PT3319969T - Polimorfo de macrociclo de diarilo - Google Patents
Polimorfo de macrociclo de diariloInfo
- Publication number
- PT3319969T PT3319969T PT168218725T PT16821872T PT3319969T PT 3319969 T PT3319969 T PT 3319969T PT 168218725 T PT168218725 T PT 168218725T PT 16821872 T PT16821872 T PT 16821872T PT 3319969 T PT3319969 T PT 3319969T
- Authority
- PT
- Portugal
- Prior art keywords
- polymorph
- macrocycle
- diaryl
- diaryl macrocycle
- macrocycle polymorph
- Prior art date
Links
- -1 Diaryl macrocycle Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188846P | 2015-07-06 | 2015-07-06 | |
| US201562218672P | 2015-09-15 | 2015-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3319969T true PT3319969T (pt) | 2024-06-17 |
Family
ID=57685592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT168218725T PT3319969T (pt) | 2015-07-06 | 2016-07-05 | Polimorfo de macrociclo de diarilo |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US10294242B2 (enExample) |
| EP (2) | EP3319969B1 (enExample) |
| JP (2) | JP6917974B2 (enExample) |
| KR (1) | KR102623734B1 (enExample) |
| CN (2) | CN108026108B (enExample) |
| AU (1) | AU2016289454B2 (enExample) |
| BR (1) | BR112018000297A2 (enExample) |
| CA (1) | CA2990020C (enExample) |
| DK (1) | DK3319969T3 (enExample) |
| ES (1) | ES2979111T3 (enExample) |
| FI (1) | FI3319969T3 (enExample) |
| HR (1) | HRP20240780T1 (enExample) |
| HU (1) | HUE067352T2 (enExample) |
| IL (2) | IL256443B (enExample) |
| LT (1) | LT3319969T (enExample) |
| MX (2) | MX386680B (enExample) |
| PL (1) | PL3319969T3 (enExample) |
| PT (1) | PT3319969T (enExample) |
| RS (1) | RS65593B1 (enExample) |
| RU (1) | RU2765181C2 (enExample) |
| SI (1) | SI3319969T1 (enExample) |
| SM (1) | SMT202400213T1 (enExample) |
| WO (1) | WO2017007759A1 (enExample) |
| ZA (1) | ZA201708436B (enExample) |
Families Citing this family (19)
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| PL3097107T3 (pl) | 2014-01-24 | 2020-01-31 | Turning Point Therapeutics, Inc. | Diarylowe związki makrocykliczne jako modulatory kinaz białkowych |
| AU2016287568B2 (en) | 2015-07-02 | 2020-08-20 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| HRP20240780T1 (hr) | 2015-07-06 | 2024-09-13 | Turning Point Therapeutics, Inc. | Polimorf diaril makrocikla |
| KR102772574B1 (ko) * | 2015-07-21 | 2025-02-24 | 터닝 포인트 테라퓨틱스, 인크. | 키랄 디아릴 매크로사이클 및 이것의 용도 |
| RU2019105587A (ru) | 2016-07-28 | 2020-08-28 | Тёрнинг Поинт Терапьютикс, Инк. | Макроциклические ингибиторы киназ |
| TWI808958B (zh) * | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| CN107586796B (zh) * | 2017-07-20 | 2021-08-06 | 暨明医药科技（苏州）有限公司 | (r)-2-(1-氨基乙基)-4-氟苯酚的合成方法 |
| JP7224334B2 (ja) * | 2017-07-28 | 2023-02-17 | ターニング・ポイント・セラピューティクス・インコーポレイテッド | 大環式化合物およびその使用 |
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| KR102772574B1 (ko) | 2015-07-21 | 2025-02-24 | 터닝 포인트 테라퓨틱스, 인크. | 키랄 디아릴 매크로사이클 및 이것의 용도 |
| US10724102B2 (en) | 2015-10-26 | 2020-07-28 | Loxo Oncology, Inc. | Point mutations in TRK inhibitor-resistant cancer and methods relating to the same |
| JP6580495B2 (ja) | 2016-02-02 | 2019-09-25 | 三菱重工業株式会社 | 保持治具 |
| CN109153643B (zh) | 2016-03-04 | 2022-06-21 | 范德比尔特大学 | 取代的吲哚mcl-1抑制剂 |
| US10632076B2 (en) | 2016-11-18 | 2020-04-28 | Fertin Pharma A/S | Tablet comprising separate binder and erythritol |
| EP3555137A1 (en) | 2016-12-14 | 2019-10-23 | Development Center for Biotechnology | Antibody-drug conjugates and uses thereof |
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2016
- 2016-07-05 HR HRP20240780TT patent/HRP20240780T1/hr unknown
- 2016-07-05 BR BR112018000297A patent/BR112018000297A2/pt not_active Application Discontinuation
- 2016-07-05 CN CN201680051405.5A patent/CN108026108B/zh active Active
- 2016-07-05 RU RU2018104269A patent/RU2765181C2/ru active
- 2016-07-05 PL PL16821872.5T patent/PL3319969T3/pl unknown
- 2016-07-05 PT PT168218725T patent/PT3319969T/pt unknown
- 2016-07-05 FI FIEP16821872.5T patent/FI3319969T3/fi active
- 2016-07-05 RS RS20240632A patent/RS65593B1/sr unknown
- 2016-07-05 ES ES16821872T patent/ES2979111T3/es active Active
- 2016-07-05 LT LTEPPCT/US2016/040972T patent/LT3319969T/lt unknown
- 2016-07-05 JP JP2018500582A patent/JP6917974B2/ja active Active
- 2016-07-05 DK DK16821872.5T patent/DK3319969T3/da active
- 2016-07-05 US US15/741,893 patent/US10294242B2/en active Active
- 2016-07-05 WO PCT/US2016/040972 patent/WO2017007759A1/en not_active Ceased
- 2016-07-05 CN CN202110623105.2A patent/CN113354653B/zh active Active
- 2016-07-05 SM SM20240213T patent/SMT202400213T1/it unknown
- 2016-07-05 AU AU2016289454A patent/AU2016289454B2/en active Active
- 2016-07-05 MX MX2017017081A patent/MX386680B/es unknown
- 2016-07-05 KR KR1020187002778A patent/KR102623734B1/ko active Active
- 2016-07-05 EP EP16821872.5A patent/EP3319969B1/en active Active
- 2016-07-05 SI SI201631817T patent/SI3319969T1/sl unknown
- 2016-07-05 HU HUE16821872A patent/HUE067352T2/hu unknown
- 2016-07-05 EP EP24158643.7A patent/EP4397665A3/en active Pending
- 2016-07-05 CA CA2990020A patent/CA2990020C/en active Active
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2017
- 2017-12-12 ZA ZA2017/08436A patent/ZA201708436B/en unknown
- 2017-12-20 MX MX2021008145A patent/MX2021008145A/es unknown
- 2017-12-20 IL IL256443A patent/IL256443B/en active IP Right Grant
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2019
- 2019-04-08 US US16/378,095 patent/US20190233437A1/en not_active Abandoned
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2020
- 2020-10-15 US US17/071,569 patent/US20210094974A1/en not_active Abandoned
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2021
- 2021-04-16 JP JP2021069649A patent/JP7212713B2/ja active Active
- 2021-05-13 IL IL283184A patent/IL283184B2/en unknown
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2022
- 2022-09-19 US US17/933,434 patent/US12187739B2/en active Active
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2024
- 2024-11-22 US US18/957,501 patent/US20250223298A1/en active Pending
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