LT3319969T - Diarilo makrociklo polimorfas - Google Patents
Diarilo makrociklo polimorfasInfo
- Publication number
- LT3319969T LT3319969T LTEPPCT/US2016/040972T LTUS2016040972T LT3319969T LT 3319969 T LT3319969 T LT 3319969T LT US2016040972 T LTUS2016040972 T LT US2016040972T LT 3319969 T LT3319969 T LT 3319969T
- Authority
- LT
- Lithuania
- Prior art keywords
- polymorph
- macrocycle
- diaryl
- diaryl macrocycle
- macrocycle polymorph
- Prior art date
Links
- -1 DIARYL MACROCYCLE Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188846P | 2015-07-06 | 2015-07-06 | |
| US201562218672P | 2015-09-15 | 2015-09-15 | |
| PCT/US2016/040972 WO2017007759A1 (en) | 2015-07-06 | 2016-07-05 | Diaryl macrocycle polymorph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3319969T true LT3319969T (lt) | 2024-06-10 |
Family
ID=57685592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/US2016/040972T LT3319969T (lt) | 2015-07-06 | 2016-07-05 | Diarilo makrociklo polimorfas |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US10294242B2 (enExample) |
| EP (2) | EP4397665A3 (enExample) |
| JP (2) | JP6917974B2 (enExample) |
| KR (1) | KR102623734B1 (enExample) |
| CN (2) | CN108026108B (enExample) |
| AU (1) | AU2016289454B2 (enExample) |
| BR (1) | BR112018000297A2 (enExample) |
| CA (1) | CA2990020C (enExample) |
| DK (1) | DK3319969T3 (enExample) |
| ES (1) | ES2979111T3 (enExample) |
| FI (1) | FI3319969T3 (enExample) |
| HR (1) | HRP20240780T1 (enExample) |
| HU (1) | HUE067352T2 (enExample) |
| IL (2) | IL256443B (enExample) |
| LT (1) | LT3319969T (enExample) |
| MX (2) | MX386680B (enExample) |
| PL (1) | PL3319969T3 (enExample) |
| PT (1) | PT3319969T (enExample) |
| RS (1) | RS65593B1 (enExample) |
| RU (1) | RU2765181C2 (enExample) |
| SI (1) | SI3319969T1 (enExample) |
| SM (1) | SMT202400213T1 (enExample) |
| WO (1) | WO2017007759A1 (enExample) |
| ZA (1) | ZA201708436B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3636649T3 (da) | 2014-01-24 | 2024-05-21 | Turning Point Therapeutics Inc | Diarylmakrocykler som modulatorer af proteinkinaser |
| EP3317285B1 (en) | 2015-07-02 | 2021-01-27 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| WO2017007759A1 (en) * | 2015-07-06 | 2017-01-12 | Tp Therapeutics, Inc. | Diaryl macrocycle polymorph |
| DK3733187T3 (da) * | 2015-07-21 | 2025-01-02 | Turning Point Therapeutics Inc | Chiral diarylmakrocyklus og anvendelse deraf i behandling af cancer |
| US10689400B2 (en) | 2016-07-28 | 2020-06-23 | Turning Point Therapeutics, Inc. | Macrocycle kinase inhibitors |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| CN107586796B (zh) * | 2017-07-20 | 2021-08-06 | 暨明医药科技（苏州）有限公司 | (r)-2-(1-氨基乙基)-4-氟苯酚的合成方法 |
| JP7224334B2 (ja) | 2017-07-28 | 2023-02-17 | ターニング・ポイント・セラピューティクス・インコーポレイテッド | 大環式化合物およびその使用 |
| PT3728271T (pt) | 2017-12-19 | 2022-10-06 | Turning Point Therapeutics Inc | Compostos macrocíclicos para tratar doenças |
| CN110386944B (zh) * | 2018-04-16 | 2021-10-29 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的二(杂)芳基大环化合物 |
| WO2020086616A1 (en) | 2018-10-22 | 2020-04-30 | Fronthera U.S. Pharmaceuticals Llc | Tyk2 inhibitors and uses thereof |
| EP3974434B1 (en) | 2019-05-21 | 2025-11-19 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Macrolide derivatives, preparation method and application thereof |
| CN114025765A (zh) * | 2019-06-19 | 2022-02-08 | 特普医药公司 | 巨环激酶抑制剂的多晶型 |
| IL293208A (en) | 2019-11-27 | 2022-07-01 | Turning Point Therapeutics Inc | Combination therapy involving diaryl macrocyclic compounds |
| AU2020391222A1 (en) * | 2019-11-27 | 2022-06-30 | Turning Point Therapeutics, Inc. | Combination therapy involving diaryl macrocyclic compounds |
| EP4114530A4 (en) * | 2020-03-02 | 2024-04-17 | Turning Point Therapeutics, Inc. | Therapeutic uses of macrocyclic compounds |
| CN113620974B (zh) * | 2020-05-08 | 2023-01-31 | 山东轩竹医药科技有限公司 | 大环类酪氨酸激酶抑制剂的晶型及其制备方法 |
| CN112174982A (zh) * | 2020-09-10 | 2021-01-05 | 上海希迈医药科技有限公司 | 一种洛普替尼晶型及其制备方法 |
| WO2025217347A2 (en) | 2024-04-11 | 2025-10-16 | Bristol-Myers Squibb Company | Process of preparing repotrectinib |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4838925A (en) | 1986-04-25 | 1989-06-13 | E. I. Du Pont De Nemours And Company | Heterocyclic acyl sulfonamides |
| DE3861031D1 (de) | 1987-03-07 | 1990-12-20 | Bayer Ag | Verfahren zur herstellung von 5-amino-4,6-dihalogenpyridinen. |
| EP0690843B1 (en) | 1993-03-25 | 2000-08-30 | PHARMACIA & UPJOHN COMPANY | Formyl- or cyano- substituted indole derivatives having dopaminergic activity |
| PL182124B1 (pl) | 1993-12-07 | 2001-11-30 | Lilly Co Eli | Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL |
| GB9403639D0 (en) * | 1994-02-25 | 1994-04-13 | Boots Co Plc | Therapeutic agents |
| FR2746309B1 (fr) | 1996-03-22 | 1998-04-17 | Oreal | Composition de teinture des fibres keratiniques contenant des pyrazolopyrimidineoxo ; leur utilisation pour la teinture comme coupleurs, procedes de teinture |
| RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
| FR2793791B1 (fr) | 1999-05-19 | 2002-01-25 | Univ Paris 7 Denis Diderot | Nouveaux composes inhibiteurs specifiques de phospholipases a2 |
| DK1325008T3 (da) | 2000-07-31 | 2006-02-13 | Hoffmann La Roche | Piperazinderivater |
| AU2737102A (en) | 2000-12-08 | 2002-06-18 | Ortho Mcneil Pharm Inc | Macroheterocylic compounds useful as kinase inhibitors |
| CA2441080A1 (en) | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| WO2003011222A2 (en) * | 2001-07-27 | 2003-02-13 | Merck & Co., Inc. | Thrombin inhibitors |
| EP1402888A1 (en) * | 2002-09-18 | 2004-03-31 | Jerini AG | The use of substituted carbocyclic compounds as rotamases inhibitors |
| US8005919B2 (en) | 2002-11-18 | 2011-08-23 | Aol Inc. | Host-based intelligent results related to a character stream |
| WO2004052315A2 (en) | 2002-12-11 | 2004-06-24 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| UA91698C2 (ru) * | 2005-01-10 | 2010-08-25 | Арена Фармасьютікалз, Інк. | Комбинированная терапия для лечения диабета и родственных ему состояний и для лечения состояний, улучшенных увеличением уровня glp-1 крови |
| US8960547B2 (en) | 2007-09-19 | 2015-02-24 | E-Seek, Inc. | Document scanner with instant retrieval process |
| US8270176B2 (en) | 2008-08-08 | 2012-09-18 | Stats Chippac Ltd. | Exposed interconnect for a package on package system |
| TWM352384U (en) | 2008-08-22 | 2009-03-11 | Luff Technology Co Ltd | Wireless detection device for club and system thereof |
| MX2011002470A (es) | 2008-09-08 | 2011-04-05 | Merck Patent Gmbh | Pirimidinas macrociclicas como inhibidores de aurora cinasa. |
| PT2350075E (pt) | 2008-09-22 | 2014-06-09 | Array Biopharma Inc | Compostos imidazo[1,2b]piridazina substituídos como inibidores da trk cinase |
| ME03010B (me) | 2008-10-22 | 2018-10-20 | Array Biopharma Inc | Jedinjenja supstituisanog pirazol0[1,5-]pirimidina као inhibitori trk kinaze |
| CN102271515B (zh) | 2008-10-31 | 2014-07-02 | 健泰科生物技术公司 | 吡唑并嘧啶jak抑制剂化合物和方法 |
| WO2010063487A1 (en) | 2008-12-05 | 2010-06-10 | Merz Pharma Gmbh & Co. Kgaa | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
| WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| KR20120087916A (ko) | 2009-10-13 | 2012-08-07 | 엘랑코 애니멀 헬쓰 아일랜드 리미티드 | 마크로시클릭 인테그라제 억제제 |
| JP2013512952A (ja) | 2009-12-07 | 2013-04-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インドールコアを含有する複素環化合物 |
| US9073926B2 (en) | 2009-12-07 | 2015-07-07 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core |
| SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
| PL2918588T3 (pl) * | 2010-05-20 | 2017-10-31 | Array Biopharma Inc | Związki makrocykliczne jako inhibitory kinazy TRK |
| GB2482674B (en) | 2010-08-09 | 2012-08-22 | Rolls Royce Plc | An aerofoil, an aerofoil sub-assembly and a method of making the same |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| WO2012075393A2 (en) | 2010-12-02 | 2012-06-07 | President And Fellows Of Harvard College | Activators of proteasomal degradation and uses thereof |
| EP2508607A1 (en) | 2011-04-07 | 2012-10-10 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for liver regeneration and for treatment of liver failure |
| EP2541470B1 (en) | 2011-06-29 | 2017-10-04 | Denso Wave Incorporated | Information code and information code reader |
| WO2013001310A1 (en) | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| EP2744331A4 (en) * | 2011-08-19 | 2015-01-21 | Merck Sharp & Dohme | METHOD AND INTERMEDIATE PRODUCTS FOR THE MANUFACTURE OF MACROLACTAMEN |
| WO2013045702A2 (en) | 2011-09-29 | 2013-04-04 | L'oreal | Dye composition comprising a non-glycosyl iridoid compound and a specific nucleophile or an amino or thio polymer, dyeing process, and device therefor |
| WO2013045701A2 (en) | 2011-09-29 | 2013-04-04 | L'oreal | Dyeing process using a composition comprising a glycosyl iridoid compound and a nucleophile or an amino or thio polymer, composition and devices therefor |
| HUE027318T2 (en) | 2011-09-30 | 2016-10-28 | Oncodesign Sa | Macrocyclic FLT3 kinase inhibitors |
| CA2852936A1 (en) | 2011-10-20 | 2013-04-25 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
| KR101692600B1 (ko) | 2012-03-06 | 2017-01-03 | 화이자 인코포레이티드 | 증식성 질환 치료용 거대환형 유도체 |
| US8946415B2 (en) | 2012-03-09 | 2015-02-03 | Lexicon Pharmaceuticals, Inc. | Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use |
| BR112014022271B1 (pt) | 2012-03-09 | 2021-09-21 | Lexicon Pharmaceuticals, Inc | Compostos com base em imidazo[1,2-b]piridazina, composições compreendendo-os, e usos dos mesmos |
| GB201205669D0 (en) | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
| HK1215250A1 (zh) | 2013-01-30 | 2016-08-19 | Bayer Pharma Aktiengesellschaft | 氨基取代的异噻唑 |
| EP2989082A1 (en) | 2013-04-23 | 2016-03-02 | LEK Pharmaceuticals d.d. | Novel synthetic process to 8-chloro-1-methyl-benzo[d]azepine, novel intermediates and the production thereof |
| JPWO2015012328A1 (ja) | 2013-07-24 | 2017-03-02 | 武田薬品工業株式会社 | 複素環化合物 |
| US10497029B2 (en) * | 2013-10-21 | 2019-12-03 | Disney Enterprises, Inc. | Systems and methods for facilitating brand integration within online content and promoting that online content |
| WO2015073267A1 (en) | 2013-11-15 | 2015-05-21 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| DK3636649T3 (da) * | 2014-01-24 | 2024-05-21 | Turning Point Therapeutics Inc | Diarylmakrocykler som modulatorer af proteinkinaser |
| BR202014004079U2 (pt) | 2014-02-21 | 2015-10-27 | Mix For You Ltda | higienizador íntimo |
| WO2016070241A1 (en) | 2014-11-03 | 2016-05-12 | Ctxt Pty Ltd | Triazine compounds, compositions and synthesis |
| AU2015365587B2 (en) | 2014-12-15 | 2020-07-23 | Cmg Pharmaceutical Co., Ltd. | Fused ring heteroaryl compounds and their use as TRK inhibitors |
| US9981944B2 (en) | 2015-02-20 | 2018-05-29 | Rigel Pharmaceuticals, Inc | GDF-8 inhibitors |
| CN107250201B (zh) | 2015-03-09 | 2020-04-28 | 住友橡胶工业株式会社 | 轮胎 |
| WO2016144846A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine inhibitors of irak4 activity |
| US10155765B2 (en) | 2015-03-12 | 2018-12-18 | Merck Sharp & Dohme Corp. | Carboxamide inhibitors of IRAK4 activity |
| CA2984848A1 (en) | 2015-05-05 | 2016-11-10 | Bayer Pharma Aktiengesellschaft | Amido-substituted cyclohexane derivatives |
| EP3317285B1 (en) * | 2015-07-02 | 2021-01-27 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| US9524416B1 (en) | 2015-07-03 | 2016-12-20 | Fingerprint Cards Ab | Fingerprint sensing device comprising three-dimensional pattern |
| WO2017007759A1 (en) | 2015-07-06 | 2017-01-12 | Tp Therapeutics, Inc. | Diaryl macrocycle polymorph |
| US10239565B2 (en) | 2015-07-17 | 2019-03-26 | John Michael Baker | Pickup truck tailgate lifting apparatus |
| DK3733187T3 (da) * | 2015-07-21 | 2025-01-02 | Turning Point Therapeutics Inc | Chiral diarylmakrocyklus og anvendelse deraf i behandling af cancer |
| CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| JP6580495B2 (ja) | 2016-02-02 | 2019-09-25 | 三菱重工業株式会社 | 保持治具 |
| EP3423435B1 (en) | 2016-03-04 | 2023-08-23 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
| US10632076B2 (en) | 2016-11-18 | 2020-04-28 | Fertin Pharma A/S | Tablet comprising separate binder and erythritol |
| JP2020533269A (ja) | 2016-12-14 | 2020-11-19 | デベロップメント センター フォー バイオテクノロジー | 抗体−薬物複合体およびその使用 |
-
2016
- 2016-07-05 WO PCT/US2016/040972 patent/WO2017007759A1/en not_active Ceased
- 2016-07-05 US US15/741,893 patent/US10294242B2/en active Active
- 2016-07-05 FI FIEP16821872.5T patent/FI3319969T3/fi active
- 2016-07-05 CA CA2990020A patent/CA2990020C/en active Active
- 2016-07-05 AU AU2016289454A patent/AU2016289454B2/en active Active
- 2016-07-05 JP JP2018500582A patent/JP6917974B2/ja active Active
- 2016-07-05 CN CN201680051405.5A patent/CN108026108B/zh active Active
- 2016-07-05 RU RU2018104269A patent/RU2765181C2/ru active
- 2016-07-05 LT LTEPPCT/US2016/040972T patent/LT3319969T/lt unknown
- 2016-07-05 RS RS20240632A patent/RS65593B1/sr unknown
- 2016-07-05 CN CN202110623105.2A patent/CN113354653B/zh active Active
- 2016-07-05 HU HUE16821872A patent/HUE067352T2/hu unknown
- 2016-07-05 EP EP24158643.7A patent/EP4397665A3/en active Pending
- 2016-07-05 SI SI201631817T patent/SI3319969T1/sl unknown
- 2016-07-05 SM SM20240213T patent/SMT202400213T1/it unknown
- 2016-07-05 DK DK16821872.5T patent/DK3319969T3/da active
- 2016-07-05 PL PL16821872.5T patent/PL3319969T3/pl unknown
- 2016-07-05 BR BR112018000297A patent/BR112018000297A2/pt not_active Application Discontinuation
- 2016-07-05 PT PT168218725T patent/PT3319969T/pt unknown
- 2016-07-05 MX MX2017017081A patent/MX386680B/es unknown
- 2016-07-05 HR HRP20240780TT patent/HRP20240780T1/hr unknown
- 2016-07-05 KR KR1020187002778A patent/KR102623734B1/ko active Active
- 2016-07-05 ES ES16821872T patent/ES2979111T3/es active Active
- 2016-07-05 EP EP16821872.5A patent/EP3319969B1/en active Active
-
2017
- 2017-12-12 ZA ZA2017/08436A patent/ZA201708436B/en unknown
- 2017-12-20 MX MX2021008145A patent/MX2021008145A/es unknown
- 2017-12-20 IL IL256443A patent/IL256443B/en active IP Right Grant
-
2019
- 2019-04-08 US US16/378,095 patent/US20190233437A1/en not_active Abandoned
-
2020
- 2020-10-15 US US17/071,569 patent/US20210094974A1/en not_active Abandoned
-
2021
- 2021-04-16 JP JP2021069649A patent/JP7212713B2/ja active Active
- 2021-05-13 IL IL283184A patent/IL283184B2/en unknown
-
2022
- 2022-09-19 US US17/933,434 patent/US12187739B2/en active Active
-
2024
- 2024-11-22 US US18/957,501 patent/US20250223298A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL301301I2 (nl) | ciltacabtagene autoleucel | |
| DK3319969T3 (da) | Diaryl-makrocyklus-polymorf | |
| DK3331869T3 (da) | Muscarinagonister | |
| PT3298027T (pt) | Compostos depsipéptidos antelmínticos | |
| DK3277719T3 (da) | Polypeptider | |
| EP3316375A4 (en) | Redox flow cell | |
| DK3305788T3 (da) | Janus-kinase-hæmmer | |
| DK3360890T3 (da) | Genterapi | |
| DK3310450T3 (da) | Olie-vand-separator | |
| EP3290364A4 (en) | Conveyor belt wear monitoring system | |
| DK3270930T3 (da) | Præeklampsi | |
| EP3381654A4 (en) | Liquid blow molding method | |
| LT3464336T (lt) | Junginiai | |
| CL2016002165A1 (es) | Compuestos de aminocarbonilcarbamato | |
| EP3363322A4 (en) | Hair extender | |
| HUE054351T2 (hu) | Vegyületek | |
| DK3597189T3 (da) | Krystallinske forbindelser | |
| DE112015006486A5 (de) | Inkubationsrinne | |
| BR112018001062A2 (pt) | compostos inovadores | |
| DK3274482T3 (da) | Stenborsknop | |
| EP3377179A4 (en) | DEUTERED EPI-743 | |
| DE102015206660A8 (de) | Plattenaufteilanlage | |
| IT201600102119A1 (it) | Seminatrice | |
| LT3331885T (lt) | Junginiai | |
| DE112015005906A5 (de) | Gurtschlossbringer |