KR970705385A - 뼈 치료법 및 골절 치유법(methods for bone healing and fracture repair) - Google Patents

뼈 치료법 및 골절 치유법(methods for bone healing and fracture repair)

Info

Publication number
KR970705385A
KR970705385A KR1019970701098A KR19970701098A KR970705385A KR 970705385 A KR970705385 A KR 970705385A KR 1019970701098 A KR1019970701098 A KR 1019970701098A KR 19970701098 A KR19970701098 A KR 19970701098A KR 970705385 A KR970705385 A KR 970705385A
Authority
KR
South Korea
Prior art keywords
compound
bone healing
fracture repair
methods
image
Prior art date
Application number
KR1019970701098A
Other languages
English (en)
Inventor
조오지 조셉 컬리난
마사히코 사토
Original Assignee
스트링거 피터 지
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스트링거 피터 지, 일라이 릴리 앤드 캄파니 filed Critical 스트링거 피터 지
Publication of KR970705385A publication Critical patent/KR970705385A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

하기 화합식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용가능한 염 또는 용매화합물을 이를 필요로 하는 사람에게 유효량 투여함을 포함하는, 뼈 치료 및 골절 치유를 용이하게 하는 방법;
상기 식에서, R1및 R3는 독립적으로 수소, -CH3, (a) 또는 (b)(여기서, Ar은 선택적으로 치환된 페닐이다)이고, R2는 피롤리딘, 헥사메틸렌이미노 및 피페리디노로 이루어진 군으로부터 선택된다;

Description

뼈 치료법 및 골절 치유법(METHODS FOR BONE HEALING AND FRACTURE REPAIR)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 화학식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용가능한 염 또는 용매화합물을 이를 필요로 하는 사람에게 유효량 투여함을 포함하는, 뼈 치료 및 골절 치유를 용이하게 하는 방법;
    상기 식에서, R1및 R3는 독립적으로 수소, -CH3,(C1-C6알킬), 또는(여기서, Ar은 선택적으로 치환된 페닐이다)이고, R2는 피롤리딘, 헥사메틸렌이미노 및 피페리디노로 이루어진 군으로부터 선택된다;
  2. 제1항에 있어서, 상기 화합물이 이의 염화수소염인 방법.
  3. 제1항에 있어서, 상기 투여가 예방용인 방법.
  4. 제1항에 있어서, 상기 화합물이 하기 화합물 또는 이의 염화수소염인 방법;
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970701098A 1994-08-22 1995-08-21 뼈 치료법 및 골절 치유법(methods for bone healing and fracture repair) KR970705385A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/294,130 US5502074A (en) 1994-08-22 1994-08-22 Benzothiophenes for bone healing and fracture repair
US08/294,130 1994-08-22
PCT/US1995/010618 WO1996005825A1 (en) 1994-08-22 1995-08-21 Methods for bone healing and fracture repair

Publications (1)

Publication Number Publication Date
KR970705385A true KR970705385A (ko) 1997-10-09

Family

ID=23132010

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970701098A KR970705385A (ko) 1994-08-22 1995-08-21 뼈 치료법 및 골절 치유법(methods for bone healing and fracture repair)

Country Status (20)

Country Link
US (1) US5502074A (ko)
EP (1) EP0769945B1 (ko)
JP (1) JPH10504578A (ko)
KR (1) KR970705385A (ko)
AT (1) ATE240101T1 (ko)
AU (1) AU701946B2 (ko)
CA (1) CA2198012A1 (ko)
CZ (1) CZ51997A3 (ko)
DE (1) DE69530771T2 (ko)
DK (1) DK0769945T3 (ko)
ES (1) ES2197207T3 (ko)
FI (1) FI970715A (ko)
HU (1) HUT76855A (ko)
IL (1) IL115016A (ko)
MX (1) MX9701332A (ko)
NO (1) NO970785D0 (ko)
PH (1) PH31620A (ko)
PT (1) PT769945E (ko)
WO (1) WO1996005825A1 (ko)
ZA (1) ZA956989B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856340A (en) 1995-02-28 1999-01-05 Eli Lilly And Company Method of treating estrogen dependent cancers
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
SI1112095T1 (en) * 1998-09-11 2003-04-30 Gerhard Dr. Schmidmaier Biologically active implants
CZ20013912A3 (cs) 1999-05-04 2002-05-15 Strakan Limited Androgen glykosid, sloučenina, testosteron-ß-D-glukosid, 5 alfa-Dihydrotestosteron- 17ß-D-glukosid, farmaceutický prostředek a pouľití sloučeniny

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US5075321A (en) * 1987-03-24 1991-12-24 University Of Pennsylvania Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
DE4122484A1 (de) * 1991-07-06 1993-01-07 Teves Gmbh Alfred Schaltungsanordnung zur erkennung von radsensordefekten
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
TW303299B (ko) * 1993-07-22 1997-04-21 Lilly Co Eli

Also Published As

Publication number Publication date
JPH10504578A (ja) 1998-05-06
ATE240101T1 (de) 2003-05-15
DK0769945T3 (da) 2003-06-10
US5502074A (en) 1996-03-26
NO970785L (no) 1997-02-20
IL115016A (en) 1999-09-22
PH31620A (en) 1999-01-12
FI970715A0 (fi) 1997-02-20
DE69530771D1 (de) 2003-06-18
EP0769945A1 (en) 1997-05-02
MX9701332A (es) 1997-05-31
FI970715A (fi) 1997-02-20
EP0769945B1 (en) 2003-05-14
AU3409795A (en) 1996-03-14
EP0769945A4 (en) 1997-09-03
ES2197207T3 (es) 2004-01-01
ZA956989B (en) 1997-02-21
CA2198012A1 (en) 1996-02-29
PT769945E (pt) 2003-09-30
HUT76855A (en) 1997-12-29
NO970785D0 (no) 1997-02-20
CZ51997A3 (en) 1997-08-13
AU701946B2 (en) 1999-02-11
IL115016A0 (en) 1995-12-08
DE69530771T2 (de) 2004-03-11
WO1996005825A1 (en) 1996-02-29

Similar Documents

Publication Publication Date Title
KR950010893A (ko) 자궁내막증 억제 방법
KR950016732A (ko) 피부 및 질의 위축 억제방법
KR950016738A (ko) 알쯔하이머 질병의 억제 방법
KR950016745A (ko) 생리증상의 치료방법 및 이를 위한 조성물
KR950010892A (ko) 자궁 섬유증 억제 방법
KR950016725A (ko) 폐 고혈압성 질병을 억제하는 방법
KR950010890A (ko) 폐경기 증후군의 치료방법
KR950016724A (ko) 폐경기 후 여성의 리비도를 증가시키는 방법
KR950016731A (ko) 지루 및 좌창의 억제 방법
KR950010889A (ko) 혈관형성 및 혈관형성성 질병을 억제하는 방법
KR950016723A (ko) 자가면역 질병의 억제 방법
KR950016726A (ko) 기능부전성 자궁 출혈을 억제하는 방법
KR950016727A (ko) 트롬보모듈린 발현을 증가시키는 방법
KR950010887A (ko) 연골 퇴화 억제 방법
KR950016742A (ko) 폐경후 여성의 씨엔에스 질환을 억제하는 방법
KR970705384A (ko) 골 보철 파손의 억제 방법(methods for inhibiting bone prosthesis degeneration)
KR950016734A (ko) 성적 조숙증의 억제방법
KR970705385A (ko) 뼈 치료법 및 골절 치유법(methods for bone healing and fracture repair)
EA199700136A1 (ru) Способы ингибирования экзогенных эстрогенов
KR950016728A (ko) 여성에서 다모증 및 탈모증을 억제하는 방법
KR970706819A (ko) 브라디키닌 관련 증상 억제 방법(Method of Inhibiting Conditions Associated with Bradykinin)
KR970705387A (ko) 자궁내막암의 억제 방법(methods of inhibiting endometrial cancer)
KR970706000A (ko) 자궁내막 유사분열의 저해 방법(methods of inihibiting endometrial mitoses)
KR970705386A (ko) 치아 및 구강 뼈의 유지방법(methods of maintaining teeth and oralbone)
KR970705388A (ko) 원발성 자궁 내막 증식증의 억제 방법(methods of inhibiting primary endometrial hyperplasia)

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid