KR970005838B1 - 안지오텐신-전환효소 억제제와 칼슘 길항제를 함유하는 약제학적 조성물 - Google Patents

안지오텐신-전환효소 억제제와 칼슘 길항제를 함유하는 약제학적 조성물 Download PDF

Info

Publication number
KR970005838B1
KR970005838B1 KR1019870011035A KR870011035A KR970005838B1 KR 970005838 B1 KR970005838 B1 KR 970005838B1 KR 1019870011035 A KR1019870011035 A KR 1019870011035A KR 870011035 A KR870011035 A KR 870011035A KR 970005838 B1 KR970005838 B1 KR 970005838B1
Authority
KR
South Korea
Prior art keywords
alkyl
substituted
phenyl
group
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1019870011035A
Other languages
English (en)
Korean (ko)
Other versions
KR880005150A (ko
Inventor
벡커 라인하르트
헤닝 라이너
뤼거 볼프강
티츠 볼커
우르바흐 한스요르그
Original Assignee
훽스트 아크티엔게젤샤프트
하인리히 벡커·베른 하르트 벡크
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36747182&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR970005838(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 훽스트 아크티엔게젤샤프트, 하인리히 벡커·베른 하르트 벡크 filed Critical 훽스트 아크티엔게젤샤프트
Publication of KR880005150A publication Critical patent/KR880005150A/ko
Application granted granted Critical
Publication of KR970005838B1 publication Critical patent/KR970005838B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019870011035A 1986-10-02 1987-10-02 안지오텐신-전환효소 억제제와 칼슘 길항제를 함유하는 약제학적 조성물 Expired - Lifetime KR970005838B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP3633496.0 1986-10-02
DE19863633496 DE3633496A1 (de) 1986-10-02 1986-10-02 Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
AT0260087A AT402894B (de) 1986-10-02 1987-10-08 Kombination von angiotensin-converting-enzyme- hemmern mit calciumantagonisten sowie ein erzeugnis, das diese enthält, zur anwendung bei der behandlung des bluthochdrucks

Publications (2)

Publication Number Publication Date
KR880005150A KR880005150A (ko) 1988-06-28
KR970005838B1 true KR970005838B1 (ko) 1997-04-21

Family

ID=36747182

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870011035A Expired - Lifetime KR970005838B1 (ko) 1986-10-02 1987-10-02 안지오텐신-전환효소 억제제와 칼슘 길항제를 함유하는 약제학적 조성물

Country Status (26)

Country Link
US (3) US5098910A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0265685B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JP2752043B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR970005838B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR243083A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (2) ATE78697T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU611863B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1317545C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD272035A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (3) DE3633496A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK167904B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EG (1) EG18081A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2043626T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI874281A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006042T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU199302B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE59975B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL84054A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU90345I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MA (1) MA21072A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX8639A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL980030I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (2) NO175621C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ221989A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT85843B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA877385B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7355581B2 (en) 2003-07-02 2008-04-08 Lg.Philips Lcd Co., Ltd. Analog buffer circuit for liquid crystal display device

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
NL8702502A (nl) * 1986-11-03 1988-06-01 Sandoz Ag Farmaceutisch preparaat voor toepassing tegen hypertensie en congestieve cardiale insufficientie.
FR2607004B1 (fr) * 1986-11-20 1990-06-01 Synthelabo Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine
USH734H (en) * 1988-03-07 1990-02-06 E. R. Squibb & Sons, Inc. Method for inhibiting onset of or treating migraine headaches employing an ACE inhibitor
JPH01275529A (ja) * 1988-03-21 1989-11-06 E R Squibb & Sons Inc 晩発性運動障害の抑制治療剤
DE3818245A1 (de) * 1988-05-28 1989-12-07 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit kaliumkanal-modulatoren sowie deren verwendung in arzneimitteln
EP0391462A1 (en) * 1989-04-05 1990-10-10 Janssen Pharmaceutica N.V. Synergistic compositions containing ketanserin
TW197945B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-11-27 1993-01-11 Hoechst Ag
DE4109134A1 (de) * 1991-03-20 1992-09-24 Knoll Ag Erzeugnisse, enthaltend verapamil und trandolapril
US6162802A (en) * 1992-03-10 2000-12-19 Papa; Joseph Synergistic combination therapy using benazepril and amlodipine for the treatment of cardiovascular disorders and compositions therefor
DE4314962A1 (de) * 1993-05-06 1994-11-10 Bayer Ag Substituierte Piperazine
JP3057471B2 (ja) 1993-06-07 2000-06-26 武田薬品工業株式会社 アンジオテンシンｉｉ介在性諸疾患の予防または治療剤
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
US5658832A (en) * 1994-10-17 1997-08-19 Regents Of The University Of California Method of forming a spacer for field emission flat panel displays
US6245787B1 (en) * 1995-03-16 2001-06-12 Pfizer Inc. Composition containing amlodipine or a pharmaceutically acceptable salt thereof, and an ACE inhibitor
FR2733911B1 (fr) * 1995-05-09 1998-05-29 Takeda Chemical Industries Ltd Composition pharmaceutique pour maladies renales ou cardio-vasculaires
EP0795327A1 (en) * 1996-03-13 1997-09-17 Pfizer Inc. Use of Amlodipine for the treatment and prophylaxis of congestive cardiac failure of non-ischaemic origin
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
CN1268331C (zh) * 1999-08-30 2006-08-09 萨诺费－阿文蒂斯德国有限公司 肾素－血管紧张素系统抑制剂在制备预防心血管疾病的药物中的用途
US20040005359A1 (en) * 2002-06-27 2004-01-08 Cheng Xiu Xiu Controlled release oral dosage form
US20040147566A1 (en) * 2002-10-16 2004-07-29 Amedeo Leonardi Lisinopril/lercanidipine combination therapy
US20050101640A1 (en) * 2002-10-16 2005-05-12 Recordati Ireland Limited Lisinopril/lercanidipine combination therapy
US20050032784A1 (en) * 2003-04-01 2005-02-10 University Of Florida Research Foundation, Inc. Combination drug therapy for treating hypertension
EP1817007A2 (en) * 2004-11-05 2007-08-15 King Pharmaceuticals Research and Development Inc. Stabilized individually coated ramipril particles, compositions and methods
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
US20110123612A1 (en) * 2008-04-10 2011-05-26 Sung Wuk Kim Pharmaceutical preparation containing non-dihydropyridine calcium channel blocker and angiotensin-2 receptor blocker
KR20120130761A (ko) 2010-02-24 2012-12-03 사노피-아벤티스 도이칠란트 게엠베하 라미프릴 및 암로디핀 베실레이트의 고형 약제학적 제형, 및 이의 제조
RU2543637C2 (ru) * 2012-12-06 2015-03-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здавоохранения Российской Федерации Пролонгированная фармацевтическая композиция гипотензивного действия и способ ее изготовления

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
AT358908B (de) * 1979-02-20 1980-10-10 Heinzle August Stickmaschine
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2491469A1 (fr) * 1980-10-02 1982-04-09 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
DE3032709A1 (de) * 1980-08-30 1982-04-29 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3177130D1 (de) * 1980-08-30 1990-01-11 Hoechst Ag Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
IL63813A0 (en) * 1980-09-17 1981-12-31 Univ Miami Carboxyalkyl peptides and thioethers and ethers of peptides,antihypertensive compositions and methods for their use
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
SU1327787A3 (ru) * 1981-11-05 1987-07-30 Хехст Аг (Фирма) Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
DE3242151A1 (de) * 1982-11-13 1984-05-17 Hoechst Ag, 6230 Frankfurt Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3300316A1 (de) * 1983-01-07 1984-07-12 Hoechst Ag, 6230 Frankfurt Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3300774A1 (de) * 1983-01-12 1984-07-12 Hoechst Ag, 6230 Frankfurt Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung
DE3303112A1 (de) * 1983-01-31 1984-08-09 Hoechst Ag, 6230 Frankfurt Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
DE3324263A1 (de) * 1983-07-06 1985-01-17 Hoechst Ag, 6230 Frankfurt Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE3345355A1 (de) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
DE3437917A1 (de) * 1984-10-17 1986-04-17 Bayer Ag, 5090 Leverkusen Kombination von dihydropyridinen mit ace-hemmern sowie ihre verwendung in arzneimitteln
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
IL77843A (en) * 1985-02-11 1989-07-31 Syntex Inc Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them
US5256687A (en) * 1985-09-09 1993-10-26 Hoechst Aktiengesellschaft Pharmaceutical composition for the treatment of high blood pressure
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives
DE3629060A1 (de) * 1986-08-27 1988-03-03 Bayer Ag Kombination von positiv inotrop wirkenden dihydropyridinen mit ace-hemmern, sowie ihre verwendung in arzneimitteln
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
US4882894A (en) * 1986-10-14 1989-11-28 W. R. Grace & Co.-Conn. Agent for imparting antistatic characteristics to a thermoplastic polymer and a thermoplastic polymer composition containing the agent
FR2607004B1 (fr) * 1986-11-20 1990-06-01 Synthelabo Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7355581B2 (en) 2003-07-02 2008-04-08 Lg.Philips Lcd Co., Ltd. Analog buffer circuit for liquid crystal display device

Also Published As

Publication number Publication date
JP3003995B2 (ja) 2000-01-31
HU199302B (en) 1990-02-28
US5500434A (en) 1996-03-19
JPH10182456A (ja) 1998-07-07
LU90345I2 (fr) 1999-04-06
DE3633496A1 (de) 1988-04-14
CA1317545C (en) 1993-05-11
ATE78697T1 (de) 1992-08-15
DK516487D0 (da) 1987-10-01
AU611863B2 (en) 1991-06-27
NO1998022I1 (no) 1998-10-12
HUT47030A (en) 1989-01-30
NO175621C (no) 1994-11-09
ES2043626T3 (es) 1994-01-01
AT402894B (de) 1997-09-25
DD272035A5 (de) 1989-09-27
AR243083A1 (es) 1993-07-30
NO874141L (no) 1988-04-05
AU7928087A (en) 1988-04-14
FI874281A7 (fi) 1988-04-03
JPS6396136A (ja) 1988-04-27
IE59975B1 (en) 1994-05-04
IE872636L (en) 1988-04-02
MX8639A (es) 1993-11-01
NL980030I2 (nl) 1999-10-01
EP0265685A2 (de) 1988-05-04
ZA877385B (en) 1988-05-25
EP0265685A3 (en) 1989-10-11
EG18081A (en) 1991-08-30
EP0265685B1 (de) 1992-07-29
DK167904B1 (da) 1994-01-03
FI874281A0 (fi) 1987-09-30
DE3780753D1 (de) 1992-09-03
NZ221989A (en) 1990-11-27
NO175621B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-08-01
MA21072A1 (fr) 1988-07-01
NO874141D0 (no) 1987-10-01
GR3006042T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-21
NL980030I1 (nl) 1999-01-04
ATA260087A (de) 1997-02-15
US5721244A (en) 1998-02-24
IL84054A (en) 1993-01-31
DK516487A (da) 1988-04-03
PT85843A (de) 1987-11-01
JP2752043B2 (ja) 1998-05-18
IL84054A0 (en) 1988-03-31
PT85843B (pt) 1991-02-08
KR880005150A (ko) 1988-06-28
DE19975008I2 (de) 2004-07-01
US5098910A (en) 1992-03-24

Similar Documents

Publication Publication Date Title
KR970005838B1 (ko) 안지오텐신-전환효소 억제제와 칼슘 길항제를 함유하는 약제학적 조성물
US5256687A (en) Pharmaceutical composition for the treatment of high blood pressure
KR930008094B1 (ko) 안기오텐신 전환효소 억제제의 제조방법
KR0185969B1 (ko) 심장 및 혈관의 비대 및 과형성을 치료하기 위한 약제학적 조성물
US5744496A (en) Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors
US4975453A (en) Combination of angiotensin converting enzyme inhibitors with potassium channel modulators and use thereof in pharmaceuticals
JP2608355B2 (ja) カルシウムアンタゴニストおよびアンギオテンシン変換酵素阻害剤の組合せからなるタンパク質尿症治療剤
US5684016A (en) Method of treating cardiac insufficiency
AU597270B2 (en) A pharmaceutical composition for the treatment of high blood pressure
HK1006148B (en) Use of a combination of an ace inhibitor with a calcium antagonist in the treatment of proteinuria

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19871002

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19921002

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19871002

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19960329

Patent event code: PE09021S01D

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19960919

Patent event code: PE09021S01D

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19970320

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19970624

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19970919

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19970919

End annual number: 3

Start annual number: 1

PR1001 Payment of annual fee

Payment date: 20000212

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20010217

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20020227

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20030304

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 20040729

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20050729

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20060801

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20070906

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20080911

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20090910

Start annual number: 13

End annual number: 13

PR1001 Payment of annual fee

Payment date: 20100910

Start annual number: 14

End annual number: 14

FPAY Annual fee payment

Payment date: 20110811

Year of fee payment: 15

PR1001 Payment of annual fee

Payment date: 20110811

Start annual number: 15

End annual number: 15

EXPY Expiration of term
PC1801 Expiration of term