KR890005087A - 4- 피페리딘 카르복사미드 유도체 - Google Patents

4- 피페리딘 카르복사미드 유도체 Download PDF

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Publication number
KR890005087A
KR890005087A KR1019880012054A KR880012054A KR890005087A KR 890005087 A KR890005087 A KR 890005087A KR 1019880012054 A KR1019880012054 A KR 1019880012054A KR 880012054 A KR880012054 A KR 880012054A KR 890005087 A KR890005087 A KR 890005087A
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South Korea
Prior art keywords
group
hydrogen atom
cyclohexanespiro
integer
carbon atoms
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KR1019880012054A
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English (en)
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KR970011295B1 (ko
Inventor
구니히로 니노미야
겐이찌 사이또
스지 모리따
아끼히로 도베
이세이 니다
Original Assignee
시바따 마쓰지로
미쓰비시 가세이 가부시끼 가이샤
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Publication of KR890005087A publication Critical patent/KR890005087A/ko
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Publication of KR970011295B1 publication Critical patent/KR970011295B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

4-피페리딘 카르복사미드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식(Ⅰ)으로 표시되는 4-피페리딘카르복사미드 유도체:
    상기식에서, R1및 R2각각은 수소원자이고, 또는 R1이 R2와 합쳐져서 시클로페나스피로기 또는 시콜로헥산스피로기이고 ; R3은 수소원자, 1내지 4개 탄소원자를 갖는 알킬기, 아르알킬기 또는 인돌릴알킬기이며; 또는 n이 1 또는 2의 정수임.
  2. 제 1 항에 있어서, 일반식(Ⅰ)내의 R3가 수소원자, 메틸기, 이소프로필기, 벤질기 또는 인돌-3-일-메틸기인 화합물.
  3. 유효성분으로 하기 일반식(Ⅰ)으로 표시되는 4-피페리딘카르복사미드 유도체를 적어도 1개 포함하는 손상된 뇌기능 개선제로 유용한 약제 조성물 :
    상기식에서,R1및R2는 가가 수소원자이고, 도는 R1이R2와 합쳐져서 시클로펜탄스피로기 또는 시클로헥산스피로기이고 ; R3은 수소원자, 1내지 4개 탄소원자를 알킬기,아르알킬기 또는 인돌릴알킬기이며 ; 또 n이 1 또는 2의 정수임.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880012054A 1987-09-16 1988-09-16 4-피페리딘 카르복사 미드 유도체 KR970011295B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-231591 1987-09-16
JP62231591A JPH0696574B2 (ja) 1987-09-16 1987-09-16 ４−ピペリジンカルボキサミド誘導体
JP231591/87 1987-09-16

Publications (2)

Publication Number Publication Date
KR890005087A true KR890005087A (ko) 1989-05-11
KR970011295B1 KR970011295B1 (ko) 1997-07-09

Family

ID=16925916

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880012054A KR970011295B1 (ko) 1987-09-16 1988-09-16 4-피페리딘 카르복사 미드 유도체

Country Status (8)

Country Link
US (1) US4883802A (ko)
EP (1) EP0308319B1 (ko)
JP (1) JPH0696574B2 (ko)
KR (1) KR970011295B1 (ko)
AT (1) ATE86629T1 (ko)
CA (1) CA1315473C (ko)
DE (1) DE3879058T2 (ko)
HU (1) HU199830B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100957147B1 (ko) 2007-12-07 2010-05-11 현대자동차주식회사 차량의 소음기 및 이를 사용한 배기 장치
DE102016103196A1 (de) 2015-07-22 2017-01-26 Fischerwerke Gmbh & Co. Kg Befestigungsanordnung und Spreizanker

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE864269A (fr) * 1977-03-03 1978-06-16 Parke Davis & Co Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
FI840260A (fi) * 1983-01-27 1984-07-28 Ciba Geigy Ag Pyrrolidinonderivat och foerfarande foer deras framstaellning.
GB8332704D0 (en) * 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals

Also Published As

Publication number Publication date
ATE86629T1 (de) 1993-03-15
EP0308319A3 (en) 1990-07-04
US4883802A (en) 1989-11-28
JPH0696574B2 (ja) 1994-11-30
CA1315473C (en) 1993-03-30
EP0308319B1 (en) 1993-03-10
EP0308319A2 (en) 1989-03-22
DE3879058D1 (de) 1993-04-15
KR970011295B1 (ko) 1997-07-09
HUT47929A (en) 1989-04-28
HU199830B (en) 1990-03-28
DE3879058T2 (de) 1993-06-24
JPS6475483A (en) 1989-03-22

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