DE69330130T2 - Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen - Google Patents

Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen

Info

Publication number
DE69330130T2
DE69330130T2 DE69330130T DE69330130T DE69330130T2 DE 69330130 T2 DE69330130 T2 DE 69330130T2 DE 69330130 T DE69330130 T DE 69330130T DE 69330130 T DE69330130 T DE 69330130T DE 69330130 T2 DE69330130 T2 DE 69330130T2
Authority
DE
Germany
Prior art keywords
dihydropyridines
nitrophenyl
dihydro
dimethyl
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69330130T
Other languages
English (en)
Other versions
DE69330130D1 (de
Inventor
Kunio Isshiki
Takashi Nakashima
Takeo Yoshioka
Hiroshi Tsunekawa
Takashi Adachi
Tomomi Ota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mercian Corp
Original Assignee
Mercian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercian Corp filed Critical Mercian Corp
Publication of DE69330130D1 publication Critical patent/DE69330130D1/de
Application granted granted Critical
Publication of DE69330130T2 publication Critical patent/DE69330130T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69330130T 1992-08-31 1993-08-31 Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen Expired - Fee Related DE69330130T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23187792 1992-08-31
PCT/JP1993/001222 WO1994005637A1 (en) 1992-08-31 1993-08-31 Optically active 1,4-dihydropyridine compound and process for producing the same

Publications (2)

Publication Number Publication Date
DE69330130D1 DE69330130D1 (de) 2001-05-17
DE69330130T2 true DE69330130T2 (de) 2001-08-02

Family

ID=16930427

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330130T Expired - Fee Related DE69330130T2 (de) 1992-08-31 1993-08-31 Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen

Country Status (8)

Country Link
US (1) US5635395A (de)
EP (1) EP0657429B1 (de)
KR (1) KR100244728B1 (de)
AT (1) ATE200484T1 (de)
AU (1) AU4981893A (de)
CA (1) CA2143106A1 (de)
DE (1) DE69330130T2 (de)
WO (1) WO1994005637A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006829A1 (fr) * 1994-08-29 1996-03-07 Mercian Corporation Derive de 1,4-dihydropyrydine
US6143541A (en) * 1995-07-31 2000-11-07 Mercian Corporation Gene encoding a protein having symmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives and its expression product
EP0985667A4 (de) * 1997-04-25 2000-03-22 Ajinomoto Kk Neue dihydropyridin-derivate
US6145143A (en) * 1999-06-03 2000-11-14 Kinetic Concepts, Inc. Patient support systems with layered fluid support mediums

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法
US5234821A (en) * 1990-09-01 1993-08-10 Kazuo Achiwa Process for preparing 1,4 dihydropyridine compounds
US5100892A (en) * 1990-11-13 1992-03-31 Glaxo Inc. Dihydropyridine vasodilator agents
JPH0584089A (ja) * 1991-03-01 1993-04-06 Taisho Pharmaceut Co Ltd 光学活性１，４−ジヒドロピリジン化合物の製造法
JPH04299994A (ja) * 1991-03-26 1992-10-23 Taisho Pharmaceut Co Ltd 光学活性１，４−ジヒドロピリジン化合物の製造法
JP3286645B2 (ja) * 1993-03-26 2002-05-27 メルシャン株式会社 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法

Also Published As

Publication number Publication date
KR100244728B1 (ko) 2000-03-02
WO1994005637A1 (en) 1994-03-17
AU4981893A (en) 1994-03-29
DE69330130D1 (de) 2001-05-17
ATE200484T1 (de) 2001-04-15
CA2143106A1 (en) 1994-03-17
EP0657429B1 (de) 2001-04-11
EP0657429A4 (de) 1996-03-27
EP0657429A1 (de) 1995-06-14
US5635395A (en) 1997-06-03
KR950702963A (ko) 1995-08-23

Similar Documents

Publication Publication Date Title
DE69226822T2 (de) Diastereomeres Salz von optisch aktiver Chinolinmevalonsäure
NO303574B1 (no) Ny fremgangsmÕte for fremstilling av 9-amino-6-demetyl-6-deoksytetracykliner
UA6344A1 (uk) Спосіб одержання бензолсульфонатної солі 3-етіл-5метілового ефіру 2-(2-аміноетоксіметіл)-4-(2-хлорфеніл)-6-метіл-1,4-дігідропірідін-3,5-дікарбонової кислоти
DE69712784T2 (de) Säureadditionssalze einer optisch aktiven piperidinverbindung und verfahren zu seiner herstellung
ATE150456T1 (de) Verfahren zur herstellung von an 4-position substituierten 1,4-dihydropyridinen
ATE137266T1 (de) Verfahren zur herstellung von n-substituiertem 1- deoxynojirimycin
DE69525950D1 (de) Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen
ATE201025T1 (de) Verfahren zur herstellung von cephalosporinen und zwischenprodukte in diesem verfahren
DE3765157D1 (de) Verfahren zur herstellung von macrolid-derivaten.
MXPA04004063A (es) Procedimientos para elaboracion de 3-hidroxi-n, 1, 6-trialquil-4 -oxo-1 ,4-dihidropiridin-2 -carboxamida.
DE69330130D1 (de) Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen
ATE136541T1 (de) Herstellung substituierter tetrahydropyridine
DK0388188T3 (da) Benzoxepinderivater
ATE182140T1 (de) Optisch aktive 1,4-dihydropyridinderivate sowie verfahren zu ihrer herstellung
DE3673064D1 (de) Verfahren zur herstellung von 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarbonsaeure-3 beta-(n-benzyl-n-methylamino)-ethylester-5-methylester und dessen hydrochlorid-salz.
HU911039D0 (en) Process for the production of hydroxymethyl-indolizidine and kynolizidine derivatives
ATE233267T1 (de) Verfahren zur herstellung von 3- vinylcephalosporinen
DE59306506D1 (de) 4-Heterocyclyl substituierte Dihydropyridine
DE68919531D1 (de) Verfahren zur Herstellung von 5-Amino-7(substituierte amino)-chinolin-3-carbonsäure.
ATE311382T1 (de) Verfahren zur herstellung von 2-carbamoyl- pyridinen
ATE122340T1 (de) Verfahren zur herstellung von (-)2-(2-(2- aminoethoxy)ethoxy)methyl)-4-(2,3-dichlorphenyl - 3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4 dihydropyridin, und zwischenprodukt zu dessen herstellung.
MX9504954A (es) Nuevo procedimiento altamente selectivo para la fabricacion de derivados del acido 1,4-dihidropiridin-3,5-dicarboxilico, sustituidos por fenilo, de enantiomeros puros.
DE69608698D1 (de) Verfahren zur herstellung von optisch aktiven carbonsäuren
ATE144285T1 (de) Mikrobiologisches verfahren zur herstellung von 5-hydroxy-2-pyrazincarbonsäure
DE69021518D1 (de) 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-nitropyridin-3-carbonsäure-1-azabicyclo[2.2.2]oct-3-ylester-Isomere.

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee