionelle inhibitorer af e-selektiner og cxcr4-kemokin-receptorer |
WO2017127422A1 (fr) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Inhibiteurs glycomimétiques des lectines pa-il et pa-iil |
US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
WO2018068010A1 (fr) | 2016-10-07 | 2018-04-12 | Glycomimetics, Inc. | Antagonistes de e-sélectine multimériques très puissants |
EP3596096A1 (fr) | 2017-03-15 | 2020-01-22 | GlycoMimetics, Inc. | Dérivés de galactopyranosyle-cyclohexyle utilisés en tant qu'antagonistes d'e-sélectine |
WO2019108750A1 (fr) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Méthodes de mobilisation de lymphocytes infiltrant la moelle et leurs utilisations |
AU2018395417B2 (en) | 2017-12-29 | 2023-07-13 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
CA3091454A1 (fr) | 2018-03-05 | 2019-09-12 | Glycomimetics, Inc. | Methodes de traitement de la leucemie aigue myeloide et d'etats pathologiques associes |
CN112638944A (zh) | 2018-08-23 | 2021-04-09 | 西进公司 | 抗tigit抗体 |
KR20210110645A (ko) | 2018-12-27 | 2021-09-08 | 글리코미메틱스, 인크. | 갈렉틴-3 억제 c-글리코사이드 |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1603609A (en) * | 1977-04-14 | 1981-11-25 | Chembiomed Ltd | O-protected 2-azido-2-deoxy-glycosyl nitrates |
FR2509313A1 (fr) * | 1981-07-08 | 1983-01-14 | Choay Sa | Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques |
DE3220427A1 (de) * | 1982-05-29 | 1983-12-01 | Behringwerke Ag, 3550 Marburg | Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung |
DK17685D0 (da) * | 1985-01-14 | 1985-01-14 | Hans Goeran Magnusson | Glycosidderivater |
AU609999B2 (en) * | 1988-06-21 | 1991-05-09 | Marion Laboratories, Inc. | Bismuth (phosph/sulf)ated saccharides |
-
1993
- 1993-06-25 DK DK93761A patent/DK76193D0/da not_active Application Discontinuation
-
1994
- 1994-06-17 WO PCT/SE1994/000604 patent/WO1995000527A1/fr not_active Application Discontinuation
- 1994-06-17 EP EP94919945A patent/EP0706528A1/fr not_active Withdrawn
- 1994-06-17 CA CA002164961A patent/CA2164961A1/fr not_active Abandoned
- 1994-06-17 AU AU70891/94A patent/AU7089194A/en not_active Abandoned
- 1994-06-17 JP JP7502720A patent/JPH08512026A/ja active Pending
- 1994-06-21 IL IL11007494A patent/IL110074A0/xx unknown
- 1994-06-22 IS IS4181A patent/IS4181A/is unknown
- 1994-06-27 LT LTIP1978A patent/LT3446B/lt not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014120799A1 (fr) * | 2013-01-31 | 2014-08-07 | Pioneer Hi-Bred International, Inc. | Lipochitooligosaccharides synthétiques pour l'amélioration de la croissance et du rendement des plantes |
CN105101972A (zh) * | 2013-01-31 | 2015-11-25 | 先锋国际良种公司 | 用于改善植物生长和产量的合成型脂质几丁寡糖 |
Also Published As
Publication number | Publication date |
---|---|
EP0706528A1 (fr) | 1996-04-17 |
WO1995000527A1 (fr) | 1995-01-05 |
IL110074A0 (en) | 1994-10-07 |
AU7089194A (en) | 1995-01-17 |
IS4181A (is) | 1994-12-26 |
DK76193D0 (da) | 1993-06-25 |
JPH08512026A (ja) | 1996-12-17 |
LT3446B (en) | 1995-10-25 |
LTIP1978A (en) | 1995-01-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |