KR970704463A - 스트렙토그라민 유도체, 이의 제조 방법 및 이를 함유하는 약학 조성물(streptogramine derivatives, preparation of same and pharmaceutical compositions containing same) - Google Patents
스트렙토그라민 유도체, 이의 제조 방법 및 이를 함유하는 약학 조성물(streptogramine derivatives, preparation of same and pharmaceutical compositions containing same) Download PDFInfo
- Publication number
- KR970704463A KR970704463A KR1019970700653A KR19970700653A KR970704463A KR 970704463 A KR970704463 A KR 970704463A KR 1019970700653 A KR1019970700653 A KR 1019970700653A KR 19970700653 A KR19970700653 A KR 19970700653A KR 970704463 A KR970704463 A KR 970704463A
- Authority
- KR
- South Korea
- Prior art keywords
- radical
- methyl
- same
- derivatives
- pct
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
라디칼 R1은 메틸 또는 에틸 라디칼이고, 라디칼 R2는 브롬 또는 염소원자 또는 R3및 R4가 메틸일때는 3내지 5개의 탄소원자를 갖는 알케닐 라디칼이며, R3및 R4중의 하나는 수소원자 또는 메틸 라디칼이고 다른 하나는 메틸 라디칼인 화학식(I)의 스트렙토그라민 유도체이다. 화학식(I)의 스트렙토그라민 유도체는 특히 유용한 항균성을 갖고 프리스티나마이신 Ⅱ유도체와 배합되어 사용될 수 있다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 하기 식 (Ⅰ)의 스트렙토그라민 유도체 :상기 식에서, -라디칼R1은 메틸 또는 에틸 라디칼이고, -라디칼 R2는 염소 또는 브롬 원자이거나 R3및R4가 메틸라디칼일 경우 3 내지 5개의 탄소 원자를 함유하는 알케실 라디칼을 나타내며, -R3및 R4는 이중 하나는 수소원자 또는 메틸 라디칼이고, 다른 하나는 메틸 라디칼이다.
- R2가염소 또는 브롬 원자인 경우에, 상응하는 N-할로숙신이미드 유도체가 R2가 수소원자인 경우의 프리스티나마이신 Ⅰ와 반응하는 것을 특징으로 하는 제1항에 따른 스트렙토그라민 유도체의 제조 방법.
- R2가 3내지 5개의 탄소원자를 함유하는 알케닐 라디칼인 경우, 화학식(Ⅱ)의 4-N-알케닐암모니오 프리스티나마이신 IA로부터 유도된 염의 전위방응이 염기성 배지에서 수행되는 것을 특징으로 하는 제1항에 따른 스트렙토그라민 유도체의 제조 방법.상기 식에서, R1은 상기에서 정의한 바와 같고, R5,R6,R7및 R8은 수소원자 또는 메틸 라디칼이며, 단 이들중 적어도 2개는 수소원자이며, X는 음이온이다.
- 순수한 상태 또는 프리스티나마이신 Ⅱ 유도체와의 배합물 상태 및/또는 임의로 하나 이상의 상용성이고 약학적으로 허용되는 희석제 및 보조제와의 배합물 상태의 제1항에 따른 적어도 하나의 스트렙토그라민 유도체로 이루어짐을 특징으로 하는 약학 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9409563A FR2723372B1 (fr) | 1994-08-02 | 1994-08-02 | Nouveaux derives de streptogramine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR94/09563 | 1994-08-02 | ||
| PCT/FR1995/001025 WO1996004299A1 (fr) | 1994-08-02 | 1995-07-31 | Derives de streptogramine, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR970704463A true KR970704463A (ko) | 1997-09-06 |
Family
ID=9465983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019970700653A KR970704463A (ko) | 1994-08-02 | 1995-07-31 | 스트렙토그라민 유도체, 이의 제조 방법 및 이를 함유하는 약학 조성물(streptogramine derivatives, preparation of same and pharmaceutical compositions containing same) |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5786449A (ko) |
| EP (1) | EP0772630B1 (ko) |
| JP (2) | JP3775686B2 (ko) |
| KR (1) | KR970704463A (ko) |
| AT (1) | ATE205853T1 (ko) |
| AU (1) | AU696226B2 (ko) |
| BR (1) | BR9508793A (ko) |
| CA (1) | CA2196102A1 (ko) |
| CZ (1) | CZ284383B6 (ko) |
| DE (1) | DE69522810T2 (ko) |
| DK (1) | DK0772630T3 (ko) |
| ES (1) | ES2162932T3 (ko) |
| FR (1) | FR2723372B1 (ko) |
| GR (1) | GR3036908T3 (ko) |
| MX (1) | MX9700712A (ko) |
| NO (1) | NO970240L (ko) |
| NZ (1) | NZ290436A (ko) |
| PL (1) | PL318435A1 (ko) |
| PT (1) | PT772630E (ko) |
| SK (1) | SK14297A3 (ko) |
| WO (1) | WO1996004299A1 (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2775288B1 (fr) * | 1998-02-26 | 2000-03-31 | Rhone Poulenc Rorer Sa | Derives de streptogramines, leur preparation et les compositons qui les contiennent |
| FR2796949B1 (fr) | 1999-07-27 | 2001-09-21 | Aventis Pharma Sa | Derives de streptogramines, leur preparation et les compositions qui les contiennent |
| DK1204676T3 (da) * | 1999-07-27 | 2003-12-01 | Aventis Pharma Sa | Streptograminderivater, deres fremstilling samt præparater indeholdende disse derivater |
| FR2796950B1 (fr) * | 1999-07-27 | 2001-09-21 | Aventis Pharma Sa | Derives de streptogramines, leur preparation et les compositions qui les contiennent |
| US20200325177A1 (en) * | 2017-08-01 | 2020-10-15 | The Regents Of The University Of California | Methods of making streptogramin compositions and the use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2549062B1 (fr) * | 1983-07-13 | 1985-10-25 | Rhone Poulenc Sante | Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1994
- 1994-08-02 FR FR9409563A patent/FR2723372B1/fr not_active Expired - Fee Related
-
1995
- 1995-07-31 AU AU31173/95A patent/AU696226B2/en not_active Ceased
- 1995-07-31 AT AT95926995T patent/ATE205853T1/de not_active IP Right Cessation
- 1995-07-31 EP EP95926995A patent/EP0772630B1/fr not_active Expired - Lifetime
- 1995-07-31 DK DK95926995T patent/DK0772630T3/da active
- 1995-07-31 PL PL95318435A patent/PL318435A1/xx unknown
- 1995-07-31 BR BR9508793A patent/BR9508793A/pt not_active Application Discontinuation
- 1995-07-31 US US08/776,665 patent/US5786449A/en not_active Expired - Lifetime
- 1995-07-31 NZ NZ290436A patent/NZ290436A/en unknown
- 1995-07-31 CA CA002196102A patent/CA2196102A1/fr not_active Abandoned
- 1995-07-31 JP JP50625496A patent/JP3775686B2/ja not_active Expired - Fee Related
- 1995-07-31 MX MX9700712A patent/MX9700712A/es unknown
- 1995-07-31 PT PT95926995T patent/PT772630E/pt unknown
- 1995-07-31 WO PCT/FR1995/001025 patent/WO1996004299A1/fr active IP Right Grant
- 1995-07-31 KR KR1019970700653A patent/KR970704463A/ko not_active Application Discontinuation
- 1995-07-31 DE DE69522810T patent/DE69522810T2/de not_active Expired - Lifetime
- 1995-07-31 CZ CZ97300A patent/CZ284383B6/cs not_active IP Right Cessation
- 1995-07-31 ES ES95926995T patent/ES2162932T3/es not_active Expired - Lifetime
- 1995-07-31 SK SK142-97A patent/SK14297A3/sk unknown
-
1997
- 1997-01-20 NO NO970240A patent/NO970240L/no unknown
-
2001
- 2001-10-17 GR GR20010400675T patent/GR3036908T3/el not_active IP Right Cessation
-
2005
- 2005-05-20 JP JP2005148164A patent/JP4277015B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10503510A (ja) | 1998-03-31 |
| FR2723372B1 (fr) | 1996-10-04 |
| PT772630E (pt) | 2002-02-28 |
| DK0772630T3 (da) | 2001-11-26 |
| ATE205853T1 (de) | 2001-10-15 |
| BR9508793A (pt) | 1997-12-23 |
| DE69522810D1 (de) | 2001-10-25 |
| MX9700712A (es) | 1997-05-31 |
| EP0772630B1 (fr) | 2001-09-19 |
| EP0772630A1 (fr) | 1997-05-14 |
| DE69522810T2 (de) | 2002-04-04 |
| CA2196102A1 (fr) | 1996-02-15 |
| WO1996004299A1 (fr) | 1996-02-15 |
| JP2005290012A (ja) | 2005-10-20 |
| PL318435A1 (en) | 1997-06-09 |
| NO970240D0 (no) | 1997-01-20 |
| NZ290436A (en) | 1998-07-28 |
| ES2162932T3 (es) | 2002-01-16 |
| FR2723372A1 (fr) | 1996-02-09 |
| NO970240L (no) | 1997-01-20 |
| US5786449A (en) | 1998-07-28 |
| SK14297A3 (en) | 1997-08-06 |
| AU3117395A (en) | 1996-03-04 |
| JP4277015B2 (ja) | 2009-06-10 |
| CZ30097A3 (en) | 1997-05-14 |
| JP3775686B2 (ja) | 2006-05-17 |
| GR3036908T3 (en) | 2002-01-31 |
| AU696226B2 (en) | 1998-09-03 |
| CZ284383B6 (cs) | 1998-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |