KR970027070A - 신규 피페라진 유도체 및 그 제조방법 - Google Patents

신규 피페라진 유도체 및 그 제조방법 Download PDF

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KR970027070A
KR970027070A KR1019950043607A KR19950043607A KR970027070A KR 970027070 A KR970027070 A KR 970027070A KR 1019950043607 A KR1019950043607 A KR 1019950043607A KR 19950043607 A KR19950043607 A KR 19950043607A KR 970027070 A KR970027070 A KR 970027070A
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South Korea
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group
atom
hydrogen atom
integer
substituted
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KR1019950043607A
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KR0162710B1 (ko
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조의환
정순간
김중영
이순환
권호석
김병철
공재명
이재웅
강동욱
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최승주
삼진제약 주식회사
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Priority to KR1019950043607A priority Critical patent/KR0162710B1/ko
Application filed by 최승주, 삼진제약 주식회사 filed Critical 최승주
Priority to CZ19962960A priority patent/CZ288002B6/cs
Priority to AU44007/96A priority patent/AU699619B2/en
Priority to BR9605309A priority patent/BR9605309A/pt
Priority to NZ298499A priority patent/NZ298499A/en
Priority to EP96900459A priority patent/EP0749425A1/en
Priority to RO96-01781A priority patent/RO115159B1/ro
Priority to CN96190006A priority patent/CN1128139C/zh
Priority to SK889-96A priority patent/SK282252B6/sk
Priority to PCT/KR1996/000005 priority patent/WO1996021648A1/en
Priority to US08/676,174 priority patent/US5780472A/en
Priority to HU9602489A priority patent/HUP9602489A3/hu
Priority to JP8521570A priority patent/JP2978967B2/ja
Priority to RU96120092A priority patent/RU2126001C1/ru
Priority to CA002184919A priority patent/CA2184919C/en
Priority to MX9603308A priority patent/MX9603308A/es
Priority to PL96316613A priority patent/PL183865B1/pl
Priority to ZA96517A priority patent/ZA96517B/xx
Priority to ARP960101372A priority patent/AR003109A1/es
Priority to MYPI96000813A priority patent/MY132324A/en
Priority to TW085105093A priority patent/TW356466B/zh
Priority to BG100704A priority patent/BG61875B1/bg
Priority to NO963792A priority patent/NO307459B1/no
Priority to FI963566A priority patent/FI963566A/fi
Publication of KR970027070A publication Critical patent/KR970027070A/ko
Publication of KR0162710B1 publication Critical patent/KR0162710B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)

Abstract

본 발명은 다음의 일반구조식(Ⅰ)로 표시되는 화합물 및 그 제약적으로 허용되는 산부가염, 및 그것을 함유하는 약학적 제제에 관한 것이다.
상기 식에서, R1및 R2는 각각 수소원자, C1-C8의 알킬기 또는 C3-C8의 치환 또는 비치환의 3-6원의 사이클로알킬기이며, R3, R4, R5, R6및 R7은 각각 수소원자, 할로겐원자, 히드록시기, 니트로기, C1-C4의 저급 에스테르기, C1-C4의 저급알킬기, C1-C4의 저급알콕시기, 아릴기, 아릴알콕시기, 불포화아민기이며, 1은 0 내지 7의 정수이며, m 및 n은 각각 0 또는 1의 정수이며, W는 탄소원자 또는 질소원자이며, X는 산소원자, 유황원자, 치환 또는 비치환의 이민기이며, Y는 질소원자, 산소원자, Z는 수소원자, C1-C8의 저급알콕시기, 아릴옥시기, C1-C4의 저급알킬아민기, 질소원자 1-5개까지를 함유할 수 있는 환상아민기 또는 옥소기이다.
본 발명에 따른 화합물은 탁월한 함암활성을 가지며 그 독성이 낮아 항암제제로서의 우수한 효과가 기대된다.

Description

신규 피페라진 유도체 및 그 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 다음의 일반구조식(Ⅰ)로 표시되는 화합물 및 그 제약적으로 허용되는 산부가염.
    상기 식에서, R1및 R2는 각각 수소원자, C1-C8의 알킬기 또는 C3-C8의 치환 또는 비치환의 3-6원의 사이클로알킬기이며, R3, R4, R5, R6및 R7은 각각 수소원자, 할로겐원자, 히드록시기, 니트로기, C1-C4의 저급 에스테르기, C1-C4의 저급알킬기, C1-C4의 저급알콕시기, 아릴기, 아릴알콕시기, 불포화아민기이며, 1은 0 내지 7의 정수이며, m 및 n은 각각 0 또는 1의 정수이며, W는 탄소원자 또는 질소원자이며, X는 산소원자, 유황원자, 치환 또는 비치환의 이민기이며, Y는 질소원자, 산소원자, Z는 수소원자, C1-C8의 저급알콕시기, 아릴옥시기, C1-C4의 저급알킬아민기, 질소원자 1-5개까지를 함유할 수 있는 환상아민기 또는 옥소기이다.
  2. 제1항에서, Z가 옥소기인 다음 일반구조식(Ⅰ')의 화합물 및 그 제약학적으로 허용되는 산부가염.
    상기 식에서, R1, R2, R3, R4, R5, R6, R7, l, m, n, W, X 및 Y는 제1항에서와 같다.
  3. 일반구조식(Ⅰ)의 화합물을 통상의 약제학적으로 허용되는 부형제, 결합제, 붕해제, 활탁제, 용제, 용해 보조제, 보존제, 안정화제, 연고기제, pH조절제, 방향제에서 선택된 1종 이상의 보조제와 혼합하고 통상의 약제학적으로 사용되는 방법으로 통상의 약제학적으로 사용되는 제제 형태로 제형화한 약학적 제제.
    상기 식에서, R1및 R2는 각각 수소원자, C1-C8의 알킬기 또는 C3-C8의 치환 또는 비치환의 3-6원의 사이클로알킬기이며, R3, R4, R5, R6및 R7은 각각 수소원자, 할로겐원자, 히드록시기, 니트로기, C1-C4의 저급에스테르기, C1-C4의 저급알킬기, C1-C4의 저급알콕시기, 아릴기, 아릴알콕시기, 불포화아민기이며, 1은 0 내지 7의 정수이며, m 및 n은 각각 0 또는 1의 정수이며, W는 탄소원자 또는 질소원자이며, X는 산소원자, 유황원자, 치환 또는 비치환의 이민기이며, Y는 질소원자, 산소원자, Z는 수소원자, C1-C8의 저급알콕시기, 아릴옥시기, C1-C4의 저급알킬아민기, 질소원자 1-5개까지를 함유할 수 있는 환상아민기 또는 옥소기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950043607A 1995-01-10 1995-11-24 신규 피페라진 유도체 및 그 제조방법 KR0162710B1 (ko)

Priority Applications (24)

Application Number Priority Date Filing Date Title
KR1019950043607A KR0162710B1 (ko) 1995-01-10 1995-11-24 신규 피페라진 유도체 및 그 제조방법
CA002184919A CA2184919C (en) 1995-01-11 1996-01-10 New piperazine derivatives and methods for the preparation thereof and compositions containing the same
AU44007/96A AU699619B2 (en) 1995-01-11 1996-01-10 New piperazine derivatives and methods for the preparation thereof and compositions containing the same
MX9603308A MX9603308A (es) 1995-01-11 1996-01-10 Nuevos derivados piperazina y metodos para su preparacion y composicion que los contiene.
EP96900459A EP0749425A1 (en) 1995-01-11 1996-01-10 New piperazine derivatives and methods for the preparation thereof and compositions containing the same
RO96-01781A RO115159B1 (ro) 1995-01-11 1996-01-10 Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin
CN96190006A CN1128139C (zh) 1995-01-11 1996-01-10 新哌嗪衍生物及其制造方法
SK889-96A SK282252B6 (sk) 1995-01-11 1996-01-10 Piperazínové deriváty a farmaceutický prostriedok s ich obsahom
PCT/KR1996/000005 WO1996021648A1 (en) 1995-01-11 1996-01-10 New piperazine derivatives and methods for the preparation thereof and compositions containing the same
US08/676,174 US5780472A (en) 1995-01-11 1996-01-10 Piperazine derivatives and methods for the preparation thereof and compositions containing the same
HU9602489A HUP9602489A3 (en) 1995-01-11 1996-01-10 Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
JP8521570A JP2978967B2 (ja) 1995-01-11 1996-01-10 新規ピペラジン誘導体、その製造方法及びそれを含有する組成物
CZ19962960A CZ288002B6 (cs) 1995-01-11 1996-01-10 Piperazinové deriváty a farmaceutický prostředek s protinádorovou aktivitou je obsahující
BR9605309A BR9605309A (pt) 1995-01-11 1996-01-10 Composições de derivados piperazina
NZ298499A NZ298499A (en) 1995-01-11 1996-01-10 Aromatic piperazine or pyridine derivatives; medicaments thereof
PL96316613A PL183865B1 (pl) 1995-01-11 1996-01-10 Nowe pochodne piperazyny i środek farmaceutyczny
RU96120092A RU2126001C1 (ru) 1995-01-10 1996-01-10 Производные пиперазина и фармацевтическая композиция на их основе
ZA96517A ZA96517B (en) 1995-11-24 1996-01-23 Piperazine derivatives and methods for the preparation thereof and compositions containing the same
ARP960101372A AR003109A1 (es) 1995-11-24 1996-02-13 Compuesto con actividad antitumoral importante y toxicidad baja y sal farmaceuticamente aceptable compuesto y composicion farmaceutica que locontiene
MYPI96000813A MY132324A (en) 1995-11-24 1996-03-05 New piperazine derivatives and methods for the preperation thereof and compositions containing the same
TW085105093A TW356466B (en) 1995-11-24 1996-04-29 Piperazine derivatives and pharmaceutical compositions containing the same for anti-cancer
BG100704A BG61875B1 (bg) 1995-01-10 1996-07-08 Нови пиперазинови производни и методи за получаването им,както и на съдържащи ги съединения
NO963792A NO307459B1 (no) 1995-01-11 1996-09-10 Piperazinderivater, samt farmasøytiske preparater inneholdende slike
FI963566A FI963566A (fi) 1995-01-11 1996-09-10 Uusia piperatsiinijohdoksia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä koostumuksia

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19950000399 1995-01-10
KR95-399 1995-01-11
KR1019950043607A KR0162710B1 (ko) 1995-01-10 1995-11-24 신규 피페라진 유도체 및 그 제조방법

Publications (2)

Publication Number Publication Date
KR970027070A true KR970027070A (ko) 1997-06-24
KR0162710B1 KR0162710B1 (ko) 1998-12-01

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KR2019950002769U KR970007010Y1 (ko) 1995-01-10 1995-02-17 필기구
KR1019950043607A KR0162710B1 (ko) 1995-01-10 1995-11-24 신규 피페라진 유도체 및 그 제조방법

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010112841A (ko) * 2000-06-15 2001-12-22 주정호 항암제로서 유용한 ｎ-치환된 피페라지닐우레아 유도체 및그의 제조방법

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KR960026874U (ko) 1996-08-17
KR0162710B1 (ko) 1998-12-01

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