DE3891212T1 - Assays unter verwendung von verbesserten chemilumineszierenden estern, thioestern und amiden - Google Patents

Assays unter verwendung von verbesserten chemilumineszierenden estern, thioestern und amiden

Info

Publication number
DE3891212T1
DE3891212T1 DE883891212T DE3891212T DE3891212T1 DE 3891212 T1 DE3891212 T1 DE 3891212T1 DE 883891212 T DE883891212 T DE 883891212T DE 3891212 T DE3891212 T DE 3891212T DE 3891212 T1 DE3891212 T1 DE 3891212T1
Authority
DE
Germany
Prior art keywords
ring
linkage
ring system
substituent groups
heterocyclic ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE883891212T
Other languages
English (en)
Inventor
Frank Mccapra
Iraj Beheshti
Russel C Hart
Harlen Koelling
Ashokkumar Patel
Kastooriranganath Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
London Diagnostics Inc
Original Assignee
London Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26837818&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3891212(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by London Diagnostics Inc filed Critical London Diagnostics Inc
Publication of DE3891212T1 publication Critical patent/DE3891212T1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DE883891212T 1987-12-31 1988-12-30 Assays unter verwendung von verbesserten chemilumineszierenden estern, thioestern und amiden Withdrawn DE3891212T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14004087A 1987-12-31 1987-12-31
US29184388A 1988-12-29 1988-12-29
PCT/US1988/004719 WO1989006231A1 (en) 1987-12-31 1988-12-30 Assays utilizing improved chemiluminescent esters, thioesters and amides

Publications (1)

Publication Number Publication Date
DE3891212T1 true DE3891212T1 (de) 1991-01-10

Family

ID=26837818

Family Applications (3)

Application Number Title Priority Date Filing Date
DE883891212T Withdrawn DE3891212T1 (de) 1987-12-31 1988-12-30 Assays unter verwendung von verbesserten chemilumineszierenden estern, thioestern und amiden
DE3856358T Expired - Lifetime DE3856358T3 (de) 1987-12-31 1988-12-30 Für Tests verwendbare chemilumineszierende Ester, Thioester und Amide
DE3856597T Expired - Lifetime DE3856597D1 (de) 1987-12-31 1988-12-30 Testverfahren mit verbesserten Chemilumineszierenden Estern, Thioestern und Amiden

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE3856358T Expired - Lifetime DE3856358T3 (de) 1987-12-31 1988-12-30 Für Tests verwendbare chemilumineszierende Ester, Thioester und Amide
DE3856597T Expired - Lifetime DE3856597D1 (de) 1987-12-31 1988-12-30 Testverfahren mit verbesserten Chemilumineszierenden Estern, Thioestern und Amiden

Country Status (14)

Country Link
EP (2) EP0916658B1 (de)
JP (1) JP3172522B2 (de)
KR (1) KR900700888A (de)
AT (2) ATE183311T1 (de)
AU (1) AU635890B2 (de)
CA (1) CA1341613C (de)
DE (3) DE3891212T1 (de)
ES (1) ES2134185T5 (de)
GB (4) GB2232995B (de)
GR (1) GR3031647T3 (de)
IE (1) IE61614B1 (de)
IL (1) IL88848A (de)
NZ (1) NZ227506A (de)
WO (1) WO1989006231A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918192A (en) * 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
ES2063735T3 (es) * 1986-10-22 1995-01-16 Abbott Lab Sales de acridinio quimioluminiscentes.
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
JP2681061B2 (ja) * 1988-06-08 1997-11-19 ロンドン・ダイアグノスティック・インコーポレーテッド 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ
US5656426A (en) * 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
WO1994002486A1 (en) * 1992-07-20 1994-02-03 Syntex (U.S.A.) Inc. Novel chemiluminescent compounds and methods of use
US6002000A (en) * 1992-07-20 1999-12-14 Dade Behring Marburg Gmbh Chemiluminescent compounds and methods of use
EP0653066B1 (de) * 1992-07-31 1998-01-28 BEHRINGWERKE Aktiengesellschaft Photoaktivierbare chemiluminizierende matrices
JP3584379B2 (ja) * 1993-02-04 2004-11-04 持田製薬株式会社 アクリジニウム化合物およびアクリジニウム化合物複合体
US5395752A (en) * 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
US5393891A (en) * 1993-06-08 1995-02-28 The Du Pont Merck Pharmaceutical Company Immunoassay reagents and methods for detecting brequinar and analogs
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
EP0761652A1 (de) * 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Acridiniumverbindung mit mehreren lumineszierenden Gruppen und Bindungsgruppen und Konjugate derselben
US6030803A (en) * 1996-07-16 2000-02-29 De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Welzijn, Volksgeszonheid En Cultuur Dibenzodihydropyridinecarboxylic esters and their use in chemiluminescent assay methods
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
WO1999009012A1 (en) * 1997-08-21 1999-02-25 Maine Medical Center Peroxide-based chemiluminescent assays and chemiluminescent compounds used therein
US6723851B2 (en) * 2001-10-31 2004-04-20 Quest Diagnostics Investment Incorporated Chemiluminescent compounds and use thereof
DE102005020384A1 (de) * 2005-05-02 2006-11-09 Therainvention Gmbh Spektroskopisches Verfahren zum Nachweis von Analyten

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082636A1 (de) * 1981-12-11 1983-06-29 The Welsh National School of Medicine Lumineszierende Markierungssubstanzen und -verfahren
EP0216553A2 (de) * 1985-09-06 1987-04-01 Integrated Genetics, Inc. Herstellung von Acridinestern und von Acridiniumestern
US4687747A (en) * 1984-07-02 1987-08-18 Mallinckrodt, Inc. Phenanthridinium ester as a labelling compound in luminometric immunoassay

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
DE3645292C2 (de) * 1986-08-22 1997-12-11 Hoechst Ag Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
ES2063735T3 (es) * 1986-10-22 1995-01-16 Abbott Lab Sales de acridinio quimioluminiscentes.
EP0638807B1 (de) * 1987-09-21 2002-07-17 Gen-Probe Incorporated Schutztest
NL8703075A (nl) † 1987-12-18 1989-07-17 Nederlanden Staat Acridiniumverbindingen als chemiluminescentie-merkstof.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082636A1 (de) * 1981-12-11 1983-06-29 The Welsh National School of Medicine Lumineszierende Markierungssubstanzen und -verfahren
US4687747A (en) * 1984-07-02 1987-08-18 Mallinckrodt, Inc. Phenanthridinium ester as a labelling compound in luminometric immunoassay
EP0216553A2 (de) * 1985-09-06 1987-04-01 Integrated Genetics, Inc. Herstellung von Acridinestern und von Acridiniumestern

Also Published As

Publication number Publication date
IE61614B1 (en) 1994-11-16
DE3856597D1 (de) 2009-04-30
EP0322926A2 (de) 1989-07-05
ES2134185T5 (es) 2004-11-01
IL88848A0 (en) 1989-07-31
ES2134185T3 (es) 1999-10-01
GB9203180D0 (en) 1992-04-01
DE3856358T3 (de) 2004-12-30
AU635890B2 (en) 1993-04-08
DE3856358D1 (de) 1999-09-16
WO1989006231A1 (en) 1989-07-13
ATE425970T1 (de) 2009-04-15
IL88848A (en) 1994-02-27
IE883895L (en) 1989-06-30
GB9014479D0 (en) 1990-10-03
DE3856358T2 (de) 2000-04-20
EP0322926B2 (de) 2004-03-31
EP0322926A3 (de) 1991-03-20
JP3172522B2 (ja) 2001-06-04
ATE183311T1 (de) 1999-08-15
GB9203181D0 (en) 1992-04-01
GB2232995B (en) 1992-10-14
EP0322926B1 (de) 1999-08-11
GB2252161A (en) 1992-07-29
GB2252162A (en) 1992-07-29
EP0916658A1 (de) 1999-05-19
EP0916658B1 (de) 2009-03-18
AU2927089A (en) 1989-08-01
GR3031647T3 (en) 2000-02-29
GB2251942A (en) 1992-07-22
JPH03501772A (ja) 1991-04-18
GB9203179D0 (en) 1992-04-01
KR900700888A (ko) 1990-08-17
GB2232995A (en) 1991-01-02
CA1341613C (en) 2011-05-10
NZ227506A (en) 1992-06-25

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OP8 Request for examination as to paragraph 44 patent law
8139 Disposal/non-payment of the annual fee