KR930700106A - 혈전증 치료제 및 포스포 디에스테라제 저해제 - Google Patents
혈전증 치료제 및 포스포 디에스테라제 저해제Info
- Publication number
- KR930700106A KR930700106A KR1019920703088A KR920703088A KR930700106A KR 930700106 A KR930700106 A KR 930700106A KR 1019920703088 A KR1019920703088 A KR 1019920703088A KR 920703088 A KR920703088 A KR 920703088A KR 930700106 A KR930700106 A KR 930700106A
- Authority
- KR
- South Korea
- Prior art keywords
- carbostyryl
- amino
- derivative
- hydroxy propoxy
- carbostyryl derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (15)
- 일반식[식중, R1은 수소원자 또는 치환기로서 수산기를 갖을수 있는 저급 알킬기를 나타낸다. R2는 페닐고리상에 치환기로서 저급 알콕시기 및 할로겐 원자로된 군에서 선택된 기를 1-3개 갖을수 있는 페닐 저급 알킬기, 피리딜 저급 알킬기 또는 -A-NR3R4(여기서, A는 저급알킬렌기, R3및 R4는 동일하거나 다를수 있으며 각각 저급알킬기 또는 페닐기임)을 나타낸다.]로 표시되는 카르보스티릴 유도체 및 그 염으로된 군에서 선택된 적어도 1종을 함유하는 혈전증 치료제.
- 제1항에 있어서의 카르보스티릴 유도체 및 그 염의 적어도 1종을 함유하는 혈소판 응집억제제.
- 제1항에 있어서의 카르보스티릴 유도체 및 그 염의 적어도 1종을 함유하는 포스포 디에스테라제 저해제.
- 제1항에 있어서의 카르보스티릴 유도체 및 그 염의 적어도 1종을 함유하는 뇌순환 개선제.
- 제1항에 있어서의 카르보스티릴 유도체 및 그 염의 적어도 1종을 함유하는 혈소판 덩어리 해리제.
- 제1항에 있어서, 카르보스티릴 유도체가 6-[3-(3-메톡시벤질)아미노-2-히드록시 프로폭시]카르보 스티릴인 혈전증 치료제.
- 제1항에 있어서, 카르보스티릴 유도체가 6-[3-(3,4-디메톡시 벤질)아미노-2-히드록시 프로폭시]카르보스티릴인 혈전증 치료제.
- 제3항에 있어서, 카르보스티릴 유도체가 6-[3(3-메톡시벤질)아미노-2-히드록시 프로폭시]카르보스티릴인 포스포 디에스테라제 저해제.
- 제3항에 있어서, 카르보스티릴 유도체가 6-[3-(3,4-디메톡시벤질)아미노-2-히드록시 프로폭시]카르보스티릴인 포스포 디에스테라제 저해제.
- 제2항에 있어서, 카르보스티릴 유도체가 6-[3-(3-메톡시벤질)아미노-2-히드록시 프로폭시]카르보티릴인 혈소판 응집억제제.
- 제2항에 있어서, 카르보스티릴 유도체가 6-[3-(3,4-디메톡시벤질)아미노-2-히드록시 프로폭시]카르보스티릴인 혈소판 응집억제제.
- 제4항에 있어서, 카르보스티릴 유도체가 6-[3-(3-메톡시벤질)아미노-2-히드록시 프로폭시]카르보티릴인 뇌순환 개선제.
- 제4항에 있어서, 카르보스티릴 유도체가 6-[3-(3,4-디메톡시벤질)아미노-2-히드록시 프로폭시]카르보스티릴인 뇌순환 개선제.
- 제5항에 있어서, 카르보스티릴 유도체가 6-[3-(3-메톡시벤질)아미노-2-히드록시 프로폭시]카르보스티릴인 혈소판 덩어리 해리제.
- 제5항에 있어서, 카르보스티릴 유도체가 6-[3-(3,4-디메톡시벤질)아미노-2-히드록시 프로폭시]카르보스티릴인 혈소판 덩어리 해리제.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7022391 | 1991-04-03 | ||
JP91-70223 | 1991-04-03 | ||
JP92-21137 | 1992-02-06 | ||
JP2113792 | 1992-02-06 | ||
PCT/JP1992/000368 WO1992017178A1 (en) | 1991-04-03 | 1992-03-26 | Remedy for thrombosis and phosphodiesterase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
KR930700106A true KR930700106A (ko) | 1993-03-13 |
Family
ID=26358162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920703088A KR930700106A (ko) | 1991-04-03 | 1992-03-26 | 혈전증 치료제 및 포스포 디에스테라제 저해제 |
Country Status (8)
Country | Link |
---|---|
US (2) | US5401754A (ko) |
EP (2) | EP0531548B1 (ko) |
JP (1) | JPH05279256A (ko) |
KR (1) | KR930700106A (ko) |
DE (2) | DE69205106T2 (ko) |
DK (1) | DK0531548T3 (ko) |
TW (1) | TW201305B (ko) |
WO (1) | WO1992017178A1 (ko) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2121148A1 (en) * | 1992-08-19 | 1994-03-03 | Satoru Nakai | Apoptosis regulator |
US5654317A (en) * | 1992-09-18 | 1997-08-05 | Otsuka Pharmaceutical Company, Limited | Antiarrhythmic agent |
KR19980701286A (ko) * | 1995-01-09 | 1998-05-15 | 오스카 아키히코 | Tnf-알파 억제제 |
US7018627B1 (en) | 1995-06-07 | 2006-03-28 | Icos Corporation | Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof |
US5958982A (en) * | 1998-04-17 | 1999-09-28 | Cell Pathways, Inc. | Method for treating patients with sarcoidosis by administering substituted sulfonyl indenyl acetic acids, esters and alcohols |
US5902827A (en) * | 1998-04-17 | 1999-05-11 | Cell Pathways | Method for treating patients with psoriasis by administering substituted sulfonyl indenyl acetic acids, esters and alcohols |
US6025394A (en) * | 1999-01-29 | 2000-02-15 | Cell Pathways, Inc. | Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols |
US6531603B1 (en) | 2001-06-29 | 2003-03-11 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6388080B1 (en) | 2001-06-29 | 2002-05-14 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6660864B2 (en) | 2001-06-29 | 2003-12-09 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6573382B2 (en) | 2001-06-29 | 2003-06-03 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6657061B2 (en) | 2001-06-29 | 2003-12-02 | Grayson Walker Stowell | Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6596871B2 (en) | 2001-06-29 | 2003-07-22 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
TW200402402A (en) * | 2002-06-05 | 2004-02-16 | Komuro Toshio | Antithrombogenic platiniferous ceramic composition and article containing the same |
JP2006513222A (ja) * | 2002-12-23 | 2006-04-20 | アルテシアン セラピューティック,インコーポレイティド | アドレナリン性β受容体およびホスホジエステラーゼに対する抑制活性を有する強心性化合物 |
US20050113314A1 (en) * | 2003-08-29 | 2005-05-26 | Fong Benson M. | Cicletanine in combination with oral antidiabetic and/or blood lipid-lowering agents as a combination therapy for diabetes and metabolic syndrome |
WO2005009446A1 (en) * | 2003-07-17 | 2005-02-03 | Cotherix, Inc. | Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome |
US20060089374A1 (en) * | 2003-07-17 | 2006-04-27 | Glenn Cornett | Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease |
US20050130971A1 (en) * | 2003-08-22 | 2005-06-16 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury |
US20060154959A1 (en) * | 2005-01-13 | 2006-07-13 | Navitas Pharma | Combination therapies of cicletanine and carvedilol |
US20080096915A1 (en) * | 2005-01-13 | 2008-04-24 | Greenberg Traurig LLP | Compositions for the treatment of metabolic disorders |
US20070141174A1 (en) * | 2005-01-13 | 2007-06-21 | Navitas Pharma, Inc. | Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension |
US20070105817A1 (en) * | 2005-11-09 | 2007-05-10 | Jim Page | Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension |
JP2010514841A (ja) * | 2007-01-03 | 2010-05-06 | グレン ブイ. コルネット, | 肺疾患および心疾患の処置におけるシクレタニンおよびpkc阻害剤 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4951271A (ko) * | 1972-09-28 | 1974-05-18 | ||
JPS5082218A (ko) * | 1973-11-10 | 1975-07-03 | ||
JPS5310989B2 (ko) * | 1974-04-25 | 1978-04-18 | ||
JPS5936617B2 (ja) * | 1976-03-05 | 1984-09-05 | 大塚製薬株式会社 | カルボスチリル誘導体 |
JPS6059912B2 (ja) * | 1978-02-28 | 1985-12-27 | 大塚製薬株式会社 | カルボスチリル誘導体 |
IE46852B1 (en) * | 1977-06-10 | 1983-10-05 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives |
JPS5430184A (en) * | 1977-08-10 | 1979-03-06 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril derivative |
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
DK36980A (da) * | 1979-01-30 | 1980-07-31 | Otsuka Pharma Co Ltd | Fremgangsmaade til bestemmelse af tumorforbundet glycobindingsholdigt stof og diagnosticering af cancer |
JPS55129268A (en) * | 1979-03-28 | 1980-10-06 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS5646812A (en) * | 1979-09-27 | 1981-04-28 | Otsuka Pharmaceut Co Ltd | Central nervous system depressant |
JPS568319A (en) * | 1980-03-26 | 1981-01-28 | Otsuka Pharmaceut Co Ltd | Antihistamine |
JPS572274A (en) * | 1980-06-06 | 1982-01-07 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS5714574A (en) * | 1980-06-27 | 1982-01-25 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS5780322A (en) * | 1980-11-05 | 1982-05-19 | Otsuka Pharmaceut Co Ltd | Cardiotonic agent |
JPS5793962A (en) * | 1980-12-01 | 1982-06-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
EP0355583B1 (en) * | 1988-08-10 | 1995-01-25 | Otsuka Pharmaceutical Co., Ltd. | Cardiotonics |
-
1992
- 1992-03-25 TW TW081102261A patent/TW201305B/zh active
- 1992-03-26 DE DE69205106T patent/DE69205106T2/de not_active Expired - Fee Related
- 1992-03-26 KR KR1019920703088A patent/KR930700106A/ko not_active Application Discontinuation
- 1992-03-26 DK DK92907618.0T patent/DK0531548T3/da active
- 1992-03-26 WO PCT/JP1992/000368 patent/WO1992017178A1/ja active IP Right Grant
- 1992-03-26 DE DE69233356T patent/DE69233356D1/de not_active Expired - Lifetime
- 1992-03-26 EP EP92907618A patent/EP0531548B1/en not_active Expired - Lifetime
- 1992-03-26 EP EP94115420A patent/EP0647447B1/en not_active Expired - Lifetime
- 1992-04-03 JP JP4081948A patent/JPH05279256A/ja active Pending
-
1994
- 1994-03-11 US US08/208,803 patent/US5401754A/en not_active Expired - Fee Related
- 1994-12-02 US US08/352,835 patent/US5532253A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
TW201305B (ko) | 1993-03-01 |
DE69205106D1 (de) | 1995-11-02 |
US5401754A (en) | 1995-03-28 |
DE69233356D1 (de) | 2004-07-01 |
EP0647447B1 (en) | 2004-05-26 |
WO1992017178A1 (en) | 1992-10-15 |
JPH05279256A (ja) | 1993-10-26 |
EP0647447A1 (en) | 1995-04-12 |
EP0531548A1 (en) | 1993-03-17 |
US5532253A (en) | 1996-07-02 |
EP0531548B1 (en) | 1995-09-27 |
EP0531548A4 (en) | 1993-12-08 |
DK0531548T3 (da) | 1995-11-27 |
DE69205106T2 (de) | 1996-02-29 |
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