KR950702963A - 광학활성 1,4-디히드로피리딘 화합물 및 그의 제조방법 - Google Patents

광학활성 1,4-디히드로피리딘 화합물 및 그의 제조방법 Download PDF

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KR950702963A
KR950702963A KR1019950700567A KR19950700567A KR950702963A KR 950702963 A KR950702963 A KR 950702963A KR 1019950700567 A KR1019950700567 A KR 1019950700567A KR 19950700567 A KR19950700567 A KR 19950700567A KR 950702963 A KR950702963 A KR 950702963A
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group
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lower alkanoyl
optically active
dihydropyridine compound
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KR1019950700567A
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KR100244728B1 (ko
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구니오 이시히키
다카시 나카시마
다케오 요시오카
히로시 츠네카와
다카시 아다치
토모미 오타
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스즈키 타다오
메르시안 가부시키 가이샤
우에하라 아키라
다이쇼 세이야쿠 가부시키 가이샤
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Publication of KR950702963A publication Critical patent/KR950702963A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

비스(치환 아미노알킬) 1,4-디히드로-2,6-디메틸-4-(니트로페닐)피리딘-3,5-디카르복실레이트를 스트렙토 마이세스속, 파애실로마이세스속, 보트리오디오플로디아속, 알터나리아속 또는 헬민트스포리움속에 속하는 부제 가수분해능을 갖는 미생물 또는 그의 처리물과 반응시킴으로써 (4R)-3-(치환 아미노알킬)옥시카르보닐-1,4-디히드로-2,6-디메틸-4-(니트로페닐)피리딘-5-카르복실산이 효율 좋게 얻어진다. 이 화합물은 협심중, 고혈압 등의 예방 또는 치료약으로서 유용한 의약품의 중요한 제조중간체로서 극히 유용하다.

Description

광학활성 1,4-디히드로피리딘 화합물 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식(I)
    (식중, R은 저급알카노일기, 복소환카르복실기, 할로치환아세틸기, 알콕시아세틸기, 아릴옥시아세틸기, 치환 또는 비치환페닐 저급알카노일기, 페닐치환 또는 비치환치급 알케노일기, 알콕시 또는 알케닐옥시카르보닐기, 아르알킬옥시카르보닐기 또는 유기에스테르기를 나타내고, n은 2∼4의 정수를 나타낸다)로 표시되는 화합물 또는 그의 염을 스트렙토마이세스속, 파애실로마이세스속, 보트리오디오플로다이속, 알터나리아속 또는 헬민트스포리움속에 속하는 부제가수분해 기능을 갖는 미생물 또는 그의 처리물과 반응시킴으로서 생성하는 하기 식(II)
    (식중, R및 n은 전술한 바와 같다)로 표시되는 광학활성 1,4-디히드로피리딘 화합물 또는 그의 염을 채취하는 것을 특징으로 하는 광학활성(4R)-1,4-디히드로-2,6-디메틸-4-(니트로페닐)피리딘-3,5-디카르복실산모노 에스테르 유도체의 제조방법.
  2. 하기 일반식(III)
    (식중, R1는 저급알카노일기를 나타내고, n은 2∼4의 정수를 나타낸다)로 표시되는 1,4-디히드로피리딘 화합물.
  3. 하기 일반식(IV)
    (식중, R1은 저급알카노일기를 나타내고, n은 2∼4의 정수를 나타낸다)로 표시되는 광학활성 1,4-디히드로 피리딘 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950700567A 1992-08-31 1993-08-31 광학활성 1,4-디히드로피리딘 화합물 및 그의 제조방법 KR100244728B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP231877/1992 1992-08-31
JP23187792 1992-08-31
PCT/JP1993/001222 WO1994005637A1 (en) 1992-08-31 1993-08-31 Optically active 1,4-dihydropyridine compound and process for producing the same

Publications (2)

Publication Number Publication Date
KR950702963A true KR950702963A (ko) 1995-08-23
KR100244728B1 KR100244728B1 (ko) 2000-03-02

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KR1019950700567A KR100244728B1 (ko) 1992-08-31 1993-08-31 광학활성 1,4-디히드로피리딘 화합물 및 그의 제조방법

Country Status (8)

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US (1) US5635395A (ko)
EP (1) EP0657429B1 (ko)
KR (1) KR100244728B1 (ko)
AT (1) ATE200484T1 (ko)
AU (1) AU4981893A (ko)
CA (1) CA2143106A1 (ko)
DE (1) DE69330130T2 (ko)
WO (1) WO1994005637A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE220395T1 (de) * 1994-08-29 2002-07-15 Mercian Corp 1,4-dihydropyridin-derivate
JP3529099B2 (ja) 1995-07-31 2004-05-24 メルシャン株式会社 ４−置換−１，４−ジヒドロピリジン誘導体の不斉加水分解酵素活性タンパク質をコードする遺伝子およびその発現産物
KR20010020267A (ko) * 1997-04-25 2001-03-15 에가시라 구니오 신규한 디하이드로피리딘 유도체
US6145143A (en) * 1999-06-03 2000-11-14 Kinetic Concepts, Inc. Patient support systems with layered fluid support mediums

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法
US5234821A (en) * 1990-09-01 1993-08-10 Kazuo Achiwa Process for preparing 1,4 dihydropyridine compounds
US5100892A (en) * 1990-11-13 1992-03-31 Glaxo Inc. Dihydropyridine vasodilator agents
JPH0584089A (ja) * 1991-03-01 1993-04-06 Taisho Pharmaceut Co Ltd 光学活性１，４−ジヒドロピリジン化合物の製造法
JPH04299994A (ja) * 1991-03-26 1992-10-23 Taisho Pharmaceut Co Ltd 光学活性１，４−ジヒドロピリジン化合物の製造法
JP3286645B2 (ja) * 1993-03-26 2002-05-27 メルシャン株式会社 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法

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Publication number Publication date
EP0657429A1 (en) 1995-06-14
EP0657429A4 (en) 1996-03-27
KR100244728B1 (ko) 2000-03-02
CA2143106A1 (en) 1994-03-17
EP0657429B1 (en) 2001-04-11
US5635395A (en) 1997-06-03
DE69330130D1 (de) 2001-05-17
WO1994005637A1 (en) 1994-03-17
AU4981893A (en) 1994-03-29
DE69330130T2 (de) 2001-08-02
ATE200484T1 (de) 2001-04-15

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