KR960017670A - 결정성 세펨 산부가염 및 이의 제조방법 - Google Patents

결정성 세펨 산부가염 및 이의 제조방법 Download PDF

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KR960017670A
KR960017670A KR1019950040388A KR19950040388A KR960017670A KR 960017670 A KR960017670 A KR 960017670A KR 1019950040388 A KR1019950040388 A KR 1019950040388A KR 19950040388 A KR19950040388 A KR 19950040388A KR 960017670 A KR960017670 A KR 960017670A
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acid
formula
compound
general formula
carboxylic
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KR1019950040388A
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KR100449191B1 (ko
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라트렐 루돌프
뒤르크하이머 발터
슈미트 페터
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로제르트, 루츠
훽스트 아크티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 항균 활성을 갖는 하기 일반식(Ⅰ)의 화합물에 관한 것이다.
상기식에서 n은 1 또는 2이고, m은 0.4 내지 0.6이며, X는 카복실산의 음이온이다.

Description

결정성 세펨 산부가염 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(Ⅰ)의 화합물.
    상기식에서 n은 1 또는 2이고, m은 0.4 내지 0.6이며, X는 일반식
    의 페놀성 카복실산의 음이온 또는 일반식의 하이드록시 페닐아세트산의 음이온 또는 일반식의 하이드록시 신남산의 음이온 또는 일반식의 하이드록시 힙푸르산의 음이온이고, R 및 R′는 서로 독립적으로 수소, 카복실, 하이드록실, 할로겐, 직쇄 또는 측쇄 포화 또는 불포화 지방족 C1-C5-알킬 라디칼 또는 C1-C5-알콕시 라디칼이며, 이염기산(diprotic acid)일 경우 X는일 수 있다.
  2. 제1항에 있어서, X가 일반식(Ⅱ) 내지 (Ⅴ)의 카복실산의 음이온이고, R 및 R′가 서로 독립적으로 수소, 카복실, 하이드록실, 메틸 또는 메톡시이며, m이 0.5 내지 2인 일반식(Ⅰ)의 화합물.
  3. 제1항 또는 제2항에 있어서, X가 2,4-, 2,5- 또느 3,5-디-하이드록시벤조산과 같은 디하이드록시벤조산; 갈산과 같은 트리하이드록시벤조산; 4-하이드록시이소프탈산과 같은 하이드록시디디카복실산; 2-하이드록시나프탈렌-1-카복실산 또는 6-하이드록시나프탈렌-1-1-카복실산과 같은 하이드록시나프탈렌 카복실산; 5,5′-메틸렌비스-4-하이드록시벤조산과 같은 메틸렌비스하이드록시벤조산;엠본산과 같은 메틸렌비스하이드록시나프토산; 페롤산과 같은 하이드록시신남산; 및 살리푸르산과 같은 하이드록시힙푸르산으로 이루어진 그룹중에서 선택환 화합물의 음이온인 일반식(Ⅰ)의 화합물.
  4. 디하이드로클로라이드, 디하이드로요오다이드 또는 설페이트와 같은 일반식(Ⅰ)의 수용성 염과 일반식 (Ⅱ), (Ⅲ), (Ⅳ) 또는 (Ⅴ)의 카복실산 염을 반응시키거나, 또는 일반식(Ⅵ)의 세팸 베타인과 일반식(Ⅱ), (Ⅲ), (Ⅳ) 또는 (Ⅴ)의 카복실산을 반응시킴을 포함하여, 제1항 내지 제3항 중 어느 한 항에 따른 일반식(Ⅰ)의 화합물을 제조하는 방법
    상기식에서, n은 일반식(Ⅰ)에 대해 정의한 바와같다.
  5. 약제로서 사용하기 위한 제1항 내지 제3항 중 어느 한 항에 따른 일반식(Ⅰ)의 화합물.
  6. 세균 감염 치료용 약제의 제조를 위한 일반식(Ⅰ)의 화합물의 용도.
  7. 제1항 내지 제3항 중 어느 한 항에 따른 일반식(Ⅰ)의 화합물을, 경우에 따라 적합한 부형제, 회석제 또는 완층물질을 사용하여 적합한 투여 형태로 만듦을 포함하는, 제7항에 따른 약제의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950040388A 1994-11-10 1995-11-09 결정성세펨산부가염,이의제조방법및이를함유하는약제학적조성물 KR100449191B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4440141A DE4440141A1 (de) 1994-11-10 1994-11-10 Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung
DEP4440141.8 1994-11-10

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KR960017670A true KR960017670A (ko) 1996-06-17
KR100449191B1 KR100449191B1 (ko) 2006-01-12

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US (1) US5747484A (ko)
EP (1) EP0711774B1 (ko)
JP (1) JP3920939B2 (ko)
KR (1) KR100449191B1 (ko)
CN (1) CN1066452C (ko)
AR (1) AR002246A1 (ko)
AT (1) ATE213248T1 (ko)
AU (1) AU707730B2 (ko)
BR (1) BR9505132A (ko)
CA (1) CA2162530C (ko)
CZ (1) CZ290936B6 (ko)
DE (2) DE4440141A1 (ko)
DK (1) DK0711774T3 (ko)
ES (1) ES2172549T3 (ko)
FI (1) FI120263B (ko)
HU (1) HU219475B (ko)
IL (1) IL115914A (ko)
MA (1) MA23709A1 (ko)
NO (1) NO311891B1 (ko)
NZ (1) NZ280424A (ko)
OA (1) OA10242A (ko)
PL (1) PL182806B1 (ko)
PT (1) PT711774E (ko)
RU (1) RU2161619C2 (ko)
SK (1) SK282545B6 (ko)
TR (1) TR199501392A2 (ko)
TW (1) TW422847B (ko)
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Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
WO1998049130A2 (en) * 1997-04-29 1998-11-05 The University Of New Mexico Hydroxynaphthoic acids and derivatives
CA2501395C (en) * 2002-10-25 2011-05-24 Akzo Nobel Nv Prolonged release pharmaceutical composition
US20080318919A1 (en) * 2005-10-29 2008-12-25 Intervet International B.V. Cefquinome Compositions and Methods of Their Use
AR077320A1 (es) * 2009-07-20 2011-08-17 Intervet Int Bv Metodo para la preparacion de particulas de cefquinoma y formulaciones farmaceuticas que las comprenden.
EP2862569A1 (en) 2011-09-09 2015-04-22 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
EP2750706A4 (en) * 2011-09-29 2015-04-15 Alere San Diego Inc 2-HYDROXYHIPPURIC ACID ANALOGUES AND METHODS FOR THEIR SYNTHESIS AND USE
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9320740B2 (en) 2013-03-15 2016-04-26 Merck Sharp & Dohme Corp. Ceftolozane-tazobactam pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
KR102226197B1 (ko) 2013-03-15 2021-03-11 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE3316797A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung

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KR100449191B1 (ko) 2006-01-12
AU707730B2 (en) 1999-07-15
PL182806B1 (pl) 2002-03-29
AU3772895A (en) 1996-05-16
CA2162530C (en) 2007-07-31
OA10242A (fr) 1997-09-19
ES2172549T3 (es) 2002-10-01
CA2162530A1 (en) 1996-05-11
AR002246A1 (es) 1998-03-11
BR9505132A (pt) 1997-09-09
FI955382A (fi) 1996-05-11
NO311891B1 (no) 2002-02-11
MA23709A1 (fr) 1996-07-01
DE59510048D1 (de) 2002-03-21
IL115914A (en) 2002-08-14
RU2161619C2 (ru) 2001-01-10
DK0711774T3 (da) 2002-04-22
TR199501392A2 (tr) 1996-07-21
EP0711774A1 (de) 1996-05-15
HU219475B (hu) 2001-04-28
JP3920939B2 (ja) 2007-05-30
FI955382A0 (fi) 1995-11-08
NZ280424A (en) 1997-06-24
EP0711774B1 (de) 2002-02-13
PT711774E (pt) 2002-07-31
SK282545B6 (sk) 2002-10-08
HUT74163A (en) 1996-11-28
PL311326A1 (en) 1996-05-13
HU9503213D0 (en) 1996-01-29
CN1066452C (zh) 2001-05-30
JPH08208662A (ja) 1996-08-13
CZ293395A3 (en) 1996-05-15
ATE213248T1 (de) 2002-02-15
TW422847B (en) 2001-02-21
SK139795A3 (en) 1996-06-05
US5747484A (en) 1998-05-05
IL115914A0 (en) 1996-01-31
NO954511L (no) 1996-05-13
CZ290936B6 (cs) 2002-11-13
NO954511D0 (no) 1995-11-09
DE4440141A1 (de) 1996-05-15
CN1129220A (zh) 1996-08-21
ZA959510B (en) 1996-05-28
FI120263B (fi) 2009-08-31

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