KR950704252A - N-치환 이미다졸 유도체 - Google Patents

N-치환 이미다졸 유도체

Info

Publication number
KR950704252A
KR950704252A KR1019950702463A KR19950702463A KR950704252A KR 950704252 A KR950704252 A KR 950704252A KR 1019950702463 A KR1019950702463 A KR 1019950702463A KR 19950702463 A KR19950702463 A KR 19950702463A KR 950704252 A KR950704252 A KR 950704252A
Authority
KR
South Korea
Prior art keywords
group
substituted
halogen atom
carbon atoms
phenyl
Prior art date
Application number
KR1019950702463A
Other languages
English (en)
Inventor
도모유키 이케모토
아키요 호리구치
유타카 가와시마
가츠오 하타야마
Original Assignee
우에하라 아키라
다이쇼 세야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우에하라 아키라, 다이쇼 세야쿠 가부시키가이샤 filed Critical 우에하라 아키라
Publication of KR950704252A publication Critical patent/KR950704252A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

목적 :
α1―아드레날린 수용체를 차단함으로서 강압작용 및 배뇨장해 개선 작용을 갖는 화합무을 제공하는 것.
구성 :
하기 식
(식중, R1은 알킬기, 페닐기 또는 할로겐원자, 알킬기 또는 알콕시기로 치환된 페닐기를 나타내며; R2는 페닐기, 할로겐 원자, 알킬기, 알콕시기 및 피페리디노기로부터 선택된 기 중 1개 또는 2개로 치환된 페닐기, 2―피리딜기 또는 할로겐원자, 알킬기 및 알콕시기로부터 선택된 기 중 1개 또는 2개로 치환된 2―피리딜기를 나타내고, n은 2∼5의 정수를 나타낸다)로 표시되는 N―치환 인돌 유도체 및 산부가염.

Description

N―치환 이미다졸 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 식
    (식중, R1은 탄소원자수 1∼8개의 알킬기, 페닐기 또는 「할로겐 원자, 탄소원자수 1∼4개의 알킬기 또는 탄소원자수 1∼4개의 알콕시기」로 치환된 페닐기를 나타내며; R2는 페닐기, 「할로겐 원자, 탄소원자수 1∼4개의 알킬기, 탄소원자수 1∼4개의 알콕시기 및 피페리디노기」로부터 선택된 기 중 1개 또는 2개로 치환된 페닐기, 2―피리딜기 또는 「할로겐원자, 탄소원자수 1∼4개의 알킬기 및 탄소원자수 1∼4개의 알콕시기」로부터 선택된 기 중1개 또는 2개로 치환된 2―피리딜기를 나타내고; n은 2∼5의 정수를 나타낸다)로 표시되는 N―치환 인돌유도체 및 산부가염.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019950702463A 1992-12-21 1993-12-21 N-치환 이미다졸 유도체 KR950704252A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP34044892 1992-12-21
JP340448/1992 1992-12-21
JP4492793 1993-03-05
JP44927/1993 1993-03-05
PCT/JP1993/001845 WO1994014769A1 (en) 1992-12-21 1993-12-21 N-substituted indole derivative

Publications (1)

Publication Number Publication Date
KR950704252A true KR950704252A (ko) 1995-11-17

Family

ID=26384893

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950702463A KR950704252A (ko) 1992-12-21 1993-12-21 N-치환 이미다졸 유도체

Country Status (5)

Country Link
EP (1) EP0675109A1 (ko)
KR (1) KR950704252A (ko)
AU (1) AU5715494A (ko)
CA (1) CA2152160A1 (ko)
WO (1) WO1994014769A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760040A (en) * 1994-03-30 1998-06-02 Zeria Pharmaceutical Co., Ltd. Indole derivative for treating overproduction of dihydrotestosterone
WO1999057131A1 (en) 1998-05-06 1999-11-11 Duke University Method of treating bladder and lower urinary tract syndromes
US6133453A (en) * 1998-05-15 2000-10-17 Pharm-Eco Laboratories, Inc. Method for making substituted indoles
FR2793793B1 (fr) * 1999-05-19 2004-02-27 Adir Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2827287B1 (fr) * 2001-07-13 2003-10-31 Servier Lab Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2015090235A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62258369A (ja) * 1986-05-02 1987-11-10 Nippon Soda Co Ltd キナゾリノン誘導体及びその製造方法
US4980365A (en) * 1987-07-13 1990-12-25 Hoechst-Roussel Pharmaceuticals Inc. N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds

Also Published As

Publication number Publication date
AU5715494A (en) 1994-07-19
WO1994014769A1 (en) 1994-07-07
CA2152160A1 (en) 1994-07-07
EP0675109A1 (en) 1995-10-04

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