LT3305B - Hydroxyquinolone derivatives - Google Patents

Hydroxyquinolone derivatives Download PDF

Info

Publication number
LT3305B
LT3305B LTIP491A LTIP491A LT3305B LT 3305 B LT3305 B LT 3305B LT IP491 A LTIP491 A LT IP491A LT IP491 A LTIP491 A LT IP491A LT 3305 B LT3305 B LT 3305B
Authority
LT
Lithuania
Prior art keywords
hydroxy
quinolone
chloro
phenyl
hydrogen
Prior art date
Application number
LTIP491A
Other languages
English (en)
Lithuanian (lt)
Inventor
Janusz J Kulagowski
Paul D Leeson
Ian Michael Mawer
Michael Rowley
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of LTIP491A publication Critical patent/LTIP491A/xx
Publication of LT3305B publication Critical patent/LT3305B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
LTIP491A 1990-10-19 1993-04-19 Hydroxyquinolone derivatives LT3305B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909022785A GB9022785D0 (en) 1990-10-19 1990-10-19 Therapeutic agents

Publications (2)

Publication Number Publication Date
LTIP491A LTIP491A (en) 1994-11-25
LT3305B true LT3305B (en) 1995-06-26

Family

ID=10684029

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP491A LT3305B (en) 1990-10-19 1993-04-19 Hydroxyquinolone derivatives

Country Status (9)

Country Link
US (2) US5348962A (ja)
EP (1) EP0481676B1 (ja)
JP (1) JPH0780853B2 (ja)
AT (1) ATE148458T1 (ja)
CA (1) CA2053465A1 (ja)
DE (1) DE69124454T2 (ja)
GB (1) GB9022785D0 (ja)
IE (1) IE913671A1 (ja)
LT (1) LT3305B (ja)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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GB9022785D0 (en) * 1990-10-19 1990-12-05 Merck Sharp & Dohme Therapeutic agents
GB9125515D0 (en) * 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
PT647137E (pt) * 1992-06-22 2008-11-24 Univ California Antagonistas dos receptores da glicina e a sua utilização
US5622965A (en) * 1993-03-12 1997-04-22 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
EP0685466A1 (de) * 1994-06-02 1995-12-06 Ciba-Geigy Ag 3-Heteroaliphatyl- und 3-Hetero-(aryl)aliphatyl-2(1H)-chinolonderivate
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
FR2722786B1 (fr) * 1994-07-20 1996-08-23 Rhone Poulenc Rorer Sa Derives de 4-hydroxy-3-phenyl-indeno(1,2-b)pyridine-2(1h)- one, leur preparation et les medicaments les contenant
DE4444815A1 (de) * 1994-12-15 1996-06-20 Merck Patent Gmbh Thienopyridone
US5773434A (en) * 1995-08-30 1998-06-30 Gary A. Rogers Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia
JP2943725B2 (ja) 1996-01-17 1999-08-30 大日本インキ化学工業株式会社 キノリノン誘導体及びそれを有効成分とする抗アレルギー剤
DE19601782A1 (de) * 1996-01-19 1997-07-24 Merck Patent Gmbh Chinolin-2-(1H)one
GB9604400D0 (en) 1996-03-01 1996-05-01 Pfizer Ltd Compounds useful in therapy
PL330042A1 (en) 1996-05-15 1999-04-26 Pfizer Novel 2,3-disubstituted 4(3h)-quinazolynones
US6150352A (en) * 1996-05-20 2000-11-21 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997044321A1 (en) * 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6147088A (en) * 1996-05-20 2000-11-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CN1248248A (zh) * 1997-02-28 2000-03-22 辉瑞产品公司 3－芳基－4(3h)－喹唑啉酮化合物的阻转异构体及其作为ampa－受体拮抗剂的应用
EP0869122B1 (en) * 1997-03-31 2002-12-04 Korea Research Institute Of Chemical Technology Quinolinic sulfide derivatives acting as NMDA receptor antagonists and process for preparation thereof
US6962930B1 (en) 1997-06-06 2005-11-08 Lohocla Research Corporation Compounds, compositions and method suitable for amelioration of withdrawal syndromes and withdrawal-induced brain damage
ES2245015T3 (es) * 1997-06-09 2005-12-16 Pfizer Products Inc. Quinazolin-4-onas como antagonistas de ampa.
US6627755B1 (en) 1997-06-09 2003-09-30 Pfizer Inc Quinazolin-4-one AMPA antagonists
US5783700A (en) * 1997-07-03 1998-07-21 Nichols; Alfred C. Quinolic acid derivatives
IL125950A0 (en) * 1997-09-05 1999-04-11 Pfizer Prod Inc Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
US6323208B1 (en) 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
WO2001039664A1 (en) * 1999-12-02 2001-06-07 The General Hospital Corporation Method and apparatus for measuring indices of brain activity
US6907280B2 (en) * 1999-12-02 2005-06-14 The General Hospital Corporation Method and apparatus for objectively measuring pain, pain treatment and other related techniques
AU3408901A (en) * 2000-02-15 2001-08-27 Teijin Ltd Cancer remedy comprising anthranilic acid derivative as active ingredient
US6602182B1 (en) 2000-11-28 2003-08-05 Abiomed, Inc. Cardiac assistance systems having multiple fluid plenums
GB0031315D0 (en) * 2000-12-21 2001-02-07 Glaxo Group Ltd Indole derivatives
DE10135466A1 (de) * 2001-07-20 2003-02-06 Bayer Cropscience Ag Biphenylsubstituierte 4-Hydroxy-chinolone
US20040152694A1 (en) * 2003-02-04 2004-08-05 Istvan Kurucz Methods and compositions for treating inflammatory disorders of the airways
GB0325175D0 (en) * 2003-10-28 2003-12-03 Novartis Ag Organic compounds
US7960548B2 (en) * 2005-04-29 2011-06-14 The Ohio State University Research Foundation Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis
WO2007089634A2 (en) * 2006-01-30 2007-08-09 Merck & Co., Inc. Inhibitors of fatty acid synthase (fas)
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
CN110143918B (zh) * 2019-06-19 2020-08-04 青岛农业大学 3,4-二氢-3-(2-羟基苯甲酰)-2(1h)-喹啉酮活性骨架及合成方法和应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
JPS63295561A (ja) 1987-05-26 1988-12-01 Kissei Pharmaceut Co Ltd ２−キノロン誘導体

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EP0293146A1 (en) * 1987-05-26 1988-11-30 Kissei Pharmaceutical Co. Ltd. Benzofuro [3,2-c] quinoline compounds
GB8719102D0 (en) * 1987-08-12 1987-09-16 Merck Sharp & Dohme Therapeutic agents
JPH01242585A (ja) * 1988-03-23 1989-09-27 Kissei Pharmaceut Co Ltd ベンゾフロ〔３，２−ｃ〕キノリン誘導体の製造方法
DE59009368D1 (de) * 1989-09-26 1995-08-10 Ciba Geigy Ag Phosphonsäure, Verfahren zur Herstellung und Verwendung als Arzneimittelwirkstoff.
US5039528A (en) * 1989-12-11 1991-08-13 Olney John W EAA antagonists as anti-emetic drugs
GB9022785D0 (en) * 1990-10-19 1990-12-05 Merck Sharp & Dohme Therapeutic agents

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
JPS63295561A (ja) 1987-05-26 1988-12-01 Kissei Pharmaceut Co Ltd ２−キノロン誘導体

Non-Patent Citations (9)

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Title
ANTHONY H. DICKENSON AND EBRU AYDAR: "Antagonism at the glycine site on the NMDA receptor reduces spinal nociception in the rat", NEUROSCIENCE LETTERS, pages 263 - 266
BAGETTA ET AL.: "Prevention by the NMDA receptor antagonist, MK801 of neuronal loss produced by tetanus toxin in the rat hippocampus", BRITISH JOURNAL OF PHARMACOLOGY, 1990, pages 776 - 780
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CH. W. MURRAY ET AL.: "Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model", PAIN, pages 179 - 185
J.H.KEHNE ET AL.: "NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations", EUR. J. PHARMACOL., 1991, pages 283, XP025545116, DOI: doi:10.1016/0014-2999(91)90141-C
TRULLAS R. AND SKOLNICK P.: "Functional antagonists at the NMDA receptor complex exhibit antidepressant actions", EUR. J. PHARMACOL., 1990, pages 185
TURSKI L. ET AL.: "Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists", NATURE (LONDON), 1991, pages 414 - 8
VAN DEN POL ET ASL.: "Glutamate, the dominant excitatory transmitter in neuroendocrine regulation", SCIENCE, 1990, pages 1276 - 1278
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Also Published As

Publication number Publication date
JPH05112531A (ja) 1993-05-07
GB9022785D0 (en) 1990-12-05
US5559125A (en) 1996-09-24
US5348962A (en) 1994-09-20
IE913671A1 (en) 1992-04-22
JPH0780853B2 (ja) 1995-08-30
DE69124454T2 (de) 1997-08-07
CA2053465A1 (en) 1992-04-20
DE69124454D1 (de) 1997-03-13
LTIP491A (en) 1994-11-25
ATE148458T1 (de) 1997-02-15
EP0481676A1 (en) 1992-04-22
EP0481676B1 (en) 1997-01-29

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Effective date: 19970419