JPS572274A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS572274A
JPS572274A JP7703980A JP7703980A JPS572274A JP S572274 A JPS572274 A JP S572274A JP 7703980 A JP7703980 A JP 7703980A JP 7703980 A JP7703980 A JP 7703980A JP S572274 A JPS572274 A JP S572274A
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound
agent
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7703980A
Other languages
Japanese (ja)
Other versions
JPH0135827B2 (en
Inventor
Takao Nishi
Tatsuyoshi Tanaka
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP7703980A priority Critical patent/JPS572274A/en
Publication of JPS572274A publication Critical patent/JPS572274A/en
Publication of JPH0135827B2 publication Critical patent/JPH0135827B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B37/00—Manufacture or treatment of flakes, fibres, or filaments from softened glass, minerals, or slags
    • C03B37/005—Manufacture of flakes

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A carbostyril derivative of formula I [R is H or group of formula II [A is alkylene; R<3> is alkyl, etc.; R<4> is alkyl, cycloalkyl, phenyl, etc.; R<3> and R<4> may together with the N atom to which they are attached form group of formula III (R<5> is phenyl, etc.; B is methine or N)]; R<1> is H, alkyl alkenyl, or phenylalkyl; R<2> is H, alkyl, or group of formula II; the bond between the 3- and 4-carbon atoms in the carbostyril skeleton is single or double bond]. EXAMPLE:6-[ 3-[ N-( 2-hydroxyethyl )-N-cyclohexylaminocarbonyl ]propoxy ]-3,4- dihydrocarbostyril. USE:Preventive and remedy for thrombosis such as cerebral apoplexy, cerebral infarction, cardiac infarction, etc. Cerebral circulation improving agent. Antiphlogistic agent. Anti-asthmatic agent. Cardiac stimmulant. Hypotensor. Phosphodiesterease inhibiting agent. The compound has prolonged activity and low toxicity. PROCESS:The compound of formula V which is one of the compounds of formula I is prepared, e.g. by reacting a compound of formula IV (R<2>' is H or alkyl) with an amine of formula NH(R3)R4.
JP7703980A 1980-06-06 1980-06-06 Carbostyril derivative Granted JPS572274A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7703980A JPS572274A (en) 1980-06-06 1980-06-06 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7703980A JPS572274A (en) 1980-06-06 1980-06-06 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS572274A true JPS572274A (en) 1982-01-07
JPH0135827B2 JPH0135827B2 (en) 1989-07-27

Family

ID=13622620

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7703980A Granted JPS572274A (en) 1980-06-06 1980-06-06 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS572274A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57175168A (en) * 1981-04-17 1982-10-28 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPH01148369A (en) * 1987-12-04 1989-06-09 Kobe Steel Ltd Surface treatment of galvanized steel sheet
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JPH0361191U (en) * 1989-06-02 1991-06-14
WO1992017178A1 (en) * 1991-04-03 1992-10-15 Otsuka Pharmaceutical Company, Limited Remedy for thrombosis and phosphodiesterase inhibitor
WO1993004042A1 (en) * 1991-08-23 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor
WO1996021447A1 (en) * 1995-01-09 1996-07-18 Otsuka Pharmaceutical Company, Limited Use of carbostyril compounds for inhibition of tnf-alpha

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2021117618A1 (en) 2019-12-10 2021-06-17

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6334845A (en) * 1986-07-28 1988-02-15 Mitsubishi Electric Corp Incandescent lamp type fluorescent lamp

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6334845A (en) * 1986-07-28 1988-02-15 Mitsubishi Electric Corp Incandescent lamp type fluorescent lamp

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57175168A (en) * 1981-04-17 1982-10-28 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPH01148369A (en) * 1987-12-04 1989-06-09 Kobe Steel Ltd Surface treatment of galvanized steel sheet
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JPH0249768A (en) * 1988-05-02 1990-02-20 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPH0361191U (en) * 1989-06-02 1991-06-14
WO1992017178A1 (en) * 1991-04-03 1992-10-15 Otsuka Pharmaceutical Company, Limited Remedy for thrombosis and phosphodiesterase inhibitor
EP0531548A1 (en) * 1991-04-03 1993-03-17 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as anti-thrombotic agents
EP0531548B1 (en) * 1991-04-03 1995-09-27 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as anti-thrombotic agents
WO1993004042A1 (en) * 1991-08-23 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor
US5506239A (en) * 1991-08-23 1996-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent
US5658926A (en) * 1991-08-23 1997-08-19 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent
WO1996021447A1 (en) * 1995-01-09 1996-07-18 Otsuka Pharmaceutical Company, Limited Use of carbostyril compounds for inhibition of tnf-alpha

Also Published As

Publication number Publication date
JPH0135827B2 (en) 1989-07-27

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