KR960014095A - O-치환된 히드록실암모늄염의 제조 방법 - Google Patents

O-치환된 히드록실암모늄염의 제조 방법 Download PDF

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KR960014095A
KR960014095A KR1019950036526A KR19950036526A KR960014095A KR 960014095 A KR960014095 A KR 960014095A KR 1019950036526 A KR1019950036526 A KR 1019950036526A KR 19950036526 A KR19950036526 A KR 19950036526A KR 960014095 A KR960014095 A KR 960014095A
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South Korea
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formula
acetone oxime
acetone
iii
give
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KR1019950036526A
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KR100374953B1 (ko
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카일 미하엘
바알 죠세프
클라인 울리히
빌 볼프강
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방게르트, 빅케
바스프 악티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/12—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reactions not involving the formation of oxyimino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/10—Process efficiency

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

본 발명은 중간체를 분리함이 없이 a) 아세톤을 히드록실암모늄 황산염 및 수산화나트륨 용액과 반응시켜 아세톤 옥심을 얻고; b) 상기와 같이 얻어진 아세톤 옥심 용액을 수산화나트륨 용액과 반응시키고 물을 완전히 제거한 다음, c)상기와 같이 얻어진 아세톤 옥심 나트륨염 현탄액을 0.5 내지 15bar, 140℃이하에서 알킬화제와 반응시켜 아세톤 옥심 에테르를 생성시키고; d) 산 HX로 아세톤 옥심 에테르를 분해해서 일반식(I)의 생성물을 얻는 것(상기 a) 내지 d)의 모든 단계에서 균질한 비극성 비양성자성 용매가 사용된다)으로 이루어진, 통합된 방식의 하기 일반식(I)의 O-치환된 히드록실암모늄염의 제조방법이다.
상기식에서, R은 C1-C6-알킬 또는 C2-C6-알케닐 라디칼이며, 각 가리칼은 할로겐-치환될 수 있고; X는 염소 또는 브롬이다.

Description

O-치환된 히드록실암모늄염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 중간체를 분리함이 없이 a) 아세톤을 히드록실암모늄 황산염 및 수산화타트륨 용액과 반응시켜 구조식 (II)의 아세톤 옥심을 얻고 ;
    b) 상기와 같이 얻어진 아세톤 옥심 용액을 수산화나트륨 용액으로 처리하고 물을 완전히 제거한 다음, c) 상기와 같이 얻어진 아세톤 옥심 나트륨염 (III)의 현탁액을 0.5 내지 15bar 및 140℃이하에서, 필요에 따라 상 전환 촉매 첨가하에, 일반식(IV)의 알킬화제와 반응시켜 일반식(V)의아세톤 옥심 에테르를 생성시키고;
    (상기 식에서, R은 일반식(I)에서와 같은 의미를 가지며; Y는 탈핵성 이탈기이다.), d) 산 HX로 아세톤 옥심 에테르를 분해해서 일반식(I)의 생성물을 얻는 것(상기 a) 내지 d)의 모든 단계에서 균질한 비극성 비양성자성 용매가 사용된다)으로 이루어진, 통합된 방식의 하기 일반식(I)의 O-치환된 히드록실암모늄염의 제조방법
    상기식에서, R은 C1-C6-알킬 또는 C2-C6-알케닐 라디칼이며, 각 가리칼은 할로겐-치환될 수 있고; X는 염소 또는 브롬이다.
  2. 제1항에 있어서, 사용되는 용매가 톨루엔, 크실렌, 헥산 또는 시클로헥산인 방법.
  3. 제1항에 있어서, 사용되는 용매가 톨루엔인 방법.
  4. 제1항에 있어서, 사용되는 알킬화제가 메틸 클로라이드인 방법.
  5. 제1항에 있어서, 사용되는 상-전환 촉매가 테트라부틸암모늄 브로마이드인 방법.
  6. 제1항에 있어서, 사용되는 산 HX가 진한 염산인 방법.
  7. 제1항에 있어서, 아세톤 옥심(II)를 거의 등 몰량의 수산화나트륨 용액과 반응시켜 나트륨염 (III)을 얻는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950036526A 1994-10-22 1995-10-21 O-치환된히드록실암모늄염의제조방법 KR100374953B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4437905.6 1994-10-22
DE4437905A DE4437905A1 (de) 1994-10-22 1994-10-22 Verfahren zur Herstellung von O-substituierten Hydroxylammoniumsalzen

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KR960014095A true KR960014095A (ko) 1996-05-22
KR100374953B1 KR100374953B1 (ko) 2003-11-20

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US (1) US5557013A (ko)
EP (2) EP0885878B1 (ko)
JP (1) JP4062369B2 (ko)
KR (1) KR100374953B1 (ko)
AT (2) ATE234277T1 (ko)
CA (1) CA2161062C (ko)
DE (3) DE4437905A1 (ko)
ES (2) ES2195240T3 (ko)
HU (1) HU218586B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5777164A (en) * 1997-04-14 1998-07-07 Eastman Chemical Company Process for the preparation of high purity O-substituted hydroxylamine derivatives
DE19911234A1 (de) * 1999-03-15 2000-09-28 Basf Ag Verfahren zur kontinuierlichen Herstellung von Methoxyamin-Hydrochlorid
CN102976968A (zh) * 2012-12-01 2013-03-20 张家港市大伟助剂有限公司 一种甲氧胺盐酸盐的制备方法
CN113429313B (zh) * 2021-06-09 2022-07-12 浙江锦华新材料股份有限公司 一种丙酮肟甲醚的制备方法
CN113735736A (zh) * 2021-07-06 2021-12-03 四平市精细化学品有限公司 一种以间苯三酚为平台分子合成甲氧胺的方法
CN114591197A (zh) * 2022-03-01 2022-06-07 浙江圣安化工股份有限公司 一种连续合成肟醚的工艺方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2927117A1 (de) * 1979-07-05 1981-01-08 Basf Ag Verfahren zur herstellung von o-substituierten ketoximen
FR2472482B1 (fr) * 1979-07-25 1985-11-08 Feron De Longcamp Le Nouvelle roue deformable, utilisable en particulier comme roue de vehicule ou dans un engrenage
EP0121701B1 (en) * 1983-04-04 1988-08-24 Allied Corporation Process for the production of o-substituted oximes
IT1210093B (it) * 1984-03-28 1989-09-06 Ispe Di Erminio Giana E C Sas Dispositivo per la protezione di strutture edefici o simili dai fulmini
DE3565398D1 (en) * 1984-04-12 1988-11-10 Allied Signal Inc Process for the synthesis of o-substituted oxime compounds and the conversion thereof into the corresponding hydroxylamine o-substituted
US4755738A (en) * 1986-09-11 1988-07-05 Kabushiki Kaisha Toshiba Reactive power compensation apparatus
DE4233333A1 (de) * 1992-10-05 1994-04-07 Basf Ag Verfahren zur Herstellung von O-substituierten Hydroxylammoniumsalzen
US5488162A (en) * 1994-01-03 1996-01-30 Buckland; Paul R. Process for preparing o-alkylhydroxylamine salts without the isolation of intermediates

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US5557013A (en) 1996-09-17
ATE234277T1 (de) 2003-03-15
JPH08176088A (ja) 1996-07-09
EP0708082B1 (de) 1999-04-07
DE4437905A1 (de) 1996-04-25
EP0885878A1 (de) 1998-12-23
ATE178587T1 (de) 1999-04-15
DE59510588D1 (de) 2003-04-17
HUT73159A (en) 1996-06-28
ES2195240T3 (es) 2003-12-01
CA2161062C (en) 2003-12-16
JP4062369B2 (ja) 2008-03-19
HU9503038D0 (en) 1995-12-28
HU218586B (hu) 2000-10-28
ES2129728T3 (es) 1999-06-16
CA2161062A1 (en) 1996-04-23
EP0885878B1 (de) 2003-03-12
KR100374953B1 (ko) 2003-11-20
EP0708082A1 (de) 1996-04-24
DE59505578D1 (de) 1999-05-12

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