LT3359564T - Antikūnai, kurie stipriai neutralizuoja hepatito b virusą, ir jų panaudojimas - Google Patents

Antikūnai, kurie stipriai neutralizuoja hepatito b virusą, ir jų panaudojimas

Info

Publication number
LT3359564T
LT3359564T LTEP16779075.7T LT16779075T LT3359564T LT 3359564 T LT3359564 T LT 3359564T LT 16779075 T LT16779075 T LT 16779075T LT 3359564 T LT3359564 T LT 3359564T
Authority
LT
Lithuania
Prior art keywords
antibodies
virus
potently neutralize
neutralize hepatitis
hepatitis
Prior art date
Application number
LTEP16779075.7T
Other languages
English (en)
Inventor
Davide Corti
Original Assignee
Humabs Biomed Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Humabs Biomed Sa filed Critical Humabs Biomed Sa
Publication of LT3359564T publication Critical patent/LT3359564T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
LTEP16779075.7T 2015-10-07 2016-10-07 Antikūnai, kurie stipriai neutralizuoja hepatito b virusą, ir jų panaudojimas LT3359564T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2015/001970 WO2017059878A1 (en) 2015-10-07 2015-10-07 Antibodies that potently neutralize hepatitis b virus and uses thereof
PCT/EP2016/074114 WO2017060504A1 (en) 2015-10-07 2016-10-07 Antibodies that potently neutralize hepatitis b virus and uses thereof

Publications (1)

Publication Number Publication Date
LT3359564T true LT3359564T (lt) 2020-10-26

Family

ID=54330711

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP16779075.7T LT3359564T (lt) 2015-10-07 2016-10-07 Antikūnai, kurie stipriai neutralizuoja hepatito b virusą, ir jų panaudojimas

Country Status (24)

Country Link
US (3) US10683344B2 (lt)
EP (2) EP3753949A1 (lt)
JP (4) JP6869968B2 (lt)
CN (3) CN108137675B (lt)
AU (1) AU2016334735B2 (lt)
BR (1) BR112018002406A2 (lt)
CA (1) CA2993745A1 (lt)
CY (1) CY1123462T1 (lt)
DK (1) DK3359564T3 (lt)
EA (1) EA038301B1 (lt)
ES (1) ES2813927T3 (lt)
HK (1) HK1256869A1 (lt)
HR (1) HRP20201345T1 (lt)
HU (1) HUE050231T2 (lt)
IL (1) IL258326B (lt)
LT (1) LT3359564T (lt)
MX (1) MX2018004127A (lt)
MY (1) MY187161A (lt)
PH (1) PH12018500199A1 (lt)
PL (1) PL3359564T3 (lt)
PT (1) PT3359564T (lt)
SI (1) SI3359564T1 (lt)
WO (2) WO2017059878A1 (lt)
ZA (1) ZA201800710B (lt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017059878A1 (en) 2015-10-07 2017-04-13 Humabs Biomed Sa Antibodies that potently neutralize hepatitis b virus and uses thereof
JP2021522864A (ja) 2018-05-10 2021-09-02 クリアビー セラピューティクス リミテッド Ｂ型肝炎感染症を処置するための方法および組成物
US20210214424A1 (en) * 2018-05-16 2021-07-15 Chang Gung Memorial Hospital, Linkou Novel leucine-rich repeat neuronal protein 1 (lrrn1) antibodies and uses thereof
EP3801766A1 (en) * 2018-05-31 2021-04-14 Novartis AG Hepatitis b antibodies
US20220127336A1 (en) * 2018-12-19 2022-04-28 Humabs Biomed Sa Antibodies that neutralize hepatitis b virus and uses thereof
TW202039000A (zh) * 2018-12-20 2020-11-01 瑞士商休曼斯生物醫藥公司 組合ｈｂｖ療法
KR102084912B1 (ko) * 2019-01-17 2020-03-05 주식회사 녹십자 B형 간염 바이러스 표면 항원의 입체 에피토프 및 이에 특이적으로 결합하는 항체
EP3999533A4 (en) * 2019-07-20 2022-09-07 Huahui Health Ltd. METHOD FOR TREATING HEPATITIS B VIRUS INFECTION USING PRE-S1 ANTI-HBV ANTIBODIES
CN114630680B (zh) * 2019-08-29 2024-10-11 维尔生物科技有限公司 用于治疗乙型肝炎病毒感染的抗体组合物和方法
CN113717283B (zh) * 2020-05-25 2023-05-26 厦门万泰凯瑞生物技术有限公司 一种抗乙型肝炎病毒e抗原的单克隆抗体及其应用
US20230242621A1 (en) 2020-06-24 2023-08-03 Vir Biotechnology, Inc. Engineered hepatitis b virus neutralizing antibodies and uses thereof
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
US20240092872A1 (en) 2021-01-26 2024-03-21 Vir Biotechnology, Inc. Compositions and methods for treating hepatitis b virus infection
CN113234144B (zh) * 2021-05-26 2022-02-25 武汉工程大学 一种人源性抗乙肝表面抗原的单链抗体、制剂、编码基因、载体质粒及宿主细胞
US20240327500A1 (en) * 2021-07-15 2024-10-03 National University Of Singapore Anti-hbv antibodies and uses thereof
CN113777312B (zh) * 2021-09-03 2024-02-02 普十生物科技(北京)有限公司 乙肝抗体片段的制备方法、乙肝抗体片段、试剂盒及应用
WO2023039243A2 (en) * 2021-09-13 2023-03-16 Achelois Biopharma, Inc. Hepatitis b virus antivirus (hbv-antivirus) compositions and methods of use
WO2023122555A2 (en) * 2021-12-21 2023-06-29 Hbvtech, Llc. Methods for eliminating hepatitis b virus cccdna and rcdna and the hepatitis b drugs used in the methods thereof
WO2023230439A1 (en) 2022-05-23 2023-11-30 Vir Biotechnology, Inc. Fc-engineered hepatitis b virus neutralizing antibodies and uses thereof
CN116162153B (zh) * 2022-09-01 2024-09-10 复旦大学附属中山医院 一种乙肝病毒表面抗原的单克隆抗体及其应用

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Also Published As

Publication number Publication date
ZA201800710B (en) 2019-05-29
EP3359564B1 (en) 2020-06-03
EA038301B1 (ru) 2021-08-06
CN114539392B (zh) 2024-01-26
US20230303663A1 (en) 2023-09-28
CN108137675A (zh) 2018-06-08
MX2018004127A (es) 2018-06-13
WO2017059878A1 (en) 2017-04-13
CN114539392A (zh) 2022-05-27
AU2016334735A1 (en) 2018-02-15
JP7171809B2 (ja) 2022-11-15
DK3359564T3 (da) 2020-08-17
US12037381B2 (en) 2024-07-16
CA2993745A1 (en) 2017-04-13
EP3753949A1 (en) 2020-12-23
CY1123462T1 (el) 2022-03-24
US11390664B2 (en) 2022-07-19
US10683344B2 (en) 2020-06-16
EP3359564A1 (en) 2018-08-15
AU2016334735B2 (en) 2022-10-27
MY187161A (en) 2021-09-06
PL3359564T3 (pl) 2020-11-30
WO2017060504A1 (en) 2017-04-13
US20190016785A1 (en) 2019-01-17
EA201890874A1 (ru) 2018-11-30
JP2024097078A (ja) 2024-07-17
CN114539391A (zh) 2022-05-27
CN108137675B (zh) 2022-03-22
HUE050231T2 (hu) 2020-11-30
SI3359564T1 (sl) 2020-10-30
IL258326B (en) 2021-10-31
JP2023011809A (ja) 2023-01-24
PH12018500199A1 (en) 2018-08-13
US20210040183A1 (en) 2021-02-11
HRP20201345T1 (hr) 2020-11-27
ES2813927T3 (es) 2021-03-25
IL258326A (en) 2018-05-31
BR112018002406A2 (pt) 2018-09-18
JP2018535650A (ja) 2018-12-06
HK1256869A1 (zh) 2019-10-04
JP6869968B2 (ja) 2021-05-12
JP2021121188A (ja) 2021-08-26
PT3359564T (pt) 2020-09-04
KR20180056777A (ko) 2018-05-29

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