DE69530771D1 - Verwendung von 2-phenyl-3-aroylbenzothiophenderivaten zur herstellung eines medikaments zur knochen- und bruchheilung - Google Patents

Verwendung von 2-phenyl-3-aroylbenzothiophenderivaten zur herstellung eines medikaments zur knochen- und bruchheilung

Info

Publication number
DE69530771D1
DE69530771D1 DE69530771T DE69530771T DE69530771D1 DE 69530771 D1 DE69530771 D1 DE 69530771D1 DE 69530771 T DE69530771 T DE 69530771T DE 69530771 T DE69530771 T DE 69530771T DE 69530771 D1 DE69530771 D1 DE 69530771D1
Authority
DE
Germany
Prior art keywords
healing
phenyl
breakage
bone
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69530771T
Other languages
English (en)
Other versions
DE69530771T2 (de
Inventor
George Joseph Cullinan
Masahiko Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69530771D1 publication Critical patent/DE69530771D1/de
Publication of DE69530771T2 publication Critical patent/DE69530771T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69530771T 1994-08-22 1995-08-21 Verwendung von 2-phenyl-3-aroylbenzothiophenderivaten zur herstellung eines medikaments zur knochen- und bruchheilung Expired - Fee Related DE69530771T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US294130 1994-08-22
US08/294,130 US5502074A (en) 1994-08-22 1994-08-22 Benzothiophenes for bone healing and fracture repair
PCT/US1995/010618 WO1996005825A1 (en) 1994-08-22 1995-08-21 Methods for bone healing and fracture repair

Publications (2)

Publication Number Publication Date
DE69530771D1 true DE69530771D1 (de) 2003-06-18
DE69530771T2 DE69530771T2 (de) 2004-03-11

Family

ID=23132010

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530771T Expired - Fee Related DE69530771T2 (de) 1994-08-22 1995-08-21 Verwendung von 2-phenyl-3-aroylbenzothiophenderivaten zur herstellung eines medikaments zur knochen- und bruchheilung

Country Status (20)

Country Link
US (1) US5502074A (de)
EP (1) EP0769945B1 (de)
JP (1) JPH10504578A (de)
KR (1) KR970705385A (de)
AT (1) ATE240101T1 (de)
AU (1) AU701946B2 (de)
CA (1) CA2198012A1 (de)
CZ (1) CZ51997A3 (de)
DE (1) DE69530771T2 (de)
DK (1) DK0769945T3 (de)
ES (1) ES2197207T3 (de)
FI (1) FI970715A0 (de)
HU (1) HUT76855A (de)
IL (1) IL115016A (de)
MX (1) MX9701332A (de)
NO (1) NO970785L (de)
PH (1) PH31620A (de)
PT (1) PT769945E (de)
WO (1) WO1996005825A1 (de)
ZA (1) ZA956989B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856340A (en) 1995-02-28 1999-01-05 Eli Lilly And Company Method of treating estrogen dependent cancers
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
DK1112095T3 (da) 1998-09-11 2003-03-17 Michael Dr Raschke Biologisk aktive implantater
PT1175433E (pt) 1999-05-04 2005-11-30 Strakan Int Ltd Glicosidos androgenos e sua actividade androgenica

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US5075321A (en) * 1987-03-24 1991-12-24 University Of Pennsylvania Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
DE4122484A1 (de) * 1991-07-06 1993-01-07 Teves Gmbh Alfred Schaltungsanordnung zur erkennung von radsensordefekten
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
TW303299B (de) * 1993-07-22 1997-04-21 Lilly Co Eli

Also Published As

Publication number Publication date
WO1996005825A1 (en) 1996-02-29
EP0769945A4 (de) 1997-09-03
NO970785D0 (no) 1997-02-20
DK0769945T3 (da) 2003-06-10
IL115016A (en) 1999-09-22
HUT76855A (en) 1997-12-29
ES2197207T3 (es) 2004-01-01
US5502074A (en) 1996-03-26
IL115016A0 (en) 1995-12-08
PH31620A (en) 1999-01-12
CZ51997A3 (en) 1997-08-13
ZA956989B (en) 1997-02-21
NO970785L (no) 1997-02-20
MX9701332A (es) 1997-05-31
EP0769945B1 (de) 2003-05-14
DE69530771T2 (de) 2004-03-11
PT769945E (pt) 2003-09-30
KR970705385A (ko) 1997-10-09
EP0769945A1 (de) 1997-05-02
FI970715A (fi) 1997-02-20
AU701946B2 (en) 1999-02-11
AU3409795A (en) 1996-03-14
FI970715A0 (fi) 1997-02-20
JPH10504578A (ja) 1998-05-06
CA2198012A1 (en) 1996-02-29
ATE240101T1 (de) 2003-05-15

Similar Documents

Publication Publication Date Title
ATE189601T1 (de) Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen
ATE205712T1 (de) Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung der angiogenese und angiogene krankheiten
ATE199642T1 (de) Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung des knorpelabbaus
NO970786L (no) Fremgangsmåte for hemming av benprotesedegradering
DE69227583T2 (de) Arylmorpholine, herstellung und verwendung
DE69530771D1 (de) Verwendung von 2-phenyl-3-aroylbenzothiophenderivaten zur herstellung eines medikaments zur knochen- und bruchheilung
EA199700136A1 (ru) Способы ингибирования экзогенных эстрогенов
DE69520741T2 (de) Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung der primären endometriumhyperplasie
DE69509657T2 (de) Verwendung von benzothiophenen zur herstellung eines medikaments zur verminderung der narbenbildung bei der wundheilung
MX9701331A (es) Metodos para mantener los dientes y los huesos bucales.
MX9709536A (es) Metodo para reducir el factor de transcripcion bef-1.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee